检索结果-南通市图书馆

Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

Cancer Biology & Medicine 2024年第3期21卷 230-251页

作者： Hantao Zhang Dan Deng Shujun Li Jing Ren Wei Huang Dan liu Weiya Wang Department of Pathology West China HospitalSichuan UniversityChengdu 610000China West China Biobank West China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China

Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of death.Early diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer patients.At present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor heterogeneity.liquid biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor tissues.Bronchoalveolar lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell components.BALF contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung biopsy.In this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is summarized.The advantages and disadvantages of different components of BALF,including cells,cell-free DNA,extracellular vesicles,and micro RNA are introduced.In particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is highlighted.In addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.

关键词： Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Component Size on the Corrosion Behavior of Ti6Al4V Alloy Fabricated by Electron Beam Powder Bed Fusion

引用

Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 159-168页

作者： Hongyu Zheng Xin Gai Yun Bai Wentao Hou Shujun Li Yulin Hao R.D.K.Misra Rui Yang Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Nuclear Power Institute of China Chengdu610213China Department of Metallurgical Materialsand Biomedical EngineeringThe University of Texas at El Paso500WUniversity AvenueEl PasoTX79968USA

The electrochemical behavior of Ti-6Al-4V with 1 mm and 16 mm thickness prepared by electron beam powder bed fusion(EB-PBF)was investigated in phosphate buffered saline.Electrochemical results showed that EB-PBF Ti-6Al-4V with a larger component size was more resistant to corrosion compared to the smaller component,because of less acicularαʹphase content and moreβphase content.As a non-equilibrium phase in the“high-energy state”,αʹphase has a greater susceptibility to corrode and reduces the corrosion resistance of the material,whileβphase improves corrosion resistance of titanium alloys.The results show that the phase composition has a more significant effect on the corrosion performance than the grain size.

关键词： Electron beam powder bed fusion Ti6Al4V alloy Corrosion resistance Component size Polarisation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Epidemiological Study of a Human Brucellosis Outbreak—Weihai City,Shandong Province,China,2022

引用

China CDC weekly 2024年第12期6卷 230-234页

作者： Yan li Yifan Yu Jian Zhao shujun Ding Guoying Zhang Xiaolin Yu Zengqiang Kou Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Shandong First Medical University Shandong Academy of Medical SciencesJinan CityShandong ProvinceChina Weihai Municipal Center for Disease Control and Prevention Weihai CityShandong ProvinceChina

What is already known about this topic?Brucellosis,mainly caused by Brucella melitensis(B.melitensis),is regarded as a significant zoonotic disease in China.In Weihai,located at the eastern end of the Shandong Peninsula,brucellosis has been in a low epidemic phase for the past five years.What is added by this report?This was the initial report of a brucellosis outbreak in the last five years.Strains of B.melitensis bv.3 from Weihai and other cities showed a close genetic relationship,suggesting a potential common ancestry.What are the implications for public health practice?Epidemiological investigations depend on standardized and effective molecular typing methods and analysis tools for public health laboratories to identify and trace outbreaks.Understanding the circulation patterns of livestock in free-range households in heavily affected areas is essential for controlling the spread of brucellosis.

关键词： Shandong China. break

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on hydrodynamic diffusion law of the swelling particle slurry in karst pipeline

引用

Particuology 2024年第4期87卷 218-231页

作者： Bingchuan Cheng Haibo li Guangming Pan Runhuai Deng Yu'an Gong shujun Xu Kun Zhou Zhuo Zheng School of Civil Engineering Geotechnical and Structural Engineering Research CenterShandong UniversityJinan250061China The Fourth Prospecting of Shandong Coal Geology Bureau Weifang261000China China Railway 14th Bureau Group Corporation limited Jinan250101China School of Trafic Engineering Shandong Jianzhu University.Fengming RoadLingang Development ZoneJinan250101China

The swelling particle grouting material has demonstrated remarkable plugging effectiveness in high-pressure and large-flow burst water within karst pipelines.Currently,current research on the rheolog-ical model,flow computation theory,and plugging mechanism of this material is lacking.The conven-tional grouting slurry diffusion process,using the liquid-liquid two-phase flow method,fails to accurately simulate high solubility slurry and particle swelling.To address these limitations,this study established a precise constitutive model to describe the swelling particle slurry diffusion process in dynamic water.Additionally,a coupling calculation method was proposed to analyze the spatiotemporal heterogeneity of viscosity during slurry diffusion by considering the migration of slurry and the changes in viscosity.To investigate the interaction between particle swelling and flow field changes,a Compu-tational Fluid Dynamics-Discrete Element Method(CFD-DEM)coupling model was developed for the diffusion of swelling particle slurry.It is demonstrated that slurry viscosity increases exponentially within the diffusion front as the particle swelling rate rises,and the drag force exhibits an intriguing behavior of initially increasing and then decreasing as the slurry flows through the pipeline.Further-more,the CFD-DEM coupling model proved to be more accurate in describing viscosity distribution and diffusion distance compared to the finite element solution.The primary objective of this paper is to reveal the plugging mechanism and provide theoretical support for the engineering application of the swelling particle grouting material.

关键词： Karst pipeline Swelling particle grouting material Dynamic water diffusion Spatiotemporal variation of viscosity CFD-DEM coupling model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyoxymethylene dimethyl ethers synthesis from methanol and formaldehyde solution over one-pot synthesized spherical mesoporous sulfated zirconia

引用

Chinese Journal of Chemical Engineering 2022年第6期35卷 161-172页

作者： Xiangjun li Shujun Li Xiaoping Wang Muhammad Asif Nawaz Dianhua liu State Key Lab of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

The synthesis of polyoxymethylene dimethyl ethers as an ideal diesel fuel additive is the current hot topic of modern petrochemical industry for their expedient properties in mitigating air pollutants emission during combustion.In this work,a series of spherical sulfated zirconia catalysts were prepared by a one-pot hydrothermal method assisted with surfactant cetyltrimethylammonium bromide(CTAB).The prepared sulfated zirconia catalysts were used to catalyze PODEn synthesis from methanol and formaldehyde solution.Various characterization(XRD,BET,SEM,TGA,NH_(3)-TPD,FTIR,and Py-IR)were employed to elaborate the structure–activity relationship of the studied catalytic system.The results demonstrated that S/Zr molar ratio in precursor solution played an effective role on catalyst morphology and acidic properties,where the weak Brønsted acid sites and strong Lewis acid sites were favorable to the conversion of methanol and formation of long-chain PODEn,respectively.The reaction parameters such as catalyst amount,molar ratio of FA/MeOH,reaction time,temperature and pressure were optimized.The speculated reaction pathway for PODEn synthesis was proposed based on the synergy of Brønsted and Lewis acid sites,which suggested that Brønsted and Lewis acid sites might be advantageous to the activation of polyoxymethylene hemiformals[CH_(3)(OCH_(2))_(n)OH]and methylene glycol(HOCH_(2)OH),respectively.

关键词： Polyoxymethylene dimethyl ethers Spherical sulfated zirconia Methanol Formaldehyde Reaction pathway Synergistic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-cost surface modification of a biomedical Zr-2.5Nb alloy fabricated by electron beam melting

引用

Journal of Materials Science & Technology 2023年第12期143卷 178-188页

作者： Caixu Wang Xiaoli Zhao Shujun Li Lu liu Deliang Zhang Mitsuo Niinomi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China Tianjin Key Laboratory of Bone Implants Interface Functionalization and Personalization Tianjin 300190China Institute for Materials Research Tohoku UniversitySendaiMiyagi 9808577Japan Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka UniversityOsaka 565-0871Japan Department of Materials Science and Engineering Graduate School of Science and TechnologyMeijo UniversityNagoya 468-8502Japan Faculty of Chemistry Materials and BioengineeringKansai UniversityOsaka 564-860Japan

The Zr-2.5Nb alloy with a fine microstructure consisting ofαlaths was successfully prepared by electron beam melting(EBM).The thermal oxidation behaviors and kinetics of the as-built,and the EBM-built and hot isostatically pressed(HIPed)Zr-2.5Nb materials in a temperature range of 450-600°C were in-vestigated and compared with those of the alloy prepared by conventional casting and forging.It was found that the oxidation kinetics of the as-built and the forged materials followed the parabolic rate law during isothermal oxidation at 550°C,but the HIPed materials exhibited a parabolic-to-linear kinetic transition,suggesting that the larger grain sizes enhanced the oxidation.The oxide layers of all materials were composed of a large fraction of monoclinic zirconia phase(m-ZrO_(2))and a small fraction of tetrago-nal zirconia phase(t-ZrO_(2)),and transformed from t-ZrO_(2)to m-ZrO_(2)with increasing oxidation time.The surface hardness of the as-built,the forged and the HIPed materials increased from 215,204,and 188 HV before oxidation to 902,1070,and 1137 HV after oxidation,respectively.The cross-sections of the materi-als showed the presence of micropores and microcracks inside the oxide layers with thicknesses ranging from 4 to 8μm.With the oxidation temperature of 600°C and oxidation time duration of 3 h,a dense black m-ZrO_(2)oxide layer with smooth surface and 902 HV hardness was obtained on the EBM as-built Zr-2.5Nb materials.

关键词： Zr-2.5Nb alloy Electron beam melting Thermal oxidation Oxidation behaviors and kinetics Grain size

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finite Element Prediction of Residual Stress in Rhombic Dodecahedron Ti‑6Al‑4V Titanium Alloy Additively Manufactured by Electron Beam Melting

引用

Acta Metallurgica Sinica(English Letters) 2023年第1期36卷 35-47页

作者： Shangzhou Zhang Yuankang Wang Bing Zhou Fanchao Meng Hua Zhang Shujun Li Qingmiao Hu li Zhou Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China School of Electromechanical and Automotive Engineering Yantai UniversityYantai 264005China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

In this work,a three-dimensional nonlinear transient thermo-mechanically coupled finite element model(FEM)is established to investigate the variation in temperature and stress fields during electron beam melting(EBM)of rhombic dodecahedron Ti-6Al-4V alloy.The influence of the processing parameters on the temperature and residual stress evolutions was predicted and verified against existing literature data.The calculated results indicate that the interlayer cooling time has very little effect on both the temperature and stress evolutions,indicating that the interlayer cooling time can be set up as short as possible to reduce manufacturing time.It is presented that the residual stress of the intersection is higher than that of non-intersection.With increasing preheating temperature,the residual stress decreases continuously,which is about 20%–30%for every 50℃rise in temperature.The temperature and stress fields repeated every four layers with the complex periodic scanning strategy.Both x and y-component residual stresses are tensile stresses,while z-component stress is weak compressive or tensile stress in typical paths.It is proposed that the interlayer cooling is necessary to obtain a rhombic dodecahedron with low residual stress.These results can bring insights into the understanding of the residual stress during EBM.

关键词： Electron beam melting Ti-6Al-4V Rhombic dodecahedron Residual stress Finite element analysis Parametric study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on Path Selection and Implementation Effect of Counselors in College Students’Career Planning Education

引用

Journal of Contemporary Educational Research 2024年第5期8卷 59-64页

作者： Fang Guo shujun Luo Weihan li School of Finance and Economics Shenzhen Institute of Information TechnologyShenzhen 518000Guangdong ProvinceChina

Under the background of a severe job market and fierce talent competition,the career planning education of college students is of great importance.In this study,a combination of quantitative and qualitative research methods was used;500 students in Shenzhen Polytechnic of Information Technology were surveyed by questionnaire,and 40 counselors were interviewed in depth to comprehensively analyze the role and practical effect of counselors in career planning education.The research showed that the role positioning of counselors includes the guide of students’career development,emotional support,and job-hunting strategy,and the specific path selection involves the strengthening of professional knowledge,the construction of interpersonal relationship networks,and personalized counseling.Based on the survey and interview data,this paper constructed a model for enhancing the role of counselors in career planning education and put forward a set of targeted work paths.

关键词： College counselors Career planning Role positioning Path selection Implementation effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contrasting vertical distribution between prokaryotes and fungi in different water masses on the Ninety-East Ridge, Southern Indian Ocean

引用

Journal of Oceanology and limnology 2022年第2期40卷 605-619页

作者： Shujun Li Zhisong CUI Mutai BAO Xiao LUAN Fei TENG Shujiang li Tengfei XU li ZHENG Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of Educationand College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China Marine Bioresources and Environment Research Center First Institute of OceanographyMinistry of Natural Resources of ChinaQingdao 266061China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Although the microbial diversity of the Indian Ocean has been extensively investigated,little is known about the community composition of microbes in the Southern Indian Ocean.In the present study,we divided 60 water column samples on the Ninety-East Ridge(NER)into fi ve water masses according to the temperature-salinity curves.We presented,for the fi rst time,a full description of the microbial biodiversity on NER through high-throughput amplicon sequencing approach,including bacteria,archaea,and fungi.We found that bacteria exhibited higher richness and diversity than archaea and fungi across the water masses on NER.More importantly,each water mass on NER featured distinct prokaryotic microbial communities,as indicated by the results of non-metric multidimensional scaling.In contrast,fungi were eurybathic across the water masses.Redundancy analysis results demonstrated that environmental factors might play a pivotal role in the formation and stability of prokaryotic communities in each water mass,especially that of archaea.In addition,indicator species might be used as fi ngerprints to identify corresponding water masses on NER.These results provide new insights into the vertical distribution,structure,and diversity of microorganisms on NER from the perspective of water mass.

关键词： Ninety-East Ridge(NER) temperature-salinity curve microbial vertical distribution water mass microbial diversity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two transition-metal-modified Nb/W mixed-addendum polyoxometalates for visible-light-mediated aerobic benzylic C–H oxidations

引用

Chinese Chemical Letters 2022年第9期33卷 4395-4399页

作者： Yubin Ma Fan Gao Wanru Xiao Na li Shujun Li Bing Yu Xuenian Chen School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced Energy MaterialsHenan Normal UniversityXinxiang 453007China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

The visible-light-induced selective oxidation of ubiquitous C–H bonds into valuable C=O bonds under aerobic conditions is one of the most attractive approaches for the construction of carbonyl-containing molecules.In this work,two transition metal-containing Nb/W mixed-addendum POMs dimers with the formula of K_(2)Na_(2)H_(5)[(Fe(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·24H_(2)O(POM[Fe])and K_(2)Na_(3)H_(4)[(Cr(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·32H_(2)O(POM[Cr])have been synthesized and characterized by various analytical and spectral techniques.POM[Fe]was proved to be an efficient photocatalyst for benzylic C–H oxidation under visible light and using oxygen as an oxidant to produce the corresponding carbonyl complex in good yields.A plausible mechanism involving superoxide radical was proposed for the catalytic reaction.POM[Fe]showed good reusability in the recycling experiments.IR spectroscopy and XRD analysis indicate that POM[Fe]can retain its integrity after catalysis.

关键词： Polyoxometalates Mixed-addendum POMs Visible-light-induced catalysis Photocatalysis C-H bonds oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：