Overview of lethal human coronaviruses
作者机构：Division of Respiratory and Critical Care MedicineState Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Emergency MedicineWest China HospitalSichuan UniversityChengdu 610041China Kappa Crystals Ltd.DublinIreland
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：1672-1687页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：support from the National Natural Science Foundation of China(Grant No.31870836) the 1.3.5 Project for Disciplines Excellence,West China Hospital,Sichuan University(ZYYC20005 to W.C.)
主 题：diagnosis respiratory vaccine
摘 要：Coronavirus infections of multiple origins have spread to date worldwide,causing severe respiratory *** coronaviruses that infect humans have been identified:HCoV-229E,HCoV-OC43,HCoV-NL63,HCoV-HKU1,SARS-CoV,MERS-CoV,and *** them,SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012,***-CoV-2(COVID-19)is the most recently *** has created a severe worldwide outbreak beginning in late 2019,leading to date to over 4 million cases *** are genetically simple,yet highly ***,the recent outbreaks of SARS-CoV and MERS-CoV,and the ongoing outbreak of SARS-CoV-2,indicate that there remains a long way to go to identify and develop specific therapeutic *** after gaining a better understanding of their pathogenic mechanisms can we minimize viral *** paper mainly focuses on SARS-CoV,MERS-CoV,and ***,recent studies are summarized and reviewed,with a focus on virus–host interactions,vaccine-based and drug-targeted therapies,and the development of new approaches for clinical diagnosis and treatment.
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