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SPATULA as a Versatile Tool in Plant:The Progress and Perspectives of SPATULA(SPT)Transcriptional Factor

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 517-531页

作者： lei Liang Xiangyang Hu Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China

With the rapid development of modern molecular biology and bioinformatics,many studies have proved that transcription factors play an important role in regulating the growth and development of ***(SPT)belongs to the bHLH transcription family and participates in many processes of regulating plant growth and *** review systemically summarizes the multiple roles of SPT in plant growth,development,and stress response,including seed germination,ﬂowering,leaf size,carpel development,and root elongation,which is helpful for us to better understand the functions of SPT.

关键词： SPT bHLH plant growth plant development Arabidopsis thaliana

Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan QIU Sheng-lei SHANG Ju-ju WANG Zi LAI Xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

Semi-tensor product approach for partially symmetric games

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Journal of Control and Decision 2024年第1期11卷 98-106页

作者： lei Wang Jiandong Zhu School of Mathematical Sciences Nanjing Normal UniversityNanjingPeople’s Republic of China

In this paper,a criterion for the partially symmetric game(PSG)is derived by using the semitensor product *** dimension and the basis of the linear subspace composed of all the PSGs with respect to a given set of partial players are *** testing equations with the minimum number are concretely determined,and the computational complexity is ***,two examples are displayed to show the theoretical results.

关键词： Partially symmetric game semi-tensor product of matrices adjacent transpositions

Strong,tough,and thermally conductive nacre-inspired boron nitride nanosheet/epoxy layered nanocomposites

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Nano Research 2024年第2期17卷 820-828页

作者： Huagao Wang Rongjian Lu lei Li Cheng Liang Jia Yan Rui Liang Guoxing Sun lei Jiang Qunfeng Cheng School of Chemistry Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of EducationBeihang UniversityBeijing 100191China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Department of Stomatology Fifth Medical CenterChinese PLA General HospitalBeijing 100039China Department of Engineering Science Faculty of Innovation EngineeringMacao University of Science and TechnologyAvenida Wai LongTaipaMacao 999078 China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078China Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Thermally conductive polymer nanocomposites integrated with lightweight,excellent flexural strength,and high fracture toughness(KIc)would be of great use in many ***,achieving all of these properties simultaneously remains a great *** by natural nacre,here we demonstrate a lightweight,strong,tough,and thermally conductive boron nitride nanosheet/epoxy layered(BNNEL)*** of the layered structure and enhancing the interfacial interactions through hydrogen bonding and Si–O–B covalent bonding,the resulting nacre-inspired BNNEL nanocomposites show high fracture toughness of~4.22 MPa·m^(1/2),which is 7 folds as high as pure ***,the BNNEL nanocomposites demonstrate sufficient flexural strength(~168.90 MPa,comparable to epoxy resin),while also being lightweight(~1.23 g/cm^(3)).Additionally,the BNNEL nanocomposites display a thermal conductivity(κ)of~0.47 W/(m·K)at low boron nitride nanosheet loading of 2.08 vol.%,which is 2.7 times higher than that of pure epoxy *** developed nacre-inspired strategy of layered structure design and interfacial enhancement provides an avenue for fabricating high mechanical properties and thermally conductive polymer nanocomposites.

关键词： nacre-inspiration nanocomposites flexural strength fracture toughness(KIc) thermal conductivity

A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics

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Petroleum Science 2024年第1期21卷 327-342页

作者： Qian Zhang Wen-Dong Wang Yu-Liang Su Wei Chen Zheng-Dong lei lei Li Yong-Mao Hao Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Oil Development Branch Changqing Oilfield CompanyPetroChinaQingyang745708GansuChina PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China

A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.

关键词： Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory

Molecules for COVID-19 treatment

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Chinese Chemical Letters 2024年第7期35卷 59-65页

作者： Zhigang Zeng Changzhou Liao lei Yu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry&BiologyHubei University of Science and TechnologyXianning 437100China Hubei Industry Technology Research Institute of Intelligent Health Xianning 437100China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

COVID-19 is a major event with worldwide *** the beginning of the epidemic,pharmaceutical chemists have paid attention to the therapeutic effect of a variety of small molecule medicines on COVID-19 infection.A series of organic molecules are designed and found to be effective in the treatment of COVID-19 *** fact,no matter how effective they are,with the development of the COVID-19 epidemic,various small molecule medicines are gradually recognized by *** is equivalent to a good science popularization of pharmaceutical *** review aims to introduce the molecules for COVID-19 treatment on the basis of their chemical structures,synthetic methods as well as their effects.

关键词： COVID-19 Small molecule medicines "Star"drugs Chemical structure Synthetic method

Dynamic motion of quadrupedal robots on challenging terrain:a kinodynamic optimization approach

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Frontiers of Mechanical Engineering 2024年第3期19卷 23-40页

作者： Qi LI lei DING Xin LUO Engineering Research Center of Hubei Province for Clothing Information Wuhan 430200China School of Computer Science and Artificial Intelligence Wuhan Textile UniversityWuhan 430200China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

The dynamic motion of quadrupedal robots on challenging terrain generally requires elaborate spatial–temporal kinodynamic motion planning and accurate control at higher refresh rate in comparison with regular ***,conventional quadrupedal robots usually generate relatively coarse planning and employ motion replanning or reactive strategies to handle terrain *** resultant complex and computation-intensive controller may lead to nonoptimal motions or the breaking of locomotion *** this paper,a kinodynamic optimization approach is *** generate long-horizon optimal predictions of the kinematic and dynamic behavior of the quadruped robot on challenging terrain,we formulate motion planning as an optimization problem;jointly treat the foot’s locations,contact forces,and torso motions as decision variables;combine smooth motion and minimal energy consumption as the objective function;and explicitly represent feasible foothold region and friction constraints based on terrain *** track the generated motions accurately and stably,we employ a whole-body controller to compute reference position and velocity commands,which are fed forward to joint controllers of the robot’s *** verify the effectiveness of the developed approach through simulation and on a physical quadruped robot *** show that the quadruped robot can successfully traverse a 30°slope and 43% of nominal leg length high step while maintaining the rhythm of dynamic trot gait.

关键词： quadrupedal robot kinodynamic planning nonlinear optimization challenging terrain whole-body control

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Science China Mathematics 2024年第2期67卷 405-430页

作者： Junzhuo Gao lei Wang Heng Lian School of Statistics and Data Science&LPMC Nankai UniversityTianjin 300071China Department of Mathematics City University of Hong KongHong KongChina

In this paper, we consider the unified optimal subsampling estimation and inference on the lowdimensional parameter of main interest in the presence of the nuisance parameter for low/high-dimensionalgeneralized linear models (GLMs) with massive data. We first present a general subsampling decorrelated scorefunction to reduce the influence of the less accurate nuisance parameter estimation with the slow convergencerate. The consistency and asymptotic normality of the resultant subsample estimator from a general decorrelatedscore subsampling algorithm are established, and two optimal subsampling probabilities are derived under theA- and L-optimality criteria to downsize the data volume and reduce the computational burden. The proposedoptimal subsampling probabilities provably improve the asymptotic efficiency of the subsampling schemes in thelow-dimensional GLMs and perform better than the uniform subsampling scheme in the high-dimensional GLMs.A two-step algorithm is further proposed to implement, and the asymptotic properties of the correspondingestimators are also given. Simulations show satisfactory performance of the proposed estimators, and twoapplications to census income and Fashion-MNIST datasets also demonstrate its practical applicability.

关键词： A-optimality decorrelated score subsampling high-dimensional inference L-optimality massive data

Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases

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Neural Regeneration Research 2024年第10期19卷 2115-2116页

作者： lei Cao Bin Ji Ruiqing Ni Changes Technology Corporation Ltd. ShanghaiChina Fudan University ShanghaiChina School of Pharmacy Fudan UniversityShanghaiChina Institute for Biomedical Engineering University of Zurich&ETH Zurich Institute for Regenerative MedicineUniversity of ZurichZurichSwitzerland

Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific *** studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders.

关键词： diseases degenerative clinical