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Dysregulation of CDK8 and Cyclin C in tumorigenesis

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Journal of Genetics and Genomics 2011年第10期38卷 439-452页

作者： Wu Xu jun-Yuan ji Department of Chemistry University of Louisiana at Lafayette P.O. Box 44370 Lafayette LA 70504 USA Department of Molecular and Cellular Medicine College of Medicine Texas A＆M Health Science Center College Station TX 77843 USA

Appropriately controlled gene expression is fundamental for normal growth and survival of all living organisms. In eukaryotes, the tran- scription of protein-coding mRNAs is dependent on RNA polymerase II （Pol II）. The multi-subunit transcription cofactor Mediator complex is proposed to regulate most, if not all, of the Pol II-dependent transcription. Here we focus our discussion on two subunits of the Mediator complex, cyclin-dependent kinase 8 （CDK8） and its regulatory partner Cyclin C （CycC）, because they are either mutated or amplified in a variety of human cancers. CDK8 functions as an oncoprotein in melanoma and colorectal cancers, thus there are considerable interests in developing drugs specifically targeting the CDK8 kinase activity. However, to evaluate the feasibility of targeting CDK8 for cancer therapy and to understand how their dysregulation contributes to tumorigenesis, it is essential to elucidate the in vivo function and regulation of CDKS-CycC, which are still poorly understood in multi-cellular organisms. We summarize the evidence linking their dysregulation to various cancers and present our bioinformatics and computational analyses on the structure and evolution of CDK8. We also discuss the implications of these observations in tumorigenesis. Because most of the Mediator subunits, including CDK8 and CycC, are highly conserved during eukaryotic evolution, we expect that investigations using model organisms such as Drosophila will provide important insights into the function and regulation of CDK8 and CycC in different cellular and developmental contexts.

关键词： Mediator complex CDKS Transcription Tumorigenesis MD simulation

Synthesis and Crystal Structure of 1,7,7-Trimethyl-4-(4-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under Microwave Irradiation

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Chinese Journal of Structural Chemistry 2006年第5期25卷 599-603页

作者： HUA Guo-Ping ZHU Xiao-Tong ZHANG jin-Peng XU jia-Ning WANG Qian ji shun-jun ZHANG Yong TU Shu-jiang Xuzhou Institute of Architectural Technology Xuzhou Jiangsu 221008 China Department of Chemistry Xuzhou Normal University Key Laboratory of Biotechnology on Medical Plant Xuzhou Jiangsu 221116 China College of Chemistry and Chemical Engineering Key Laboratory of Organic Synthesis of Jiangsu Province Suzhou University Suzhou Jiangsu 215006 China

The title compound （C19H23NO3） was synthesized by the one-pot reaction ofp-methoxybenzaldehyde, Meldrum＇s acid, dimedone and CH3NH3Cl （NaOAc） in ethanol under microwave irradiation without catalyst and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 8.7462（10）, b = 17.7367（19）, c = 11.5959（14） A, β = 110.981（3）°, V= 1679.6（3） A^3, Z = 4, Dc = 1.239 g/cm^3,μ（MoKa） = 0.083 mm^-1, F（000） = 672 and Mr = 313.38. The structure was refined to R = 0.0530 and wR = 0.1216. X-ray analysis reveals that the dihedral angle between plane 1 （N（1）, C（1）, C（2）, C（3）） and plane 2 （C（1）, C（2）, C（6）, C（7）, C（9）） is 3.64°, andt hat between plane 2 and plane 3 （C（11）～C（16）） is 85.33°.

关键词： 4,6,7,8-tetrahydroquinoline-2,5-diones synthesis microwave irradiation crystal structure

Treatment of pyogenic liver abscess by surgical incision and drainage combined with platelet-rich plasma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7082-7089页

作者： jun-Hong Wang Zhen-Hua Gao Hong-Liang Qian jin-shun Li Hao-Min ji Ming-Xu Da The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hepatobiliary Surgery The First People’s Hospital of BaiyinBaiyin 730900Gansu ProvinceChina Department of General Surgery People’s Hospital of Gansu ProvinceLanzhou 730000Gansu ProvinceChina

BACKGROUND Pyogenic liver abscesses are insidious in the early *** cases progress rapidly,and the patient’s condition can worsen and even become life-threatening if timely treatment is not *** and prolonged antibiotic treatment are often required if the abscess is large and liquefied and becomes separated within the *** SUMMARY We report a case of bacterial liver abscess with a poor outcome following pharmacological treatment,review the literature related to the use of platelet-rich plasma(PRP)in the treatment of hepatic impairment and partial hepatectomy in animals,and discuss the prognostic features of surgical incision and drainage combined with PRP in the treatment of bacterial liver *** is the first case describing the use of PRP in the treatment of a bacterial liver abscess in humans,providing new ideas for the treatment of this *** This case highlights the importance of surgical treatment for bacterial liver abscesses that are well liquefied and poorly managed *** may produce antimicrobial effects and promote the regeneration and repair of liver tissue.

关键词： Pyogenic liver abscess Surgical incision and drainage Platelet-rich plasma Case report

Effects of UV intensity and water turbidity on microbial indicator Inactivation

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Journal of Environmental Sciences 2006年第4期18卷 650-653页

作者： LIU Wen-jun ZHANG Yong-ji Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

The effects of UV intensity and turbidity on selected microbial indicator inactivation were investigated. Results showed that UV disinfection was effective in killing all the selected microbial indicators, the resistance order of the microorganisms was as follows： MS-2 coliphage 〉 Bacillus subtilis 〉 E. coil 〉 Staphylococcus aureus and Candida albicans. UV intensity had influence on the inactivation of all the microorganisms, high UV disinfection efficency was obtained with higher UV intensity. Turbidity had impact on the bacteria inactivation rate, but there was no evidence that turbidity had any negative contribution to MS-2 coliphage. Under the same UV dosage, higher UV intensity could overcome the negative influence of turbidity on UV performance, enhanced microorganism inactivation effect in turbidity water.

关键词： UV disinfection intensity exposure time microbial indicator

Canonical Characteristic Relation for Two Dimensional Euler Equations

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Applied Mathematics(A Journal of Chinese Universities) 2011年第3期26卷 327-333页

作者： SUN shun-kai SHEN Long-jun ZHOU Yu-lin Institute of Applied Physics and Computational Mathematics Beijing B.O. Box 8009 P.R.China

We propose a new way of rewriting the two dimensional Euler equations and derive an original canonical characteristic relation based on the characteristic theory of hyperbolic systems. This relation contains the derivatives strictly along the bicharacteristic directions, and can be viewed as the 2D extension of the characteristic relation in 1D case.

关键词： Euler equations characteristic relation bicharacteristics hyperbolic system.

Reconstruction of the Space-dependent Source from Partial Neumann Data for Slow Diffusion System

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Acta Mathematicae Applicatae Sinica 2020年第1期36卷 166-182页

作者： Chun-long SUN ji-jun LIU School of Mathematics S.T.Yau Center of Southeast UniversitySoutheast UniversityNanjing 210096China

Consider a linear inverse problem of determining the space-dependent source term in a diffusion equation with time fractional order derivative from the flux measurement specified in partial *** on the analysis on the forward problem and the adjoint problem with inhomogeneous boundary condition,a variational identity connecting the inversion input data with the unknown source function is *** uniqueness and the conditional stability for the inverse problem are proven by weak unique continuation and the variational identity in some *** inversion scheme minimizing the regularizing cost functional is implemented by using conjugate gradient method,with numerical examples showing the validity of the proposed reconstruction scheme.

关键词： time-fractional diffusion inverse source problem variational method Lipschitz stability

Holomorphic Curves into Projective Varieties Intersecting Closed Subschemes in Subgeneral Position

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Chinese Annals of Mathematics,Series B 2022年第6期43卷 1023-1032页

作者： Qingchun ji jun YAO Guangsheng YU School of Mathematical Sciences and Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,the authors introduce the index of subgeneral position for closed subschemes and obtain a second main theorems based on this *** also give the corresponding Schmidt’s subspace type theorem via the analo... 详细信息

关键词： Nevanlinna theory Second main theorem Holomorphic curve Subgeneral position Closed subschemes Schmidt’s subspace theorem

Light Flavor Vector and Pseudo Vector Mesons from a Light-Cone QCD Inspired Effective Hamiltonian Model with SU（3） Flavor Mixing Interactions

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Chinese Physics Letters 2010年第6期27卷 37-39页

作者： GUO Xiao-Bo TAO jun LI Lei WANG shun-jin Center of Theoretical Physics School of Physics and Technology Sichuan University Chengdu 610064 School of Science Southwest University of Science and Technology Mianyang 621010 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000

Based on the light-cone effective Hamiltonian with confining potential and SU （3） flavor mixing interactions, the flavor mixing mesons on the u, d, and s quark sectors are investigated. The mass eigen equations of the flavor mixing vector and pseudo vector mesons are solved. The calculated masses are in good agreement with the experimental data.

关键词： Vectors Weight Mixing Flavour

Ileo-colonic intussusception secondary to small-bowel lipomatosis:A case report

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World Journal of Gastroenterology 2014年第8期20卷 2117-2119页

作者： Peng-ji Gao Lei Chen Fu-shun Wang ji-Ye Zhu Department of Hepatobiliary Surgery Peking University People’s Hospital

Intestinal lipomatosis is a rare disease with an incidence at autopsy ranging from 0.04% to 4.5%.Because the lipomas are diffusely distributed in the intestine,most patients are symptom-free,and invasive intervention is not advised by most ***,we describe a case with intussusception due to small-bowel *** small bowel resection and anastomosis were performed because the intestinal wall was on the verge of *** case indicates that regular followup is necessary and endoscopic treatment should be considered to avoid surgical procedures if the lipoma is large enough to cause intestinal obstruction.

关键词： Intussusception Lipomatosis Lipoma Obstruction Endoscopy