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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-Bo Tan Wen-Bo Liu shuo guo Li-Mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are unknown.AIM To investigate the role and mechanism of CALD1 in GC progression,invasion,and migration.METHODS In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by experiments.CALD1-siRNA was synthesized and used to trans-fect GC cells.Cell activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of GC.The prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and evaluated.The experimental results were consistent with the results of the bioinformatics analysis.The expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 cells.Cell activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 cells.The ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was altered.According to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely related to the PI3K-Akt signaling pathway.Experimen

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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Single-shot non-line-of-sight imaging based on chromato-axial differential correlography

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Photonics Research 2024年第1期12卷 106-114页

作者： LINGFENG LIU shuo ZHU WENJUN ZHANG LIANFA BAI ENLAI guo JING HAN Jiangsu Key Laboratory of Spectral Imaging and Intelligent Sense Nanjing University of Science and TechnologyNanjing 210094China

Non-line-of-sight(NLOS)imaging is a challenging task aimed at reconstructing objects outside the direct view of the observer.Nevertheless,traditional NLOS imaging methods typically rely on intricate and costly equipment to scan and sample the hidden object.These methods often suffer from restricted imaging resolution and require high system stability.Herein,we propose a single-shot high-resolution NLOS imaging method via chromato-axial differential correlography,which adopts low-cost continuous-wave lasers and a conventional camera.By leveraging the uncorrelated laser speckle patterns along the chromato-axis,this method can reconstruct hidden objects of diverse complexity using only one exposure measurement.The achieved background stability through singleshot acquisition,along with the inherent information redundancy in the chromato-axial differential speckles,enhances the robustness of the system against vibration and colored stain interference.This approach overcomes the limitations of conventional methods by simplifying the sampling process,improving system stability,and achieving enhanced imaging resolution using available equipment.This work serves as a valuable reference for the real-time development and practical implementation of NLOS imaging.

关键词： axial speckle overcome

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The coordinated evolution of ecological environment,public service,and tourism economy along the Silk Road Economic Belt,using the Dual-Carbon Targets

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 34-47页

作者： shuo Yang Wei guo Tianjun Xu Tongtong Liu School of Economic and Management Yanshan UniversityQinhuangdao 066004China Regional Economic Development Center Yanshan UniversityQinhuangdao 066004China

Carbon peak and carbon neutrality(dual-carbon)are important targets for the international response to climate change.The Silk Road Economic Belt is a strategic resource region and is important for future ecological environment and tourism development.Based on the“dual-carbon”targets,the Single index quantification,Multiple index synthesis,and Poly-criteria integration evaluation model were used in this study to measure the coordinated development index of the ecological environment,public service,and tourism economy along the Silk Road Economic Belt and to analyze its spatial and temporal evolution.Further,it explores the dynamic evolution and development trend of the three systems using the Kernel Density and Grey Markov Prediction Model.The results show that the coordinated development index along this region needs to be improved during the study period.Furthermore,the coordinated development index of the Southwest region is relatively higher than that of the Northwest region.From the development trend of the three systems,all of them develop in a stable manner;however,the tourism economy system is easily affected by external disturbances.The coordinated development index of the three systems changes dynamically and tends to be in a good state of coordination.There is a certain spatial and temporal heterogeneity.The gravity center of the coordinated development index has been in the Southwest region.During the forecast period,the coordinated development index along this region will improve significantly,while insufficient and unbalanced development will continue.

关键词： Dual-carbon Ecological environment Public services Tourist economy Silk Road Economic Belt

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Dual-additives enable stable electrode-electrolyte interfaces for long life Li-SPAN batteries

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Chinese Chemical Letters 2024年第5期35卷 459-465页

作者： Zhenqiang guo Huicong Yang Qian Wei Shengjun Xu Guangjian Hu shuo Bai Feng Li School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Biochemistry and Molecular Biology College of Life ScienceChina Medical UniversityShenyang 110122China Dalian National Laboratory for Clean Energy Dalian 116023China Shenyang King Power Technology Co. Ltd.Shenyang 110016China

Sulfurized polyacrylonitrile(SPAN)is proposed as a promising cathode material for lithium sulfur batteries.However,the continuous side reactions at the electrolyte-electrode interfaces as well as the slow redox kinetics of SPAN cathode deteriorate the electrochemical performance.In this study,an electrolyte with dual-additives comprising 2-fluoropyridine(2-FP)and lithium difluorobis(oxalato)phosphate(LiDFBOP)was used to improve the performance of Li||SPAN cells.2-FP has a lower lowest occupied molecular orbital energy than that of the solvents in the electrolyte,leading to its prior reduction.A LiF-rich film can be formed on the electrode,effectively improving the stability of the electrolyte-electrode interfaces and prolonging the life.Simultaneously,LiDFBOP could form an electrolyte-electrode interface film containing a large amount of Li_(x)PO_(y)F_(z) species,compensating for the kinetic deterioration caused by the lower ionic conductive of LiF formed at the electrolyte-electrode interface.Hence,an electrode-interface film with good chemical stability and high Li^(+) transport was established by LiF and Li_(x)PO_(y)F_(z)-rich species.The Li||SPAN cell with the electrolyte containing dual-additives demonstrates an excellent capacity retention of 97.5%after 200 cycles at 1.0 C,25℃,comparing to 56.2%capacity retention without additives.Moreover,the rate capacities of cells with dual-additives can reach 1128.1 mAh/g at 5 C,comparing to only 813.5 mAh/g using electrolyte without additives.Our results shown that the dual-additives in electrolyte provide a promising strategy for practical application of lithium sulfur batteries with SPAN cathodes.

关键词： Sulfurized polyacrylonitrile Lithium metal Interface film 2-Fluoropyridine Difluorobis(oxalato)phosphate

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A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment

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Nano Research 2024年第5期17卷 3942-3949页

作者： Ningning Song Zhanjun guo shuo Wang Yongli Li Yunpeng Liu Meishuai Zou Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large demand.Here,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room temperature.This hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase mimics.Furthermore,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from aluminum.In contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future.

关键词： hydrogenase mimic nanozyme hydrogen evolution reaction aluminum activation water-splitting

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Polysaccharides from Chinese herbal medicine:a review on the hepatoprotective and molecular mechanism

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Chinese Journal of Natural Medicines 2024年第1期22卷 4-14页

作者： LI Jifeng guo Haolin DONG Ying YUAN shuo WEI Xiaotong ZHANG Yuxin DONG Lu WANG Fei BAI Ting YANG Yong Dalian Key Laboratory of Chronic Disease Research Center Dalian UniversityDalian 116622China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China

Polysaccharides,predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum,Angelica sinensis,Astragalus membranaceus,Dendrobium officinale,Ganoderma lucidum,and Poria cocos,represent principal bioactive constituents extensively utilized in Chinese medicine.These compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities,while exhibiting minimal adverse effects.This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides.It underscored the role of these polysaccharides in regulating hepatic function,enhancing immunological responses,and improving antioxidant capacities,thus contributing to the attenuation of hepatocyte apoptosis and liver protection.Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management.Therefore,this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.

关键词： Polysaccharides Hepatoprotective Chinese herbal medicine Mechanism

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Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao Wang Tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-Long Yuan A-Long Cui Wei-Wei guo Yan-Fang Wang Shi-Ming Yang Jian-guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for society.To investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are necessary.Pigs have been extensively used as valuable large animal models in biomedical research.In this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss.Additionally,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL research.Overall,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

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Anti-corrosive and highly reversible zinc metal anode enabled by the phenolic resin coating

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Rare Metals 2024年第5期43卷 2115-2124页

作者： Ya-Ping Wang Ya-Di Yang Shu-Qi Duan Li Wang Jia-shuo guo An-Qiang Pan School of Materials Science and Engineering Hebei University of Technology Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology) Ministry of Education Key Laboratory for New Type of Functional Materials in Hebei Province Hebei University of Technology School of Materials Science and Engineering Central South University

Aqueous zinc-ion batteries have attracted much attention due to their high theoretical capacity,low cost high safety,and eco-friendly.However,challenges such as dendrite growth and side reactions severely hinder the electrochemical performance of the Zn anode,leading to low Coulombic efficiency （CE） or even short circuits Herein,phenolic resin （PF） is used as a protective coating on the surface of the zinc metal electrode.The PF layer can greatly improve the corrosion resistance of the Zn electrode in the electrolyte.Importantly,this artificial electrode/electrolyte interphase also elevates the nucleation barrier and restrains Zn2+2D diffusion,regulating the zinc deposition/dissolution behavior.As a result,PF@Zn symmetric cells exhibit superior performance than that of bare Zn symmetric cells,achieving a stable and dendrite-free cycle of 1400 h.Furthermore,the carbon nanotube MnO2||PF@Zn （CNT/MnO2||PF@Zn） full cell also delivers a long cycle life with a high-capacity retention of about 180.0 m Ah·g-1after 1400 cycles,far exceeding that of bare Zn anode.This work provides a facile strategy for achieving a dendrite-free and rechargeable zinc anode.

关键词： Rechargeable aqueous batteries Zn metal anode Phenolic resin Anti-corrosion

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Experimental Study on Vortex-Induced Vibration of Rough Risers with Coupling Interference Effect Under Side-by-Side Arrangement

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China Ocean Engineering 2024年第1期38卷 18-28页

作者： HU Ze-bo LIU Zhen LI Peng guo Hai-yan WANG Shu-bing REN Xiao-hui HOU Hao WANG Ye-shuo College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China CHEC Dredging Co. LtdShanghai 200136China

A vortex-induced vibration(VIV)experiment of rough risers with coupling interference effect under a side-by-side arrangement was carried out in a wave-current combined flume.The roughness of the riser was characterized by arranging different specifications of surface attachments on the surface of the riser.Rough risers with three different roughnesses were arranged side by side with smooth risers to explore the VIV response of the riser under the combined action of roughness and interference effect,and to reveal the coupling mechanism between roughness and interference effect.The experimental results show that,compared with that of a smooth riser,the VIV of a rough riser under the coupling interference effect has a wider"lock-in"region,and the displacement decreases more significantly at a high reduced velocity,which is more likely to excite higher-order modes and frequency responses.In addition,the displacement response and frequency response of the smooth riser are not significantly affected by wake interference from the rough riser,which is caused by the decrease of the wake region due to the delay of the boundary layer separation point of the rough riser.

关键词： marine riser vortex-induced vibration side-by-side arrangement roughness interference effect

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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 427-442页

作者： shuo Han Tao Wei Sijia Wang Yanlong Zhu Xingtong guo Liang He Xiongzhuang Li Qing Huang Daifen Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas sealing.To solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output voltage.This work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical studies.Finally,the challenges and future development of tubular SIS-SOFCs are also discussed.The findings of this work can help guide the direction and inspire innovation of future development in this field.

关键词： solid oxide fuel cell segmented-in-series tubular experimental study numerical study

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