检索结果-南通市图书馆

Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy

引用

Cancer Communications 2020年第8期40卷 329-344页

作者： shuning ding Xiaosong Chen Kunwei Shen Department of General Surgery Comprehensive Breast Health CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

Single-cell RNA sequencing(scRNA-seq)is a novel technology that allows transcriptomic analyses of individual *** the past decade,scRNA-seq sensitivity,accuracy,and efficiency have improved due to innovations including more sensitive,automated,and cost-effective single-cell isolation methods with higher throughput as well as ongoing technological development of scRNA-seq *** the variety of current approaches with distinct features,researchers can choose the most suitable method to carry out their *** profiling single cells in a complex population mix,scRNA-seq presents great advantages over traditional sequencing methods in dissecting heterogeneity in cell populations hidden in bulk analysis and exploring rare cell types associated with tumorigenesis and ***-seq studies in recent years in the field of breast cancer research have clustered breast cancer cell populations with different molecular subtypes to identify distinct populations that may correlate with poor prognosis and drug *** technology has also been used to explain tumor microenvironment heterogeneity by identifying distinct immune cell subsets that may be associated with immunosurveillance and are potential immunotherapy ***,scRNA-seq has diverse applications in breast cancer research besides exploring heterogeneity,including the analysis of cell-cell communications,regulatory single-cell states,immune cell distributions,and ***-seq is also a promising tool that can facilitate individualized therapy due to its ability to define cell subsets with potential treatment *** scRNA-seq studies of therapeutic selection in breast cancer are currently limited,the application of this technology in this field is *** efforts and original ideas are needed to better implement scRNA-seq technologies in breast cancer research to pave the way for individualized treatment *** review provides a brief introduction o

关键词： Single-cell sequencing tumor heterogeneity breast cancer individualized therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微腔真空场对辐射过程的调控及应用(特邀)

引用

光子学报 2024年第5期53卷 57-79页

作者：程晓天汪玲芳于家望丁舒宁倪之博王宏斌周晓青金潮渊浙江大学信息电子与工程学院杭州310027 西湖大学理学院杭州310030

真空电磁模式与辐射源之间的相互耦合决定了辐射源的辐射特性。光学微腔能够对真空光子态密度进行有效调控,进而影响辐射源的辐射过程。微腔内真空电磁场的局域分布可以通过微纳结构来改变,从而调节辐射源与光子的相互作用,为微纳激光... 详细信息

真空电磁模式与辐射源之间的相互耦合决定了辐射源的辐射特性。光学微腔能够对真空光子态密度进行有效调控,进而影响辐射源的辐射过程。微腔内真空电磁场的局域分布可以通过微纳结构来改变,从而调节辐射源与光子的相互作用,为微纳激光、量子光源、片上光学网络等应用领域提供新颖的功能性器件。然而,真空场的静态调控方法存在其固有限制,即一旦完成制备无法更改其性能,因此微腔光子器件迫切需要动态或者准动态的调控技术来实现相应的功能。本文综述了基于材料性质、环境参数和耦合效应的多种调控手段,以期实现对器件真空场分布的后端调控。总结了国内外在半导体微腔真空场调控方面的研究进展,并提出了未来的研究展望。主动后端调控手段有望在集成微纳光学和量子信息处理等领域得到广泛的应用。

关键词：半导体微腔辐射过程纳米光子学及光子晶体半导体激光器件

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer

引用

Cancer Communications 2023年第6期43卷 661-684页

作者： shuning ding Niu Qiao Qingchen Zhu Yiwei Tong Shengyue Wang Xiaosong Chen Qiang Tian Yichuan Xiao Kunwei Shen Department of General Surgery Comprehensive Breast Health CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiP.R.China

Background:Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer ***,the unique features of the immune microenvironment of triple negative breast cancer(TNBC)compared with other subtypes of breast cancer remain ***,we aimed to depict and compare the immune landscape among TNBC,human epidermal growth factor receptor 2-positive(HER2^(+))breast cancer,and luminal-like breast ***:Single-cell RNA sequencing(scRNA-seq)was performed on CD45^(+)immune cells isolated from human normal breast tissues and primary breast tumors of various *** analyzing the scRNA-seq data,immune cell clusters were identified and their proportions as well as transcriptome features were compared among TNBC,human HER2^(+)breast cancer,and luminal-like breast *** and cell-cell communication analyses were also conducted to characterize the immune ***:ScRNA-seq data of 117,958 immune cells were obtained and 31 immune clusters were identified.A unique immunosuppressive microenvironment in TNBC was decoded as compared to that in HER2^(+)or luminal-like breast cancer,which was characterized by higher proportions of regulatory T cells(Tregs)and exhausted CD8+T cells and accompanied by more abundant plasma *** and exhausted CD8+T cells in TNBC exhibited increased immunosuppression signature and dysfunctional *** analyses showed that B cells tended to differentiate to plasma cells in ***-cell communication analyses indicated that these unique features are fostered by the diversified T cell-B cell crosstalk in *** on the T cell-B cell crosstalk,a prognostic signaturewas established that could effectively predict the prognosis status for patients with ***,it was found that TNBC had a higher proportion of cytotoxic natural killer(NK)cells,whereas HER2^(+)or luminal-like breast cancer lost this f

关键词： breast cancer prognostic signature single-cell RNA sequencing T cell-B cell crosstalk triplenegative breast cancer tumor immune microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly selective and efficient photocatalytic NO removal:Charge carrier kinetics and interface molecular process

引用

Nano Research 2024年第3期17卷 1003-1026页

作者： Huan Shang Hongbao Jia Pengpeng Li Hao Li Wenbin Zhang Shuangjun Li Qing Wang shuning Xiao ding Wang Guisheng Li Dieqing Zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry of Ministry of EducationShanghai Key Laboratory of Rare Earth Functional Materialsand Shanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The widespread nitrogen oxides(NOx,mainly in NO)in the atmosphere have threatened human health and ecological *** dilute NO(ppb)is difficult to efficiently remove via the traditional process due to its characteristics of low concentration,wide range,large total amount,*** can utilize solar energy to purify NO pollutants under mild conditions,but its application is limited due to the low selectivity of nitrate and poor activity of NO *** underlying reason is that the interface mechanism of NO oxidation is not clearly understood,which leads to the inability to accurately regulate the NO oxidation ***,the recent advances in the photocatalytic oxidation of NO are ***,the common strategies to effectively regulate carrier dynamics such as morphology control,facet engineering,defect engineering,plasma coupling,heterojunction and single-atom catalysts are ***,the progress of enhancing the adsorption and activation of reactants such as NO and O_(2) during NO oxidation is described in detail,and the corresponding NO oxidation mechanisms are ***,the challenges and prospects of photocatalytic NO oxidation are presented in term of nanotechnology for air pollution *** review can shed light on the interface mechanism of NO oxidation and provide illuminating information on designing novel catalysts for efficient NOx control.

关键词： nitrogen oxide(NO)oxidation photocatalysis NO/O_(2)activation charge carrier kinetics interfacial mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

温阳解毒方治疗结直肠癌的核心靶基因筛选及其机制分析

引用

山东医药 2024年第11期64卷 31-35页

作者：陈伊伦钱力汇李文迪孙磊涛丁书凝浙江中医药大学第一临床医学院杭州310053 浙江中医药大学附属第一医院浙江省中医院肿瘤科

目的利用网络药理学及分子对接技术筛选温阳解毒方治疗结直肠癌的核心靶基因,并探讨其可能的作用机制。方法通过TCMSP、Uniprot数据库检索温阳解毒方6种中药的有效成分及相关靶基因,经Genecards数据库筛选得到结直肠癌相关疾病靶基因... 详细信息

目的利用网络药理学及分子对接技术筛选温阳解毒方治疗结直肠癌的核心靶基因,并探讨其可能的作用机制。方法通过TCMSP、Uniprot数据库检索温阳解毒方6种中药的有效成分及相关靶基因,经Genecards数据库筛选得到结直肠癌相关疾病靶基因,二者取交集后得到温阳解毒方治疗结直肠癌的潜在靶基因。基于STRING数据库、Cytoscape软件绘制蛋白质互相作用网络(PPI)图并进行拓扑学分析,得到温阳解毒方治疗结直肠癌的核心靶基因。对核心靶基因进行基因本体(GO)功能、KEGG通路富集分析,采用分子对接技术对6种中药重复的关键活性成分和核心靶基因进行结构验证。结果温阳解毒方6种中药的相关靶基因269个,与1 349个结直肠癌相关疾病靶基因取交集后,得到温阳解毒方治疗结直肠癌的潜在靶基因131个。PPI图的拓扑学分析结果显示,温阳解毒方治疗结直肠癌的核心靶基因有6个,分别是丝氨酸/苏氨酸蛋白激酶1(Akt1)、p53、表皮生长因子受体(EGFR)、JUN、雌激素受体1(ESR1)、肿瘤坏死因子(TNF)。GO功能及KEEG富集分析结果显示,核心靶基因主要作用于综合肿瘤信号通路、细胞衰老信号通路、p53信号通路、TNF信号通路、PI3K/Akt信号通路等。分子对接结果显示,Akt1、TNF、EGFR与温阳解毒方6种中药的11种关键活性成分均有较低的结合能,其中TNF与甲基黄连碱、EGFR与β-谷甾醇是结合能最低的两组,结合能分别为-6.78、-6.56。结论温阳解毒方治疗结直肠癌的核心靶基因有Akt1、p53、JUN、EGFR、ESR1、TNF,其机制可能与调控p53、TNF、PI3K/Akt等信号通路有关。

关键词：温阳解毒方结直肠癌网络药理学分子对接细胞增殖细胞凋亡 PI3K/Akt信号通路

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

眼镜蛇血液凝固机理研究(眼镜蛇科)

引用

武夷科学 1985年第1期7卷 177-181页

作者：吴瑞敏丁淑宁福建医学院

Fantl(1961)、Hackett 等(1987)、Lavras 等(1979)和 Nachas(1981)分别在虎蛇(Notechis)、美洲矛头蝮(Bothrops jararaca)和 Waglerophis merremii 进行血凝机理的研究。他们一致认为蛇类凝血的过程比哺乳动物凝血的过程缓慢。但对引起蛇类血疑过程缓慢的原因结论却不一致。Fantl 和 Lavras 认为虎蛇和美洲矛头蝮血凝过程慢的原因是这两种蛇的血浆中都缺乏因子Ⅻ。Fantl

关键词：眼镜蛇科氯化钙液凝血时间血液凝固

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

第8版美国癌症联合委员会分期对乳腺黏液腺癌预后的预测价值

引用

中华肿瘤杂志 2019年第11期41卷 854-858页

作者：丁淑宁吴佳毅陈伟国李亚芬沈坤炜朱丽上海交通大学医学院附属瑞金医院乳腺疾病诊治中心 200025

目的分析和评估第8版美国癌症联合委员会(AJCC)分期系统提出的解剖学分期(AS)和预后分期(PS)两种分期方式在单纯型乳腺黏液腺癌(PMBC)患者中的预后价值.方法收集接受根治性手术的3 628例PMBC患者的临床和随访资料,比较不同分期PMBC患... 详细信息

目的分析和评估第8版美国癌症联合委员会(AJCC)分期系统提出的解剖学分期(AS)和预后分期(PS)两种分期方式在单纯型乳腺黏液腺癌(PMBC)患者中的预后价值.方法收集接受根治性手术的3 628例PMBC患者的临床和随访资料,比较不同分期PMBC患者的乳腺癌特异性生存情况,通过AS和PS模型下的似然比卡方(LR x2)、赤池信息准则(AIC)和一致性指数(C-index)评估第8版AJCC分期在PMBC中的预后价值.结果在PMBC中,肿瘤大小(P=0.002)、淋巴结状态(P=0.002)、组织学分级(P=0.003)、孕激素状态(P=0.017)及是否接受辅助放疗(P=0.040)与BCSS有关.与AS相比,1 326例(37.54%)患者的PS发生了改变,其中分期上升和分期下降的患者分别占总人群的6.50%和31.04%.AS和PS各期患者的BCSS差异均有统计学意义(均P<0.001).AS模型和PS模型的LR x2分别为16.41和17.50,差异无统计学意义(P=0.296);AIC分别为357.44和358.35;C-index分别为0.72和0.73,差异无统计学意义(P=0.667).结论第8版AJCC分期中的AS和PS均是PMBC患者预后的影响因素,但与AS相比,PS并无更强的预后预测能力.

关键词：单纯型乳腺黏液腺癌美国癌症联合委员会分期预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国内紫外像增强器视场瑕疵检测技术研究现状

引用

红外技术 2024年第2期46卷 129-137页

作者：丁习文程宏昌袁渊张若愚杨书宁杨晔党小刚昆明物理研究所云南昆明650223 微光夜视技术重点实验室陕西西安710065

紫外像增强器是一种对紫外辐射敏感的成像器件,视场瑕疵是其成像效果的主要制约因素。目前,视场瑕疵检测技术主要分为人工和机器视觉两种方法。本文首先阐述了视场瑕疵的定义和检测标准。接着从瑕疵交叠靠近、大小和数量特性的角度,分... 详细信息

紫外像增强器是一种对紫外辐射敏感的成像器件,视场瑕疵是其成像效果的主要制约因素。目前,视场瑕疵检测技术主要分为人工和机器视觉两种方法。本文首先阐述了视场瑕疵的定义和检测标准。接着从瑕疵交叠靠近、大小和数量特性的角度,分析了视场瑕疵检测的难点。随后,重点介绍了紫外像增强器视场瑕疵检测技术的研究现状。结合当前的检测需求和不足,调研了深度学习技术在其他领域的瑕疵检测效果。最后,从理论上进行了可行性分析,并提出了基于深度学习视场瑕疵检测的思路,旨在为紫外像增强器视场瑕疵检测提供一种新的解决方案,推动其向着更加实用、智能化的方向发展。

关键词：像增强器视场瑕疵检测机器视觉深度学习

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MAGUS: machine learning and graph theory assisted universal structure searcher

引用

National Science Review 2023年第7期10卷 213-233页

作者： Junjie Wang Hao Gao Yu Han Chi ding shuning Pan Yong Wang Qiuhan Jia Hui-Tian Wang dingyu Xing Jian Sun National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced Microstructures Nanjing University

Crystal structure predictions based on first-principles calculations have gained great success in materials science and solid state ***,the remaining challenges still limit their applications in systems with a large number of atoms,especially the complexity of conformational space and the cost of local optimizations for big ***,we introduce a crystal structure prediction method,MAGUS,based on the evolutionary algorithm,which addresses the above challenges with machine learning and graph *** used in the program are summarized in detail and benchmark tests are *** intensive tests,we demonstrate that on-the-fly machine-learning potentials can be used to significantly reduce the number of expensive first-principles calculations,and the crystal decomposition based on graph theory can efficiently decrease the required configurations in order to find the target *** also summarized the representative applications of this method on several research topics,including unexpected compounds in the interior of planets and their exotic states at high pressure and high temperature(superionic,plastic,partially diffusive state,etc.);new functional materials(superhard,high-energy-density,superconducting,photoelectric materials),*** successful applications demonstrated that MAGUS code can help to accelerate the discovery of interesting materials and phenomena,as well as the significant value of crystal structure predictions in general.

关键词： crystal structure searching materials design ab-initio calculations density functional theory high-pressure phase transition

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

高压单芯电缆工频运行下金属护套雷电冲击电压的仿真研究

引用

电瓷避雷器 2024年第2期 27-35页

作者：孙铭张周胜谢书凝张磊上海电力大学电气工程学院上海200090

为了研究高压单芯电缆金属护套冲击电压的影响因素,本研究用PSCAD/EMTDC建立220 kV架空线-高压单芯电缆线路模型并仿真雷电绕击架空线后沿线入侵电缆的波过程,在工频运行条件下,通过改变电缆接地方式、电缆参数以及雷电流参数,研究对金... 详细信息

为了研究高压单芯电缆金属护套冲击电压的影响因素,本研究用PSCAD/EMTDC建立220 kV架空线-高压单芯电缆线路模型并仿真雷电绕击架空线后沿线入侵电缆的波过程,在工频运行条件下,通过改变电缆接地方式、电缆参数以及雷电流参数,研究对金属护套雷电冲击电压幅值的降低作用。结果表明:其他条件相同时,采用首端接地方式的不接地点金属护套雷电冲击电压幅值比末端接地方式和交叉互联接地方式降低约90%;由于金属护套在交叉互联点发生换位,导致金属护套雷电冲击电压幅值最大相在第二个互联点处由侵入相变为非侵入相;通过改变电缆长度、分段均匀度以及排列方式等方法对金属护套雷电冲击电压的降低作用有限,仍需增设电压保护器加以限制;雷电流入侵电缆工频电压波谷时,能比入侵波峰时降低约80%的金属护套雷电冲击电压。

关键词：高压单芯电缆工频运行接地方式雷电侵入波金属护套雷电冲击电压 PSCAD/EMTDC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：