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The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation

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Asian Journal of Urology 2022年第4期9卷 480-482页

作者： Hiroshi Hongo Takeo Kosaka Kohei Nakamura shuji mikami Hiroshi Nishihara Mototsugu Oya Department of Urology Keio University School of MedicineJapan Genomics Unit Keio Cancer CenterKeio University School of MedicineJapan Department of Diagnostic Pathology Keio University HospitalJapan

Dear editor:Intraductalcarcinomaoftheprostate(IDC-P)ischaracterized by expansive growth of cancer cells in normal prostatic ducts with basal cell layer and associated with high grade invasive prostate cancer(PCa).However,the molecular profile or clinical character of IDC-P in progressive castration-resistant PCa(CRPC)was not fully characterized yet.

关键词： cancer clinical prostatic

An Evaluation of Value-Oriented Review for Software Requirements Specification

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Computer Systems Science & Engineering 2021年第6期37卷 443-461页

作者： Qiang Zhi shuji Morisaki Tokyo Institute of Technology Tokyo152-8550Japan Nagoya University Nagoya464-8601Japan

A software requirements specification(SRS)is a detailed description of a software system to be *** paper proposes and evaluates a lightweight review approach called value-oriented review(VOR)to detect defects in *** approach comprises setting core values based on SRS and detecting the defects disturbing the core *** evaluate the effectiveness of the proposed approach,we conducted a controlled experiment to investigate whether reviewers could identify and record the core values based on SRS and find defects disturbing the core *** of the evaluation with 56 software engineers showed that 91%of the reviewers identified appropriate core values and 82%of the reviewers detected defects based on the identified core ***,the average number of defects detected using the proposed approach was slightly smaller than that detected using perspective-based reading(PBR);however,PBR requires defining review scenarios before attempting to detect any *** results also demonstrated that the proposed approach helped reviewers detect the omission defects,which are more difficult to detect from SRS than defects because of ambiguity or incorrect requirements.

关键词： Value-oriented review perspective-based reading scenario-based reading lightweight review software requirements specification

Novel insights into the mechanism of reactive oxygen species-mediated neurodegeneration

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Neural Regeneration Research 2023年第4期18卷 746-749页

作者： shuji Wakatsuki Toshiyuki Araki Department of Peripheral Nervous System Research National Institute of NeuroscienceNational Center of Neurology and PsychiatryTokyoJapan

Neurite degeneration,a major component of many neurodegenerative diseases,such as Parkinson’s disease,Alzheimer’s disease,and amyotrophic lateral sclerosis,is not part of the typical apoptosis signaling mechanism,but rather it appears that a self-destructive process is in *** stress is a well-known inducer of neurodegenerative pathways:neuronal cell death and neurite *** oxidative stress exerts cytotoxic effects leading to neuronal loss,the pathogenic mechanisms and precise signaling pathways by which oxidative stress causes neurite degeneration have remained entirely *** previously reported that reactive oxygen species generated by NADPH oxidases induce activation of the E3 ubiquitin ligase ZNRF1 in neurons,which promotes neurite *** this process,the phosphorylation of an NADPH oxidase subunit p47-phox at the 345serine residue serves as an important checkpoint to initiate the ZNRF1-dependent neurite *** provides new insights into the mechanism of reactive oxygen species-mediated *** this review,we focus specifically on reactive oxygen species-induced neurite degeneration by highlighting a phosphorylation-dependent regulation of the molecular interaction between ZNRF1 and the NADPH oxidase complex.

关键词： neurite degeneration oxidative stress phosphorylation reactive oxygen species ubiquitin ligase

Interaction between Potassium Phosphate Buffer Solution and Modeling Cell Membrane Investigated by Sum Frequency Generation Vibrational Spectroscopy

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Weilai Yang Kangzhen Tian shuji Ye Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 China

Potassium phosphate buffer solution has been widely used in the biological experiments, which represents an important process of the interaction between ions and biomolecules, yet the influences of potassium phosphate on biomolecules such as the cell membrane are still poorly understood at the molecular level. In this work, we have applied sum frequency generation vibrational spectroscopy and carried out a detailed study on the interaction between potassium phosphate buffer solution (PBS) and negative 1,2-dimyristoyl-d54-sn-glycero-3-[phospho-rac-(1-glycerol)] (d54-DMPG) lipid bilayer in real time. The PBS-induced dynamic change in the molecular structure of d54-DMPG lipid bilayer was monitored using the spectral features of CD2, CD3, lipid head phosphate, and carbonyl groups for the first time. It is found that K+ can bind to the cell membrane and cause the signal change of CD2, CD3, lipid head phosphate, and carbonyl groups quickly. Potassium PBS interacts with lipid bilayers most likely by formation of toroidal pores inside the bilayer matrix. This result can provide a molecular basis for the interpretation of the effect of PBS on the ion-assisted transport of protein across the membrane.

关键词： Sum frequency generation Potassium phosphate buffer Lipid bilayer Toroidal pore Interaction

Thermal Conductivity and Tensile Properties of Carbon Nanofiber-Reinforced Aluminum-Matrix Composites Fabricated via Powder Metallurgy: Effects of Ball Milling and Extrusion Conditions on Microstructures and Resultant Composite Properties

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 573-584页

作者： Fumio Ogawa shuji Yamamoto Chitoshi Masuda Department of Mechanical Engineering College of Science and Engineering Ritsumeikan University Kanto Gakuin University Kagami Memorial Institute for Materials Science and Technology Waseda University

Carbon nanofiber(CNF)-reinforced aluminum-matrix composites were fabricated via ball milling and spark plasma sintering(SPS), SPS followed by hot extrusion and powder extrusion. Two mixing conditions of CNF and aluminum powder were adopted: milling at 90 rpm and milling at 200 rpm. After milling at 90 rpm, the mixed powder was sintered using SPS at 560 °C. The composite was then extruded at 500 °C at an extrusion ratio of 9. Composites were also fabricated via powder extrusion of powder milled at 200 rpm and 550 °C with an extrusion ratio of 9(R9) or 16(R16). The thermal conductivity and tensile properties of the resultant composites were evaluated. Anisotropic thermal conductivity was observed even in the sintered products. The anisotropy could be controlled via hot extrusion. The thermal conductivity of composites fabricated via powder extrusion was higher than those fabricated using other methods. However, in the case of specimens with a CNF volume fraction of 4.0%, the thermal conductivity of the composite fabricated via SPS and hot extrusion was the highest. The highest thermal conductivity of 4.0% CNF-reinforced composite is attributable to networking and percolation of CNFs. The effect of the fabrication route on the tensile strength and ductility was also investigated. Tensile strengths of the R9 composites were the highest. By contrast, the R16 composites prepared under long heating duration exhibited high ductility at CNF volume fractions of 2.0% and 5.0%. The microstructures of composites and fracture surfaces were observed in detail, and fracture process was elucidated. The results revealed that controlling the heating and plastic deformation during extrusion will yield strong and ductile composites.

关键词： Al composite Carbon nanofiber Ball milling Hot extrusion Microstructure and performance

The dehydration dynamics of a model cell membrane induced by cholesterol analogue 6-ketocholestanol investigated using sum frequency generation vibrational spectroscopy

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Science China Chemistry 2015年第7期58卷 1176-1186页

作者： Sulan Ma Kangzhen Tian shuji Ye Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical Physics University of Science and Technology of China Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China

Dehydration of a surface is the first step for the interaction between biomolecules and the surface. In this study, we systemati- cally investigated the influence of cholesterol analog 6-ketocholestanol （6-KC） on the dehydration of model cell membrane, using sum frequency generation vibrational spectroscopy. In pure DI water environment, two separate dehydration dynamic components were observed in neutrally charged and isotopically labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine （DMPC） and positively charged 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine（chloride salt）（DMEPC） bilayer： a large-amplitude fast component and a small-amplitude slow component, which originated from the water molecules with a weak and a strong water-membrane bound strengths, respectively. Dehydration of a negatively charged mixed DMPC/DMPG bilayer lead to the membrane-bound water being reorganized to ordered structures quickly. It is evident that the water-membrane bound strengths depend largely on the charge status of the lipid and has an order of neutrally charged membrane〈〈positively charged mem- brane〈〈negatively charged membrane. In an ionic environment, KC1 solution can not only dehydrate DMPC bilayer, but also prevent the 6-KC fiom further dehydrating this model cell membrane. We observed that the dehydration dynamics behavior of DMPC bilayer in the presence of the chaotropic anions is similar to that of the negatively charged DMPG bilayer because of the penetration of chaotropic anions into the DMPC bilayer. The degree of dehydration difficulty in kosmotropic anions fol- lows a Hofmeister series and linearly correlates with the hydration Gibbs free energy of the anions. Our results provide a molecular basis for the interpretation of the Hofmeister effect of kosmotropic anions on ion transport proteins.

关键词： membrane dehydration sum frequency generation membrane-bound water membrane dipole potential Hofmeistereffect

Endoscopic surveillance of gastric cancers after Helicobacter pylori eradication

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World Journal of Gastroenterology 2015年第37期21卷 10553-10562页

作者： Masaaki Kobayashi Yuichi Sato shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences

The incidence and mortality of gastric cancer remains high in East Asian countries. Current data suggest that Helicobacter pylori(H. pylori) eradication might be more effective for preventing gastric cancer in young people before they develop atrophic gastritis and intestinal metaplasia. However, the long-term effect of H. pylori eradication on metachronous cancer prevention after endoscopic resection(ER) of early gastric cancer remains controversial, with some discordance between results published for Japanese and Korean *** detection ability of synchronous lesions before ER and eradication of H. pylori directly influences these results. After eradication, some gastric cancers are more difficult to diagnose by endoscopy because of morphologic changes that lead to a flat or depressed appearance. Narrow-band imaging with magnifying endoscopy(NBI-ME) is expected to be useful for identifying metachronous cancers. However, some gastric cancers after eradication show a "gastritislike"appearance under NBI-ME. The gastritis-like appearance correlates with the histological surface differentiation of the cancer tubules and superficial non-neoplastic epithelium atop or interspersed with the cancer. Till date, it remains unclear whether *** eradication could prevent progression of gastric cancer. Until we can establish more useful endoscopic examination methodologies, regular endoscopic surveillance of high-risk groups is expected to be the most beneficial approach for detection.

关键词： Gastric cancer Helicobacter pylori Atrophic gastri

Risk prediction of common bile duct stone recurrence based on new common bile duct morphological subtypes

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 874-876页

作者： Hirokazu Saito shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto 862-8505Japan

Stones in the common bile duct(CBD) are reported worldwide, and this condition is majorly managed through endoscopic retrograde cholangiopancreatography(ERCP). CBD stone recurrence is an important issue after endoscopic stone removal. Therefore, it is essential to identify its risk factors to determine the necessity of regular follow-up in patients who underwent endoscopic removal of CBD stones. The authors identified that the S and polyline morphological subtypes of CBD were associated with increased stone recurrence. New morphological subtypes of CBD presented by the authors can be important risk predictors of recurrence after endoscopic stone removal. Furthermore, the new morphological subtypes of CBD may predict the risk of residual CBD stones or technical difficulty in CBD stone removal. Further studies with a large sample size and longer follow-up durations are warranted to examine the usefulness of the newly identified morphological subtypes of CBD in predicting the outcomes of ERCP for CBD stone removal.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct stone Stone removal Recurrence Common bile duct morphology Risk prediction

Metalorganic chemical vapor deposition of InN quantum dots and nanostructures

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Light(Science & Applications) 2021年第8期10卷 1409-1420页

作者： Caroline E.Reilly Stacia Keller shuji Nakamura Steven P.DenBaars Materials University of CaliforniaSanta BarbaraCA 93106USA Electrical and Computer Engineering University of CaliforniaSanta BarbaraCA 93106USA

Using one material system from the near infrared into the ultraviolet is an attractive goal,and may be achieved with(ln,AI,Ga)***Ⅲ-N material system,famous for enabling blue and white solid-state lighting,has been pushing towards longer wavelengths in more recent *** a bandgap of about 0.7 eV,InN can emit light in the near infrared,potentially overlapping with the part of the electromagnetic spectrum currently dominated byⅢ-As andⅢ-P *** has been the case in these otherⅢ-V material systems,nanostructures such as quantum dots and quantum dashes provide additional benefits towards optoelectronic *** the case of InN,these nanostructures have been in the development stage for some time,with more recent developments allowing for InN quantum dots and dashes to be incorporated into larger device *** review will detail the current state of metalorganic chemical vapor deposition of InN nanostructures,focusing on how precursor choices,crystallographic orientation,and other growth parameters affect the *** optical properties of InN nanostructures will also be assessed,with an eye towards the fabrication of optoelectronic devices such as light-emitting diodes,laser diodes,and photodetectors.

关键词： optoelectronic quantum chemical