Association of altered serum acylcarnitine levels in early pregnancy and risk of gestational diabetes mellitus

作     者：Hongzhi Zhao Han Li Yuanyuan Zheng Lin Zhu Jing Fang Li Xiang Shunqing Xu Yanqiu Zhou Hemi Luan Wei Xia Zongwei Cai Hongzhi Zhao;Han Li;Yuanyuan Zheng;Lin Zhu;Jing Fang;Li Xiang;Shunqing Xu;Yanqiu Zhou;Hemi Luan;Wei Xia;Zongwei Cai

作者机构：State Key Laboratory of Environmental and Biological AnalysisDepartment of ChemistryHong Kong Baptist UniversityHong KongChina Key Laboratory of Environment and HealthMinistry of Education&Ministry of Environmental ProtectionState Key Laboratory of Environmental Health(Incubation)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2020年第63卷第1期

页      面：126-134页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(21437002) the General Research Fund(12319716)from Research Grants Council of Hong Kong 

主　　题：acylcarnitines gestational diabetes mellitus epidemiology targeted metabolomics ultra-high performance liquid chromatography coupled with tandem mass spectrometry 

摘      要：Gestational diabetes mellitus(GDM)is a high-prevalence disease and diagnosed in middle *** are a series of fatty acid esters of carnitine and play important roles in fatty acid and carbohydrate ***,the role of acylcarnitine on the development of GDM remains *** case-control study involving 214 study participants(107 GDM cases and 107 matched controls)was conducted in a cohort,in China,from 2013 to *** levels of carnitine and 36 acylcarnitines in serum samples collected at the early stage of pregnancy were determined by using ultra-high performance liquid chromatography coupled with tandem mass *** associations of the levels of the 37 targeted compounds with GDM risk were investigated by using binary conditional logistic regression *** in acylcarnitine levels were observed 9–17 weeks before GDM *** increases in levels of propionyl-carnitine,malonyl-carnitine,isovaleryl-carnitine,palmitoyl-carnitine and linoleoyl-carnitine were associated with GDM risk with odds ratios(ORs)per standard deviation(SD)increment greater than 1(p0.05),after adjustment for potential confounding factors(pre-pregnancy body mass index and parity).On the contrary,the increases of decanoyl-carnitine,decenoyl-carnitine,tetradecenoyl-carnitine,tetradecandienoylcarnitine levels were associated with the reduced risk for GDM(ORs per SD1,p0.05).To our knowledge,the present study is the largest case-control study to investigate the association between early-pregnancy acylcarnitine levels in serum and GDM *** findings add to the evidence for the association between acylcarnitine levels and GDM risk.