检索结果-南通市图书馆

Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

Cancer Biology & Medicine 2024年第3期21卷 230-251页

作者： Hantao Zhang Dan Deng shujun li Jing Ren Wei Huang Dan liu Weiya Wang Department of Pathology West China HospitalSichuan UniversityChengdu 610000China West China Biobank West China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China

Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of death.Early diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer patients.At present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor heterogeneity.liquid biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor tissues.Bronchoalveolar lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell components.BALF contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung biopsy.In this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is summarized.The advantages and disadvantages of different components of BALF,including cells,cell-free DNA,extracellular vesicles,and micro RNA are introduced.In particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is highlighted.In addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.

关键词： Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Component Size on the Corrosion Behavior of Ti6Al4V Alloy Fabricated by Electron Beam Powder Bed Fusion

引用

Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 159-168页

作者： Hongyu Zheng Xin Gai Yun Bai Wentao Hou shujun li Yulin Hao R.D.K.Misra Rui Yang Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Nuclear Power Institute of China Chengdu610213China Department of Metallurgical Materialsand Biomedical EngineeringThe University of Texas at El Paso500WUniversity AvenueEl PasoTX79968USA

The electrochemical behavior of Ti-6Al-4V with 1 mm and 16 mm thickness prepared by electron beam powder bed fusion(EB-PBF)was investigated in phosphate buffered saline.Electrochemical results showed that EB-PBF Ti-6Al-4V with a larger component size was more resistant to corrosion compared to the smaller component,because of less acicularαʹphase content and moreβphase content.As a non-equilibrium phase in the“high-energy state”,αʹphase has a greater susceptibility to corrode and reduces the corrosion resistance of the material,whileβphase improves corrosion resistance of titanium alloys.The results show that the phase composition has a more significant effect on the corrosion performance than the grain size.

关键词： Electron beam powder bed fusion Ti6Al4V alloy Corrosion resistance Component size Polarisation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A robust adversarial attack against speech recognition with UAP

高置信计算(英文)

引用

高置信计算(英文) 2023年第1期3卷 18-22页

作者： Ziheng Qin Xianglong Zhang shujun li Shandong University School of Computer Science and TechnologyQingdao 266237China Yancheng Teachers University School of Information EngineeringYancheng 224002China

Speech recognition(SR)systems based on deep neural networks are increasingly widespread in smart devices.However,they are vulnerable to human-imperceptible adversarial attacks,which cause the SR to generate incorrect or targeted adversarial commands.Meanwhile,audio adversarial attacks are particularly susceptible to various factors,e.g.,ambient noise,after applying them to a real-world attack.To circumvent this issue,we develop a universal adversarial perturbation(UAP)generation method to construct robust real-world UAP by integrating ambient noise into the generation process.The proposed UAP can work well in the case of input-agnostic and independent sources.We validate the effectiveness of our method on two different SRs in different real-world scenarios and parameters,the results demonstrate that our method yields state-of-the-art performance,i.***.given any audio waveform,the word error rate can be up to 80%.Extensive experiments investigate the impact of different parameters(e.g,signal-to-noise ratio,distance,and attack angle)on the attack success rate.

关键词： Machine learning security Audio adversarial attack

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyoxymethylene dimethyl ethers synthesis from methanol and formaldehyde solution over one-pot synthesized spherical mesoporous sulfated zirconia

引用

Chinese Journal of Chemical Engineering 2022年第6期35卷 161-172页

作者： Xiangjun li shujun li Xiaoping Wang Muhammad Asif Nawaz Dianhua liu State Key Lab of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

The synthesis of polyoxymethylene dimethyl ethers as an ideal diesel fuel additive is the current hot topic of modern petrochemical industry for their expedient properties in mitigating air pollutants emission during combustion.In this work,a series of spherical sulfated zirconia catalysts were prepared by a one-pot hydrothermal method assisted with surfactant cetyltrimethylammonium bromide(CTAB).The prepared sulfated zirconia catalysts were used to catalyze PODEn synthesis from methanol and formaldehyde solution.Various characterization(XRD,BET,SEM,TGA,NH_(3)-TPD,FTIR,and Py-IR)were employed to elaborate the structure–activity relationship of the studied catalytic system.The results demonstrated that S/Zr molar ratio in precursor solution played an effective role on catalyst morphology and acidic properties,where the weak Brønsted acid sites and strong Lewis acid sites were favorable to the conversion of methanol and formation of long-chain PODEn,respectively.The reaction parameters such as catalyst amount,molar ratio of FA/MeOH,reaction time,temperature and pressure were optimized.The speculated reaction pathway for PODEn synthesis was proposed based on the synergy of Brønsted and Lewis acid sites,which suggested that Brønsted and Lewis acid sites might be advantageous to the activation of polyoxymethylene hemiformals[CH_(3)(OCH_(2))_(n)OH]and methylene glycol(HOCH_(2)OH),respectively.

关键词： Polyoxymethylene dimethyl ethers Spherical sulfated zirconia Methanol Formaldehyde Reaction pathway Synergistic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A systematic literature review of the tension between the GDPR and public blockchain systems

引用

Blockchain(Research and Applications) 2023年第2期4卷 113-135页

作者： Rahime Belen-Saglam Enes Altuncu Yang Lu shujun li Institute of Cyber Security for Society(ICSS)&School of Computing University of KentKeynes CollegeCanterburyCT27NPUnited Kingdom School of Science Technology and Health YorkSt John UniversityLord Mayor's WalkYorkYO317EXUnited Kingdom

Blockchain technology has been rapidly growing since Bitcoin was invented in 2008.The most common type of blockchain system,public(permissionless)blockchain system,has some unique features that lead to a tension with the European Union’s General Data Protection Regulation(GDPR)and other similar data protection laws.In this paper,we report the results of a systematic literature review(SLR)on 114 research papers discussing and/or addressing such a tension.To the best of our knowledge,our SLR is the most comprehensive review of this tension,leading to a more in-depth and broader analysis of related research work on this important topic.Our results revealed three main types of issues:(i)difficulties in exercising data subjects’rights such as the‘right to be forgotten’(RTBF)due to the immutable nature of public blockchains;(ii)difficulties in identifying roles and responsibilities in the public blockchain data processing ecosystem(particularly on the identification of data controllers and data processors);and(iii)ambiguities regarding the application of the relevant law(s)due to the distributed nature of blockchains.Our work also led to a better understanding of solutions for improving the GDPR compliance of public blockchain systems.It can help inform not only blockchain researchers and developers but also policymakers and law markers to consider how to reconcile the tension between public blockchain systems and data protection laws(the GDPR and beyond).

关键词： Blockchain Distributed ledgers Privacy Data protection law Legal compliance GDPR EU EEA UK

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low-cost surface modification of a biomedical Zr-2.5Nb alloy fabricated by electron beam melting

引用

Journal of Materials Science & Technology 2023年第12期143卷 178-188页

作者： Caixu Wang Xiaoli Zhao shujun li Lu liu Deliang Zhang Mitsuo Niinomi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China Tianjin Key Laboratory of Bone Implants Interface Functionalization and Personalization Tianjin 300190China Institute for Materials Research Tohoku UniversitySendaiMiyagi 9808577Japan Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka UniversityOsaka 565-0871Japan Department of Materials Science and Engineering Graduate School of Science and TechnologyMeijo UniversityNagoya 468-8502Japan Faculty of Chemistry Materials and BioengineeringKansai UniversityOsaka 564-860Japan

The Zr-2.5Nb alloy with a fine microstructure consisting ofαlaths was successfully prepared by electron beam melting(EBM).The thermal oxidation behaviors and kinetics of the as-built,and the EBM-built and hot isostatically pressed(HIPed)Zr-2.5Nb materials in a temperature range of 450-600°C were in-vestigated and compared with those of the alloy prepared by conventional casting and forging.It was found that the oxidation kinetics of the as-built and the forged materials followed the parabolic rate law during isothermal oxidation at 550°C,but the HIPed materials exhibited a parabolic-to-linear kinetic transition,suggesting that the larger grain sizes enhanced the oxidation.The oxide layers of all materials were composed of a large fraction of monoclinic zirconia phase(m-ZrO_(2))and a small fraction of tetrago-nal zirconia phase(t-ZrO_(2)),and transformed from t-ZrO_(2)to m-ZrO_(2)with increasing oxidation time.The surface hardness of the as-built,the forged and the HIPed materials increased from 215,204,and 188 HV before oxidation to 902,1070,and 1137 HV after oxidation,respectively.The cross-sections of the materi-als showed the presence of micropores and microcracks inside the oxide layers with thicknesses ranging from 4 to 8μm.With the oxidation temperature of 600°C and oxidation time duration of 3 h,a dense black m-ZrO_(2)oxide layer with smooth surface and 902 HV hardness was obtained on the EBM as-built Zr-2.5Nb materials.

关键词： Zr-2.5Nb alloy Electron beam melting Thermal oxidation Oxidation behaviors and kinetics Grain size

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finite Element Prediction of Residual Stress in Rhombic Dodecahedron Ti‑6Al‑4V Titanium Alloy Additively Manufactured by Electron Beam Melting

引用

Acta Metallurgica Sinica(English Letters) 2023年第1期36卷 35-47页

作者： Shangzhou Zhang Yuankang Wang Bing Zhou Fanchao Meng Hua Zhang shujun li Qingmiao Hu li Zhou Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China School of Electromechanical and Automotive Engineering Yantai UniversityYantai 264005China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

In this work,a three-dimensional nonlinear transient thermo-mechanically coupled finite element model(FEM)is established to investigate the variation in temperature and stress fields during electron beam melting(EBM)of rhombic dodecahedron Ti-6Al-4V alloy.The influence of the processing parameters on the temperature and residual stress evolutions was predicted and verified against existing literature data.The calculated results indicate that the interlayer cooling time has very little effect on both the temperature and stress evolutions,indicating that the interlayer cooling time can be set up as short as possible to reduce manufacturing time.It is presented that the residual stress of the intersection is higher than that of non-intersection.With increasing preheating temperature,the residual stress decreases continuously,which is about 20%–30%for every 50℃rise in temperature.The temperature and stress fields repeated every four layers with the complex periodic scanning strategy.Both x and y-component residual stresses are tensile stresses,while z-component stress is weak compressive or tensile stress in typical paths.It is proposed that the interlayer cooling is necessary to obtain a rhombic dodecahedron with low residual stress.These results can bring insights into the understanding of the residual stress during EBM.

关键词： Electron beam melting Ti-6Al-4V Rhombic dodecahedron Residual stress Finite element analysis Parametric study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contrasting vertical distribution between prokaryotes and fungi in different water masses on the Ninety-East Ridge, Southern Indian Ocean

引用

Journal of Oceanology and limnology 2022年第2期40卷 605-619页

作者： shujun li Zhisong CUI Mutai BAO Xiao LUAN Fei TENG Shujiang li Tengfei XU li ZHENG Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of Educationand College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China Marine Bioresources and Environment Research Center First Institute of OceanographyMinistry of Natural Resources of ChinaQingdao 266061China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Although the microbial diversity of the Indian Ocean has been extensively investigated,little is known about the community composition of microbes in the Southern Indian Ocean.In the present study,we divided 60 water column samples on the Ninety-East Ridge(NER)into fi ve water masses according to the temperature-salinity curves.We presented,for the fi rst time,a full description of the microbial biodiversity on NER through high-throughput amplicon sequencing approach,including bacteria,archaea,and fungi.We found that bacteria exhibited higher richness and diversity than archaea and fungi across the water masses on NER.More importantly,each water mass on NER featured distinct prokaryotic microbial communities,as indicated by the results of non-metric multidimensional scaling.In contrast,fungi were eurybathic across the water masses.Redundancy analysis results demonstrated that environmental factors might play a pivotal role in the formation and stability of prokaryotic communities in each water mass,especially that of archaea.In addition,indicator species might be used as fi ngerprints to identify corresponding water masses on NER.These results provide new insights into the vertical distribution,structure,and diversity of microorganisms on NER from the perspective of water mass.

关键词： Ninety-East Ridge(NER) temperature-salinity curve microbial vertical distribution water mass microbial diversity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two transition-metal-modified Nb/W mixed-addendum polyoxometalates for visible-light-mediated aerobic benzylic C–H oxidations

引用

Chinese Chemical Letters 2022年第9期33卷 4395-4399页

作者： Yubin Ma Fan Gao Wanru Xiao Na li shujun li Bing Yu Xuenian Chen School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced Energy MaterialsHenan Normal UniversityXinxiang 453007China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

The visible-light-induced selective oxidation of ubiquitous C–H bonds into valuable C=O bonds under aerobic conditions is one of the most attractive approaches for the construction of carbonyl-containing molecules.In this work,two transition metal-containing Nb/W mixed-addendum POMs dimers with the formula of K_(2)Na_(2)H_(5)[(Fe(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·24H_(2)O(POM[Fe])and K_(2)Na_(3)H_(4)[(Cr(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·32H_(2)O(POM[Cr])have been synthesized and characterized by various analytical and spectral techniques.POM[Fe]was proved to be an efficient photocatalyst for benzylic C–H oxidation under visible light and using oxygen as an oxidant to produce the corresponding carbonyl complex in good yields.A plausible mechanism involving superoxide radical was proposed for the catalytic reaction.POM[Fe]showed good reusability in the recycling experiments.IR spectroscopy and XRD analysis indicate that POM[Fe]can retain its integrity after catalysis.

关键词： Polyoxometalates Mixed-addendum POMs Visible-light-induced catalysis Photocatalysis C-H bonds oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon dots confined in 3D polymer network: Producing robust room temperature phosphorescence with tunable lifetimes

引用

Chinese Chemical Letters 2022年第2期33卷 783-787页

作者： Yingxiang Zhai Ping Wang Xinyue Zhang Shouxin liu Jian li Zhijun Chen shujun li Key Laboratory of Bio-based Material Science&Technology Ministry of EducationNortheast Forestry UniversityHarbin 150040China

Room temperature phosphorescence(RTP) is important in both organic electronics and encryption. Despite rapid advances, a universal approach to robust and tunable RTP materials based on amorphous polymers remains a formidable challenge. Here, we present a strategy that uses three-dimensional(3 D)confinement of carbon dots in a polymer network to achieve ultra-long lifetime phosphorescence. The RTP of the as-obtained materials was not quenched in different polar organic solvents and the lifetime of the RTP was easily tuned by adjusting the amount of crosslinking or varying the drying temperature of the 3 D molecular network. As a demonstration of potential application, as-obtained RTP materials were successfully used to prepare RTP fibres for flexible textiles. As well as bringing to light a fundamental principle for the construction of polymer materials with RTP, we have endowed traditional carbon dots and polymers with fresh features that will expand potential applications.

关键词： Carbon dots 3D polymer network Room temperature phosphorescence Tunable lifetime Generality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：