检索结果-南通市图书馆

Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy,vascularization and anti-inflammation for diabetic infected wound healing

引用

Bioactive Materials 2023年第8期26卷 306-320页

作者： shuangli zhu Bangjiao Zhao Maocai Li Hao Wang Jiayi zhu Qingtao Li Huichang Gao Qi Feng Xiaodong Cao School of Materials Science and Engineering South China University of TechnologyGuangzhou510641PR China National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006PR China School of Medicine South China University of TechnologyGuangzhou510006PR China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou510006PR China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006PR China Zhongshan Institute of Modern Industrial Technology of SCUT ZhongshanGuangdong528437PR China

Bacterial infection,excessive inflammation and damaging blood vessels network are the major factors to delay the healing of diabetic *** present,most of wound repair materials are passive and can’t response to the wound microenvironment,resulting in a low utilization of bioactive substances and hence a poor therapeutic ***,it’s essential to design an intelligent wound dressing responsive to the wound microenvironment to achieve the release of drugs on-demand on the basis of *** this work,metformin-laden CuPDA NPs composite hydrogel(Met@CuPDA NPs/HG)was fabricated by dynamic phenylborate bonding of gelatin modified by dopamine(Gel-DA),Cu-loaded polydopamine nanoparticles(CuPDA NPs)with hyaluronic acid modified by phenyl boronate acid(HA-PBA),which possessed good injectability,self-healing,adhesive and DPPH scavenging *** slow release of metformin was achieved by the interaction with CuPDA NPs,boric groups(B-N coordination)and the constraint of hydrogel *** had a pH and glucose responsive release behavior to treat different wound microenvironment ***,CuPDA NPs endowed the hydrogel excellent photothermal responsiveness to kill bacteria of>95%within 10 min and also the slow release of Cu^(2+)to protect wound from infection for a long ***@CuPDA NPs/HG also recruited cells to a certain direction and promoted vascularization by releasing Cu^(2+).More importantly,Met@CuPDA NPs/HG effectively decreased the inflammation by eliminating ROS and inhibiting the activation of NF-κB *** experiments demonstrated that Met@CuPDA NPs/HG significantly promoted wound healing of diabetic SD rats by killing bacteria,inhibiting inflammation,improving angiogenesis and accelerating the deposition of ECM and ***,Met@CuPDA NPs/HG had a great application potential for diabetic wound healing.

关键词： Diabetic ulcer Hydrogel dressing Cu-loaded polydopamine nanoparticles Metformin Photothermal responsiveness Angiogenesis and anti-inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimation of the TBM advance rate under hard rock conditions using XGBoost and Bayesian optimization

引用

Underground Space 2021年第5期6卷 506-515页

作者： Jian Zhou Yingui Qiu shuangli zhu Danial Jahed Armaghani Manoj Khandelwal Edy Tonnizam Mohamad School of Resources and Safety Engineering Central South UniversityChangsha 410083China Department of Civil Engineering Faculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia School of Engineering Information Technology and Physical SciencesFederation University AustraliaBallaratAustralia Centre of Tropical Geoengineering(GEOTROPIK) School of Civil EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310 Johor BahruMalaysia

The advance rate(AR)of a tunnel boring machine(TBM)under hard rock conditions is a key parameter in the successful implementation of tunneling *** this study,we improved the accuracy of prediction models by employing a hybrid model of extreme gradient boosting(XGBoost)with Bayesian optimization(BO)to model the TBM *** develop the proposed models,1286 sets of data were collected from the Peng Selangor Raw Water Transfer tunnel project in *** database consists of rock mass and intact rock features,including rock mass rating,rock quality designation,weathered zone,uniaxial compressive strength,and Brazilian tensile *** specifications,including revolution per minute and thrust force,were considered to predict the TBM *** accuracies of the predictive models were examined using the root mean squares error(RMSE)and the coefficient of determination(R^(2))between the observed and predicted yield by employing a five-fold cross-validation *** showed that the BO algorithm can capture better hyper-parameters for the XGBoost prediction model than can the default XGBoost *** robustness and generalization of the BO-XGBoost model yielded prominent results with RMSE and R^(2) values of 0.0967 and 0.9806(for the testing phase),*** results demonstrated the merits of the proposed BO-XGBoost *** addition,variable importance through mutual information tests was applied to interpret the XGBoost model and demonstrated that machine parameters have the greatest impact as compared to rock mass and material properties.

关键词： TBM performance Advance rate XGBoost Bayesian optimization Predictive modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting TBM penetration rate in hard rock condition:A comparative study among six XGB-based metaheuristic techniques

引用

Geoscience Frontiers 2021年第3期12卷 201-213页

作者： Jian Zhou Yingui Qiu Danial Jahed Armaghani Wengang Zhang Chuanqi Li shuangli zhu Reza Tarinejad School of Resources and Safety Engineering Central South UniversityChangsha 410083China Institute of Research and Development Duy Tan UniversityDa Nang 550000Vietnam School of Civil Engineering Chongqing UniversityChongqing 400045China Faculty of Civil Engineering University of Tabriz29 Bahman Blvd51666 TabrizIran

A reliable and accurate prediction of the tunnel boring machine(TBM)performance can assist in minimizing the relevant risks of high capital costs and in scheduling tunneling *** research aims to develop six hybrid models of extreme gradient boosting(XGB)which are optimized by gray wolf optimization(GWO),particle swarm optimization(PSO),social spider optimization(SSO),sine cosine algorithm(SCA),multi verse optimization(MVO)and moth flame optimization(MFO),for estimation of the TBM penetration rate(PR).To do this,a comprehensive database with 1286 data samples was established where seven parameters including the rock quality designation,the rock mass rating,Brazilian tensile strength(BTS),rock mass weathering,the uniaxial compressive strength(UCS),revolution per minute and trust force per cutter(TFC),were set as inputs and TBM PR was selected as model *** with the mentioned six hybrid models,four single models i.e.,artificial neural network,random forest regression,XGB and support vector regression were also built to estimate TBM PR for comparison *** models were designed conducting several parametric studies on their most important parameters and then,their performance capacities were assessed through the use of root mean square error,coefficient of determination,mean absolute percentage error,and *** of this study confirmed that the best predictive model of PR goes to the PSO-XGB technique with system error of(0.1453,and 0.1325),R^(2) of(0.951,and 0.951),mean absolute percentage error(4.0689,and 3.8115),and a10-index of(0.9348,and 0.9496)in training and testing phases,*** developed hybrid PSO-XGB can be introduced as an accurate,powerful and applicable technique in the field of TBM performance *** conducting sensitivity analysis,it was found that UCS,BTS and TFC have the deepest impacts on the TBM PR.

关键词： TBM penetration rate Hard rock XGB-based hybrid model Predictive model Metaheuristic optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular analysis of Coxsackievirus A24 variant isolates from three outbreaks of acute hemorrhagic conjunctivitis in 1988,1994 and 2007 in Beijing,China

引用

Virologica Sinica 2022年第2期37卷 168-176页

作者： Junhan Li Fang Huang Yong Zhang Tianjiao Ji shuangli zhu Dongyan Wang Zhenzhi Han Jinbo Xiao Fenfen Si Wenbo Xu Dongmei Yan National Polio Laboratory WHO WPRO Regional Polio Reference LaboratoryNational Health Commission Key Laboratory for BiosecurityNational Health Commission Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Nanguan District Center for Disease Control and Prevention Changchun130042China Beijing Center for Disease Control and Prevention Beijing100000China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan430000China

Coxsackievirus A24 variant(CVA24v)is a major pathogen that causes continued outbreaks and pandemics of acute hemorrhagic conjunctivitis(AHC).In China,the first confirmed outbreak of CVA24v-related AHC occurred in Beijing in 1988,followed by another two significant outbreaks respectively in 1994 and 2007,which coincides with the three-stage dynamic distribution of AHC in the world after *** illustrate the genetic characteristics of CVA24v in different periods,a total of 23 strains were isolated from those three outbreaks and the whole genome of those isolations were sequenced and *** with the prototype strain,the 23 strains shared four nucleotide deletions in the 5'UTR except the 0744 strain isolated in *** at the 98th site,one nucleotide insertion was found in all the strains collected from *** 1994 to 2007,amino acid polarity in the VP1 region at the 25th and the 32nd site were *** the 3C and VP1 phylogenetic tree indicated that isolates from 1988 and 1994 belonged to Genotype III(GIII),and 2007 strains to Genotype IV(GIV).According to the Bayesian analysis based on complete genome sequence,the most recent common ancestors for the isolates in1988,1994 and 2007 were respectively estimated around October 1987,February 1993 and December *** evolutionary rate of the CVA24v was estimated to be 7.45×10^(-3) substitutions/site/*** study indicated that the early epidemic of CVA24v in Chinese mainland was the *** mutations and amino acid changes in different genotypes of CVA24v may generate intensity differences of the AHC ***24v has been evolving constantly with a relatively rapid rate.

关键词： Coxsackievirus A24 variant(CVA24v) Acute hemorrhagic conjunctivitis(AHC) Phylogenetic analysis Complete genome sequence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New Simian Enterovirus 19(EV-A122) Strains in China Reveal Large-Scale Inter-Serotype Recombination between Simian EV-As

引用

Virologica Sinica 2021年第6期36卷 1652-1655页

作者： Zhenzhi Han Jinbo Xiao Yang Song shuangli zhu Dongyan Wang Huanhuan Lu Tianjiao Ji Dongmei Yan Wenbo Xu Yong Zhang WHO WPRO Regional Polio Reference Laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan430071China

Dear Editor,The genus Enterovirus(EV),belonging to the family Picornaviridae,order Picornavirales,comprises 15 species:Enterovirus A–L and rhinovirus A–C(Zell et al.2017).Enterovirus A(EV-A)has 25 serotypes,including several pathogens,such as EV-A71,coxsackievirus A16(CV-A16),and CV-A6 that infect humans,as well as four serotypes(EV-A122,123,124,and 125)isolated from simians(Zell et al.2017).EV genomes share a similar structure with a length of 7.5 kb,and two open reading frames(ORFs)flanked by 5′-and 3′-untranslated regions(UTRs)in some EVs(Oberste et al.2013b;Zell et al.2017;Guo et al.2019;Lulla et al.2019).

关键词： Enterovirus frames

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71

引用

Science China(Life Sciences) 2022年第12期65卷 2517-2526页

作者： Zhe Chen Linlin Bao Bin zhu Hua Fu shuangli zhu Tianjiao Ji Ying Xue Chuan Liu Xurong Wang Fengdi Li Qi Lv Feifei Qi Pin Yu Wei Deng Wenbo Xu Chuan Qin Hongrong Liu Qi Jin MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China National Institute for Viral Disease Control and Prevention China CDCBeijing 102206China Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua UniversityBeijing 100084China Key Laboratory for Matter Microstructure and Function of Hunan Province Key Laboratory of Low-dimensional Quantum Structures and Quantum ControlSchool of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310058China

Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to ***,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are ***,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in *** cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of *** a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic *** particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment.

关键词： enterovirus A71 antibody mouse models cryo-electron microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai,China,2022

引用

Virologica Sinica 2024年第4期39卷 694-698页

作者： Jiayu Wang Wencheng Wu Wei Wang Jingyi Zhang Jianwei Xiao Mingyi Cai Jiaying Guo Run Li shuangli zhu Wanju Zhang Min Chen Zheng Teng Microbiology Department Shanghai Municipal Center for Disease Control and PreventionShanghai200336China Microbiology Department Yangpu Municipal Center for Disease Control and PreventionShanghai200090China Microbiology Department Jing’an Municipal Center for Disease Control and PreventionShanghai200070China Microbiology Department Changning Municipal Center for Disease Control and PreventionShanghai200050China WHO WPRO Regional Polio Reference Laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China

Dear Editor,Hand,foot and mouth disease(HFMD)is one of the most common infectious diseases,particularly in the Asia-Pacific *** the past two decades,HFMD rises to prominence for its heavy burden,with over one million cases reported *** 2013,enterovirus A71(EV-A71)and Coxsackievirus A16(CVA16)were the main pathogens leading to HFMD in the mainland of China(Yang et al.,2017).In recent years,non-EV-A71-non-CVA16 other enteroviruses,such as Coxsackievirus A6(CVA6),Coxsackievirus A10(CVA10)and Coxsackievirus A4(CVA4),were frequently reported and replaced EV-A71 and CVA16 becoming the major causative agents of HFMD(Zhou et al.,2021;Wang et al.,2022).

关键词： enterovirus HFMD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolation of 2019-nCoV from a Stool Specimen of a Laboratory- Confirmed Case of the Coronavirus Disease 2019 (COVID-19)

引用

China CDC weekly 2020年第8期2卷 123-124页

作者： Yong Zhang Cao Chen shuangli zhu Chang Shu Dongyan Wang Jingdong Song Yang Song Wei Zhen Zijian Feng Guizhen Wu Jun Xu Wenbo Xu National Health Commission Key Laboratory for Medical Virology National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Heilongjiang Center for Disease Control and Prevention HaerbinChina Chinese Center for Disease Control and Prevention BeijingChina

The novel coronavirus(2019-nCoV)is spreading very fast in Hubei Province of *** of February 14,2020,51,986 confirmed cases(including laboratory-confirmed cases and clinically-confirmed cases)were reported in Hubei Province,and 1,318 of them *** droplets and contact transmission are considered to be the most important routes of transmission of 2019-nCoV,but do not fully account for the occurrence of all coronavirus disease 2019(COVID-19)cases,previously known as novel coronavirus pneumonia(NCP),and the reasons for the rapid spread of this virus(1).

关键词： China. fir Hubei

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

引用

China CDC weekly 2024年第16期6卷 344-349页

作者： Hong Yang Ning Wen Chunxiang Fan Fuzhen Wang Yong Zhang Lei Cao shuangli zhu Lixin Hao Dongmei Yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China

引用

Infectious Diseases of Poverty 2022年第6期11卷 99-100页

作者： Mingyu Zhang Jianhui Yang Yiran Bai Hui zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang shuangli zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang Henan Center for Disease Control and Prevention ZhengzhouHenanPeople’s Republic of China WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingPeople’s Republic of China

Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio *** study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in ***:The patient was diagnosed with type 3 ***,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization *** samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic ***:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV *** were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 *** substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,***,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 ***:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in *** the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of *** results hig

关键词： Epidemiological Survey Genetic characterization Type 3 vaccine-derived poliovirus Recombination Henan China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：