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Gene expression profiling of HepG_(2) cells after treatment with black tea polyphenols

BIOCELL 2018年第3期42卷 99-104页

作者： Jie Zhong Li Deng Yu Jiang Lianhong Zou Huabing Yuan shuang-xiang tan Scientific Research Department Hunan Province Institute of GerontologyHunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal UniversityChangshaChina Center of Reproductive Medicine Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal UniversityChangshaChina Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal UniversityChangshaChina Pharmacy Department Tianmen First People’s HospitalTianmenHubeiChina

This study aimed to determine the effects of black tea polyphenols on gene expression in hepatocellular cancer *** total RNA from HepG_(2) hepatocellular cancer cells treated with black tea polyphenols was subjected to Human 14K cDNA microarray ***-time PCR and Western blot analysis were conducted to verify microarray *** tea polyphenols treatment at the dose of 20 mg/L,40 mg/L or 80 mg/L for one to three days inhibited the growth of HepG_(2) cells in a dose and time dependent manner.A total of 48 genes showed more than two-fold change after black tea polyphenols treatment,including 17 upregulated genes and 31 downregulated genes,and they were involved in the regulation of cell growth,cell cycle,apoptosis,signaling,angiogenesis,tumor invasion and ***-time PCR analysis of the selected genes showed that their mRNA expression changes were consistent with the microarray *** addition,Western blot analysis of the selected genes showed that their protein expression changes were consistent with mRNA *** conclusion,gene expression profiles provide comprehensive molecular mechanisms by which black tea polyphenols exerts growth inhibition effects on cancer *** novel molecular targets identified in this study may be further exploited as therapeutic strategies for hepatocellular cancer.

关键词： Black tea polyphenols Microarray HepG_(2)cells Gene expression

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Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

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Acta Pharmaceutica Sinica B 2024年第2期14卷 517-532页

作者： shuang xiang Xiaoyun Lu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE) Guangdong Provincial Key Laboratory of New Drug Design and EvaluationGuangzhou City Key Laboratory of Precision Chemical Drug DevelopmentSchool of PharmacyJinan UniversityGuangzhou 510632China

Neurotrophic receptor kinase(NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors,and tropomyosin receptor kinase(TRK) has been considered as an attractive therapeutic target for "pan-cancer" harboring these ***,two generations TRK inhibitors have been *** representative second-generation inhibitors selitrectinib and repotrectinib were designed to overcome clinic acquired resistance of the first-generation inhibitors larotrectinib or entrectinib resulted from solvent-front and gatekeeper on-target ***,xDFG(TRKAG667C/A/S,homologous TRKCG696C/A/S) and some double mutations still confer resistance to selitrectinib and repotrectinib,and overcoming these resistances represents a major unmet clinical *** this review,we summarize the acquired resistance mechanism of the first-and second-generation TRK inhibitors,and firstly put forward the emerging selective type Ⅱ TRK inhibitors to overcome xDFG mutations mediated ***,we concluded our perspectives on new challenges and future directions in this field.

关键词： NTRK fusions TRK kinase Clinical resistance xDFG mutations Selective type II inhibitors

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Real-time in-situ monitoring of chiral changes during a reaction at single-molecule level

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Science China Chemistry 2024年第2期67卷 422-423页

作者： Min tan Dong xiang Institute of Modern Optics and Center of Single-Molecule Science Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyNankai UniversityTianjin300350China School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China TongLu FeiRan Garment–Nankai University Joint Laboratory Nankai UniversityTianjin300350China

Molecular chirality is a widespread phenomenon in nature,playing a critical role in various fields such as chemistry [1],life sciences [2], and materials science [3], and has therefore attracted significant attention and research by scholars [4–6].However, the chirality in chemical reactions is often dynamic, making real-time monitoring of chiral changes during chemical reactions at the single-molecule level extremely challenging.

关键词： chiral chirality critical

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Engineering the Interface Between Au Nanoparticles and CoO-Ov to Enhance the Catalytic Performance of 5-Hydroxymethylfurfural(HMF)to 2,5-Dimethylfuran(DMF)

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Chemical Research in Chinese Universities 2024年第1期40卷 47-54页

作者： xiang shuang GUO Yong LIU Xiaohui WANG Yanqin Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterResearch Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237P.R.China

The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis ***,we create the Au-CoO-OV interface in the 1.0%Au/Co3O4-Rod-250 catalyst,which could dissociate H2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-dimethylfuran(DMF).The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-OV surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen(signals of Au-D and O-D vibration)compared with bare CoO(Co3O4-Rod-250).This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.

关键词： Au-CoO-OV interface Hydride species Heterolytic dissociation 5-Hydroxymethylfurfural(HMF) 2 5-Dimethylfuran(DMF)

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Effect of different bottom blowing elements on stirring characteristics of molten bath in converter

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Journal of Iron and Steel Research International 2024年第2期31卷 368-376页

作者： Ming Lv shuang-ping Chen Hong-min Guo Yi-jie Hao xiang-dong Xing School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Shaanxi Longmen Steel Company Hancheng715405ShaanxiChina

The bottom blowing element is the key equipment to ensure the bottom blowing effect of the *** types of bottom blowing elements,dispersive type(D1),double circular seam(D2)and straight cylinder type(D3),were built,and the effects of bottom blowing element type on molten bath flow,wall erosion and furnace bottom erosion were *** was found that when the bottom blowing elements of dispersive type(D1)and double circular seam(D2)were used,the dead zone area in the lower part of the molten bath was smaller,and the high-speed zone area was larger;therefore,the stirring effect on the bottom melt was *** the straight cylinder type(D3)bottom blowing element was used,the gas penetrated the molten bath at a faster rate to reach the surface of molten bath and failed to disperse in the bottom molten bath,and the wall shear stress near the nozzle outlet was *** argon was blown by three different bottom blowing elements,the area of the wall shear stress greater than 3 Pa was 4.8,5.6 and 8.7 cm2,respectively,within 0.2 m of the bottom blowing nozzle outlet.

关键词： Converter steelmaking Bottom blowing element Molten bath stirring Wall erosion

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Recent progress and strategies of cathodes toward polysulfides shuttle restriction for lithium-sulfur batteries

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Rare Metals 2024年第9期43卷 4132-4161页

作者： Xing-You Rao shuang-Fei xiang Jian Zhou Zhen Zhang xiang-Yu Xu Yuan-Yuan Xu Xin-Chi Zhou Zheng-Dao Pan Su-Chong tan Shi-Xing Dong Zhou-Lu Wang Yu-Tong Wu Yun-Lei Zhou xiang Liu Yi Zhang Shan Jiang School of Energy Sciences and Engineering Nanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering and Institute of Smart Fiber Materials Zhejiang Sci-Tech UniversityHangzhou 310018China JiangSu Sailboat Petrochemical Co. LtdLianyungang 222000China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

Lithium-sulfur batteries(LSBs)have already developed into one of the most promising new-generation high-energy density electrochemical energy storage systems with outstanding features including high-energy density,low cost,and environmental ***,the development and commercialization path of LSBs still presents significant limitations and challenges,particularly the notorious shuttle effect triggered by soluble longchain lithium polysulfides(LiPSs),which inevitably leads to low utilization of cathode active sulfur and high battery capacity degradation,short cycle life,*** research efforts have been conducted to develop various sulfur host materials capable of effectively restricting the shuttle *** review firstly introduces the fundamental electrochemical aspects of LSBs,followed by a comprehensive analysis of the mechanism underlying the shuttle effect in Li–S batteries and its profound influence on various battery components as well as the overall battery ***,recent advances and strategies are systematically reviewed,including physical confinement,chemisorption,and catalytic conversion of sulfur hosts for restricting LiPSs shuttle *** interplay mechanisms of sulfur hosts and LiPSs are discussed in detail and the structural advantages of different host materials are ***,key insights for the rational design of advanced host materials for LSBs are provided,and the upcoming challenges and the prospects for sulfur host materials in lithium-sulfur batteries are also explored.

关键词： Lithium-sulfur batteries Polysulfides Shuttle effect Host

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Activable Photodynamic DNA Probe with an“AND”Logic Gate for Precision Skin Cancer Therapy

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Research 2024年第3期2024卷 735-750页

作者： Jiaojiao Zhu Lanyuan Peng Shah Jehan Haiyang Wang xiang Chen shuang Zhao Wenhu Zhou xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan 410013China Department of Dermatology Hunan Engineering Research Center of Skin Health and DiseaseHunan Key Laboratory of Skin Cancer and PsoriasisXiangya HospitalCentral South UniversityChangshaHunan 410008China Key Laboratory of Biological Nanotechnology of National Health Commission ChangshaHunan 410008China. Furong Laboratory ChangshaHunanChina Department of Vascular Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China.

Photodynamic therapy(PDT)has emerged as a promising approach for squamous cell carcinoma treatment but hindered by tumor hypoxia,acquired resistance,phototoxicity,and so *** address these issues,we developed a smart strategy utilizing activable photosensitizers delivered by an aptamer-functionalized DNA probe(ADP).The ADP incorporated an AS1411 aptamer for tumor targeting and a linear antisense oligonucleotide(ASO)for recognition of Survivin *** the absence of the target,PDT remained quenched,thereby avoiding phototoxicity during circulation and nonselective *** the aid of the aptamer,ADP achieved selective targeting of *** internalization,ADP targeted recognized Survivin mRNA,triggering PDT activation,and releasing ASO to down-regulate Survivin expression and reverse tumor ***,the activable photosensitizers exhibited an“AND”logic gate,combining tumor-targeting delivery and tumor-related gene activation,thus enhancing its ***,the incorporation of hemin into the ADP provided catalase activity,converting tumor-abundant H_(2)O_(2) into O_(2),thereby ameliorating tumor *** resulting functionalized G-quadruplex/hemin–DNA probe complex demonstrated targeted delivery and activation,minimized side effects,and enhanced PDT efficacy in both xenograft tumor-bearing mice and patient-derived xenograft *** study offers a unique and promising platform for efficient and safe PDT,thus holding great potential for future clinical translation and improved cancer therapy.

关键词： specificity thereby Skin

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Mg/MgO interfaces as efficient hydrogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloys:A DFT analysis

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Journal of Magnesium and Alloys 2024年第1期12卷 110-119页

作者： Man-Fai Ng Kai xiang Kuah Teck Leong tan Daniel John Blackwood Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloys are higher than their as-cast counterparts,possibly due to increased kinetics for the hydrogen evolution reaction on secondary phases,which may include oxide *** Kelvin Probe Force Microscopy demonstrated that MgO inclusions could act as cathodes for Mg corrosion,but their low conductivity likely precludes ***,the density of state calculations through density functional theory using hybrid HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hydrogen absorption energy at the Mg/MgO interface reveals it to be an excellent catalytic site,with HER being found to be a factor of 23x more efficient at the interface than on metallic *** results not only support the plausibility of the Mg/MgO interface being an effective cathode to the adjacent anodic Mg matrix during corrosion but also contribute to the understanding of the enhanced cathodic activities observed during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hydrogen evolution DFT

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Geochemistry and origins of hydrogen-containing natural gases in deep Songliao Basin,China:Insights from continental scientific drilling

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Petroleum Science 2024年第2期21卷 741-751页

作者： shuang-Biao Han Chao-Han xiang Xin Du Lin-Feng Xie Jie Huang Cheng-Shan Wang College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing100083China

The different reservoirs in deep Songliao Basin have non-homogeneous lithologies and include multiple layers with a high content of hydrogen *** gas composition and stable isotope characteristics vary significantly,but the origin analysis of different gas types has previously been *** on the geochemical parameters of gas samples from different depths and the analysis of geological settings,this research covers the diverse origins of natural gas in different *** gas components are mainly methane with a small amount of C_(2+),and non-hydrocarbon gases,including nitrogen(N_(2)),hydrogen(H_(2)),carbon dioxide(CO_(2)),and helium(He).At greater depth,the carbon isotope of methane becomes heavier,and the hydrogen isotope points to a lacustrine sedimentary *** increasing depth,the origins of N_(2)and CO_(2)change gradually from a mixture of organic and inorganic to *** origins of hydrogen gas are complex and include organic sources,water radiolysis,water-rock(Fe^(2+)-containing minerals)reactions,and *** shales of Denglouku and Shahezi Formations,as source rocks,provide the premise for generation and occurrence of organic ***,the deep faults and fluid activities in Basement Formation control the generation and migration of mantle-derived *** discovery of a high content of H_(2)in study area not only reveals the organic and inorganic association of natural-gas generation,but also provides a scientific basis for the exploration of deep hydrogen-rich gas.

关键词： Gas compositions Stable isotopes Gas origins Hydrogen gas Songliao Basin

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Zooplankton community response to eddy during dinoflagellate Noctiluca scintillans blooms off Pakistan,northern Arabian Sea

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Journal of Oceanology and Limnology 2024年第5期42卷 1557-1570页

作者： Mahugnon Boris DEDO Xiping LIAN Kaizhi LI Chenhui xiang Yehui tan Key Laboratory of Tropical Marine Bioresources and Ecology Guangdong Provincial Key Laboratory of Applied Marine BiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of Sciences(ISEECAS)Guangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510301China

Eddies are major elements of ocean dynamics that affect ocean *** their effects on plankton distribution may help understand the dynamics of harmful phytoplankton *** studies on the effects of eddies in the northern Arabian Sea have primarily focused on the zooplankton community,and few have observed zooplankton dynamics during winter blooms of Noctiluca *** investigated zooplankton community structure and the related environmental variability during a *** bloom that was affected by an eddy in February *** sampling stations were deployed at eddy core and eddy edge distinguished in salinity,temperature,and *** show that *** bloomed at the eddy core with high-velocity currents induced by warm eddies that moved from eddy core to eddy *** a result,blooms significantly changed the zooplankton community ***-bloom stations had higher zooplankton diversity than bloom *** at non-bloom stations were dominated by either tunicates or copepods,such as Thalia democratica and Pleuromamma *** addition to the influence of *** blooms,the velocity of eddy currents was a crucial factor on the similarities in the zooplankton community composition between eddy edge and eddy ***,the lower abiotic factors in bloom area contribute to the structuring of the zooplankton community during *** blooms.

关键词： eddy zooplankton community Noctiluca scintillans northern Arabian Sea

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