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Stable carbon and oxygen isotopic compositions of carbonates in middle Mesoproterozoic Wumishan Formation and sea-level change

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Chinese Science Bulletin 1999年第23期44卷 2130-2136页

作者： Renwei Li Jinshi Chen shukun zhang Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China Chinese Acad Geol Sci Inst Geomech Beijing 100083 Peoples R China

δ13C of dolostones from the Wumishan Formation (1 310-1 207 Ma) in the Ming Tombs area near Beijing ranges from - 1.5 to 1.5‰ (PDB), and generally, the δ18O ranges from - 4 to - 5‰ (PDB). The secular variation of stable carbon isotopic compositions is cyclic. δ13C displays positive shifts from a sequence boundary to 1.5 per mil (PDB), then

关键词： carbon and oxygen isotopes Mesoproterozoic. sea-level change.

ESR Dating of the Evolution of the Shuanghu Basin in the Northern Tibetan Plateau

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Acta Geologica Sinica(English Edition) 1999年第3期73卷 289-293页

作者： WU Zhenhan JIANG Wan Peter Blisniuk BI Siwen zhang shukun Olaf Kuchel MAO Yi Institute of Geomechcmics CAGS Minzu Xueyuan Nanlu Beijing 100081 Institut für Geowissenschaften Universitat Potsdam Postfach 601553 D-14415 Potsdam Germany

The Shuanghu basin is a NE-trending rift basin bounded by NE-striking normal faults and NW-striking shear-extensional faults of the northern Tibetan Plateau. Four samples from calcite veins in marginal faults and one sample from mudstone (S-3) were collected for dating the evolution of the Shuanghu basin by using the ESR spectrograph of EXM-type. Ages were calculated according to the close-equilibrium model on the basis of the measured ESR signal spectra of samples, providing good chronological information. It is known from the ESR dating that the extensional faulting and rifting of the Shuanghu area began at 4.92 Ma B.P., followed by regional folding in 3.56–1.36 Ma, NW-striking faulting in 0.60 Ma and normal faulting in 0.024 Ma in the Shuanghu basin.

关键词： ESR dating tectonic events Shuanghu basin Tibetan Plateau.

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含水粉煤灰泡沫混凝土力学性能退化试验研究

非金属矿 2016年第3期39卷 40-42页

作者：张淑坤辽宁工程技术大学土木与交通学院辽宁阜新123000

采用普通硅酸盐水泥、发泡剂、粉煤灰及外加剂制备采空区充填材料,通过室内试验研究不同含水率影响下充填体强度特性、蠕变特性、应力应变特性和变形特性退化规律。结果表明:自由水对充填体性能退化影响明显。具体表现为:随着含水率的增... 详细信息

采用普通硅酸盐水泥、发泡剂、粉煤灰及外加剂制备采空区充填材料,通过室内试验研究不同含水率影响下充填体强度特性、蠕变特性、应力应变特性和变形特性退化规律。结果表明:自由水对充填体性能退化影响明显。具体表现为:随着含水率的增加,充填体抗压强度和抗剪强度递减,初期递减幅度较大,后期较小;充填体强度峰值、峰后残余强度及延性随着含水率增加而递减;随着含水率的增加,充填体弹性模量降低幅度较大,泊松比变化幅度较小,其他变形参数如剪切模量,体弹性模量均减小,充填体在水弱化情况下会进一步产生压缩,抗变形能力退化显著。

关键词：粉煤灰泡沫混凝土充填体含水率力学性能退化规律

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尾焰红外辐射特性的反向蒙特卡罗法模拟

红外与激光工程 2012年第10期41卷 2604-2609页

作者：张术坤蔡静杨永军北京长城计量测试技术研究所北京100095 北京航空航天大学仪器科学与光电工程学院北京100191

以发动机尾焰的红外探测为主要应用背景，利用反向蒙特卡罗法计算了液体火箭发动机尾焰红外辐射特性。首先计算了尾焰红外辐射在2．7Ixm下的轴向分布特性及空间不同角度分布特性。计算结果较为合理。重点计算了尾焰2—5μm的光谱辐射特... 详细信息

以发动机尾焰的红外探测为主要应用背景，利用反向蒙特卡罗法计算了液体火箭发动机尾焰红外辐射特性。首先计算了尾焰红外辐射在2．7Ixm下的轴向分布特性及空间不同角度分布特性。计算结果较为合理。重点计算了尾焰2—5μm的光谱辐射特性，并考虑了大气衰减的影响，与The Aerodyne Radiationcode的计算结果趋势吻合良好。实际探测时，探测器只能接收到尾焰辐射的小部分能量，因此对一定距离下探测器接收辐射进行计算，进而获得尾焰在探测器视场内的红外光谱辐射分布特性，具有重要的理论意义和实际应用前景。

关键词：尾焰红外辐射反向蒙特卡罗法空间分布特性光谱辐射特性

Pancreatic stellate cells promote tumor progression by promoting an immunosuppressive microenvironment in murine models of pancreatic cancer

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Pancreatic stellate cells promote tumor progression by promo...

The role of 2-arachidonylglyceryl in the regulation of the tumor microenvironment in murine models of pancreatic cancer

第十三届全国免疫学学术大会

作者： Caixia Li Lihua Cui Lei Yang Yuzhen Zhuo Lanqiu zhang shukun zhang Xiangfei Yuan Qi zhang Tianjin Nankai Hospital

Purpose: Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal forms of cancer with poor *** stellate cells(PSCs) play a vital role in PDAC *** aim of this study was to explore tumor microenvironment response to PSCs in an orthotopic pancreatic cancer mouse ***: To assess if PSCs secreted factors that can facilitate an immunosuppressive *** orthotopic tumor model, derived from co-injection of panc02 cells plus PSCs, was used to investigate tumor proliferation, metastasis and the population of immune cell in vivo, including regulatory T(Tregs), M2-type macrophages(M2), myeloid-derived suppressor cells(MDSCs), CD8 T cells, CD4 T cells, M1-type macrophages(M1), Natural killer(NK), and Natural killer T(NKT).Results: PSCs promoted PDAC growth not only induced cell proliferation and metastasis, but also significantly increased the suppressive immune cell population of Tregs, M2 and *** addition, PSCs decreased the immune cell population of CD8 T, CD4 T, M1, NK and NKT cells in the spleen and tumor tissues of the tumor-bearing ***: Our findings support PSCs playing multiple roles in PDAC development via promoting immunosuppressive microenvironment.

关键词： Pancreatic stellate cells pancreatic cancer myeloid-derived suppressor cells macrophages T cells

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The role of 2-arachidonylglyceryl in the regulation of the t...

第十三届全国免疫学学术大会

作者： Lei yang Lanqiu zhang Xiangfei Yuan Caixia Li Lihua Cui Yuzhen Zhuo shukun zhang Qi zhang Tianjin Nankai Hospital

Objective: 2-arachidonylglyceryl(2-AG) exhibits a direct antitumor effect in various tumor models. However, the immunomodulatory effect of 2-AG on PDAC microenvironment remains obscure. The aim of this study was to explore tumor microenvironment response to 2-AG in an orthotopic pancreatic cancer mouse ***: PDAC orthotopic tumor model was used to investigate tumor proliferation, autophagy and the population of immune cell in vivo, including dendritic cells(DCs), myeloid-derived suppressor cells(MDSCs), CD8+ T cells and CD4+ T cells. The effect of 2-AG on panc02 cell and DC2.4 cell were evaluated by flow cytometry. The protein levels of Atg5, LC3, and Belclin1 were measured by Western ***: 2-AG inhibited pancreatic cancer cell proliferation, which was blocked by AM251(a selective CB1 R antagonist) but not AM630(a selective CB2 R antagonist). In addition, 2-AG induced autophagic cell death by unregulating the expression of Atg5, LC3 and Belclin1. On the other hand, 2-AG induced DC phenotypic maturation, which was also blocked by AM251 but not AM630. However, did not affect the population of CD8+ T cells and CD4+ T cells in spleen and tumor microenvironment in murine models of pancreatic cancer. Moreover, we provide evidence that 2-AG administration induced the expansion of MDSCs in tumor bearing ***: Our findings support 2-AG playing multiple roles in PDAC development. 2-AG exhibits direct antitumor effects via inhibiting pancreatic cancer proliferation, inducing autophagic cell death and DC phenotypic, but also significantly promotes immunosuppressive microenvironment via increasing the suppressive immune cell population of MDSCs.

关键词： 2-arachidonylglyceryl pancreatic cancer myeloid-derived suppressor cells dendritic cells

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多适应性轮履复合载物移动系统的设计

中国机械工程 2017年第15期28卷 1835-1841页

作者：王淑坤曹晓捷张连青朱人杰张博长春理工大学机电工程学院长春130022

针对复杂的非结构化工作环境,为提高载物移动能力,提出了一种具有多适应性的新型轮履复合式移动系统。该移动系统由变径步行轮和履带系统组成,既发挥了轮式结构平地行走的转弯灵活性和运动高效的特点,又结合了履带式结构爬坡时良好的稳... 详细信息

针对复杂的非结构化工作环境,为提高载物移动能力,提出了一种具有多适应性的新型轮履复合式移动系统。该移动系统由变径步行轮和履带系统组成,既发挥了轮式结构平地行走的转弯灵活性和运动高效的特点,又结合了履带式结构爬坡时良好的稳定性和适应性。同时,为进一步提高爬坡时货物的安全性,设计了自适应载物升降平台,通过陀螺仪运用卡尔曼算法进行平台倾角的闭环控制,实现了平台的水平载物。运用RECURDYN软件进行动力学仿真,并制作了实物模型实施了验证,结果表明:该移动系统具有较好的复杂工作环境的适应性和载物的平稳性。

关键词：轮履复合机构变径步行轮自适应升降平台载物

伴有EML4-ALK基因融合的肺ALK重排软组织肿瘤1例

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中华病理学杂志 2023年第10期52卷 1044-1046页

作者：朱永村张玉杰张淑坤山东大学附属威海市立医院病理科威海264200

患者女,66岁,反复发热伴胸闷15 d入院。胸部CT检查:左肺上叶见一截面积大小11.4 cm×7.2 cm的软组织密度影,边界尚清,周围有分叶。随后患者行左肺上叶切除及肺门淋巴结清扫手术。镜下观察:肿瘤细胞呈上皮样,细胞核染色质粗颗粒状,缺乏... 详细信息

患者女,66岁,反复发热伴胸闷15 d入院。胸部CT检查:左肺上叶见一截面积大小11.4 cm×7.2 cm的软组织密度影,边界尚清,周围有分叶。随后患者行左肺上叶切除及肺门淋巴结清扫手术。镜下观察:肿瘤细胞呈上皮样,细胞核染色质粗颗粒状,缺乏明显的核仁,细胞质少,偏嗜酸性,细胞边界不清楚。肿瘤细胞呈实性片状排列或形成模糊的结节,可见细胞稀疏区域和密集区域混杂存在,稀疏区的肿瘤细胞可形成孤立的旋涡状结构,伴有富于黏液样和透明玻璃样变的间质。免疫组织化学染色结果:CD34、波形蛋白、INI1阳性,S-100蛋白部分阳性,间变性淋巴瘤激酶(ALK)弱阳性,Ki-67阳性指数30%。肿瘤融合基因RNA检测:ALK基因重排,与EML4融合,产生EML4-ALK融合基因。熟悉掌握ALK重排软组织肿瘤的临床病理学特征,对于软组织肿瘤精准分类以及对高度侵袭性肿瘤采取ALK抑制剂靶向治疗至关重要。

关键词：软组织肿瘤 ALK基因肺门淋巴结左肺上叶玻璃样变阳性指数分叶靶向治疗

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浅表性CD34阳性成纤维细胞肿瘤1例

中华皮肤科杂志 2022年第4期55卷 343-344页

作者：朱永村张玉杰张淑坤山东大学附属威海市立医院病理科威海264200

患者女, 34岁, 因左大腿外侧皮下结节2年于2019年6月17日就诊。2年前发现左大腿外侧皮下肿物, 约黄豆粒大小, 其表面皮肤颜色加深, 略隆起, 无破溃、红肿及疼痛, 肿物缓慢生长, 逐渐增大, 否认患处有外伤史, 期间未行任何治疗。既往体... 详细信息

患者女, 34岁, 因左大腿外侧皮下结节2年于2019年6月17日就诊。2年前发现左大腿外侧皮下肿物, 约黄豆粒大小, 其表面皮肤颜色加深, 略隆起, 无破溃、红肿及疼痛, 肿物缓慢生长, 逐渐增大, 否认患处有外伤史, 期间未行任何治疗。既往体健, 家族中无类似病史。

关键词：皮下结节成纤维细胞皮肤颜色黄豆粒外伤史左大腿皮下肿物浅表性