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Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression

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Bioactive Materials 2022年第4期7卷 443-459页

作者： Junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li Yang Huang ZheXiong Tang shuo meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen Center for Joint Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Blood Transfusion Department Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China Department of Sports Medicine Peking University Shenzhen HospitalPeking UniversityShenzhen518036China Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationLaboratory of Molecular Developmental BiologySchool of Life SciencesSouthwest UniversityChongqing400038China Biomedical Analysis Center Army Medical University(Third Military Medical University)Chongqing400038China Department of Orthopedics Zunyi Traditional Chinese Medicine HospitalZunyi563099China

Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)***,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative *** this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture ***,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in *** addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint *** of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in *** conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL *** findings may provide new insights in MSCs intra-articular injection for OA treatment.

关键词： Tropoelastin Osteoarthritis Infrapatellar fat pad MSCs

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肺动脉栓塞检测的可视中国人蒙特卡罗模拟分析

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中国激光 2022年第24期49卷 53-59页

作者：王敏孟硕郭江辉李婷天津工业大学生命科学学院天津300387 中国医学科学院北京协和医学院生物医学工程研究所天津300192 电子科技大学光电科学与工程学院四川成都611731 北京脑科学与类脑研究中心北京102206

肺动脉数字减影血管造影技术是现阶段临床检测肺动脉栓塞的主要手段,但该技术是一种有创的检查,且易对血管及周围组织造成损伤。在目前的心血管医学研究中,肺动脉栓塞的无创检测具有一定挑战性。本课题组运用蒙特卡罗方法模拟研究了光... 详细信息

肺动脉数字减影血管造影技术是现阶段临床检测肺动脉栓塞的主要手段,但该技术是一种有创的检查,且易对血管及周围组织造成损伤。在目前的心血管医学研究中,肺动脉栓塞的无创检测具有一定挑战性。本课题组运用蒙特卡罗方法模拟研究了光在人体胸部组织中的传输规律,探讨了近红外光谱技术在肺动脉栓塞无创检测中的可能性。结果表明:在2.8~3.1 cm的光源与探测器距离下,检测到信号对肺动脉部位激活的灵敏度可达到0.073%的峰值;不同栓塞水平下的归一化光照强度差异显著,且二者之间呈线性关系(R2=0.998,p<10-5)。这些结果表明,近红外光谱技术在肺动脉栓塞定量检测中具有巨大潜力。本研究为无创光学方法诊断肺动脉栓塞提供了参考。

关键词：医用光学肺动脉栓塞近红外光谱技术蒙特卡罗模拟无创检测

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Ultrahigh thermoelectric properties of p‐type Bi_(x)Sb_(2−x)Te_(3)thin films with exceptional flexibility for wearable energy harvesting

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Carbon Energy 2024年第8期6卷 273-284页

作者： Zhuang‐Hao Zheng Yi‐Ming Zhong Yi‐Liu Li Mohammad Nisar Adil Mansoor Fu Li shuo Chen Guang‐Xing Liang Ping Fan Dongyan Xu meng Wei Yue‐Xing Chen Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina Department of Mechanical and Automation Engineering The Chinese University of Hong KongSha TinChina

Use of a flexible thermoelectric source is a feasible approach to realizing selfpowered wearable electronics and the Internet of *** thin films are promising candidates for fabricating flexible power supply,but obtaining highthermoelectric‐performance thin films remains a big *** the present work,a p‐type Bi_(x)Sb_(2−x)Te_(3)thin film is designed with a high figure of merit of 1.11 at 393 K and exceptional flexibility(less than 5%increase in resistance after 1000 cycles of bending at a radius of∼5 mm).The favorable comprehensive performance of the Bi_(x)Sb_(2−x)Te_(3)flexible thin film is due to its excellent crystallinity,optimized carrier concentration,and low elastic modulus,which have been verified by experiments and theoretical ***,a flexible device is fabricated using the prepared p‐type Bi_(x)Sb_(2−x)Te_(3)and n‐type Ag_(2)Se thin ***,an outstanding power density of∼1028μWcm^(−2)is achieved at a temperature difference of 25 *** work extends a novel concept to the fabrication of highperformance flexible thin films and devices for wearable energy harvesting.

关键词： Bi_(x)Sb_(2−x)Te_(3) electrical transport properties flexibility thermoelectric

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MMP-9 deficiency accelerates the progress of periodontitis

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Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan Li meng meng Liu Graham Goldman Li-An Wu Feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

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Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin(Heart)-Pi(Spleen)Deficiency Syndrome:A Multi-centre Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 299-307页

作者： CHEN Xu CHEN Jiu-xi HAN Xue-yan ZHAO Yang CAO Jing JIAO Xiu-zhen LIU Hong-mei GUO Chun-li meng shuo LIANG Shuai QI Jiang-xia CHEN Dong LI Ming-xia JIAO Yun-xia WANG Ting-ting HONG Xia Xiyuan Clinical Medical College Beijing University of Chinese MedicineBeijing 100091China Department of Encephalopathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China First College of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Encephalopathy Botou Traditional Chinese Medicine Hospital of Hebei ProvinceBotou 062150China Institute of Basic Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology Pinggu HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:To evaluate the efficacy and safety of Jianpi Jieyu Decoction(JJD)for treating patients with mild-to-moderate depression of Xin(Heart)-Pi(Spleen)deficiency(XPD)***:In this multi-center,randomized,controlled study,140 patients with mild-to-moderate depression of XPD syndrome were included from Xiyuan Hospital of China Academy of Chinese Medical Sciences and Botou Hospital of Traditional Chinese Medicine from December 2017 to December *** were randomly divided into JJD group and paroxetine group by using a random number table,with 70 cases in each *** patients in the JJD group were given JJD one dose per day(twice daily at morning and evening,100 m L each time),and the patients in the paroxetine group were given paroxetine(10 mg/d in week 1;20 mg/d in weeks 2-6),both orally administration for a total of 6 *** primary outcome was the change of 17-item Hamilton Depression Rating Scale(HAMD-17)score at week 6 from *** secondary outcomes included the Hamilton Anxiety Scale(HAMA)score,Traditional Chinese Medicine Symptom Scale(TCMSS),and Clinlcal Global Impression(CGI)scores at the 2nd,4th,and 6th weekends of treatment,HAMD-17 response(defined as a reduction in score of>50%)and HAMD-17 remission(defined as a score of 7)at the end of the 6th week of *** events(AEs)were also ***:From baseline to week 6,the HAMD-17 scores decreased 10.2±4.0 and 9.1±4.9 points in the JJD and paroxetine groups,respectively(P=0.689).The HAMD-17 response occurred in 60%of patients in the JJD group and in 50%of those in the paroxetine group(P=0.292);HAMD-17 remission occurred in 45.7%and 30%of patients,respectively(P=0.128).The differences of CGI scores at the 6th week were not statistically significant(P>0.05).There were significant differences in HAMD-17 scores between the two groups at 2nd and 4th week(P=0.001 and P=0.014).The HAMA scores declined 8.1±3.0 and 6.9±4.3 points from baseline to week 6 in the JJD and paroxe

关键词： depression Xin(Heart)-Pi(Spleen)deficiency syndrome Chinese medicine Jianpi Jieyu Decoction depression efficacy safety

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Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection:How to achieve a better outcome

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1833-1848页

作者： Fan Mu Liang-shuo Hu Kun Xu Zhen Zhao Bai-Cai Yang Yi-meng Wang Kun Guo Jian-Hua Shi Yi Lv Bo Wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Anaesthesiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gynaecology Wenzhou Medical University Affiliated Jiaxing Women and Children HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)have been proven,researchers have not con-firmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time(at least 24 wk)and patients who received remedial antiviral therapy just before radical resection for HBV-related *** To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related *** A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was *** the history of antiviral therapy,patients were assigned to remedial antiviral therapy and preoperative antiviral therapy *** Kaplan–Meier analysis revealed significant differences in overall survival(P<0.0001)and disease-free survival(P=0.035)between the two *** analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival(hazard ratio=0.27;95%confidence interval:0.08-0.88;P=0.030).CONCLUSION In patients with HBV-related HCC,it is ideal to receive preoperative long-term antiviral therapy,which helps patients tolerate more extensive hepatectomy;however,remedial antiviral therapy,which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL,can also result in improved outcomes.

关键词： Hepatectomy Hepatitis B virus Antiviral therapy Hepatocellular carcinoma Hepatitis B virus-DNA

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Identification of new diagnostic targets for hepatitis B virus‐induced liver fibrosis

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iLABMED 2024年第1期2卷 27-37页

作者： Ying Wang shuo Qin meng Yang Xiaoling Wang Department of Clinical Laboratory Shanxi Hospital of Traditional Chinese MedicineTaiyuanShanxi ProvinceChina Academy of Medical Sciences Shanxi Medical UniversityTaiyuanShanxi ProvinceChina

Background:Liver fibrosis is a transitional stage from hepatitis to cirrhosis,and hepatitis B virus(HBV)is the most common cause of liver *** sequencing technology and bioinformatics analysis are increasingly being used to screen diagnostic targets for liver ***:The GSE171294 dataset of HBV-induced liver fibrosis tissue and normal tissue was obtained from the Gene Expression Omnibus(GEO)public database and used to screen for differentially expressed mRNAs using R *** with|log fold change|>1 and p<0.05 were considered to be differentially expressed.A heat map was drawn to visualize the expression patterns of the differentially expressed *** screen for candidate target mRNAs,the differentially expressed mRNAs were annotated by Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment ***,a protein-protein interaction(PPI)network was constructed to analyze the relationships between the differen-tially expressed ***:A total of 243 differentially expressed mRNAs were identified(p<0.05);129 were up-regulated and 114 were *** up-regulated and down-regulated mRNAs were significantly enriched in 16 and 8 KEGG pathways,*** enriched KEGG pathways included Sal-monella infection,Protein processing in the endoplasmic reticulum,IL-17 signaling pathway,and Aldosterone synthesis and *** enriched GO terms were related mainly to cell proliferation,apoptosis,endoplasmic reticulum complex assembly,and myosin *** PPI network con-tained 161 nodes and 120 pairs of *** top 10 key nodes were CAV1,CD4,NR3C1,PDIA3,EZR,IRF4,SOX9,HSP90AB1,CD40,and ***:Bioinformatics analysis of the transcriptome sequencing data in the GSE171294 dataset identified CD4,NR3C1,and EZR and other genes at key nodes as new targets for the treatment of liver fibrosis caused by *** results provide new insights for HBV‐induced liver fibrosis re

关键词： expression profiles HBV liver fibrosis transcriptome sequencing

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《十年一品温如言》:爱情底色、青春命题的文化表达

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电影评介 2022年第4期 28-31页

作者：张亿孟硕北京师范大学艺术与传媒学院

青春与爱情是电影艺术一贯讴歌赞美的经典主题,少年男女乍见之欢的诗意、纯洁与灵性被影像赋予了超越世俗的珍贵价值。近年来,依靠文学改编的青春爱情电影渐次出现于银幕,而如何呈现动人情感内核,书写青春命题,形塑理想化角色,始终是伴... 详细信息

青春与爱情是电影艺术一贯讴歌赞美的经典主题,少年男女乍见之欢的诗意、纯洁与灵性被影像赋予了超越世俗的珍贵价值。近年来,依靠文学改编的青春爱情电影渐次出现于银幕,而如何呈现动人情感内核,书写青春命题,形塑理想化角色,始终是伴随该类型影片创作发展的难点痛点,也成为多数观众审视该类型影片的首要之思。

关键词：文学改编痛点一品

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基于改进帧间差分法的经纱撞筘拥纱在线检测

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纺织学报 2021年第6期42卷 91-96页

作者：夏旭文孟朔潘如如高卫东生态纺织教育部重点实验室(江南大学) 江苏无锡214122

为实时检测浆纱过程中经纱撞筘现象,开发了基于机器视觉方法的浆纱机经纱撞筘拥纱实时自动检测系统。通过自主搭建的图像采集系统捕捉经纱通过筘齿完整图像。首先裁剪初始图像获取检测区域,然后通过高斯滤波进行图像平滑以降低图像细节... 详细信息

为实时检测浆纱过程中经纱撞筘现象,开发了基于机器视觉方法的浆纱机经纱撞筘拥纱实时自动检测系统。通过自主搭建的图像采集系统捕捉经纱通过筘齿完整图像。首先裁剪初始图像获取检测区域,然后通过高斯滤波进行图像平滑以降低图像细节层次;然后扩大帧间差,加入Canny边缘算法和膨胀的数学形态学运算来实现对帧间差分法的改进,最后通过改进帧间差分法实现浆纱机经纱撞筘拥纱的识别。实验结果表明:所开发的检测系统可准确地识别浆纱机经纱撞筘拥纱和对拥纱进行跟踪,并且达到实时检测的作用,可以为实际生产提供指导。

关键词：撞筘检测图像处理帧差法高斯滤波形态学运算

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区域技术创新体系中的市场失灵与政府政策选择的研究

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中国软科学 2007年第5期 146-153页

作者：朱雪祎方存好孟硕清华大学公共管理学院清华大学国家信息实验室北京100084 清华大学科学技术开发部北京100084

本文从研究区域技术创新各个环节中的"市场失灵"出发,致力于政府相关区域技术创新政策选择的研究。本文首先基于市场和政府在区域技术创新体系中的不同作用机制,提出了一个基于政府和市场双重作用的区域技术创新理论模型。在这一模型框... 详细信息

本文从研究区域技术创新各个环节中的"市场失灵"出发,致力于政府相关区域技术创新政策选择的研究。本文首先基于市场和政府在区域技术创新体系中的不同作用机制,提出了一个基于政府和市场双重作用的区域技术创新理论模型。在这一模型框架下,进一步以新古典经济学派关于"市场失灵"的假定为基本的分析依据,并参照新熊彼特学派的技术创新理论,以技术创新中的各个创新过程为分析对象,对各个技术创新环节中的"市场失灵"进行判断和分析,由此导出政府相应的政策工具选择。以此为依据,分析得出一个政府应对技术创新过程中"市场失灵"的政策框架。最后,本文结合深圳、无锡、宁波、东莞这四个"国家火炬创新试验城市"现有的技术创新政策工具,对本文分析得出的政策框架进行了实证分析和验证。

关键词：区域创新技术创新市场失灵政策工具

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