Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy

作     者：Hiroshi Hongo Takeo Kosaka Hideyuki Hayashi Kohei Nakamura Hiroshi Nishihara Shuji Mikami Himisha Beltran Mototsugu Oya Hiroshi Hongo;Takeo Kosaka;Hideyuki Hayashi;Kohei Nakamura;Hiroshi Nishihara;Shuji Mikami;Himisha Beltran;Mototsugu Oya

作者机构：Department of UrologyKeio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Genomics UnitKeio Cancer CenterKeio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Division of Diagnostic PathologyKeio University Hospital35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Department of Medical OncologyDana-Farber Cancer Institute450 Brookline AvenueBostonMA 02215USA 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2022年第24卷第1期

页      面：116-118页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Yoko Suzuki provided technical assistance.This study was supported in part by Grants-in-Aid for Scientific Research(#17K16813 to H Hongo and#17K11158 and#20H03817 to TK)from the Ministry of Education,Culture,Sports,Science,and Technology of Japan The study was supported in part by research Grant to TK from the Takeda Science Foundation,Japan 

主　　题：atrophy muscular cancer 

摘      要：Dear Editor,Spinal and bulbar muscular atrophy(SBMA)or Kennedy’s disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)*** of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate *** previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).