检索结果-南通市图书馆

Science China(Life Sciences) 2016年第1期59卷 89-92页

作者： shuangli mi Arne Klungland Yun-Gui Yang Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and Development CAS Center for Excellence in Molecular Cell Science Beijing Institute of Genomics Chinese Academy of Sciences Department of microbiology Division of Diagnostics and Intervention Institute of Clinical Medicine Oslo University HospitalRikshospitalet Department of Molecular Medicine Institute of Basic Medical Sciences University of Oslo

Tomas Lindahl contributed his scientific career to unveiling fundamental mechanisms of DNA decay and repair.He made several ground-breaking discoveries on genome instability,novel DNA repair activities and pathways,and disease association.The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl,Paul Modrich and Aziz Sancar for their mechanistic studies of DNA repair.Their findings

关键词：碱基切除修复诺贝尔奖得主托马斯科学成果归结化学科学生涯修复机制

Exosome and Exosomal microRNA: Trafficking, Sorting, and Function

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 17-24页

作者： Jian Zhang Sha Li Lu Li Meng Li Chongye Guo Jun Yao shuangli mi Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Obstetrics and Gynecology Jinan Central Hospital Shandong University State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua-Peking Center for Life SciencesSchool of Life Sciences Tsinghua University

Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs（mi RNAs） have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings.

关键词： Exosome Extracellular micro RNA Circulating micro RNA Sorting Cell-to-cell communication

Site-directed Mutation of Trichosanthin And Its Anti-tumor Activity

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Site-directed Mutation of Trichosanthin And Its Anti-tumor A...

植物益生元对肠道菌群的调节及对机体糖代谢吸收的影响

The Seventh China-Japan Joint Symposium on Enzyme Engineering

作者： shuangli mi Ye Wang Jiyuan Chen Chengcai An The National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life sciencesPeking University

＜正＞Introduction Trichosanthin（TCS）is a ribosome-inactivating protein（RIPs）extracted from Trichosanthes kirilowii,a Chinese herb medicine,with multiple biological and pharmacological properties,including abortifacient,anti-tumor and anti-virus activities[1].It was known that TCS belonged to type-I RIPs with a single chain[3].As a kind of rRNA N-glycosidases,TCS can cleave the glycosidic bond of adenine in a specific position

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农产品加工 2020年第6期 52-57页

作者：郭翀晔邢志凯李蒙胡晓璐吴霞陈历水米双利中国科学院北京基因组研究所精准基因组医学重点实验室北京100101 中国科学院大学北京100049 首都医科大学中医药学院中医络病研究北京市重点实验室北京100069 中粮营养健康研究院品牌食品研发中心北京102209

植物益生元作为膳食补充剂,可以选择性地刺激肠道有益菌群生长、调节胃肠菌群平衡、改善肠道微环境、抑制有害菌群的增殖,从而对宿主产生有益的影响,改善宿主健康状态。肠道菌群作为人体“第二大代谢系统”与许多疾病的发生密切相关。... 详细信息

植物益生元作为膳食补充剂,可以选择性地刺激肠道有益菌群生长、调节胃肠菌群平衡、改善肠道微环境、抑制有害菌群的增殖,从而对宿主产生有益的影响,改善宿主健康状态。肠道菌群作为人体“第二大代谢系统”与许多疾病的发生密切相关。对植物益生元调节机体肠道菌群、调节糖代谢的作用机制进行了研究,为食品工业使用植物益生元作为膳食补充剂进行精准膳食选择提供理论基础,并为健康食品的加工和生产提供科学依据。

关键词：糖类营养调节植物益生元肠道菌群微生态

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双里水库大坝除险加固方案研究

四川理工学院学报（自然科学版） 2013年第6期26卷 64-67页

作者：米伟亚福建船政交通职业学院福州350000

双里水库建于70年代,由于当时的技术条件和历史原因,水库属"三边"工程,工程建设先天不足,运行近30年,年久失修,大坝出现多条裂缝,危及大坝安全,对其进行除险加固是必要的。经过比选,采用大坝基础帷幕灌浆、大坝上下游压载及上游干砌石... 详细信息

双里水库建于70年代,由于当时的技术条件和历史原因,水库属"三边"工程,工程建设先天不足,运行近30年,年久失修,大坝出现多条裂缝,危及大坝安全,对其进行除险加固是必要的。经过比选,采用大坝基础帷幕灌浆、大坝上下游压载及上游干砌石、大坝高压旋喷及钻孔灌注桩防渗和充填灌浆的除险加固方案,消除了水库大坝带病运行的安全隐患。

关键词：双里水库除险加固钻孔灌注桩高压旋喷桩