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A Transfer Learning Based Approach for COVID-19 Detection Using Inception-v4 Model

Intelligent Automation & Soft Computing 2023年第2期35卷 1721-1736页

作者： Ali Alqahtani shumaila akram Muhammad Ramzan Fouzia Nawaz Hikmat Ullah Khan Essa Alhashlan Samar MAlqhtani Areeba Waris Zain Ali College of Computer Science and Information Systems Najran UniversityNajran61441Saudi Arabia Department of Computer Science and Information Technology University of SargodhaSargodha40100Pakistan School of Systems and Technology University of Management and TechnologyLahore54782Pakistan Department of Computer Science COMSATS University IslamabadWah CampusIslamabad47040Pakistan Department of Medical Imaging King Khaled HospitalNajran61441Saudi Arabia Electrical&Electronics Engineering Department Universiti TeknologiPetronas31750Malaysia Department of Electrical Engineering HITEC UniversityTaxila47080Pakistan

Coronavirus(COVID-19 or SARS-CoV-2)is a novel viral infection that started in December 2019 and has erupted rapidly in more than 150 *** rapid spread of COVID-19 has caused a global health emergency and resulted in governments imposing lock-downs to stop its *** is a signiﬁ-cant increase in the number of patients infected,resulting in a lack of test resources and kits in most *** overcome this panicked state of affairs,researchers are looking forward to some effective solutions to overcome this situa-tion:one of the most common and effective methods is to examine the X-radiation(X-rays)and computed tomography(CT)images for detection of ***-ever,this method burdens the radiologist to examine each ***,to reduce the burden on the radiologist,an effective,robust and reliable detection system has been developed,which may assist the radiologist and medical specia-list in effective detecting of *** proposed a deep learning approach that uses readily available chest radio-graphs(chest X-rays)to diagnose COVID-19 *** proposed approach applied transfer learning to the Deep Convolutional Neural Network(DCNN)model,Inception-v4,for the automatic detection of COVID-19 infection from chest X-rays *** dataset used in this study contains 1504 chest X-ray images,504 images of COVID-19 infection,and 1000 normal images obtained from publicly available medical *** results showed that the proposed approach detected COVID-19 infection with an overall accuracy of 99.63%.

关键词： COVID-19 transfer learning deep learning artiﬁcial intelligence chest X-rays machine learning

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Morphology design of microporous organic polymers and their potential applications:an overview

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Science China Chemistry 2017年第8期60卷 1056-1066页

作者： qingyin li shumaila razzaque shangbin jin bien tan Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Microporous organic polymers(MOPs) have attracted considerable research interest because of their well-defined porosity,high surface area, lightweight nature, and tunable surface chemistry. The morphology of MOPs are demonstrated to play a significant role in various applications although limited examples manifesting the importance of the MOP morphology in numerous applications have been reported. This review summarizes the recent progress in the design of MOPs using different techniques, including hard and soft template and direct synthesis methods. In addition, their applications, which possibly attribute to their shape, are discussed. Furthermore, the advantages and disadvantages of different methods are discussed, as well as their development and future challenges.

关键词： microporous organic polymers morphology control different dimensional structure

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A numerical framework for the approximate solution of fractional tumor-obesity model

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第1期10卷 106-118页

作者： Sadia Arshad Dumitru Baleanu Ozlem Defterli shumaila Department of Mathematics COMSATS University Islamabad LahorePunjab 54000Pakistan Department of Mathematics and Computer Sciences Cankaya University Ankara 06530Turkey

In this paper,we have proposed the efficient numerical methods to solve a tumor-obesity model which involves two types of the fractional operators namely Caputo and CaputoFabrizio(CF).Stability and convergence of the proposed schemes using Caputo and CF fractional operators are *** simulations are carried out to investigate the effect of low and high caloric diet on tumor dynamics of the generalized *** perform the numerical simulations of the tumor-obesity model for different fractional order by varying immune response rate to compare the dynamics of the Caputo and CF fractional operators.

关键词： Tumor-obesity model numerical approximation stability and convergence analysis

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A Novel Fractional Dengue Transmission Model in the Presence of Wolbachia Using Stochastic Based Artificial Neural Network

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1217-1238页

作者： Zeshan Faiz Iftikhar Ahmed Dumitru Baleanu shumaila Javeed Department of Mathematics COMSATS University IslamabadIslamabad45550Pakistan Department of Mathematics Cankaya UniversityAnkara06790Turkey Institute of Space Sciences Magurele-Bucharest077125Romania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan Department of Computer Science and Mathematics Lebanese American UniversityBeirut135053Lebanon Department of Mathematics Mathematics Research CenterNear East UniversityNicosia/Mersin99138Turkey

The purpose of this research work is to investigate the numerical solutions of the fractional dengue transmission model(FDTM)in the presence of Wolbachia using the stochastic-based Levenberg-Marquardt neural network(LM-NN)*** fractional dengue transmission model(FDTM)consists of 12 *** human population is divided into four compartments;susceptible humans(S_(h)),exposed humans(E_(h)),infectious humans(I_(h)),and recovered humans(R_(h)).Wolbachia-infected and Wolbachia-uninfected mosquito population is also divided into four compartments:aquatic(eggs,larvae,pupae),susceptible,exposed,and *** investigated three different cases of vertical transmission probability(η),namely when Wolbachia-free mosquitoes persist only(η=0.6),when both types of mosquitoes persist(η=0.8),and when Wolbachia-carrying mosquitoes persist only(η=1).The objective of this study is to investigate the effectiveness of Wolbachia in reducing dengue and presenting the numerical results by using the stochastic structure LM-NN approach with 10 hidden layers of neurons for three different cases of the fractional order derivatives(α=0.4,0.6,0.8).LM-NN approach includes a training,validation,and testing procedure to minimize the mean square error(MSE)values using the reference dataset(obtained by solving the model using the Adams-Bashforth-Moulton method(ABM).The distribution of data is 80% data for training,10% for validation,and,10% for testing purpose)results.A comprehensive investigation is accessible to observe the competence,precision,capacity,and efficiency of the suggested LM-NN approach by executing the MSE,state transitions findings,and regression *** effectiveness of the LM-NN approach for solving the FDTM is demonstrated by the overlap of the findings with trustworthy measures,which achieves a precision of up to 10^(-4).

关键词： Wolbachia dengue neural network vertical transmission mean square error Levenberg-Marquardt

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Regulating the fate of stem cells for regenerating the intervertebral disc degeneration

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World Journal of Stem Cells 2021年第12期13卷 1881-1904页

作者： Sobia Ekram shumaila Khalid Asmat Salim Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan

Lower back pain is a leading cause of disability and is one of the reasons for the substantial socioeconomic *** etiology of intervertebral disc(IVD)degeneration is complicated,and its mechanism is still not completely *** such as aging,systemic inflammation,biochemical mediators,toxic environmental factors,physical injuries,and genetic factors are involved in the progression of its ***,no therapy for restoring degenerated IVD is available except pain management,reduced physical activities,and surgical ***,it is imperative to establish regenerative medicine-based approaches to heal and repair the injured disc,repopulate the cell types to retain water content,synthesize extracellular matrix,and strengthen the disc to restore normal spine *** therapy has gained attention for IVD management as an alternative therapeutic *** this review,we present an overview of the anatomical and molecular structure and the surrounding pathophysiology of the *** therapeutic approaches,including proteins and growth factors,cellular and gene therapy,and cell fate regulators are ***,small molecules that modulate the fate of stem cells for their differentiation into chondrocytes and notochordal cell types are highlighted.

关键词： Stem cell Intervertebral disc Degeneration Inflammation Cell therapy Gene modification

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Application of Modified Extended Tanh Technique for Solving Complex Ginzburg-Landau Equation Considering Kerr Law Nonlinearity

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Computers, Materials & Continua 2021年第2期66卷 1369-1378页

作者： Yuming Chu Muhannad A.Shallal Seyed Mehdi Mirhosseini-Alizamini Hadi Rezazadeh shumaila Javeed Dumitru Baleanu Department of Mathematics Huzhou UniversityHuzhou313000China Hunan Provincial Key Laboratory of Mathematical Modeling and Analysis in Engineering Changsha University of Science&TechnologyChangsha410114China Mathematics Department College of ScienceUniversity of KirkukKirkukIraq Department of Mathematics Payame Noor UniversityTehranIran Amol University of Special Modern Technologies AmolIran Department of Mathematics COMSATS University IslamabadChak Shahzad Islamabad45550Pakistan Department of Mathematics Cankaya UniversityAnkaraTurkey Institute of Space Sciences Magurele-BucharestRomania

The purpose of this work is to find new soliton solutions of the complex Ginzburg–Landau equation(GLE)with Kerr law *** considered equation is an imperative nonlinear partial differential equation(PDE)in the field of *** applications of complex GLE can be found in optics,plasma and other related *** modified extended tanh technique with Riccati equation is applied to solve the Complex *** results are presented under a suitable choice for the values of *** are shown using the three and two-dimensional plots to represent the shape of the solution in real,and imaginary parts in order to discuss the similarities and difference between *** graphical representation of the results depicts the typical behavior of soliton *** obtained soliton solutions are of different forms,such as,hyperbolic and trigonometric *** results presented in this paper are novel and reported first time in the *** results establish the validity and applicability of the suggested technique for the complex *** suggested method with symbolic computational software such as,Mathematica and Maple,is proven as an effective way to acquire the soliton solutions of nonlinear partial differential equations(PDEs)as well as complex PDEs.

关键词： Modified extended tanh technique soliton solution complex Ginzburg-Landau equation Riccati equation

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Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors,and their in vivo implantation regenerated the intervertebral disc degeneration

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World Journal of Stem Cells 2022年第2期14卷 163-182页

作者： shumaila Khalid Sobia Ekram Asmat Salim G.Rasul Chaudhry Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Department of Biological Sciences Oakland UniversityRochesterMI 48309United States

BACKGROUND Intervertebral disc degeneration(IVDD)is the leading cause of lower back *** degeneration is characterized by reduced cellularity and decreased production of extracellular matrix(ECM).Mesenchymal stem cells(MSCs)have been envisioned as a promising treatment for degenerative ***-based therapy using ECM-producing chondrogenic derivatives of MSCs has the potential to restore the functionality of the intervertebral disc(IVD).AIM To investigate the potential of chondrogenic transcription factors to promote differentiation of human umbilical cord MSCs into chondrocytes,and to assess their therapeutic potential in IVD *** MSCs were isolated and characterized morphologically and immunologically by the expression of specific *** were then transfected with Sox-9 and Six-1 transcription factors to direct differentiation and were assessed for chondrogenic lineage based on the expression of specific *** differentiated MSCs were implanted in the rat model of *** regenerative potential of transplanted cells was investigated using histochemical and molecular analyses of *** Isolated cells showed fibroblast-like morphology and expressed CD105,CD90,CD73,CD29,and Vimentin but not CD45 *** of Sox-9 and Six-1 greatly enhanced the gene expression of transforming growth factor beta-1 gene,BMP,Sox-9,Six-1,and Aggrecan,and protein expression of Sox-9 and *** implanted cells integrated,survived,and homed in the degenerated intervertebral *** grading showed that the transfected MSCs regenerated the IVD and restored normal *** Genetically modified MSCs accelerate cartilage regeneration,providing a unique opportunity and impetus for stem cell-based therapeutic approach for degenerative disc diseases.

关键词： Intervertebral disc degeneration Human umbilical cord Transcription factors Mesenchymal stem cells Gene expression Regeneration

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Clinicopathological features and medium-term outcomes of histologic variants of primary focal segmental glomerulosclerosis in adults:A retrospective study

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World Journal of Nephrology 2024年第1期13卷 14-24页

作者： Nazarul Hassan Jafry shumaila Manan Rahma Rashid Muhammed Mubarak Department of Nephrology Sindh Institute of Urology and TransplantationSindhKarachi 74200Pakistan Department of Pathology Sindh Institute of Urology and TransplantationSindhKarachi 74200Pakistan

BACKGROUND The Columbia classification identified five histological variants of focal segmental glomerulosclerosis(FSGS).The prognostic significance of these variants remains *** To evaluate the relative frequency,clinicopathologic characteristics,and medium-term outcomes of FSGS variants at a single center in *** This retrospective study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan on all consecutive adults(≥16 years)with biopsy-proven primary FSGS from January 1995 to December *** subjects were treated with steroids as a first-line *** response rates,doubling of serum creatinine,and kidney failure(KF)with replacement therapy were compared between histological variants using ANOVA or Kruskal Wallis,and Chi-square tests as *** were analyzed by SPSS version 22.0.P-value≤0.05 was considered *** A total of 401 patients were diagnosed with primary FSGS during the study *** these,352(87.7%)had a designated histological *** not otherwise specified(NOS)variant was the commonest,being found in 185(53.9%)patients,followed by the tip variant in 100(29.1%)***(COL),cellular(CEL),and perihilar(PHI)variants were seen in 58(16.9%),6(1.5%),and 3(0.7%)patients,*** and PHI variants were excluded from further analysis due to small patient *** mean follow-up period was 36.5±29.2 *** response rates of variants,patients with TIP lesions achieved remission more frequently(59.5%)than patients with NOS(41.8%)and COL(24.52%)variants(P<0.001).The hazard ratio of complete response among patients with the COL variant was 0.163[95%confidence interval(CI):0.039-0.67]as compared to patients with *** TIP variant showed a hazard ratio of 2.5(95%CI:1.61-3.89)for complete remission compared to the NOS ***,progressive KF was observed more frequently in patients with the COL variant,43.

关键词： Adults Columbia classification Focal segmental glomerulosclerosis Histological variants Kidney failure Kidney failure with replacement therapy

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Zinc enhances the cell adhesion,migration,and self-renewal potential of human umbilical cord derived mesenchymal stem cells

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World Journal of Stem Cells 2023年第7期15卷 751-767页

作者： Iqra Sahibdad shumaila Khalid G Rasul Chaudhry Asmat Salim Sumreen Begum Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Department of Biological Sciences Oakland UniversityRochesterMI 48309United States Stem Cell Research Laboratory(SCRL) Sindh Institute of Urology and Transplantation(SIUT)Karachi 74200SindhPakistan

BACKGROUND Zinc(Zn)is the second most abundant trace element after Fe,present in the human *** is frequently reported in association with cell growth and proliferation,and its deficiency is considered to be a major disease contributing *** To determine the effect of Zn on in vitro growth and proliferation of human umbilical cord(hUC)-derived mesenchymal stem cells(MSCs).METHODS hUC-MSCs were isolated from human umbilical cord tissue and characterized based on immunocytochemistry,immunophenotyping,and tri-lineage *** impact of Zn on cytotoxicity and proliferation was determined by MTT and Alamar blue *** determine the effect of Zn on population doubling time(PDT),hUC-MSCs were cultured in media with and without Zn for several *** in vitro scratch assay was performed to analyze the effect of Zn on the wound healing and migration capability of hUC-MSCs.A cell adhesion assay was used to test the surface adhesiveness of *** analysis of genes involved in the cell cycle,proliferation,migration,and selfrenewal of hUC-MSCs was performed by quantitative real-time polymerase chain *** protein expression of Lin28,a pluripotency marker,was analyzed by *** Zn at lower concentrations enhanced the rate of proliferation but at higher concentrations(>100μM),showed concentration dependent cytotoxicity in ***-MSCs treated with Zn exhibited a significantly greater healing and migration rate compared to untreated *** also increased the cell adhesion rate,and colony forming efficiency(CFE).In addition,Zn upregulated the expression of genes involved in the cell cycle(CDC20,CDK1,CCNA2,CDCA2),proliferation(transforming growth factorβ1,GDF5,hypoxia-inducible factor 1α),migration(CXCR4,VCAM1,VEGF-A),and self-renewal(OCT4,SOX2,NANOG)of *** of Lin28 protein was significantly increased in cells treated with *** Our findings suggest that zinc enhances the proliferat

关键词： Human umbilical cord Mesenchymal stem cells Zinc Cell proliferation In vitro expansion

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A Novel Stochastic Framework for the MHD Generator in Ocean

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Computers, Materials & Continua 2022年第11期73卷 3383-3402页

作者： Sakda Noinang Zulqurnain Sabir shumaila Javeed Muhammad Asif Zahoor Raja Dostdar Ali Wajaree Weera Thongchai Botmart Department of Mathematics Statistics and Computer Faculty of ScienceUbon Ratchathani UniversityUbon Ratchathani 34190Thailand Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Department of Mathematics Comsats University Islamabad45550 Islamabad CampusIslamabadPakistan Future Technology Research Center National Yunlin University of Science and TechnologyYunlin 64002Taiwan Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen 40002Thailand

This work aims to study the nonlinear ordinary differential equations(ODEs)system of magnetohydrodynamic(MHD)past over an inclined plate using Levenberg-Marquardt backpropagation neural networks(LMBNNs).The stochastic procedures LMBNNs are provided with three categories of sample statistics,testing,training,and *** nonlinear MHD system past over an inclined plate is divided into three profiles,dimensionless momentum,species(salinity),and energy(heat)*** data is applied 15%,10%,and 75%for validation,testing,and training to solve the nonlinear system of MHD past over an inclined plate.A reference data set is designed to compare the obtained and proposed solutions for the MHD *** plots of the absolute error(AE)are provided to check the accuracy and precision of the considered nonlinear system of *** obtained numerical solutions of the nonlinear magnetohydrodynamic system have been considered to reduce the mean square error(MSE).For the capability,dependability,and aptitude of the stochastic LMBNNs procedure,the numerical performances are provided to authenticate the relative arrangements of MSE,error histograms(EHs),state transitions(STs),correlation,and regression.

关键词： MHD energy salinity levenberg-marquardt backpropagation Soret number nonlinear

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