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Overview of lethal human coronaviruses

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1672-1687页

作者： Bin Chen Er-Kang Tian Bin He Lejin Tian Ruiying Han shuangwen wang Qianrong Xiang Shu Zhang Toufic El Arnaout Wei Cheng Division of Respiratory and Critical Care Medicine State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Emergency Medicine West China HospitalSichuan UniversityChengdu 610041China Kappa Crystals Ltd. DublinIreland

Coronavirus infections of multiple origins have spread to date worldwide,causing severe respiratory *** coronaviruses that infect humans have been identified:HCoV-229E,HCoV-OC43,HCoV-NL63,HCoV-HKU1,SARS-CoV,MERS-CoV,and *** them,SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012,***-CoV-2(COVID-19)is the most recently *** has created a severe worldwide outbreak beginning in late 2019,leading to date to over 4 million cases *** are genetically simple,yet highly ***,the recent outbreaks of SARS-CoV and MERS-CoV,and the ongoing outbreak of SARS-CoV-2,indicate that there remains a long way to go to identify and develop specific therapeutic *** after gaining a better understanding of their pathogenic mechanisms can we minimize viral *** paper mainly focuses on SARS-CoV,MERS-CoV,and ***,recent studies are summarized and reviewed,with a focus on virus–host interactions,vaccine-based and drug-targeted therapies,and the development of new approaches for clinical diagnosis and treatment.

关键词： diagnosis respiratory vaccine

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城市生态居住区规划及建设探究

山西建筑 2015年第11期41卷 6-7页

作者：王双文长治市规划设计院山西长治046000

简述了生态居住区的概念以及生态居住区的类型和基本特征,针对我国城市居住区建设存在的问题,提出了城市生态居住区建设应该遵循的原则,以期对城市生态居住区的建设有所裨益。

关键词：生态居住区和谐相处建设规划原则

Tectonically-controlled infilling of the eastern Nihewan Basin,North China,since the middle Pleistocene

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Science China Earth Sciences 2016年第7期59卷 1378-1389页

作者： HAN ZhiYong LI XuSheng wang Yong wang XianYan YI shuangwen LU HuaYu School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

There has been a significant debate about the nature and causes of the Pleistocene evolution of the Nihewan Basin, North China. We studied the eastern Nihewan Basin sedimentary facies at two main sites, Hutouliang and Donggou. A combination of field observations and measurements of sediment grain-size distribution was used to reconstruct the sequence of sedimentary environments since the middle Pleistocene, and optically-stimulated luminescence measurements were used to date the sediments. Our results indicate that a shallow lake occupied the basin center along the Sanggan River, probably lasting until -440 kyr ago before disappearing completely -340 kyr ago. It was succeeded by a phase of fluvial-dominated sediment accumulation which ended -30 kyr ago. We suggest that the formation of the gorge resulted from the relative uplift of the Niuxin Mountain along the Liulengshan fault -140 kyr ago. However, since -30 kyr ago the fault may have become inactive and the river downcutting near Shixia was no longer offset by the relative uplift, which caused a shift from deposition to denudation in the Nihewan Basin from then on. The disappearance of the paleolake -340 kyr ago may have been the culmination of the ongoing process of basin infilling.

关键词： Nihewan Basin Sedimentary facies Paleolake Fault OSL

Dramatic weakening of the ear-shaped thermal front in the Yellow Sea during 1950s–1990s

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Acta Oceanologica Sinica 2017年第5期36卷 51-56页

作者： Tana FANG Yue LIU Baochao SUN shuangwen wang Huiwu College of Oceanic and Atmospheric Sciences Ocean University of China Center for Ocean and Climate Research The First Institute of OceanographyState Oceanic Administration Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and Technology

The ear-shaped thermal front （ESTF）, formed by the convergence of the Yellow Sea Warm Current （YSWC） and the Shandong Coastal Current （SCC）, is a very important oceanic phenomenon in the Yellow Sea （YS） in winter. In situ measurements and reanalysis datasets all demonstrate that the ESTF has been weakening during 1950s-1990s, and a similar weakening trend is also found in winter monsoon over the YS. Numerical experiments show that the weakening of winter monsoon can induce an anomalous circulation in the YS on multi-decadal timescale with northward anomalous currents along China＇s coast and southward anomalous currents in the central YS--generally opposite to seasonal mean circulation. The anomalous circulation causes slowdown of the YSWC and the SCC, and thus weakens the ESTF. Since the ESTF plays important roles in regional ocean dynamics and air-sea interactions, its weakening has important implications for regional climate in the YS in winter.

关键词： thermal front Yellow Sea circulation monsoon multi-decadal variability

Characteristics and triggering mechanisms of early negative Indian Ocean Dipole

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Acta Oceanologica Sinica 2024年第3期43卷 59-65页

作者： Yue Fang shuangwen Sun Yongcan Zu Jianhu wang Lin Feng First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Qingdao Marine Science and Technology CenterQingdao 266237China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China

Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in *** nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related ***,the characteristics and triggering mechanisms of early nIOD are *** results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six *** two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal *** early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related *** spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian *** to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon *** results of this study are helpful for improving the prediction skill of IOD and its climate impacts.

关键词： Indian Ocean Dipole(IOD) triggering mechanism Indian summer monsoon seasonal cycle negative IOD

Anchorage performance of large-diameter FRP bolts and their application in large deformation roadway

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International Journal of Mining Science and Technology 2023年第8期33卷 1037-1043页

作者： Jun Han Zuoqing Bi Bing Liang Chen Cao shuangwen Ma College of Mining Liaoning Technical UniversityFuxin 123000China ME EISUniversity of WollongongWollongongNSW 2526Australia

In underground coal mines, fibre reinforced polymer(FRP) bolt is ideal for mined rib reinforcements as it can prevent gas explosions caused by shearer frictional spark. With increasing mining depth, small diameter FRP bolts used in shallow underground mining cannot fulfil the rib support requirements. Under the engineering background of deep underground shortwall mining in Wudong coal mine, this paper systematically studies Φ27 mm FRP bolt support for large deformation coal rib. Specimens with a fan-shaped cross-section were used to enable the tensile testing of the bolt rod, the measured average tensile strength of the studied FRP bolt was(486.1 ± 9.6) MPa with a maximum elongation of 5.7%±0.6%.The shear strength of the bolt was measured as approximately 258 MPa using a self-made double shear testing apparatus. Based on the equivalent radial stiffness principle, a laboratory short encapsulation pullout test(SEPT) method for rib bolting has been developed undertaken consideration of the mechanical properties of the coal seam. Results showed that the average peak anchorage forces of the Φ27 mm FRP bolt and Φ20 mm steel rebar bolt were 108.4 and 66.4 k N, respectively, which were agreed with the theoretical calculations and field measurements. Based on theoretical analysis of the loading states of the bolt under site conditions, bolting method of full-length resin grouting was adopted to offset the weaknesses of the FRP bolt. Numerical method was employed to compare the bolting effect using Φ27 mm FRP bolts and steel rebar bolts. Large diameter FRP bolting was determined as the optimum rib support scheme to increase the productivity of the coal mine and to enhance the ground control capability for+425 level mining roadways. This study provides the laboratory testing design and theoretical prediction of large diameter FRP bolts used for rib support in large deformation roadways.

关键词： FRP bolt Laboratory SEPT Tensile strength Double shear testing Mined rib support Large deformation roadway

The IOD signal in the upper-ocean Indonesian Throughflow since the mid-1970s

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Acta Oceanologica Sinica 2007年第4期26卷 1-6页

作者： LAN Jian SUN shuangwen HONG Jieli Physical Oceanography Laboratory Ocean University of China Qingdao 266100 China

On the basis of simple ocean data assimilation （SODA） reanalysis product, the interannual variability of upper-ocean Indonesian Throughflow （ITF） volume transport since the mid 1970s is examed. The wavelet analysis shows a second prominent interannual oscillation with a period of about 2 ～ 4 a. To reveal any relationship between this band-scale oscillation of upper-ocean ITF and the Indian Ocean dipole （IOD）, the correlation and wavelet analyses are used. The correlation coefficient between the upper-ocean ITF and the IOD reaches - 0.40 with upper-ocean ITF lagging an IOD index by eight months. The wavelet power spectrum of upper-ocean ITF shows similar structure to that of the IOD index. And the evolution of IOD is reproduced by lagged correlation between the upper-ocean ITF and the sea surface temperature anomaly （SSTA） over the Indian Ocean. It suggests that the 2 ～ 4 a band-scale oscillation of upper-ocean ITF is related uniquely to the IOD over the tropical Indian Ocean.

关键词： Indonesian Throughflow Indian Ocean dipole interannual variability

Enhancing charge storage of O-doped perovskite fluorides via in-situ electrochemical oxidation for high-performance potassium-ion capacitors

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Journal of Materials Science & Technology 2023年第27期158卷 111-120页

作者： Jing Zhao Zicheng Cai Yue Fan Yunan wang Yu Song Jie Liu shuangwen Li Di Guo Xiaoxia Liu Department of Chemistry Northeastern UniversityShenyang 110819China School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China National-local Joint Engineering Research Center of High-efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang 110819China School of Materials Engineering North China Institute of Aerospace EngineeringLangfang 065000China

Potassium ion capacitors(PICs)are regarded as promising large-scale aqueous energy storage ***,due to the poor K^(+)transport kinetics and the structural instability of the cathode materials,the key issues of limited energy density and poor cyclic stability are obstacles to the in-depth growth of ***,a novel O-doped perovskite fluoride is demonstrated via an in-situ electrochemical oxidation strategy as the cathode for PICs,introducing additional defects that improve the capacitance and facilitate the reaction kinetics of the *** the electrochemical oxidation process,it is discovered that the perovskite fluoride crystal tends to transform into disordered O-doped KMnF 3(K_(x)MnF_(y)O_(z)),realizing a structural reconstruction at the electrode material/electrolyte *** First-principles calculations based on density functional theory(DFT)are performed to confirm that the improved electrical conduc-tivity and low ionic adsorption energy may be ascribed to the substitution of oxygen for *** obtained K_(1.14)MnF_(1.17)O_(1.26) cathode achieves a high specific capacitance of 694 F g^(-1) at 1 A g^(-1),as well as high capacitance retention of 91.3%after 10,000 charge/discharge cycles in mild K_(2)SO_(4) *** study provides an effective strategy to improve the capacitive performance of perovskite fluoride cathode materials in electrochemical energy storage.

关键词： Perovskite fluorides O-doped Potassium-ion capacitors Charge storage mechanism

The Distribution and Variability of Simulated Chlorophyll Concentration over the Tropical Indian Ocean from Five CMIP5 Models

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Journal of Ocean University of China 2013年第2期12卷 253-259页

作者： LIU Lin FENG Lin YU Weidong wang Huiwu LIU Yanliang SUN shuangwen Center for Ocean and Climate Research First Institute of OceanographyState Oceanic Administration

Performances of 5 models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) in simulating the chloro-phyll concentration over the tropical Indian Ocean are evaluated. Results show that these models are able to capture the dominant spatial distribution of observed chlorophyll concentration and reproduce the maximum chlorophyll concentration over the western part of the Arabian Sea, around the tip of the Indian subcontinent, and in the southeast tropical Indian Ocean. The seasonal evolution of chlorophyll concentration over these regions is also reproduced with significant amplitude diversity among models. All of 5 mod-els is able to simulate the interannual variability of chlorophyll concentration. The maximum interannual variation occurs at the same regions where the maximum climatological chlorophyll concentration is located. Further analysis also reveals that the Indian Ocean Dipole events have great impact on chlorophyll concentration in the tropical Indian Ocean. In the general successful simulation of chlorophyll concentration, most of the CMIP5 models present higher than normal chlorophyll concentration in the eastern equatorial Indian Ocean.

关键词： Indian Ocean chlorophyll concentration climatology seasonal variability interannual variability