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Treatment of gastric remnant cancer post distal gastrectomy by endoscopic submucosal dissection using an insulation-tipped diathermic knife

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World Journal of Gastroenterology 2008年第16期14卷 2550-2555页

作者： Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujitav shuji Matsumura Seiyuu suzuki Second Department of Internal Medicine Sumitomo Besshi Hospital

AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with gastric remnant cancer. METHODS: Thirty-two patients with early gastric cancer in the remnant stomach, who underwent distal gastrectomy due to gastric carcinoma, were treated with endoscopic mucosal resection (EMR) or ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 10-year period from January 1998 to December 2007, including 17 patients treated with IT-ESD. Retrospectively, patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, and perforation rate were compared between patients treated with conventional EMR and those treated with IT-ESD. RESULTS: The CR rate (40% in the EMR group vs 82% in the IT-ESD group) was significantly higher in the IT-ESD group than in the EMR group; however, the operation time was significantly longer for the IT- ESD group (57.6 ± 31.9 min vs 21.1 ± 12.2 min). No significant differences were found in the rate of underlying cardiopulmonary disease (IT-ESD group, 12% vs EMR group, 13%), one-piece resection rate (100% vs 73%), bleeding rate (18% vs 6.7%), and perforation rate (0% vs 0%) between the two groups. CONCLUSION: IT-ESD appears to be an effective treatment for gastric remnant cancer post distal gastrectomy because of its high CR rate. It is useful for histological confirmation of successful treatment. Thelong-term outcome needs to be evaluated in the future.

关键词： Remnant stomach Distal gastrectomy Gastric cancer Endoscopic mucosal resection Insulationtipped diathermic knife

Minute signet ring cell carcinoma occurring in gastric hyperplastic polyp

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World Journal of Gastroenterology 2007年第43期13卷 5779-5780页

作者： Shoji Hirasaki Seiyuu suzuki Hiromitsu Kanzaki Kohei Fujita shuji Matsumura Eiji Matsumoto Department of Internal Medicine Sumitomo Besshi Hospital 3-1 Ohji-cho Niihama 792-8543 Japan

We describe a 45-year-old woman with minute signet ring cell carcinoma occurring in a gastric hyperplastic polyp. A biopsy specimen obtained from the gastric hyperplastic polyp revealed signet ring cell carcinoma. Endoscopic mucosal resection (EMR) was performed to confirm the diagnosis. Histological examination of the EMR specimen revealed focal signet ring cell carcinoma in the hyperplastic polyp. There are few cases of gastric hyperplastic polyp associated with signet ring cell carcinoma.

关键词： Minute gastric cancer Signet ring cell Endoscopic mucosal resection

Serum vitamin A, C, E and carotenoid levels and risk of malignant transformation among oral leukoplakia： a prospective study

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中国口腔颌面外科杂志 2008年第B5期6卷 121-122页

作者： Toru Nagao Saman Warnakulasuriya Hideo Fukano Koji suzuki shuji Hashimoto Kazuo Shimozato 不详 Department of Oral and Maxillofacial Surgery Okazaki City Hospital. Okazaki 444-8553 Japan Department of Oral Medicine WHO Collaborating Centre for Oral Cancer/Precancer King's College Dental Institute at Guy's King's & St. Thomas' Hospitals. London UK Department of Maxillofacial Surgery Aichi-Gakuin University School of Dentistry. Nagoya 464-8651 Japan Department of Public Health Fujita Health University School of Health Sciences Department of Hygiene Fujita Health University School of Medicine Toyoake 470-1192 Japan

Effect of Aging and Sex on Circulating MicroRNAs in Humans

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Advances in Aging Research 2014年第2期3卷 152-159页

作者： shuji Sawada Takayuki Akimoto Masaki Takahashi Ryota Sakurai Shoji Shinkai Takashi Ushida Yoshinori Fujiwara Katsuhiko suzuki Division of Regenerative Medical Engineering Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo Japan Faculty of Sports Science Waseda University Mikajima 2-579-15 Tokorozawa Saitama Japan Institute for Nanoscience & Nanotechnology Waseda University Wakamatsu-cho 2-2 Shinjuku-ku Tokyo Japan Research Team for Social Participation and Community Health Tokyo Metropolitan Institute of Gerontology 35-2 Sakae-cho Itabashi-ku Tokyo Japan

MicroRNAs (miRNAs) have been reported as potentially being useful biomarkers for various diseases including cancer, diabetes mellitus, heart disease, neurological disease and age-related diseases. In the present study, we aimed to determine whether the expression levels of circulating miRNAs in serum were changed with aging or sex. Serum samples from seven elderly males (69.86 ± 1.77 years old) and females (72.43 ± 1.49 years old), and six young males (26.17 ± 0.83 years old) and females (23.17 ± 1.52 years old) were obtained from the subject’s forearm at rest. The expression levels of circulating miR-146a and miR-20a in serum were determined by real-time TaqMan PCR. There were no differences in the expression levels of miR-146a between all groups. There was a significant interaction in this main effect where miR-20a levels were significantly lower in elderly male subjects when compared to young male subjects with no difference observed in young or elderly female subjects (p = 0.004 and p = 0.971, respectively). These results suggest that not all the miRNAs in the circulation are influenced by the effect of aging, but only some miRNAs may be selectively changed by the effect of aging.

关键词： miRNA Serum Aging Sex Difference Biomarker

Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy

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Asian Journal of Andrology 2022年第1期24卷 116-118页

作者： Hiroshi Hongo Takeo Kosaka Hideyuki Hayashi Kohei Nakamura Hiroshi Nishihara shuji Mikami Himisha Beltran Mototsugu Oya Department of Urology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Genomics Unit Keio Cancer CenterKeio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Division of Diagnostic Pathology Keio University Hospital35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Department of Medical Oncology Dana-Farber Cancer Institute450 Brookline AvenueBostonMA 02215USA

Dear Editor,Spinal and bulbar muscular atrophy(SBMA)or Kennedy’s disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)*** of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate *** previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).

关键词： atrophy muscular cancer

IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions

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World Journal of Gastroenterology 2014年第29期20卷 10050-10061页

作者： Takafumi Naito Katsuhiko Nosho Miki Ito Hisayoshi Igarashi Kei Mitsuhashi Shinji Yoshii Hironori Aoki Masafumi Nomura Yasutaka Sukawa Eiichiro Yamamoto Yasushi Adachi Hiroaki Takahashi Masao Hosokawa Masahiro Fujita Toshinao Takenouchi Reo Maruyama Hiromu suzuki Yoshifumi Baba Kohzoh Imai Hiroyuki Yamamoto shuji Ogino Yasuhisa Shinomura Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of Medicine Department of Gastroenterology Keiyukai Sapporo Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of Medical Oncolo-gy Dana-Farber Cancer InstituteBostonMA 02115United States Department of Surgery Keiyukai SapporoHospital Department of Pathology Keiyukai Sapporo Hospital Department of Molecular Biology Sapporo Medical University School of Medicine Department of Gastroenterological Surgery Graduate School of Medical ScienceKumamoto University Division of Cancer Research The Institute of Medical ScienceThe University of Tokyo Division of Gastroenterology and Hepatology Department of Internal MedicineSt.Marianna University School of Medicine

AIM: To investigate insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions.

关键词： BRAF Colon polyp Colorectal neoplasia Colorectum Genome Insulin-like growth factor Long interspersed nucleotide element-1 Microsatellite instability Serrated pathway

非侵入性多模态成像检测心脏结节病患者的局部心肌损害及活动性炎性反应

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中华核医学与分子影像杂志 2017年第10期37卷 671-672页

作者：顾佳唐军苏州大学医学部放射医学与防护学院 215123 苏州大学附属第二医院核医学科 215004

目的心脏结节病（CS）可以通过***／CT、心血管磁共振（CMR）和123I-BMIPP／201T1C1双核素心肌SPECT显像来诊断。该研究旨在说明这3种方法之间的关系。方法和结果16例确诊为CS的患者[男性11例，年龄（55±13）岁]在类固醇治疗前进行了18... 详细信息

目的心脏结节病（CS）可以通过***／CT、心血管磁共振（CMR）和123I-BMIPP／201T1C1双核素心肌SPECT显像来诊断。该研究旨在说明这3种方法之间的关系。方法和结果16例确诊为CS的患者[男性11例，年龄（55±13）岁]在类固醇治疗前进行了18F-FDGPET／CT、CMR和双核素门控SPECT显像。以上显像时左心室心肌均被分为17段，PET／CT显像时计算各段的最大标准摄取值（SUVmax）；双核素SPECT显像时计算放射性缺损评分（0-4；0为放射性分布正常，4为放射性缺损），包括123I—BMIPP显像的缺损评分（BMDS）、201T1C1显像的缺损评分（TLDS）和两者间的不匹配评分（MS）；CMR显像时计算延时钆增强（LGE）评分（0为无延时增强；1为部分增强；2为均匀增强）。17个节段总计BMDS、TLDS和MS分别为18．6±12．6、12．9±10．9和5．7±3．1。各段的BMDS和TLDS评分随着LGE评分增加而显著增加（P〈0．001）。与LGE评分为0的节段相比，LGE评分为1的节段其MS评分显著增加（P〈0．001），但是LGE评分为1和2的节段其MS评分无明显差异。就LGE评分为1的节段而言，其SUVmax与LGE评分为0的节段相比显著增加（P〈O．025），但是与LGE评分为2的节段相比无明显差异。结论CS患者具有较高SUVmax的区域主要位于有延时增强效应的节段，提示有活动性心肌炎性反应，这些患者123I-BMIPP和和201T1C1显像有明显的不匹配。

关键词：心脏结节病心肌灌注正电子发射断层显像术心脏磁共振脂肪酸代谢

中日小学生生活习惯及行为对其运动能力的影响

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武术研究 2017年第2期2卷 107-110,126页

作者：鈴木明尹小俭季浏高橋進進藤周治小沼彰彦只隈伸也佐藤真太郎大东文化大学体育健康科学部日本东京355-8501 华东师范大学体育与健康学院上海200241

目的：为制定中日小学生成长阶段的合理锻炼规划提供理论依据。方法：随机选取日本埼玉县和中国江西省南康县横市镇773名3-5年级小学生，进行日本文部省制定的《新体能测试》体质健康项目测试，并通过问卷进行小学生生活习惯与性格调查... 详细信息

目的：为制定中日小学生成长阶段的合理锻炼规划提供理论依据。方法：随机选取日本埼玉县和中国江西省南康县横市镇773名3-5年级小学生，进行日本文部省制定的《新体能测试》体质健康项目测试，并通过问卷进行小学生生活习惯与性格调查。结果：对体育锻炼兴趣浓厚以及花费更多时间进行运动的中日小学生（8-10岁），较之同龄人的体质健康状况更好；除了柔韧指标外，日本小学生的其它体能指标均优于中国小学生；对于中国小学生而言，体温低于36℃和日常步行数少于8000步可能导致体质健康状况不佳，但睡眠时间与体质健康状况没有显著性关系；拥有开朗性格儿童的体质健康状况相比其它性格小学生更好；没有“恐高症”儿童的肌肉力量、力量和灵敏性更好。结论：中日小学生体格比较差异不明显，日本小学生体能总体状况优于中国小学生；开朗性格与中日小学生运动能力呈正相关。

关键词：小学生体质生活习惯运动习惯性格