Pancreatic stellate cells promote tumor progression by promoting an immunosuppressive microenvironment in murine models of pancreatic cancer
会议名称：《第十三届全国免疫学学术大会》
会议日期：2018年
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
关 键 词：Pancreatic stellate cells pancreatic cancer myeloid-derived suppressor cells macrophages T cells
摘 要：Purpose: Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal forms of cancer with poor *** stellate cells(PSCs) play a vital role in PDAC *** aim of this study was to explore tumor microenvironment response to PSCs in an orthotopic pancreatic cancer mouse ***: To assess if PSCs secreted factors that can facilitate an immunosuppressive *** orthotopic tumor model, derived from co-injection of panc02 cells plus PSCs, was used to investigate tumor proliferation, metastasis and the population of immune cell in vivo, including regulatory T(Tregs), M2-type macrophages(M2), myeloid-derived suppressor cells(MDSCs), CD8 T cells, CD4 T cells, M1-type macrophages(M1), Natural killer(NK), and Natural killer T(NKT).Results: PSCs promoted PDAC growth not only induced cell proliferation and metastasis, but also significantly increased the suppressive immune cell population of Tregs, M2 and *** addition, PSCs decreased the immune cell population of CD8 T, CD4 T, M1, NK and NKT cells in the spleen and tumor tissues of the tumor-bearing ***: Our findings support PSCs playing multiple roles in PDAC development via promoting immunosuppressive microenvironment.