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Multiporphyrinic architectures:Advances in structural design for photodynamic therapy

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Aggregate 2024年第1期5卷 67-84页

作者： Yuwei Gao Yan li Zhengwei Xu shuangjiang Yu Junqiu liu Hongcheng Sun College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhouChina

Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxygen species.However,there is still a gap between the structure design and their PDT performance for biomedical applications.This tutorial review provides a historical overview on(i)the basic concept of PDT for deeply understanding the porphyrin-mediated PDT reactions,(ii)developing strategies for constructing porphyrinic architectures,like nanorings,boxes,metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),vesicles,etc.,where we classified into the following three categories:multiporphyrin arrays,porphyrinic frameworks,and others porphyrin assemblies,(iii)the various application scenarios for clinical cancer therapy and antibacterial infection.Also,the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section.Moreover,the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs,design of personalized“all-in-one”theranostic agents,and the popularization and application in wider biomedical fields.

关键词： covalent-organic frameworks(COFs) metal-organic frameworks(MOFs) multiporphyrin arrays photodynamic therapy(PDT) porphyrinic architectures

Correg-Yolov3:a Method for Dense Buildings Detection in High-resolution Remote Sensing Images

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Journal of Geodesy and Geoinformation Science 2023年第2期6卷 51-61页

作者： Zhanlong CHEN shuangjiang li Yongyang XU Daozhu XU Chao MA Junli ZHAO School of Geography and Information Engineering China University of GeoscienceWuhan 430078China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430074China Key Laboratory of Urban Land Resource Monitoring and Simulation Ministry of Natural ResourceShenzhen 518034China Xi’an Research Institute of Surveying and Mapping Xi’an 710054China State Key Laboratory of Geo-Information Engineering Xi’an 710054China School of Computer Science China University of GeoscienceWuhan 430078China Central Southern China Electric Power Design Institute Co. Ltd.Wuhan 430071China

The exploration of building detection plays an important role in urban planning,smart city and military.Aiming at the problem of high overlapping ratio of detection frames for dense building detection in high resolution remote sensing images,we present an effective YOLOv3 framework,corner regression-based YOLOv3(Correg-YOLOv3),to localize dense building accurately.This improved YOLOv3 algorithm establishes a vertex regression mechanism and an additional loss item about building vertex offsets relative to the center point of bounding box.By extending output dimensions,the trained model is able to output the rectangular bounding boxes and the building vertices meanwhile.Finally,we evaluate the performance of the Correg-YOLOv3 on our self-produced data set and provide a comparative analysis qualitatively and quantitatively.The experimental results achieve high performance in precision(96.45%),recall rate(95.75%),F1 score(96.10%)and average precision(98.05%),which were 2.73%,5.4%,4.1%and 4.73%higher than that of YOLOv3.Therefore,our proposed algorithm effectively tackles the problem of dense building detection in high resolution images.

关键词： high resolution remote sensing image Correg-YOLOv3 corner regression dense buildings object detection

Biogenic volatile organic compound emissions from leaves and fruits of apple and peach trees during fruit development

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Journal of Environmental Sciences 2021年第10期33卷 152-163页

作者： shuangjiang li Xiangyang Yuan Yan Xu Zhengzhen li Zhaozhong Feng Xu Yue Elena Paoletti Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC)School of Environmental Science and EngineeringNanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Agrometeorology of Jiangsu Province School of Applied MeteorologyNanjing University of Information Science&TechnologyNanjing 210044China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Institute of Research on Terrestrial Ecosystems National Council of ResearchVia Madonna del Piano 1050019 Sesto FiorentinoFlorenceItaly

Biogenic volatile organic compounds(BVOCs)are widely involved in a variety of atmospheric chemical processes due to their high reactivity and species diversity.To date,however,research on BVOCs in agroecosystems,particularly fruit trees,remains scarce despite their large cultivation area and economic interest.BVOC emissions from different organs(leaf or fruit)of apple and peach trees were investigated throughout the stages of fruit development(FS,fruit swelling;FC,fruit coloration;FM,fruit maturity;and FP,fruit postharvest)using a proton-transfer-reaction mass spectrometer.Results indicated that methanol was the most abundant compound emitted by the leaf(apple tree leaf 492.5±47.9 ng/(g·hr),peach tree leaf 938.8±154.5 ng/(g·hr)),followed by acetic acid and green leaf volatiles.Beside the above three compounds,acetaldehyde had an important contribution to the emissions from the fruit.Overall,the total BVOCs(sum of eight compounds studied in this paper)emitted by both leaf and fruit gradually decreased along the fruit development,although the effect was significant only for the leaf.The leaf(2020.8±258.8 ng/(g·hr))was a stronger BVOC emitter than the fruit(146.0±45.7 ng/(g·hr))(P=0.006),and there were no significant differences in total BVOC emission rates between apple and peach trees.These findings contribute to our understanding on BVOC emissions from different plant organs and provide important insights into the variation of BVOC emissions across different fruit developmental stages.

关键词： Biogenic volatile organic compounds(BVOCs) Oxygenated VOCs(OVOCs) Fruit trees

血小板/血红蛋白比值预测糖尿病足溃疡严重程度

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陆军军医大学学报 2024年第9期46卷 1057-1062,F0003页

作者：李双江卞士柱王红迁李恒欣彭桂亮郭黎陆军军医大学(第三军医大学)第一附属医院内分泌科重庆400038 陆军军医大学(第三军医大学)基础医学院重庆400038 陆军军医大学(第三军医大学)第二附属医院心血管内科全军心血管病研究所重庆400037 陆军军医大学(第三军医大学)第一附属医院医学大数据与人工智能中心重庆400038 陆军军医大学(第三军医大学)第一附属医院学员管理中心重庆400038

目的探讨血小板/血红蛋白比值(platelet/hemoglobin, PHR)与糖尿病足溃疡(diabetic foot ulcer, DFU)严重程度的关系及其对DFU进展的预测价值。方法纳入陆军军医大学第一附属医院内分泌科2018年3月至2023年3月住院的345名DFU患者,收... 详细信息

目的探讨血小板/血红蛋白比值(platelet/hemoglobin, PHR)与糖尿病足溃疡(diabetic foot ulcer, DFU)严重程度的关系及其对DFU进展的预测价值。方法纳入陆军军医大学第一附属医院内分泌科2018年3月至2023年3月住院的345名DFU患者,收集患者的一般人口学资料,采血样本送本院检验科检测糖化血红蛋白(HbA1c)、空腹血糖(FPG)、血生化、血常规相关指标,并依据公式计算PHR。根据Wanger分级分为轻度溃疡组(n=145)和重度溃疡组(n=200)。比较2组患者基线资料的差异;多因素Logistic回归分析确定DFU重度溃疡的独立预测因子;绘制受试者工作特性曲线,以评估PHR预测DFU进展的价值。结果重度溃疡组患者的HbA1c、FPG、血小板计数(PLT)和PHR等均显著高于轻度溃疡组(P<0.05)。多因素Logistic回归发现PHR、男性比例是DFU患者进展为重度溃疡的独立危险因素(P<0.05),而HDL-C是其保护因素(P<0.05)。PHR预测DFU患者发生重度溃疡的曲线下面积为0.701(95%CI:0.646~0.756)。结论 PHR与DFU的严重程度密切相关,且PHR对重度糖尿病足溃疡具有一定的预测价值。

关键词：血小板/血红蛋白比值糖尿病足溃疡炎症预测因子

渭河径流输沙变化及其对降水和人类活动的响应

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水土保持研究 2024年第4期31卷 28-33页

作者：胡作龙高鹏李双江穆兴民河南水环境勘测设计有限公司河南三门峡472000 西北农林科技大学水土保持研究所陕西杨凌712100

[目的]探究渭河径流量与输沙量的变化特征及其驱动因素,为渭河流域水资源管理和生态环境建设提供科学依据。[方法]利用渭河流域降水量数据以及华县和状头两个控制水文站1957—2019年实测径流量及输沙量资料,采用现代数理统计方法,分析... 详细信息

[目的]探究渭河径流量与输沙量的变化特征及其驱动因素,为渭河流域水资源管理和生态环境建设提供科学依据。[方法]利用渭河流域降水量数据以及华县和状头两个控制水文站1957—2019年实测径流量及输沙量资料,采用现代数理统计方法,分析渭河流域年降水量、径流量和输沙量的变化趋势,检测水文要素的突变年份,计算了渭河径流量和输沙量变化的驱动因素贡献率,最后探讨了人类活动对渭河径流、输沙变化的主要影响因素。[结果]渭河1957—2019年径流量和输沙量都呈现出极显著的减少趋势(p<0.01);年降水量随机波动,没有明显的变化趋势。年径流量在1990年发生突变(p<0.01),年输沙量在1996年发生突变(p<0.01)。降水因素对渭河流域径流量减少贡献率为19%,对输沙量减少贡献率为17%;人类活动对径流量减少的贡献率为81%,对输沙量减少的贡献率为83%。[结论]人类活动在渭河径流和输沙的变化过程中具有决定性的影响,是导致渭河径流、输沙减少的主要原因。

关键词：径流输沙量人类活动渭河

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油松主要分布区林分碳储量特征与固碳潜力

东北林业大学学报 2024年第6期52卷 85-91页

作者：李畅任云卯刘嘉幸熊双江贾忠奎国家林业和草原局“油松工程技术研究中心”(北京林业大学) 北京100083 北京市西山试验林场管理处林木资源高效生产全国重点实验室(北京林业大学)

根据北京市、河北省、辽宁省、陕西省、内蒙古自治区的油松(Pinus tabuliformis)资源二类调查数据,使用材积源生物量法结合油松含碳率计算中国油松主要分布区油松林碳储量与碳密度,分析不同地区、龄组、林种、起源的油松林碳储量分布特... 详细信息

根据北京市、河北省、辽宁省、陕西省、内蒙古自治区的油松(Pinus tabuliformis)资源二类调查数据,使用材积源生物量法结合油松含碳率计算中国油松主要分布区油松林碳储量与碳密度,分析不同地区、龄组、林种、起源的油松林碳储量分布特征与固碳潜力。结果表明:油松5个主要分布区的油松林总面积为243.09万hm^(2)、总蓄积为11175.75万m^(3)、总碳储量为5043.38万t,平均碳密度为20.75 t·hm^(-2)。油松天然林碳储量为1660.14万t,碳密度为25.77 t·hm^(-2)。油松人工林碳储量为3383.24万t,碳密度为18.94 t·hm^(-2)。油松人工林碳储量高于天然林,占全部碳储量的67.08%。不同龄组中,碳储量最大是油松中龄林,为2032.38万t,占全部碳储量的40.30%;碳储量最小的为过熟林,占全部碳储量的2.32%。油松各龄组平均碳密度随林龄的增加而增加。不同林种中,碳储量来源主要为防护林及用材林,共为4360.45万t,占全部碳储量的86.46%。5处主要分布区的油松林固碳潜力为5285.63万t,相当于现有油松碳储量的1.88倍,其中,中幼龄林固碳潜力为4904.46万t,是油松林固碳潜力所在。油松林具有明显的固碳增汇能力,其人工林为油松碳库的主体,中幼龄油松林具有巨大的固碳潜力,需加强油松人工中幼龄林的抚育及管理。

关键词：油松碳储量碳密度固碳潜力森林生物量

基于扩展有限元、内聚力单元和单元失效的受弯钢筋混凝土梁数值模拟分析

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常州工学院学报 2024年第3期37卷 31-38页

作者：陈少华齐益李双江苏州科技大学土木工程学院江苏苏州215011

利用Abaqus中扩展有限元法、内聚力单元和显示动力分析模块下单元失效分析钢筋混凝土梁的受弯响应,对比混凝土4点受弯梁试验和有限元分析的整体性能、损伤与失效,提出混凝土的精细化建模方法。根据模拟结果可知:扩展有限元法和内置内聚... 详细信息

利用Abaqus中扩展有限元法、内聚力单元和显示动力分析模块下单元失效分析钢筋混凝土梁的受弯响应,对比混凝土4点受弯梁试验和有限元分析的整体性能、损伤与失效,提出混凝土的精细化建模方法。根据模拟结果可知:扩展有限元法和内置内聚力单元模拟混凝土整体性能和拉裂行为精度较高;扩展有限元法模拟的混凝土裂纹扩展路径自由,适合对受力或相互作用复杂的混凝土进行精细化建模与损伤分析;内置内聚力单元的裂纹形成与扩展依赖单元网格密度与形状,适合在相关理论成熟或试验数据全面的基础上做影响参数分析;设置单元失效准则可同时模拟混凝土的压溃和拉裂行为,但损伤发展较快,精度偏低。

关键词：混凝土损伤扩展有限元内聚力单元单元失效钢筋混凝土梁

人类活动对生境质量的影响及空间关系定量分析——以石家庄为例

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环境工程技术学报 2024年第2期14卷 574-582页

作者：闫语秦耀伟平玉荣东嘉琪李双江曹建生肖捷颖河北科技大学环境科学与工程学院中国科学院遗传与发育生物学研究所农业资源研究中心

定量分析并揭示人类活动对生境质量的影响及相关关系,可为区域生态环境的治理及修复提供科学依据。以石家庄为例,基于2010年、2015年、2021年遥感影像解译土地利用结果,利用InVEST模型评估石家庄生境质量的时空演变,结合土地利用、夜间... 详细信息

定量分析并揭示人类活动对生境质量的影响及相关关系,可为区域生态环境的治理及修复提供科学依据。以石家庄为例,基于2010年、2015年、2021年遥感影像解译土地利用结果,利用InVEST模型评估石家庄生境质量的时空演变,结合土地利用、夜间灯光、人口密度数据构建人类活动强度指标,运用双变量空间自相关和多尺度地理加权回归模型分析人类活动与生境质量的空间相关性及其对生境质量的影响。结果表明:2010—2021年,研究区的人类活动强度变化较小,整体处于较低水平,总体为增长趋势,空间上呈西低东高分布;研究区的生境质量平均值处于中等级,呈V型波动,先减小后增加,且呈西部高、中部及东部低的分布特征;人类活动对生境质量的影响存在显著空间异质性,整体以负相关为主且影响程度减弱,在河流沿线及局部山区呈正相关。未来石家庄生态环境保护及修复措施需要考虑人类活动强度与生境质量间的空间相关性,将中东部地区作为重点,控制建设用地发展,保护基本农田,加强滹沱河沿线生态修复,以提高生境质量。

关键词：人类活动强度生境质量夜间灯光数据多尺度地理加权回归模型 InVEST模型

Multi-omics Data Reveal the Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1149-1162页

作者： Jiazhen Zheng Yue li Ning liu Jihui Zhang shuangjiang liu Huarong Tan State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China College of life Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Microbial Biotechnology Shandong UniversityQingdao 266237China

Streptomycetes possess numerous gene clusters and the potential to produce a large amount of natural products.Histone deacetylase(HDAC)inhibitors play an important role in the regulation of histone modifications in fungi,but their roles in prokaryotes remain poorly understood.Here,we investigated the global effects of the HDAC inhibitor,sodium butyrate(SB),on marine-derived Streptomyces olivaceus FXJ 8.021,particularly focusing on the activation of secondary metabolite biosynthesis.The antiSMASH analysis revealed 33 secondary metabolite biosynthetic gene clusters(BGCs)in strain FXJ 8.021,among which the silent lobophorin BGC was activated by SB.Transcriptomic data showed that the expression of genes involved in lobophorin biosynthesis(ge00097–ge00139)and CoA-ester formation(e.g.,ge02824),as well as the glycolysis/gluconeogenesis pathway(e.g.,ge01661),was significantly up-regulated in the presence of SB.Intracellular CoA-ester analysis confirmed that SB triggered the biosynthesis of CoA-ester,thereby increasing the precursor supply for lobophorin biosynthesis.Further acetylomic analysis revealed that the acetylation levels on 218 sites of 190 proteins were up-regulated and those on 411 sites of 310 proteins were down-regulated.These acetylated proteins were particularly enriched in transcriptional and translational machinery components(e.g.,elongation factor GE04399),and their correlations with the proteins involved in lobophorin biosynthesis were established by protein–protein interaction network analysis,suggesting that SB might function via a complex hierarchical.

关键词： Silent gene cluster Streptomyces Sodium butyrate Protein modification Acetylome