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Trimester-specific urinary metabolome alterations associated with gestational diabetes mellitus:A study in different pregnancy stages

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Chinese Chemical Letters 2022年第6期33卷 3139-3143页

作者： Hongzhi Zhao Yuanyuan Zheng Lin Zhu Li Xiang shunqing xu Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

Gestational diabetes mellitus(GDM),a frequently-occurring disease during pregnancy,may cause some adverse healthy outcome of both mother and ***,the knowledge about metabolite alterations during the pathogenesis and development process is ***,a large longitudinal nontargeted metabolomics study of 195 pregnant women(64 women with subsequently developed GDM and131 healthy controls)was *** participant provided urine samples at three timepoints during early,middle and late pregnancy,*** metabolic profiles of 585 urine samples(195×3)were measured by using ultra-high performance liquid chromatography coupled with Orbitrap high-resolution mass *** the 56 identified metabolites,the levels of eight metabolites increased and three ones decreased in the first trimester,the concentration of one metabolite increased and those of 20 decreased in the second trimester,as well as the levels of five metabolites increased and two decreased in the third *** false discovery rate correction,the levels of valine and 5-acetamidovalerate in GDM group significantly increased in the first trimester,the levels of 1-methylguanine and 1,3-dihydro-(2 H)-indol-2-one significantly decreased in the second trimester and three metabolites(threonine,OH-octanedioyl-carnitine and pimelylcarnitine)increased and N-acetyltryptophan decreased in the third trimester,*** metabolites,such as pantothenic acid and threonine,had significant interaction effects between gestational stage(different trimester)and group(GDM or control).The differential metabolites were involved in“tryptophan metabolism”,“purine metabolism”,“valine,leucine and isoleucine degradation”and other *** findings may provide insights into further pathogenesis study of GDM.

关键词： Gestational diabetes mellitus Non-targeted metabolomics Dynamic metabolic profile Maternal urine High-resolution mass spectrometry

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Apoptosis induced by titanium dioxide nanoparticles in cultured murine microglia N9 cells

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Chinese Science Bulletin 2009年第20期54卷 3830-3836页

作者： LI XiaoBo xu shunqing ZHANG ZhiRen Hermann J Schluesener School of Public Health Southeast University Nanjing 210009 China Key Laboratory of Environment and Heath of the Ministry of Education Institute of Environmental Medicine School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Institute of Brain Research University of Tuebingen Calwer Str. 3 D-72076 Tuebingen Germany

Owing to the rapidly increasing output of nano-scale titanium dioxide(TiO2) particles,their potential risk for central nerve system(CNS) has elicited much concern *** is the resident macrophage in CNS and essential for the homeostasis of the CNS *** are supposed to response to nanoparticles depositing in the brain ***,we investigated the cytotoxic effects of TiO2 NPs on microglia N9 cells in *** of propidium iodide/fluorescein diacetate(PI/FDA) double staining and MTT test clearly showed that TiO2 NPs more efficiently affected the viability of microglia N9 *** Hoechst 33258 staining and flow cytometric analysis proved that nano-scale but not normal scale TiO2 induced apoptosis in *** data suggest that TiO2 NPs can elicit apoptosis of N9 cells in vitro and thus present a potential risk for CNS.

关键词：纳米二氧化钛胶质细胞细胞凋亡诱导培养中枢神经系统二氧化钛纳米粒流式细胞仪分析小鼠

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Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS

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Chinese Chemical Letters 2018年第1期29卷 102-106页

作者： Hongzhi Zhao Jiufeng Li Xinli Ma Wenqian Huo shunqing xu Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of Chemistry Hong Kong Baptist University Hong Kong SAR China Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430074 China School of Life Sciences Sun Yat-sen University Guongzhou 510275 China

Bisphenols, benzophenones and parabens may alter one or more functions of endocrine system and consequently cause adverse health effects on human. A rapid and sensitive analytical method for the simultaneous determination of six bisphenols, five benzophenones and seven parabens in human urine by using ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed and applied for human urine sample analysis. The eighteen targeted compounds were separated within 11 min. Heated-electrospray ionization was operated with multiple reaction monitoring in negative-ion mode. The limit of detection ranged from 0.01 ng/mL to 0.5 ng/mL. Seven isotope-labeled internal standards were used in the quantitative analysis. After the method was validated for sensitivity, linearity, precision, accuracy and matrix effect, it was applied for the analysis of human urine samples to evaluate the profiles of human exposure. Eight of the targeted analytes were detected in more than 50% urine samples.

关键词： BisphenolsBenzophenonesParabensLiquid chromatography-mass spectrometryHuman urine

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Cold chain and severe acute respiratory syndrome coronavirus 2 transmission:a review for challenges and coping strategies

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Medical Review 2022年第1期2卷 50-65页

作者： Jiangtao Liu Tongzhang Zheng Wei Xia shunqing xu Yuanyuan Li Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and Technology13 Hangkong RoadWuhan 430030HubeiChina Department of Epidemiology School of Public HealthBrown UniversityProvidenceRI 02912United States

Since June 2020,the re-emergence of coronavirus disease 2019(COVID-19)epidemics in parts of China was linked to the cold chain,which attracted extensive attention and heated discussions from the *** to the typical characteristics of these epidemics,we speculated a possible route of transmission from cold chain to human.A series of factors in the supply chain contributed to the epidemics if the cold chain were contaminated by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),such as temperature,humidity,personal hygiene/protection,and *** workers who worked in the cold chain at the receiving end faced a higher risk of being infected when they were not well *** the difficult situation,China put forward targeted and powerful countermeasures to block the cold chain-related ***,in the context of the unstable pandemic situation globally,the risk of the cold chain needs to be recognized and evaluated ***,in this review,we reviewed the cold chain-related epidemics in China,analyzed the possible mechanisms,introduced the Chinese experience,and suggested coping strategies for the global epidemic prevention and control.

关键词： cold chain coronavirus disease 2019 prevention and control severe acute respiratory syndrome coronavirus 2.

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Machine Learning for Investigation on Endocrine-Disrupting Chemicals with Gestational Age and Delivery Time in a Longitudinal Cohort

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Research 2021年第1期2021卷 1519-1529页

作者： Hemi Luan Hongzhi Zhao Jiufeng Li Yanqiu Zhou Jing Fang Hongxiu Liu Yuanyuan Li Wei Xia shunqing xu Zongwei Cai School of Medicine Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhenChina State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongSARChina Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Endocrine-disrupting chemicals(EDCs)are widespread environmental chemicals that are often considered as risk factors with weak activity on the hormone-dependent process of ***,the adverse effects of EDCs in the body of pregnant women were *** interaction between dynamic concentration of EDCs and endogenous hormones(EHs)on gestational age and delivery time remains *** define a temporal interaction between the EDCs and EHs during pregnancy,comprehensive,unbiased,and quantitative analyses of 33 EDCs and 14 EHs were performed for a longitudinal cohort with 2317 pregnant *** developed a machine learning model with the dynamic concentration information of EDCs and EHs to predict gestational age with high accuracy in the longitudinal cohort of pregnant *** optimal combination of EHs and EDCs can identify when labor occurs(time to delivery within two and four weeks,AUROC of 0.82).Our results revealed that the bisphenols and phthalates are more potent than partial EHs for gestational age or delivery *** study represents the use of machine learning methods for quantitative analysis of pregnancy-related EDCs and EHs for understanding the EDCs’mixture effect on pregnancy with potential clinical utilities.

关键词： EDCs chemicals Investigation

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Association of altered serum acylcarnitine levels in early pregnancy and risk of gestational diabetes mellitus

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Science China Chemistry 2020年第1期63卷 126-134页

作者： Hongzhi Zhao Han Li Yuanyuan Zheng Lin Zhu Jing Fang Li Xiang shunqing xu Yanqiu Zhou Hemi Luan Wei Xia Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental ProtectionState Key Laboratory of Environmental Health(Incubation)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

Gestational diabetes mellitus(GDM)is a high-prevalence disease and diagnosed in middle *** are a series of fatty acid esters of carnitine and play important roles in fatty acid and carbohydrate ***,the role of acylcarnitine on the development of GDM remains *** case-control study involving 214 study participants(107 GDM cases and 107 matched controls)was conducted in a cohort,in China,from 2013 to *** levels of carnitine and 36 acylcarnitines in serum samples collected at the early stage of pregnancy were determined by using ultra-high performance liquid chromatography coupled with tandem mass *** associations of the levels of the 37 targeted compounds with GDM risk were investigated by using binary conditional logistic regression *** in acylcarnitine levels were observed 9–17 weeks before GDM *** increases in levels of propionyl-carnitine,malonyl-carnitine,isovaleryl-carnitine,palmitoyl-carnitine and linoleoyl-carnitine were associated with GDM risk with odds ratios(ORs)per standard deviation(SD)increment greater than 1(p<0.05),after adjustment for potential confounding factors(pre-pregnancy body mass index and parity).On the contrary,the increases of decanoyl-carnitine,decenoyl-carnitine,tetradecenoyl-carnitine,tetradecandienoylcarnitine levels were associated with the reduced risk for GDM(ORs per SD<1,p<0.05).To our knowledge,the present study is the largest case-control study to investigate the association between early-pregnancy acylcarnitine levels in serum and GDM *** findings add to the evidence for the association between acylcarnitine levels and GDM risk.

关键词： acylcarnitines gestational diabetes mellitus epidemiology targeted metabolomics ultra-high performance liquid chromatography coupled with tandem mass spectrometry

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Assessment of estrogen disrupting potency in animal foodstuffs of China by combined biological and chemical analyses

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Journal of Environmental Sciences 2014年第10期26卷 2131-2137页

作者： Jun Wang Wei Xia Yonghua Xiao Chenjiang Ying Jia Long Hui Zhang Xi Chen Congda Mao Xiumin Li Lin Wang shunqing xu Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubating) School of Public Health Tongji Medical College Huazhong University of Science and Technology The Clinical Laboratory Department of Jiaozhou Central Hospital of Qingdao Wuhan City Center for Disease Prevention and Control

Food has been documented as one of major routes for human exposure to environmental estrogens（EEs）, but information on the occurrence of EEs in animal foodstuffs is still *** study analyzed estrogenic activity in 16 types of animal foodstuffs（n = 142） collected from four cities（Wuhan, Guangzhou, Wenzhou and Yantai） of China by combined yeast estrogen screen（YES） bioassay and chemical analysis. By bioassay, all samples＇ extracts were found to induce estrogenic activities and the bioassay-derived 17β-estradiol equivalent（EEQbio） ranged from 8.29 to 118.32 ng/g. In addition, the samples were analyzed by liquid chromatography coupled to tandem mass spectrometry for further chemical analysis. 17β-Estradiol was found in all samples in this survey at levels of 0.44 to 15.04 ng/*** samples had 33.1% detection rate of 17α-ethinylestradiol（EE2）, and the maximum concentration was 2.80 ng/g. Bisphenol A and 4-nonylphenols were detected in 83.8% and83.1% of samples, with concentrations up to 12.56 ng/g and 35.76 ng/g, ***, the concentrations of estrone, diethylstilbestrol and 4-t-octylphenol were found to be below the limit of detection. A comparison of EEQbiomeasured from the YES assay and EEQchemcalculated from chemical analysis showed good correlation（R2= 0.84）. Based on the results, the YES assay can be used as a rapid pre-screening method for monitoring the levels of estrogenic activity in large numbers of animal foodstuffs, and chemical analysis used in combination can be used for the identification of specific EEs.

关键词： Environmental estrogen Yeast estrogen screen LC–MS/MS Animal foodstuffs

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SARS-CoV-2 infection in animals: Patterns, transmission routes, and drivers

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Eco-Environment & Health 2024年第1期3卷 45-54页

作者： Ruying Fang Xin Yang Yiyang Guo Bingjie Peng Ruixuan Dong Sen Li shunqing xu School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Life Sciences Hainan UniversityHaikou 570228China

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is more widespread in animals than previously thought,and it may be able to infect a wider range of domestic and wild *** effectively control the spread of the virus and protect animal health,it is crucial to understand the cross-species transmission mechanisms and risk factors of *** article collects published literature on SARS-CoV-2 in animals and examines the distribution,transmission routes,biophysical,and anthropogenic drivers of infected *** reported cases of infection in animals are mainly concentrated in South America,North America,and Europe,and species affected include lions,white-tailed deer,pangolins,minks,and *** factors influencing infection of animals with SARS-CoV-2 include environmental determinants,high-risk landscapes,air quality,and susceptibility of different animal species,while anthropogenic factors comprise human behavior,intensive livestock farming,animal markets,and land *** to current research gaps and surveillance capacity shortcomings,future mitigation strategies need to be designed from a One Health perspective,with research focused on key regions with significant data gaps in Asia and Africa to understand the drivers,pathways,and spatiotemporal dynamics of interspecies transmission.

关键词： SARS-CoV-2 Biophysical factors Anthropogenic factors Transmission Cross-species

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Exposure to persistent organic pollutants as potential risk factors for developing diabetes

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Science China Chemistry 2010年第5期53卷 980-994页

作者： WANG ChunXiang,xu shunqing,LV ZiQuan,LI YuanYuan,WANG YouJie & CHEN Tian Key Laboratory of Environment and Health,Ministry of Education School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Key Laboratory of Environment and Health Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China

Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food *** to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to *** growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their *** on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental *** potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or *** research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.

关键词： persistent organic pollutants diabetes dioxins polychlorinated biphenyls organochlorine pesticides

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Advances and perspectives in environmental health research in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun Liu shunqing xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen Chen Jicheng Gong Guohua Qin Xinghua Qiu Jing Shang Haobo Wang Pengpeng Wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for Environment and Health Peking UniversityBeijing 100871China School of Life and Health Sciences Huainan UniversityHaikou 570228China Joint International Research Laboratory of Environment and Health(Ministry of Education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Research Center of Environment and Health College of Environment and ResourceShanxi UniversityTaiyuan 030006China Department of Environmental Health School of Public HealthFudan UniversityShanghai 200032China School of Environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Occupational and Environmental Health College of Public HealthZhengzhou UniversityZhengzhou 450001China

Environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： Environmental pollution Emerging pollutants Climate change Exposure Mechanism

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