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A large-scale fatal outbreak of Pasteurella multocida among wild rodents in southwestern China

Journal of Biosafety and Biosecurity 2020年第2期2卷 91-98页

作者： Chun-Hong Du Yong Huang Jia-Fu Jiang Zi-Hou Gao Na Jia Shan Yang Chao-Nian chen Shun-Gao Ma Yu-Ying Liang Bao-Gui Jiang Wei-Hong Sang Peng Wang Yun Liang Yun-Zhi Zhang Ji-Hua Zhou shui-ping chen Frans Jongejan Zhi-Zhong Song Yi-Gang Tong Wu-Chun Cao State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingPR China Yunnan Institute for Endemic Diseases Control and Prevention Dali YunnanPR China Puer Center for Disease Control and Prevention PuerYunnanPR China Simao Prefecture Center for Disease Control and Prevention PuerYunnanPR China DaLi Bai Autonomous Prefecture People’Hospital YunnanPR China Fifth Medical Center of PLA General Hospital BeijingPR China Utrecht Centre for Tick-borne Diseases(UCTD) Faculty of Veterinary MedicineUtrecht UniversityYalelaan 13584 CL UtrechtThe Netherlands College of Life Science and Technology Beijing University of Chemical Technology.BeijingPR China

Background:Pasteurella multocida is an important and old zoonotic pathogen worldwide which has an impressive host spectrum including numerous domestic and wild animals as well as birds,causing specific diseases or outbreak with great economic *** has never been reported that *** can cause an epidemic in wild *** June 5–17,2016,more than 1000 rodent deaths of an unknown cause quickly spread in the PuEr City,Yunnan province,southwestern ***:The rodents in affected areas and outside of the epidemic areas were collected and screened for possible known pathogens including Yersinia pestis,rabies virus and hantavirus as well as other *** possible bacterial pathogens were isolated both by culture medium and by mouse inoculation in *** isolates were identified by the Vitek GNI card and PCR assays for 16S rRNA *** pathogen strains were selected for whole genome sequencing ***:A total of 123 rodents were collected from 25 sample sites at affected area,among of which,all 119 dead rodents were negative for the pathogen under consideration except ***,and all four live rodents were negative for *** addition,480 rodents collected from other 23 counties outside of the epidemic area in Yunnan were negative for with ***.A total of 14 strains of ***(six directly isolated from the field rodents and eight from the experimental mice that were injected with the organ substrates from the dead rodents)belonged to serogroup A and serogroup F represented by 9 N and 20 N were identified in these epidemic *** genome sequencing revealed that the serogroup F strain shared 99%similarity to *** Pm70 from chicken,but contained a 50 k bp insertion *** serogroup A strain shared 95%similarity to *** FDAARGOS_385 from a human patient,but contained four large structural *** abnormalities were identified in the livers,lungs,hearts and brains of the ino

关键词： Pasteurella multocida Serotypes A Serotypes F Rodents Outbreak China

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从富铼渣中回收铼并制备高铼酸铵

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有色金属（冶炼部分） 2017年第10期 57-60,74页

作者：王俊娥张焕然衷水平陈杭厦门紫金矿冶技术有限公司福建厦门361101 紫金铜业有限公司福建上杭364204

研究从富铼渣中回收并制备铼产品的工艺路线,着重考察药剂浓度、相比、时间等对铼萃取—反萃的影响,并探索进行了结晶制备高铼酸铵试验。结果表明,经过压力浸出,铼的浸出率达98%以上;在优化试验条件下,铼萃取率可达99.98%,反萃率达到99... 详细信息

研究从富铼渣中回收并制备铼产品的工艺路线,着重考察药剂浓度、相比、时间等对铼萃取—反萃的影响,并探索进行了结晶制备高铼酸铵试验。结果表明,经过压力浸出,铼的浸出率达98%以上;在优化试验条件下,铼萃取率可达99.98%,反萃率达到99%以上,一次结晶所得高铼酸铵纯度为98.7%。

关键词：富铼渣萃取反萃高铼酸铵

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： ping Zhang Ying Zhu Pu chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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耐药性细菌碳青霉烯酶检测方法研究进展

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标记免疫分析与临床 2017年第3期24卷 349-355页

作者：徐建民陈水平陈建魁军事医学科学院附属医院检验科北京100071

耐碳青霉烯类抗生素细菌严重威胁着患者的身体健康和耐药菌感染的治疗和控制。为了有效地预防和治疗由产碳青霉烯酶菌株造成的感染,采取及时有效的检测方法显得尤为重要。国内外学者报道了多种试验方法用来检测产碳青霉烯酶菌株,主要包... 详细信息

耐碳青霉烯类抗生素细菌严重威胁着患者的身体健康和耐药菌感染的治疗和控制。为了有效地预防和治疗由产碳青霉烯酶菌株造成的感染,采取及时有效的检测方法显得尤为重要。国内外学者报道了多种试验方法用来检测产碳青霉烯酶菌株,主要包括表型检测方法和生物化学检测方法;近年来研制的MALDI-TOF MS技术应用于临床微生物鉴定逐渐显示出其优越性,用于产碳青霉烯酶菌株耐药的检测也有较好的临床应用前景。随着基因测序成本的不断下降,多重实时PCR、第二代测序等方法也逐渐应用于临床实验室。本文就碳青霉烯酶的检测方法研究进展加以综述,以期为医学微生物检验工作者选择检测方法提供参考。

关键词：碳青霉烯酶耐药菌基质辅助激光解析时间飞行质谱

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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原发性胆管结石手术引流方式的分析及其再认识

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世界华人消化杂志 2009年第19期17卷 2005-2009页

作者：陈水平余新邵江华邬林泉邹书兵傅华群南昌大学第二附属医院肝胆外科江西省南昌市330006

目的:探讨胆管结石手术引流方式随诊断技术和手术技巧的提高所发生的变迁.方法:收集1986-2007年南昌大学第二附属医院3691例胆管结石患者的临床资料,并利用中国生物医学文献数据库检索20世纪60-80年代初胆管结石手术引流方式资料.分析... 详细信息

目的:探讨胆管结石手术引流方式随诊断技术和手术技巧的提高所发生的变迁.方法:收集1986-2007年南昌大学第二附属医院3691例胆管结石患者的临床资料,并利用中国生物医学文献数据库检索20世纪60-80年代初胆管结石手术引流方式资料.分析胆管结石手术引流方式-T管引流和胆肠吻合引流的变化趋势,并分析其产生变化的原因.结果:20世纪60-80年代初、1986-1996年、1997-2007年这3个时间段胆管结石患者中T管引流和胆肠吻合引流在同期行手术治疗的患者中百分比分别是74.70%和16.90%、35.20%和38.42%、70.30%和10.16%.结论:近50年我国胆管结石患者手术引流方式经历了胆道探查+T管引流、胆肠吻合与病灶根治+T管引流3个阶段.

关键词：胆管结石胆道探查 T管引流胆肠吻合

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Influence of rolling temperature on the interfaces and mechanical performance of graphene-reinforced aluminum-matrix composites

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International Journal of Minerals,Metallurgy and Materials 2019年第6期26卷 752-759页

作者： chen-yang Huang shui-ping Hu Kai chen Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

To study the influence of rolling on the interfaces and mechanical performance of graphene-reinforced Al-matrix composites,a rolling method was used to process *** scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray diffraction(XRD),Raman spectroscopy,and tensile testing,this study analyzed the micromorphology,interfaces,and mechanical performance of the composites before and after *** experimental results demonstrates that the composites after hot rolling has uniform structures with strong interfacial *** an increase in rolling temperature,the tensile strength and elastic modulus of the composites gradually ***,when the rolling temperature is higher than 500°C,granular and rod-like Al4C3 phases are observed at the interfaces and the mechanical performance of the composites is *** the rolling temperature is 480°C,the composites show the optimal comprehensive mechanical performance,with a tensile strength and elastic modulus of 403.3 MPa and 77.6 GPa,respectively,which represent increases of 31.6%and 36.9%,respectively,compared with the corresponding values prior to rolling.

关键词： rolling graphene composite interface mechanical performance

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Enhanced electrochemical CO_(2)reduction coupled with urea oxidation using bifunctional atomically dispersed CuNi catalysts

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Nano Research 2025年第1期18卷 208-216页

作者： Wenjie Wu Haoyang Zhou Ying Liu Yifei Pan Qingqing chen Yu Zhang Junjie Mao Wenjie Ma ping Yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China University of Chinese Academy of Sciences Beijing 100049China

The electrochemical conversion of carbon dioxide(CO_(2))into chemical fuels represents a promising approach for addressing global carbon balance ***,this process is hindered by the kinetic limitations of anodic reactions,usually the oxygen evolution reaction,resulting in less efficient production of high value-added ***,we report an integrated electrocatalytic system that couples CO_(2)reduction reaction(CO_(2)RR)with urea oxidation reaction(UOR)using a bifunctional electrocatalyst with atomically dispersed dual-metal CuNi sites anchored on bamboo-like nitrogen-doped carbon nanotubes(CuNi-CNT),which were synthesized through a one-step pyrolysis *** bifunctional CuNi-CNT catalyst exhibits a near 100%CO Faraday efficiency for CO_(2)RR over a wide potential range and outstanding UOR performance with a negatively shifted potential of 210 mV at 10 mA·cm^(-2).In addition,we assemble a two-electrode electrolyzer using bifunctional CuNi-CNT-modified carbon fiber paper electrodes as both cathode and anode,capable of operating at a remarkably low cell voltage of 1.81 V at 10 mA·cm-2,significantly lower than conventional *** study provides a novel avenue to achieving an efficient carbon cycle with reduced electric power consumption.

关键词： electrochemical conversion bimetallic site catalyst bifunctional electrocatalyst carbon dioxide reduction urea oxidation

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Dynamic Response of the U-Typed Sandwich Panel Under Explosion Load Based on the SDOF Method

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China Ocean Engineering 2022年第5期36卷 814-826页

作者： LIU Kun GAO Yu ZHAO chen-shui WANG Ze-ping School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China Qingdao Innovation and Development Center of Harbin Engineering University Qingdao 266000China

Sandwich panel is commonly used in ship and marine engineering equipment,such as side structure and superstructure deck of a ship,which is of good anti-explosion *** paper addresses a study on the dynamic response of the U-typed sandwich panel under explosion load through the numerical simulation and theoretical *** on the orthotropic plate theory,the U-typed sandwich panel is simplified and transformed into a single degree of freedom(SDOF)spring system,the equivalent motion equation of the SDOF system and the expression of triangular explosion load function are established based on the SDOF theory,and the maximum response spectrum of the SDOF system is ***,the response of the equivalent SDOF system of the U-typed sandwich panel under explosion load is analyzed,and the theoretical results match well with the numerical simulation results,which verifies the accuracy of the theoretical method proposed in this *** theoretical method proposed in this paper could have good engineering applications for the structural anti-explosion design,and provide a reference for the evaluation of the anti-explosion performance of ship and offshore platform structures.

关键词： U-typed sandwich panel the orthotropic plate theory oil and gas explosion SDOF method dynamic response

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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