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Analysis of environmental selection pressure of superoxide dismutase in deep-sea sea cucumber

Journal of Oceanology and limnology 2024年第3期42卷 893-904页

作者： Yanan li Zongfu CHEN Haibin ZHANG Ruoyu liU Shuichun CHEN li lin Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhou 510222China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China College of Marine Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Zhanjiang Tianli Sea Cucumber New Technology Development Co. Ltd.Zhanjiang 524000China

Manganese superoxide dismutase(MnSOD)is an antioxidant that exists in mitochondria and can effectively remove superoxide anions in *** a dark,high-pressure,and low-temperature deep-sea environment,MnSOD is essential for the survival of sea *** MnSODs were identified from the transcriptomes of deep and shallow-sea sea *** explore their environmental adaptation mechanism,we conducted environmental selection pressure analysis through the branching site model of PAML *** obtained night positive selection sites,and two of them were significant(97F→H,134K→V):97F→H located in a highly conservative characteristic sequence,and its polarity c hange might have a great impact on the function of MnSOD;134K→V had a change in piezophilic a bility,which might help MnSOD adapt to the environment of high hydrostatic pressure in the *** further study the effect of these two positive selection sites on MnSOD,we predicted the point mutations of F97H and K134V on shallow-sea sea cucumber by using MAESTROweb and *** show that 97F→H,134K→V might improve MnSOD’s efficiency of scavenging superoxide a nion and its ability to resist high hydrostatic pressure by moderately reducing its *** above results indicated that MnSODs of deep-sea sea cucumber adapted to deep-sea environments through their amino acid changes in polarity,piezophilic behavior,and local *** study revealed the correlation between MnSOD and extreme environment,and will help improve our understanding of the organism’s adaptation mechanisms in deep sea.

关键词： Holothuroidea environmental adaptation positive selection point mutation

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A rare case of hepatic vein-portal vein fistula with hepatolithiasis presenting as cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 538-540页

作者： Wei li Wen lin Le Xiao General Surgery Center The General Hospital of Western Theater CommandChengdu 610083China

To the Editor: We sincerely applaud the work by Tang et al., in which they described caudate lobe-sparing subtotal hepatectomy as treatment for intrahepatic arterioportal fistulas [ 1 ]. Compared to intrahepatic arterioportal fistulas, portal vein-hepatic vein fistulas are rarely reported. Patients typically lack clinical symptoms such as hyperammonemia, cholestatic jaundice, and hypoglycemia, unless the shunt becomes relatively large [ 2, 3 ]. Herein, we describe partial hepatectomy as a treatment for cases of left portal vein-middle hepatic vein fistulas.

关键词： hepatic clinical

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Effect of MgO-Cr_(2)O_(3) and Mg0-MgAl_(2)0_(4)-based refractories on refractory-steel interface reaction and cleanliness of pipeline steel

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Journal of Iron and Steel Research International 2024年第4期31卷 849-860页

作者： Guang-mei Yang Cheng Yuan Chang liu Qiang Wang Guang-qiang li Yong-shun Zou Ao Huang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The interaction of MgO-MgAl_(2)O_(4)-based and MgO-Cr_(2)O_(3)-based refractories with X70 molten steel was studied by immersion experiments at 1560℃.The effects of immersion time(30 and 60 min)on the contents of total oxygen(TO),Al,Nb,Si,Mn,and Cr as well as the composition,number density,and size distribution of inclusions in the molten steel were *** influence of the penetration and erosion degree of the molten steel to the refractory on the steel-refractory interface layer was *** results show that,at 1560℃,the MgO-MgAl_(2)O_(4)-based refractory can better control the contents of TO and the composition of molten steel compared with the MgO-Cr_(2)O_(3)-based *** TO content is only 16×10^(-4) wt.%in the molten steel after reacted with the Mg0-MgAl_(2)O_(4)-based refractory at the end point of refining,4 accounting for 11.5%of that reacted with the MgO-Cr_(2)O_(3)-based refractory(139×10^(-4) wt.%).The number density of inclusions is only 14 mm^(-2),and the average size ofinclusions is only 1.31μm,with thelargest proportion of inclusions in 1-2μm(70%).The Al_(2)O_(3)-MnS-CaO complex inclusions in the original steel changed to complex inclusions dominated by Cr-Nb-Mn-S-O and ***_(2)O_(3),corresponding to the MgO-Cr_(2)O_(3)-based and MgO-MgAl_(2)O_(4)-based refractories,*** ***_(2)O_(3) layer was formed at the reaction interface between MgO-MgAl_(2)O_(4)-based refractory and molten steel,which is helpful to restrict the erosion of refractories and the pollution of molten *** damage mechanism of the MgO-Cr_(2)O_(3)-based refractory is mainly permeation and chemical reaction,while the damage of the MgO-MgAl_(2)O_(4)-based refractory is mainlyscouring erosion.

关键词： MgO-Cr_(2)O_(3)-based refractory MgO-MgAl O_(4)-based refractory Nonmetallic inclusion Erosion interface layer Steel penetration

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min liu Hai-lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu shun-Ying Zhao Yun-Xiao Shang ling Cao Yan-Hui Jia Luo-Na lin Jiong li Chuang-li Hao Xiao-Yan Dong Dao-Jiong lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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Combo Packet:An Encryption Traffic Classification Method Based on Contextual Information

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Computers, Materials & Continua 2024年第4期79卷 1223-1243页

作者： Yuancong Chai Yuefei Zhu Wei lin Ding li State Key Laboratory of Mathematical Engineering and Advanced Computing Information Engineering UniversityZhengzhou450001China

With the increasing proportion of encrypted traffic in cyberspace, the classification of encrypted traffic has becomea core key technology in network supervision. In recent years, many different solutions have emerged in this *** methods identify and classify traffic by extracting spatiotemporal characteristics of data flows or byte-levelfeatures of packets. However, due to changes in data transmission mediums, such as fiber optics and satellites,temporal features can exhibit significant variations due to changes in communication links and transmissionquality. Additionally, partial spatial features can change due to reasons like data reordering and *** with these challenges, identifying encrypted traffic solely based on packet byte-level features is significantlydifficult. To address this, we propose a universal packet-level encrypted traffic identification method, ComboPacket. This method utilizes convolutional neural networks to extract deep features of the current packet andits contextual information and employs spatial and channel attention mechanisms to select and locate effectivefeatures. Experimental data shows that Combo Packet can effectively distinguish between encrypted traffic servicecategories (e.g., File Transfer Protocol, FTP, and Peer-to-Peer, P2P) and encrypted traffic application categories (e.g.,BitTorrent and Skype). Validated on the ISCX VPN-non VPN dataset, it achieves classification accuracies of 97.0%and 97.1% for service and application categories, respectively. It also provides shorter training times and higherrecognition speeds. The performance and recognition capabilities of Combo Packet are significantly superior tothe existing classification methods mentioned.

关键词： Encrypted traffic classification packet-level convolutional neural network attention mechanisms

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Tailoring chaotic motion of microcavity photons in ray and wave dynamics by tuning the curvature of space

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 107-112页

作者： Wei lin Yechun Ding Yongsheng Wang Peng li Yanpeng Zhang Feng Yun Feng li Key Laboratory for Physical Electronics and Devices of the Ministry of Education Shaanxi Key Lab of Information Photonic TechniqueSchool of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Electrical and Photonics Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark Center for Regenerative and Reconstructive Medicine Med-X InstituteThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Solid-State lighting Engineering Research Center Xi’an Jiaotong UniversityXi’an 710049China

Microcavity photon dynamics in curved space is an emerging interesting area at the crossing point of nanophotonics,chaotic science,and non-Euclidean *** report the sharp difference between the regular and chaotic motions of cavity photons subjected to the varying space *** the island modes of regular motion rise in the phase diagram in the curved space,the chaotic modes show special mechanisms to adapt to the space curvature,including the fast diffusion of ray dynamics,and the localization and hybridization of the Husimi wavepackets among different periodic *** observations are unique effects enabled by the combination of the chaotic trajectory,the wave nature of light,and the non-Euclidean orbital motion,and therefore make the system a versatile optical simulator for chaotic science under quantum mechanics in curved space-time.

关键词： microcavity chaotic motion curved space

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Along-track Calibration of the Zhurong Rover Magnetometer

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Science China Earth Sciences 2024年第2期67卷 552-565页

作者： Hao LUO Aimin DU Yasong GE Ying ZHANG Haiying li lin TIAN Kuixiang ZHANG Shuquan SUN lin ZHAO Zhi li Xiao FENG CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth Science University of Chinese Academy of SciencesBeijing100049China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China

As part of the Chinese Tianwen-1 mission,the Zhurong Rover began its scientific investigation in the southern Utopia Planitia after its successful landing in 15 May,*** Zhurong Rover magnetometer(RoMAG),one of the six payloads onboard the rover,includes two identical high-sensitivity triaxial fluxgate magnetometers and can implement mobile magnetic measurements on the surface of *** a rover magnetic compensation procedure was conducted to remove the magnetic interferences pre-launch,due to the different state of the payloads and electric power system such as the solar panel,an along-track calibration of the magnetometer is necessary to obtain a more accurate Martian magnetic *** methods,mast yaw rotations and Rover yaw rotations were utilized separately to determine the Martian horizontal magnetic *** show that the Martian horizontal magnetic components determined by the two methods are in good agreement,with the root mean square deviation less than 2.0 *** vertical component was also constrained through the pitch movements of the mast by assuming the interferences field distributes like a dipole field.A linear correlation between magnetic field measurements and the solar array currents was derived to calibrate the body field during the regular *** conclude that more accurate measurements could be made when applying the calibration results in the magnetic survey on the surface of Mars.

关键词： The Zhurong Rover Magnetometer Along-track calibration Remnant magnetization

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Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release

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Virologica Sinica 2024年第1期39卷 24-30页

作者： Jia li Yong lin Xueyu Wang Mengji Lu Institute for Virology University Hospital EssenUniversity of Duisburg-EssenEssen45122Germany Key Laboratory of Molecular Biology of Infectious Diseases(Chinese Ministry of Education) Chongqing Medical UniversityChongqing400016China The Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310000China

Hepatitis B virus(HBV)produces and releases various particle types,including complete virions,subviral particles with envelope proteins,and naked *** studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways,including the endosomal vesicle trafficking and autophagy pathway,to assemble and release viral and subviral ***,we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication,assembly,and release.

关键词： Amphisome Autophagy Endosomal vesicle Hepatitis B virus(HBV)

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Identification of the Worst-case Static Voltage Stability Margin Interval of AC/DC Power System Considering Uncertainty of Renewables

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 974-987页

作者： Wanbin liu shunjiang lin Yuerong Yang Mingbo liu Qifeng li School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Guangdong Key Laboratory of Clean Energy Technology South China University of TechnologyGuangzhou 511458China Department of Electrical and Computer Engineering University of Central FloridaOrlandoFL 32816USA CSEE IEEE

Calculation of static voltage stability margin(SVSM)of AC/DC power systems with lots of renewable energy sources(RESs)integration requires consideration of uncertain load growth and renewable energy generation *** paper presents a bi-level optimal power flow(BLOPF)model to identify the worst-case SVSM of an AC/DC power system with line commutation converter-based HVDC and multi-terminal voltage sourced converter-based HVDC transmission *** of uncertain load growth’s hypercone model and control mode switching of DC converter stations are considered in the BLOPF ***,uncertain RES output fluctuations are described as intervals,and two three-level optimal power flow(TLOPF)models are established to identify interval bounds of the system worst-case *** two TLOPF models are both transformed into max–min bi-level optimization models according to independent characteristics of different uncertain ***,transforming the inner level model into its dual form,max–min BLOPF models are simplified to single-level optimization models for direct *** results on the modified IEEE-39 bus AC/DC case and an actual large-scale AC/DC case in China indicate correctness and efficiency of the proposed identification method.

关键词： AC/DC power system control mode switching convex relaxation dual programming multi-level optimization optimal power flow static voltage stability margin

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Risk-averse Robust Interval Economic Dispatch for Power Systems with Large-scale Wind Power Integration

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 105-116页

作者： Zhenjia lin Haoyong Chen Jinbin Chen Jianping Huang Mengshi li School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China Department of Electrical Engineering Technical University of DenmarkDenmark

This paper presents a robust interval economic dispatch(RIED)model for power systems with large-scale wind power *** from existing interval optimization(IO)approaches that merely rely on the upper and lower boundaries of random variables,the distribution information retained in the historical data is introduced to the IO method in this *** on the available probability distribution function(PDF),wind power curtailment and load shedding are quantified as the operational risk and incorporated into the decision-making *** this model,we need not rely on the forecasted value of wind power,which is randomly fluctuating and quite ***,when the PDFs of wind power are taken into account,the resulting dispatch solution makes a good tradeoff between the generation cost and the operational ***,the RIED model yields an optimal dispatch solution for thermal units and the allowable intervals of wind power for the wind farms,which efficiently mitigates the uncertainty in wind power generation and provides more practical suggestions for system *** studies are conducted on a modified IEEE-118 bus system and the results verify the effectiveness of the proposed RIED model.

关键词： Economic dispatch interval optimization risk-averse wind power generation

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