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Effect of FTO on cardiac hypertrophy through the regulation of OBSCN expression

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Genes & Diseases 2024年第6期11卷 84-87页

作者： Lili Chen Yiheng Zhao Wenjing Wang shuchen zhang Xiang Zhou Central Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Cardiology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Intensive Care Unit The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China

N^(6)-methyladenosine(m^(6)A)RNA methylation exerts significant functions in regulating various cardiovascular *** the recognition of the first m^(6)A demethylase,namely fat and obesity-associated protein(FTO),mounting evidence has shown that polymorphism of the FTO gene leads to an increased occurrence of cardiovascular-related risk factors including obesity,diabetes,and inflammation.

关键词： cardiovascular obesity cardiac

Carbothermal shock enabled facile and fast growth of carbon nanotubes in a second

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Nano Research 2022年第3期15卷 2576-2581页

作者： Haomin Wang Huimin Wang shuchen zhang Yong zhang Kailun Xia Zhe Yin Mingchao zhang Xiaoping Liang Haojie Lu Shuo Li Jin zhang Yingying zhang Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Carbon nanotubes(CNTs)hold great promise in many fields because of their unique structures and ***,the preparation of CNTs generally involves cumbersome equipment and time-consuming ***,we report an ultra-fast carbothermal shock(CTS)approach for synthesizing CNTs with a simple homemade setup by employing Joule heating of a carbon *** silk fabric(CSF)loaded with transition metal salts in ethanol solution was used as the substrate,which was treated with a pulse voltage of 40 V for only 50 ms and then covered with uniform CNTs grown with bimetallic alloy catalyst nanoparticles(diameter:~9 nm).The temperature ramp rate is as high as 105 K/*** as-obtained sample has a unique fluffy structure similar to the trichobothrium of spiders,endowing it versatile applications such as airflow sensors or air *** CTS technique presents an easy-accessible and highly efficient approach for synthesizing CNTs,which may be also applied in synthesizing other nanomaterials.

关键词： carbothermal shock Joule heating carbon nanotube ultra-fast growth fluffy structure

Large-area growth of ultra-high-density single-walled carbon nanotube arrays on sapphire surface

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Nano Research 2015年第11期8卷 3694-3703页

作者： Lixing Kang Yue Hu Hua Zhong Jia Si shuchen zhang Qiuchen Zhao Jingjing Lin Qingwen Li Zhiyong zhang Lianmao Peng Jin zhang Division ofAdvanced Nanomaterials Suzhou Institute of Nanotech and Nanobionics Chinese Academy of Sciences Suzhou 215123 China Center for Nanochemistry Beijing Science and Engineering Technology Research Center for Low Dimensional Carbon Materials College of Chemistry and Molecular Engineering Peking University Beijing 100871 China University of ChineseAcademy of Sciences Beijing 100049 China 4 Key Laboratory for the Physics and Chemistry of Nanodevices Department of Electronics Peking University Beijing 100871 China Key Laboratory for the Physics and Chemistry of Nanodevices Department of Electronics Peking University Beijing 100871 China

A scalable approach to obtaining high-density, large-area single-walled carbon nanotube （SWNT） arrays is essential for realizing the full potential of SWNTs in practical electronic devices; this is still a great challenge. Here, we report an improved synthetic method for large-area growth of ultra-high-density SWNT arrays on sapphire surfaces by combining Trojan catalysts （released from the substrate, to assure ultra-high density） with Mo nanoparticles （loaded on the surface, to stabilize the released Trojan catalysts） as cooperating catalysts. Dense and perfectly aligned SWNTs covered the entire substrate and the local density was as high as 160 tubes/pro. Field-effect transistors （FETs） built on such arrays gave an output current density of -488 μA/μm at the drain-source voltage （Vds） = the gate-source voltage （Vgs） = -2 V, corresponding to an on-conductance per width of 244 μS/μm. These results confirm the wide range of potential applications of Trojan-Mo catalysts in the structure-controlled growth of SWNTs.

关键词： single-walled carbon nanotube arrays ultra-high density large area cooperating catalysts

Sox2, a key factor in the regulation of pluripotency and neural differentiation

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World Journal of Stem Cells 2014年第3期6卷 305-311页

作者： shuchen zhang Wei Cui Institute of Reproductive Developmental Biology Department of Surgery and Cancer Faculty of Medicine Imperial College London Hammersmith Campus

Sex determining region Y-box 2(Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells(PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their pluripotency. Furthermore, Sox2 plays an essential role in somatic cell reprogram-ming, reversing the epigenetic configuration of differ-entiated cells back to a pluripotent embryonic state. In addition to its role in regulation of pluripotency, Sox2 is also a critical factor for directing the differentiation of PSCs to neural progenitors and for maintaining the properties of neural progenitor stem cells. Here, we review recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mecha-nisms underlying these roles.

关键词： Sex determining region Y-box 2 Pluripotent stem cells Pluripotency Neural differentiation Reprogramming

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碳纳米管可控制备的过去、现在和未来

物理化学学报 2020年第1期36卷 54-69页

作者：张树辰张娜张锦北京大学化学与分子工程学院

碳纳米管独特的几何和电子结构使其具有丰富优异的性质,因此在过去的二十余年备受研究者的关注。然而,碳纳米管结构的多样性成为其从实验室走到产业化的最大阻碍,结构决定性质,制备决定未来,完善的结构控制制备技术将成为碳纳米管基础... 详细信息

碳纳米管独特的几何和电子结构使其具有丰富优异的性质,因此在过去的二十余年备受研究者的关注。然而,碳纳米管结构的多样性成为其从实验室走到产业化的最大阻碍,结构决定性质,制备决定未来,完善的结构控制制备技术将成为碳纳米管基础研究和产业化应用中至关重要的一环。本文首先对碳纳米管的结构进行描述,然后综述了碳纳米管的结构可控制备方法和溶液纯化分离技术,提出未来理想的碳纳米管制备之路是将碳纳米管精细结构控制方法与宏量制备技术相结合,在降低碳纳米管生产成本的同时,提高其纯度,并建立碳纳米管产品的标准。最后,展望了碳纳米管的杀手锏级应用和该领域的机遇和挑战。

关键词：碳纳米管结构性质控制制备产业化杀手锏应用

Carbon nanotube: Controlled synthesis determines its future

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Science China Materials 2020年第1期63卷 16-34页

作者： shuchen zhang Liu Qian Qiuchen Zhao Zequn Wang Dewu Lin Weiming Liu Yabin Chen Jin zhang Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

Carbon nanotubes(CNTs) have received broad attention in the past decades due to their excellent physical and chemical properties and thus been regarded as a powerful candidate for future star-materials. Although various CNT products and their related applications have been demonstrated recently, their performance can hardly meet the researchers’ expectations compared with their theoretical properties. The current predicament is caused by the immature synthesis method, including the basic science and the producing technology. As the synthesis with controlled structures determines its future, this review summarizes the progress on the basic research and industrialization of CNTs in the past decades, including the fine structure control, aggregation status design and scale-up production, and further points out the way for the future development of CNTs combining with specific applications.

关键词： carbon nanotubes structure-controlled synthesis scale-up synthesis applications

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Unraveling the Effect of Stacking Configurations on Charge Transfer in WS_(2) and Organic Semiconductor Heterojunctions

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Precision Chemistry 2023年第7期1卷 443-451页

作者： shuchen zhang Dewei Sun Jiaonan Sun Ke Ma Zitang Wei Jee Yung Park Aidan H.Coffey Chenhui Zhu Letian Dou Libai Huang Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana 47907United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States Department of Chemistry Purdue UniversityWest LafayetteIndiana 47907United States

Photoinduced interfacial charge transfer plays a critical role in energy conversion involving van der Waals(vdW)heterostructures constructed of inorganic nanostructures and organic ***,the effect of molecular stacking configurations on charge transfer dynamics is less *** this study,we demonstrated the tunability of interfacial charge separation in a type-Ⅱ heterojunction between monolayer(ML)WS_(2) and an organic semiconducting molecule[2-(3″′,4′-dimethyl-[2,2′:5′,2′:5″,2″′-quaterthiophen]-5-yl)ethan-1-ammonium halide(4Tm)]by rational design of relative stacking *** assembly between ML-WS_(2) and the 4Tm molecule forms a face-to-face stacking when 4Tm molecules are in a selfaggregation *** contrast,a face-to-edge stacking is observed when 4Tm molecule is incorporated into a 2D organic-inorganic hybrid perovskite *** face-to-face stacking was proved to be more favorable for hole transfer from WS_(2) to 4Tm and led to interlayer excitons(IEs)*** absorption measurements show that the hole transfer occurs on a time scale of 150 *** the other hand,the face-to-edge stacking resulted in much slower hole transfer without formation of *** inefficient hole transfer occurs on a similar time scale as A exciton recombination in WS_(2),leading to the formation of negative *** investigations offer important fundamental insights into the charge transfer processes at organic−inorganic interfaces.

关键词： Charge transfer two-dimensional materials organic semiconductors heterojunction stacking configuration interlayer exciton

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越南拜尚堰防渗墙PVC止水带接头施工

水力发电 1999年第11期25卷 58-59页

作者：张树宸中国水利水电基础工程局天津武清301700

越南拜尚堰加固防渗墙要求埋设止水带作为墙段防渗接头。为此，中国水利水电基础工程局自行研制了止水带下设的接头箱。两套接头箱下设在一期槽孔的两端，同时将止水带安设就位。一期槽孔浇筑，止水带的一半埋入混凝土后，拔出接头... 详细信息

越南拜尚堰加固防渗墙要求埋设止水带作为墙段防渗接头。为此，中国水利水电基础工程局自行研制了止水带下设的接头箱。两套接头箱下设在一期槽孔的两端，同时将止水带安设就位。一期槽孔浇筑，止水带的一半埋入混凝土后，拔出接头箱。待二期槽孔浇筑，另一半止水带埋入混凝土后，即形成止水防渗接头。在基岩中采用此项接头技术尚属首次，实际运用的防渗效果也很好。

关键词：止水带接头接头箱防渗墙堰

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制造业大数据联盟资源推送服务算法

计算机集成制造系统 2017年第11期23卷 2371-2381页

作者：翟丽丽沃强张树臣哈尔滨理工大学管理学院黑龙江哈尔滨150080 哈尔滨理工大学高新技术产业发展研究中心黑龙江哈尔滨150080

为了提高制造业大数据联盟资源共享效果及联盟成员的满意度,提出一种基于互信息特征权重和相似度的制造业大数据联盟资源推送算法。利用互信息特征权重和特征相似度分别对制造业大数据联盟成员评分和最近邻居产生的评分加以改进,从而提... 详细信息

为了提高制造业大数据联盟资源共享效果及联盟成员的满意度,提出一种基于互信息特征权重和相似度的制造业大数据联盟资源推送算法。利用互信息特征权重和特征相似度分别对制造业大数据联盟成员评分和最近邻居产生的评分加以改进,从而提高资源推送质量。实验结果表明,该算法在一定程度上解决了制造业大数据联盟新成员资源推送和数据稀疏问题,有效提高了制造业大数据联盟成员满意度。

关键词：制造业大数据联盟资源推送互信息推送算法

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