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Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis

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Chinese Journal of Cancer Research 2018年第3期30卷 373-381页

作者： Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu shulian wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Objective：Prognosis of patients with locally advanced rectal cancer（LARC）but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy（CRT）has been shown to be *** study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early ***：From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a *** with LARC underwent total mesorectal excision（TME）surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a *** a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery *** propensity score matching（PSM）,comparisons of local regional control（LC）,distant metastasis-free survival（DMFS）,disease-free survival（DFS）and overall survival（OS）were performed using Kaplan-Meier analysis and log-rank test between yp I and p I ***-staging depth score（DDS）,a novel method of evaluating CRT response,was used for subset ***：Of the 449 patients,168 matched cases were generated for ***-year LC,DMFS,DFS and OS for stage p I *** I groups were 96.7%vs.96.4%（P=0.796）,92.7%vs.73.6%（P=0.025）,91.2%vs.73.6%（P=0.080）and 93.1%vs.72.3%（P=0.040）,*** the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group（P=0.384,0.368,0.277 and0.458,respectively）.Conclusions：LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic *** can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort.

关键词： Rectal neoplasms neoadjuvant chemo-radiotherapy down-staging propensity score-matched analysis

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放射治疗诱发淋巴细胞减少的预防和治疗进展

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中华放射肿瘤学杂志 2022年第12期31卷 1190-1194页

作者：赵旭冉孙广毅王淑莲国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021

目前已在多个实体瘤中发现放疗可诱发淋巴细胞减少,且证实其与不良预后相关。放疗诱发的淋巴细胞减少受到患者年龄、淋巴细胞基线水平、肿瘤大小和位置及放疗方案(包括放疗剂量分割方式、照射体积及放疗技术)等相关因素影响。同时,一些... 详细信息

目前已在多个实体瘤中发现放疗可诱发淋巴细胞减少,且证实其与不良预后相关。放疗诱发的淋巴细胞减少受到患者年龄、淋巴细胞基线水平、肿瘤大小和位置及放疗方案(包括放疗剂量分割方式、照射体积及放疗技术)等相关因素影响。同时,一些药物和细胞因子可能有助于促进淋巴细胞恢复。探索放疗诱发淋巴细胞减少有效的预防和治疗手段,可能是未来进一步改善肿瘤患者预后的重要研究方向。

关键词：放射疗法淋巴细胞减少预防治疗

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从整体搭建到分类发展:城乡教师共同体区域推进策略转换

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教育研究 2019年第6期40卷 145-151页

作者：王淑莲丽水学院教师教育学院

我国城乡教师共同体建设在理论上形成了许多研究热点,实践中也探索出了许多模式,为整体搭建政策提供了支持,在一定程度上促进了城乡师资的均衡,但距推动城乡义务教育一体化深度发展还存在着较大差距。为此,需要从区域视角进行分类发展... 详细信息

我国城乡教师共同体建设在理论上形成了许多研究热点,实践中也探索出了许多模式,为整体搭建政策提供了支持,在一定程度上促进了城乡师资的均衡,但距推动城乡义务教育一体化深度发展还存在着较大差距。为此,需要从区域视角进行分类发展。为此,应在价值、路径、技术三个层面,在“融入城市化、就地城镇化、农村现代化”三个路径选择中,分地域类、实体类、虚拟类、学科类、管理类、混合类建构分类发展的制度框架;在明晰城乡教师共同体发展愿景的前提下,各利益相关主体可以通过制度供给主体、制度形式要件、制度环境、制度执行创新,进行点面结合、多元策略、模式移植与建构等多种方式的分阶段实施的推进实践。

关键词：城乡教师共同体整体搭建区域分类发展制度创新

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Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China

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Chinese Journal of Cancer Research 2019年第1期31卷 152-161页

作者： Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu shulian wang Jing Jin Lin Gui Yan Sun Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Departement of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary ***: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary ***: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis.

关键词： Diffuse large B-cell lymphoma(DLBCL) distribution nodal extranodal

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Screening of Benzoic Acid Biodegradation Strains

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Wuhan University Journal of Natural Sciences 2010年第6期15卷 527-531页

作者： wang shulian,ZHANG Liping,wang Xiaoxing,CHEN Dengxia,LI Xiaocong,HUANG Yingping Alan G.MacDiarmid Research Institute of Renewable Energy,China Three Gorges University,Yichang 443002,Hubei,China Alan G. MacDiarmid Research Institute of Renewable Energy China Three Gorges University Yichang Hubei China

Three strains BQ,BJ,and BS utilizing benzoic acid as the sole carbon source were achieved from Yichang City,Hubei Province,China,through selective enrichment and *** BQ and BJ were primarily identified as *** while BS was *** three domestications,the removal rates of BQ,BJ,and BS to chemical oxygen demand（COD） value of benzoic acid were 62.41%,94.44%,and 43.34%,*** strains were mixed cultured,and the degradation rates of strains to benzoic acid at different temperature,pH and benzoic acid concentration were *** results show that the optimum degradation conditions about strains were pH 7.0,temperature 30 ℃,and aerobic with 1 500 mg/L of concentration of benzoic *** this condition,the COD removal rate of strains to benzoic acid reached 84.93%.

关键词： benzoic acid screening biodegradation

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纵向分权、横向竞争与地方政府支出预算不确定性

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财经论丛 2024年第2期 25-35页

作者：李鑫邓淑莲上海财经大学公共经济与管理学院上海200433

财政分权体制是影响我国地方政府支出预算不确定性的深层次原因。本文基于省级和地级市层面的相关数据,从财政纵向失衡和横向政府竞争两个方面探讨我国财政分权体制对地方政府支出预算不确定性的影响及其潜在机制。研究发现,财政纵向失... 详细信息

财政分权体制是影响我国地方政府支出预算不确定性的深层次原因。本文基于省级和地级市层面的相关数据,从财政纵向失衡和横向政府竞争两个方面探讨我国财政分权体制对地方政府支出预算不确定性的影响及其潜在机制。研究发现,财政纵向失衡和横向政府竞争均会加剧支出预算不确定性。机制分析表明,财政纵向失衡主要通过影响地方政府对转移支付的依赖程度加剧支出预算不确定性,且转移支付的不确定性会扩大这一影响效应;横向政府竞争主要通过地方政府对于自有财力的低估行为加剧支出预算不确定性。最后,从影响效应的大小来看,财政纵向失衡对地级市层面支出预算不确定性的影响大于省级层面,而横向政府竞争对省级层面的影响更大。

关键词：财政纵向失衡横向政府竞争支出预算不确定性

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乡村高中家校合作存在的问题及对策研究

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丽水学院学报 2023年第4期45卷 84-93页

作者：林红慧王淑莲丽水学院教师教育学院浙江丽水323000

高质量的家校合作可以提高学生学业成绩、改善学生行为,促进学生成长。本研究采用家校合作质量测评调查表对L市乡村高中家长群体进行调查,获得有效数据371份。运用SPSSAU21.0进行描述性分析和推断统计分析,目的是了解家校合作政策落实... 详细信息

高质量的家校合作可以提高学生学业成绩、改善学生行为,促进学生成长。本研究采用家校合作质量测评调查表对L市乡村高中家长群体进行调查,获得有效数据371份。运用SPSSAU21.0进行描述性分析和推断统计分析,目的是了解家校合作政策落实以及家校合作质量等情况,以期探索高质量乡村高中家校合作的实践路径。调查结果显示:L市乡村高中学校在欢迎、沟通、参与、合作四个大指标上得分较高,说明L市乡村高中有着较好的家校合作基础;然而在具体的小条目中还存在得分较低现象,表明家校合作政策的推进还需要改进和调整。建议建立高质量的家校合作伙伴模式、健全家长委员会制度、提升家长角色胜任力以及完善家庭教育指导配套服务等。

关键词：乡村高中家校合作高质量

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MORPHOLOGICAL AND FUNCTIONAL INVESTIGATIONS ON MACROPHAGES WITH HETEROGENEOUS FLUORESCENT STAINING

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Science in China,Ser.B 1985年第7期28卷 707-716页

作者：许屏高玉民李淑莲王宜 Department of Histology and Embryology Bethune Medical College Changchun

Four heterogeneous colors of fluorescence were demonstrated in macrophages from rabbit lymph nodes and mouse peritoneal exudate using fluorescent staining. They were bright blue, light blue, bluish green and yellow colors of fluorescence respectively. All of these 4 types of macrophages with heterogeneous colors of fluorescence could form EA or EAC rosettes and were able to phagocytose chicken erythrocytes and ink carbon granules. Among them the macrophages with bright blue color of fluorescence could form large EA or EAC rosettes and showed more rapid and stronger activity to phagocytose chicken erythrocytes, while those with bluish green and yellow colors of fluorescence showed stronger activity to phagocytose ink carbon granules.

关键词： COF MORPHOLOGICAL AND FUNCTIONAL INVESTIGATIONS ON MACROPHAGES WITH HETEROGENEOUS FLUORESCENT STAINING SRBC

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Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy

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Chinese Journal of Cancer Research 2021年第4期33卷 447-456页

作者： Ning Li Xin wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi shulian wang Yueping Liu Yongwen Song Yexiong Li Jing Jin State Key Laboratory of Molecular Oncology Department of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of Abdominal Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized *** examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative ***:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were *** patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were *** factors related to long-term prognosis were analyzed using univariate and multivariate *** down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term ***:The median follow-up period for survivors was 30 *** area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and *** curve analysis further affirmed that DDS had the largest net *** DDS cut-off value was *** and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS.

关键词： Gastric cancer preoperative chemoradiotherapy prediction long-term outcomes

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基于逆向工程的小型钻床立柱结构优化

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制造技术与机床 2024年第3期 94-101页

作者：汪栋成王宇刘淑莲陈岁繁浙江科技大学机械与能源工程学院浙江杭州310023

立柱的结构性能是机床工作稳定的关键。为了满足在减轻立柱质量的同时提高其动静态特性,文章从机床结构模型获取出发,通过三维扫描采集机床零部件点云数据,然后利用逆向建模技术将其转换为实体模型,再使用有限元仿真求解立柱的关键性指... 详细信息

立柱的结构性能是机床工作稳定的关键。为了满足在减轻立柱质量的同时提高其动静态特性,文章从机床结构模型获取出发,通过三维扫描采集机床零部件点云数据,然后利用逆向建模技术将其转换为实体模型,再使用有限元仿真求解立柱的关键性指标并完成优化。在模型获取方面,使用2D分析比较立柱实体外轮廓与点云数据偏差,测得整体平均偏差为-0.0509 mm,满足试验需求。在结构优化方面,采用多目标拓扑优化快速确定立柱结构整体布局,进一步使用尺寸优化减少总变形增大对机床加工精度的影响,实现在总变形基本不变的情况下,立柱1阶固有频率有效提高16%,质量减轻5.3%。该方法将逆向工程和有限元仿真集成运用,为有限元分析提供了逆向获取的模型参数,增加了结构优化的工程可靠性,为产品改进和再设计提供新思路,加快了新产品开发效率,节约了设计和制造成本。

关键词：三维扫描有限元仿真结构优化

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