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A novel recurrence-associated metabolic prognostic model for risk stratification and therapeutic response prediction in patients with stage Ⅰ lung adenocarcinoma

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Cancer Biology & Medicine 2021年第3期18卷 734-749页

作者： Chengming Liu Sihui Wang Sufei zheng Xinfeng Wang Jianbin Huang Yuanyuan Lei shuangshuang Mao Xiaoli Feng Nan Sun Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The proportion of patients with stageⅠlung adenocarcinoma(LUAD)has dramatically increased with the prevalence of low-dose computed tomography use for *** to 30%of patients with stageⅠLUAD experience recurrence within 5 years after curative surgery.A robust risk stratification tool is urgently needed to identify patients who might benefit from adjuvant ***:In this first investigation of the relationship between metabolic reprogramming and recurrence in stageⅠLUAD,we developed a recurrence-associated metabolic signature(RAMS).This RAMS was based on metabolism-associated genes to predict cancer relapse and overall prognoses of patients with stageⅠ*** clinical significance and immune landscapes of the signature were comprehensively ***:Based on a gene expression profile from the GSE31210 database,functional enrichment analysis revealed a significant difference in metabolic reprogramming that distinguished patients with stageⅠLUAD with relapse from those without *** then identified a metabolic signature(i.e.,RAMS)represented by 2 genes(ACADM and RPS8)significantly related to recurrence-free survival and overall survival times of patients with stageⅠLUAD using transcriptome data analysis of a training *** training set was well validated in a test *** discriminatory power of the 2 gene metabolic signature was further validated using protein values in an additional independent *** results indicated a clear association between a high risk score and a very poor patient *** analysis and multivariate Cox regression analysis showed that the RAMS was an independent prognostic *** also found that the risk score was positively correlated with inflammatory response,the antigen-presenting process,and the expression levels of many immunosuppressive checkpoint molecules(e.g.,PD-L1,PD-L2,B7-H3,galectin-9,and FGL-1).These results suggested that high risk patients had immune response suppre

关键词： Lung adenocarcinoma stageⅠ recurrence metabolic signature immune landscape

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering

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Bioactive Materials 2022年第1期7卷 242-253页

作者： shuangshuang Ren Yi Zhou Kai zheng Xuanwen Xu Jie Yang Xiaoyu Wang Leiying Miao Hui Wei Yan Xu Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029China Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing 210029China Nanjing Stomatological Hospital Medical School of Nanjing UniversityNanjing210093China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjingJiangsu210023China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjingJiangsu 210023China Institute of Biomaterials University of Erlangen-NurembergErlangen91058Germany

Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration,in which new attempts come out along with the development of ***,the effect of cerium oxide nanoparticles(CeO_(2)NPs)on the cell behavior and function of human periodontal ligament stem cells(hPDLSCs)was *** of CCK-8 and cell cycle tests demonstrated that CeO_(2)NPs not only had good biocompatibility,but also promoted cell ***,the levels of alkaline phosphatase activity,mineralized nodule formation and expressions of osteogenic genes and proteins demonstrated CeO_(2)NPs could promote osteogenesis differentiation of *** we chose electrospinning to fabricate fibrous membranes containing CeO_(2)*** showed that the composite membranes improved mechanical properties as well as realized release of CeO_(2)*** then applied the composite membranes to in vivo study in rat cranial defect ***-CT and histopathological evaluations revealed that nanofibrous membranes with CeO_(2)NPs further accelerated new bone *** exciting results demonstrated that CeO_(2)NPs and porous membrane contributed to osteogenic ability,and CeO_(2)NPs contained electrospun membrane may be a promising candidate material for periodontal bone regeneration.

关键词： CeO_(2)nanoparticles Periodontal ligament stem cells Bone regeneration Electrospinning Fibrous membrane

不同文心兰品种耐热性指标筛选与评价体系构建

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热带作物学报 2024年第7期45卷 1348-1358页

作者：罗小燕罗远华易双双李崇晖廖易张志群郑碧兰陆顺教中国热带农业科学院热带作物品种资源研究所海南海口571101 农业农村部华南作物基因资源与种质创制重点开放实验室海南海口571101 福建省农业科学院作物研究所福建福州350000

为比较不同文心兰品种耐热性差异,同时构建文心兰品种耐热性筛选的指标评价体系,本研究对38个文心兰(Oncidiumhybridum)常见栽培品种的叶片厚度、叶片含水量和高温半致死温度(HLT_(50))等7个指标进行了测定,并在高温胁迫条件下对不同品... 详细信息

为比较不同文心兰品种耐热性差异,同时构建文心兰品种耐热性筛选的指标评价体系,本研究对38个文心兰(Oncidiumhybridum)常见栽培品种的叶片厚度、叶片含水量和高温半致死温度(HLT_(50))等7个指标进行了测定,并在高温胁迫条件下对不同品种的黄叶率和热害等级(HIG)进行观测,通过分析不同指标间的相关性,结合主成分分析筛选文心兰耐热性评价指标,构建文心兰品种耐热性评价体系。结果表明:38个文心兰品种的耐热性存在显著差异;叶片厚度、叶片含水量、HLT_(50)、黄叶率和HIG能较好地反映文心兰对高温胁迫的响应,可作为文心兰耐热性的评价指标。基于耐热指数进行聚类分析,可将38个文心兰品种分为耐热型品种(12个)、中等耐热型品种(3个)和不耐热型品种(23个)3个类别。本研究结果为热区文心兰选材提供参考依据,同时也为文心兰高耐热新品种的培育提供亲本资源。

关键词：文心兰栽培品种耐热性聚类分析耐热评价体系

打印路径对3D打印混凝土构件力学性能的影响

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混凝土与水泥制品 2024年第7期 14-19,28页

作者：张学辉郑书玉陈雄姿安军海赵双双河北科技大学建筑工程学院河北石家庄050000

在3D打印混凝土配合比研究基础上,对打印路径进行了优化设计。采用三种路径打印成型构件,评估了打印路径对3D打印混凝土构件力学性能的影响,并分析了打印构件的力学各向异性,提出了力学各向异性系数,确定了最佳受力方向。此外,通过SEM... 详细信息

在3D打印混凝土配合比研究基础上,对打印路径进行了优化设计。采用三种路径打印成型构件,评估了打印路径对3D打印混凝土构件力学性能的影响,并分析了打印构件的力学各向异性,提出了力学各向异性系数,确定了最佳受力方向。此外,通过SEM分析了打印构件的层间界面对力学性能的影响。结果表明:3D打印混凝土构件在Z方向受力最大,打印路径优化后,可有效改善层间薄弱面;打印构件在层间界面处的水化产物未能充分填充,存在空隙、气泡、裂缝等缺陷,使打印构件的力学性能降低。

关键词： 3D打印混凝土路径优化力学性能层间薄弱面

Primary dolostone formation related to mantle-originated exhalative hydrothermal activities,Permian Yuejingou section,Santanghu area, Xinjiang,NW China

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Science China Earth Sciences 2012年第2期55卷 183-192页

作者： LIU YiQun JIAO Xin LI Hong YUAN MingSheng YANG Wan ZHOU XiaoHu LIANG Hao ZHOU DingWu zheng ChaoYang SUN Qin WANG shuangshuang State Key Laboratory of Continental Dynamics Northwest UniversityDepartment of GeologyNorthwest UniversityXi'an 710069China Tu-Ha Oilfield CNPCHami 830002China Department of Geological Sciences and Engineering Missouri University of Science and TechnologyRollaMissouri 65409USA College of Geological Science&Engineering Shandong University of Science and TechnologyQingdao 266510China

The Permian Lucaogou Formation is an important hydrocarbon source rock in the Junggar, Turpan, and Santanghu basins in Xinjiang, NW China. For the first time, dolostones associated with mantle-originated exhalative hydrothermal fluid flows are discovered in Yuejingou section in the Santanghu Basin area. They include dolomicrite, doloarenite, and a small amount of dolorudite, and are finely (0.05-0.15 cm thick) interlaminated with lime micrite and dolomicritic analcime laminites. Alkali feldspar and analcime grains are common in doloarenite and are interpreted as having been derived from analcime phonolites and peralkaline magmatic rocks. These magmatic fragments were brought up from subsurface by hydrothermal fluid flow and had experienced exhalative brecciation, transport, and deposition on the lake floor. The matrix consists dominantly of dolomite and ankerite smaller than 0.01 mm. The dolostones can be subdivided into four types on the basis of mineral composition and content. The detrital analcime and alkaline feldspar grains and tuff lithics are interpreted as intraclasts, which were deposited in an under-filled starved lake basin. The δ18OPDB values of dolostones are -5‰ to -21.1‰, and -11.9‰ on average; the 87Sr/86Sr ratios of dolostones are 0.70457 to 0.706194, and 0.705005 on average. These values, in combination with evidence of multi-episodes of peralkaline extrusion, suggest a mantle origin of the hydrothermal fluids, which may have promoted primary dolomite formation. The fluid from the upper mantle caused serpentinization of ultramafic rocks that intruded into the lower crust to obtain Mg2+ and Fe2+, and injected the ions into the lake water as the Mg and Fe sources for dolomite and ankerite. Hydro- thermal fluids associated with peralkaline magmatic rocks also provided Ca2+, Mg2+, Fe2+, and CO32-. Explosive breccias formed and dolostones were convoluted near the vent of hydrothermal fluid exhalation, whereas laminated dolostones formed farther away fr

关键词： primary dolostone mantle-originated hydrothermal exhalative deposits intracontinental rift Permian Santanghu Area

中西医临床专业学生见习或实习阶段临床能力现状及影响因素研究

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贵州中医药大学学报 2024年第1期46卷 97-102页

作者：王相玲韩双双郑纺边育红张云莎赵伟赵舒武天津中医药大学中西医结合学院天津静海区301617

目的:调查中西医临床专业学生见习或实习阶段临床能力现状及其影响因素,提出可行性建议,以期为中西医临床专业教学改革提供参考。方法:借助“问卷星”对天津中医药大学中西医临床专业高年级本科生临床能力现状及影响因素等方面进行调研... 详细信息

目的:调查中西医临床专业学生见习或实习阶段临床能力现状及其影响因素,提出可行性建议,以期为中西医临床专业教学改革提供参考。方法:借助“问卷星”对天津中医药大学中西医临床专业高年级本科生临床能力现状及影响因素等方面进行调研。结果:学生各维度临床能力自评得分最高为临床职业精神,临床基本技能和临床思维能力自评得分相对较低。学生认为主观能动性是影响其临床能力最重要的因素,此外,教师的主导作用、科学的课程设置、思政教育等也是各维度临床能力的主要影响因素。结论:中西医临床专业学生见习或实习阶段临床能力有待进一步提高,建议从教育教学理念、培养模式及加强思政教育等方面多措并举培养全面发展的中西医结合临床人才。

关键词：中西医结合临床能力见习或实习阶段现状及影响因素

A new multi-scale analytic algorithm for edge extraction of strawberry leaf images in natural light

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International Journal of Agricultural and Biological Engineering 2016年第1期9卷 99-108页

作者： Wang Jianlun Han Yu Zhao shuangshuang zheng Hongxu He Can Cui Xiaoying Xu Yun Chen Jianshu Wang Shuting College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China

In this study,a new algorithm was proposed for edge extraction of greenhouse strawberry leaf in natural light based on the 4-level daubechies 5(‘db5’)wavelet *** algorithm adopts different segmentation methods for the reconstructed images at different scales to erase the external background and the internal leaf vein *** were two advantages of this *** was that it can provide the abstraction from different spaces to express a same *** other one was that some image features are hard to be acquired in some scale spaces,while the features are easy to be obtained in other scale *** this image process methods,the Otsu threshold segmentation was to obtain the binary image areas,and the Canny segmentation is to obtain the accurate gradient edges,then the morphological methods and the logical calculus methods were to avoid the fragments inside the leaf area and the adhesions outside the leaf *** the strawberry leaf images were different respectively,and the greenhouse optical radiation and reflection may cause local non-uniform illumination of leaf image,the pseudo canny edges of leaf image ere divided into three categories in this *** first category was the external pseudo canny edges area of the first layer reconstructed leaf image,the second category was the internal pseudo canny edges area in highlight of the third layer reconstructed leaf image,the third category was the internal pseudo canny edges area of significantly different grayscale of the third layer reconstructed leaf *** different processing methods were constructed for the three kinds of different texture features based on the multi scale reconstructed images,then the complete and the accurate leaf edges without interference were ***,the multi scale method was simplified and a remarkably effective segmentation algorithm was deduced for the greenhouse strawberry leaf in natural light.

关键词： multi scale analysis edge extraction strawberry leaf images canny edges Otsu segmentation

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肝移植患者术后血糖调控方案的构建及应用

医学研究与战创伤救治 2024年第4期37卷 375-380页

作者：江方正王芳张双双施旼艳郑娴庆王桂云范杰梅李百强童智慧李维勤南京大学医学院附属金陵医院(东部战区总医院)重症医学科南京210002 南京大学医学院附属金陵医院(东部战区总医院)护理部南京210002

目的构建肝移植患者术后血糖调控方案并评价其应用效果。方法采用非同期前后对照研究。便利选择东部战区总医院2022年7-12月肝移植术后患者50例作为试验组,2022年1-6月行肝移植术后患者50例作为对照组,2组患者基线资料一致。试验组采取... 详细信息

目的构建肝移植患者术后血糖调控方案并评价其应用效果。方法采用非同期前后对照研究。便利选择东部战区总医院2022年7-12月肝移植术后患者50例作为试验组,2022年1-6月行肝移植术后患者50例作为对照组,2组患者基线资料一致。试验组采取肝移植患者术后血糖调控方案,该方案基于循证、德尔菲专家咨询法构建,对血糖值区间、复测血糖值、较前次监测值变化、胰岛素调整方案、监测频次等给予详细说明。对照组采取常规血糖调控方案。比较2组肝移植患者术后血糖调控方案48 h内血糖波动幅度、血糖监测频率、胰岛素用量、血糖调控至目标范围内所需时间、稳定在目标范围内总时间、低血糖不良事件发生率。结果试验组干预48 h内在血糖波动幅度(8.77±3.64)mmol/L、胰岛素用量(72.82±55.19)U、血糖偏高调控至目标范围内所需时间(660.80±335.45)min、稳定在目标范围内总时间(1939.20±426.36)min,与对照组[(11.38±5.03)mmol/L、(98.84±66.82)U、(871.40±459.29)min、(1611.20±530.44)min]相比较,差异均有统计意义(P0.05)。结论肝移植患者术后血糖调控方案具备精准性、可行性和安全性,能改善肝移植患者术后血糖调控效果,促进患者术后快速康复。

关键词：重症患者肝移植血糖管理血糖控制

海参贮藏过程中品质变化、影响因素和调控技术研究进展

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中国食品添加剂 2024年第3期35卷 296-305页

作者：方梓蓥郑杰曾晨范馨茹于笛傅志宇李双双宋志远大连海洋大学食品科学与工程学院大连116023 辽宁省海洋水产科学研究院水产品加工研究室大连116023 大连市水产研究所大连116023 辽宁省海洋健康食品工程研究中心大连116023 大连鑫玉龙海洋生物种业科技股份有限公司大连116222

海参高蛋白、低脂肪,具有极高的营养价值,其独特的自溶特性导致捕捞后必须马上进行加工处理。海参贮藏过程中通常会发生一系列复杂的生化变化,从而导致其营养损失、品质下降,严重影响其商业价值。本文在概述海参贮藏过程中品质变化的基... 详细信息

海参高蛋白、低脂肪,具有极高的营养价值,其独特的自溶特性导致捕捞后必须马上进行加工处理。海参贮藏过程中通常会发生一系列复杂的生化变化,从而导致其营养损失、品质下降,严重影响其商业价值。本文在概述海参贮藏过程中品质变化的基础上,对其内源性蛋白酶、微生物、非酶凝胶劣化、贮藏条件和预处理方式等主要影响因素以及低温、超高压、天然生物保鲜剂、蛋白酶抑制剂和生物交联等主要调控技术进行了系统地归纳和总结,并对未来品质劣化机制揭示、贮藏技术体系构建等研究重点方向和发展趋势进行了展望,以期能为海参精深加工产业的高质量发展提供一定的理论参考与借鉴。

关键词：海参贮藏品质内源性蛋白酶调控技术