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Microstructure and damping properties of MnCuNiFeCe alloy

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Rare Metals 2016年第8期35卷 615-619页

作者： feng-shuang lu Bin Wu Jian-Fu Zhang Ping Li Dong-Liang Zhao Functional Materials Research Institute Central Iron and Steel Research Institute Beijing 100081 China Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China Beijing Key Laboratory of Precision Alloys Beijing 100081China

Mn-Cu alloys could exhibit high damping ability and excellent mechanical properties after proper heat treatment. In order to reduce the influence of impurity elements on damping capacity of Mn-Cu alloys, rare ele- ment cerium （Ce） was added into MnCuNiFe alloys. It is indicated that the contents of C, S and Si which have adverse effects on the damping capacity decrease and the grains are refined with the Ce content increasing. The microstructure of the MnCuNiFeCe alloy was investigated by X-ray diffraction （XRD）, scanning electron microscope （SEM） and transmission electron microscopy （TEM）. The damping ability （tane） of the alloy was characterized by dynamical mechanical analyzer （DMA）. It is found that the damping ability （tane） retains a very high level which is all above 0.05 from the temperature of -50 to 75 ℃ with the addition of Ce element. It is expected that the Ce alloying MnCuNiFe alloy with refined grains could find wide applications in the field of industry.

关键词： Mn-Cu alloy Damping properties Cerium

Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

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Acta Pharmaceutica Sinica B 2024年第2期14卷 517-532页

作者： shuang Xiang Xiaoyun lu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE) Guangdong Provincial Key Laboratory of New Drug Design and EvaluationGuangzhou City Key Laboratory of Precision Chemical Drug DevelopmentSchool of PharmacyJinan UniversityGuangzhou 510632China

Neurotrophic receptor kinase(NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors,and tropomyosin receptor kinase(TRK) has been considered as an attractive therapeutic target for "pan-cancer" harboring these ***,two generations TRK inhibitors have been *** representative second-generation inhibitors selitrectinib and repotrectinib were designed to overcome clinic acquired resistance of the first-generation inhibitors larotrectinib or entrectinib resulted from solvent-front and gatekeeper on-target ***,xDFG(TRKAG667C/A/S,homologous TRKCG696C/A/S) and some double mutations still confer resistance to selitrectinib and repotrectinib,and overcoming these resistances represents a major unmet clinical *** this review,we summarize the acquired resistance mechanism of the first-and second-generation TRK inhibitors,and firstly put forward the emerging selective type Ⅱ TRK inhibitors to overcome xDFG mutations mediated ***,we concluded our perspectives on new challenges and future directions in this field.

关键词： NTRK fusions TRK kinase Clinical resistance xDFG mutations Selective type II inhibitors

Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy

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Nano Research 2024年第4期17卷 2941-2948页

作者： Ruohao Zhang Yu lu Yifei Zhou Kehong Lv Xinyu Fu Jitong Gong shuang Yao Xiaozhen Wang Jing feng Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China Department of Breast Surgery General Surgery Centerthe First Hospital of Jilin UniversityChangchun 130021China Department of Chemistry Tsinghua UniversityBeijing 100084China

Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant *** therapy(PDT)is an emerging treatment modality,and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enhance the generation of reactive oxygen species(ROS).Although the upconversion nanoparticles(UCNPs)modified with the photosensitizers could achieve PDT with strong penetration depth under near-infrared light irradiation,the ROS generated by traditional single-pathway PDT is still ***,we developed a novel nanoconjugate(UCNP-Ce6/AIEgen)for dual-pathway reinforced PDT,in which the UCNPs were co-modified with chlorin e6(Ce6)and luminogen with aggregation-induced emission(AIEgen).Due to the presence of AIEgen,UCNP-Ce6/AIEgen could avoid aggregation-caused luminescence quenching in biological water environments and convert upconversion luminescence(UCL)of UCNPs to Ce6-activatable ***,under the irradiation of 808 nm laser,UCNP-Ce6/AIEgen can not only undergo direct lanthanide-triplet energy transfer to activate Ce6,but also convert the UCL of UCNPs to the light that can activate Ce6 through Fӧrster resonance energy transfer to generate more ROS,thus promoting tumor cell *** work broadens the applications of nanoconjugates of lanthanide-based inorganic materials and organic dyes,and provides a conception for reinforced PDT of tumors.

关键词： upconversion nanoparticle aggregation-induced emission direct lanthanide-triplet energy transfer Förster resonance energy transfer photodynamic therapy

Novel Soft Magnetic Co-Based Ternary Co-Er-B Bulk Metallic Glasses

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1633-1642页

作者： Jie lu Yanhui Li shuang Ma Wanping Li feng Bao Zhengwang Zhu Qiaoshi Zeng Haifeng Zhang Man Yao Wei Zhang Key Laboratory of Materials Modification By Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China School of Metallurgy Northeastern UniversityShenyang110819China Center for High Pressure Science and Technology Advanced Research(HPSTAR) PudongShanghai201203China

In this work,a series of Co-based ternary Co-Er-B bulk metallic glasses(BMGs)with excellent soft magnetic properties and high strength were developed,and the local atomic structure of a typical Co_(71.5)Er_(3.5)B_(25) metallic glass was studied through in situ high-energy synchrotron X-ray diffraction and ab initio molecular dynamics *** results reveal that the BMG samples can be obtained in a composition region of Co_(68.5-71.5)Er_(3.5-4)B_(25-27.5) by a conventional copper-mold casting *** Co-Er-B metallic glasses possess stronger atomic bond strengths and denser local atomic packing structure composed of a higher fraction of icosahedral-like clusters but fewer deformed body-centered cubic and crystal-like polyhedrons,and they exhibit slower atomic diffusion behaviors during solidification,as compared to Co-Y-B *** enhancement in structural stability and the retardation of atomic-ordered diffusion lead to the better glass-forming ability of the Co-Er-B *** smaller magnetic anisotropy energy in the Co-Er-B metallic glasses results in a lower coercivity of less than 1.3 A/*** Co-Er-B BMGs exhibit high-yield strength of 3560-3969 MPa along with distinct plasticity of around 0.50%.

关键词： Co-based bulk metallic glass Glass-forming ability Soft magnetic property Ab initio molecular dynamics simulation Local atomic structure

Effects of Heat Transfer on Laminar-to-Turbulent Transition over a Compressor Blade Operating at Low Reynolds Number

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Journal of Thermal Science 2024年第5期33卷 1826-1838页

作者： lu Lehan WANG Mingyang ZHANG Yanfeng SUN shuang HUANG Zhen WANG Maomao Department of aviation Engineering Civil Aviation University of ChinaTianjin 300300China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Aerodynamics CARDCMianyang 621000China

To control the transition process in a laminar separation bubble(LSB)over an ultra-high load compressor blade at a Re of 1.5×10^(5),the effects of wall heat transfer were considered and numerically investigated by large eddy simulations(LES).Compared with the adiabatic wall condition,the local kinematic viscosity of airflow was reduced by wall cooling;thus the effects of turbulent dissipation on the growth of fluctuations were *** such,the transition occurred much earlier,and the size of LSB became *** the cooled surface,the spanwise vortices deformed much more rapidly and the size of hairpin vortex structures was ***,the rolling-up of 3D hairpin vortices and the ejection and sweeping process very close to the blade surface was ***,the aerodynamic losses of the compressor blade were reduced by 18.2%and 38.4%for the two cooled wall *** results demonstrated the feasibility of wall cooling in controlling the transition within an LSB and reducing the aerodynamic loss of an ultra-highly loaded compressor blade.

关键词： heat transfer compressor blade laminar-to-turbulent transition loss generation

From non-carbon host toward carbon-free lithium-sulfur batteries

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Nano Research 2024年第3期17卷 1337-1365页

作者： Yanqi feng Hui Liu Qiongqiong lu School of Materials Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science and TechnologyXi’an 710021China Institute of Materials Henan Key Laboratory of Advanced Conductor MaterialsHenan Academy of SciencesZhengzhou 450046China Leibniz Institute for Solid State and Materials Research(IFW)Dresden e.V. Helmholtzstraβe 2001069 DresdenGermany School of Materials&Environment Engineering Chengdu Technological UniversityChengdu 611730China

Lithium-sulfur(Li-S)batteries with advantages of high energy densities(2600 Wh·kg^(-1)/2800 Wh·L^(-1))and sulfur abundance are regarded as promising candidates for next-generation high-energy ***,the conventional carbon host used in sulfur cathodes suffers from poor chemical adsorption towards Li-polysulfides(LPS)in liquid electrolyte and sluggish redox kinetics,leading to low capacity and rate ***,carbon host used in Li metal anode with the intrinsic property of poor lithiophilicity and high Li-nucleation barrier gives rise to uncontrollable dendrite growth and further battery ***,non-carbon hosts with chemical adsorption toward LPS and catalytic activity for accelerating LPS redox conversion as well as lithiophilic property for guiding uniform Li deposition are proposed and demonstrated a high efficiency in both sulfur cathodes and Li metal *** this review,the principle and challenges of Li-S batteries are first presented,then recent work using non-carbon hosts in Li-S batteries is summarized comprehensively,and the mechanism of non-carbon host in improving sulfur utilization and stabilizing Li metal anode is discussed in ***,remaining challenges and outlook on the implementation of non-carbon host for practical carbon-free Li-S batteries are also provided.

关键词： sulfur cathode Li metal anode polysulfides adsorption catalytic effect Li dendrite carbon-free lithium-sulfur batteries

Temporal and Spectral Characteristics of Persistent Emission and Special Bursts of Magnetar SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第6期24卷 225-233页

作者： Xue-feng lu Li-Ming Song Ming-Yu Ge shuang-Nan Zhang Jin-lu Qu Ce Cai Cong-Zhan Liu Cheng-Kui Li Yu-Cong Fu Ying-Chen Xu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Department of Astronomy Beijing Normal UniversityBeijing 100875China

In October 2022,the magnetar SGR J1935+2154 entered the active outburst *** the episode,the InsightHXMT satellite carried out a long observation that lasted for 20 *** than 300 bursts were detected,and a certain amount of persistent radiation signals were also *** paper mainly introduces the results of persistent radiation profile folding and period search based on Insight-HXMT *** the same time,the burst phase distribution characteristics,spectral lag results of burst,the spectral characteristics of zero-lag bursts and the time-resolved spectral evolution characteristics of high-flux bursts are *** found that there is no significant delay feature during different energy bands for the bursts of SGR J1935+*** observed zero-lag burst does not have a unique *** time-resolved spectrum of the individual burst has consistent spectral types and spectral parameters at different time periods of the *** also find that the burst number phase distribution and the burst photon phase distribution have the same tendency to concentrate in specific regions of the persistent emission profile.

关键词： radiation mechanisms:general dense matter magnetic fields

CMIP 6 models simulation of the connection between North/South Pacific Meridional Mode and ENSO

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Journal of Oceanology and Limnology 2024年第2期42卷 439-453页

作者： Yunlong lu Junqiao feng Dunxin HU Key Laboratory of Ocean Circulation and Waves Chinese Academy of SciencesQingdao 266071China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not *** the early 1980,the relationship experienced an interdecadal *** in this connection can be attributed mainly to the phase change of the Pacific decadal oscillation(PDO).During the positive phase of PDO,a shallower thermocline in the central Pacific is responsible for the stronger trade wind charging(TWC)mechanism,which leads to a stronger equatorial subsurface temperature *** dynamic process strengthens the connection between NPMM and *** with the negative phase of PDO,a shallower thermocline over southeastern Pacific allows an enhanced wind-evaporation-SST(WES)feedback,strengthening the connection between SPMM and *** 35 Coupled Model Intercomparison Project Phase 6(CMIP6)models,we examined the NPMM/SPMM performance and its connection with ENSO in the historical *** great majority of CMIP6 models can reproduce the pattern of NPMM and SPMM well,but they reveal discrepant ENSO and NPMM/SPMM *** intermodal uncertainty for the connection of NPMM-ENSO is due to different TWC mechanism.A stronger TWC mechanism will enhance NPMM *** SPMM,few models can simulate a good relationship with *** intermodel spread in the relationship of SPMM and ENSO owing to SST bias in the southeastern Pacific,as WES feedback is stronger when the southeastern Pacific is warmer.

关键词： North and South Pacific Meridional Modes(NPMM and SPMM) El Niño-Southern Oscillation(ENSO) Pacific decadal oscillation(PDO) Coupled Model Intercomparison Project Phase 6(CMIP6)

Mechanistic insights into stepwise activation of malachite for enhancing surface reactivity and flotation performance

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2159-2172页

作者： Qicheng feng Wanming lu Han Wang Qian Zhang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China Yunnan Key Laboratory of Green Separation and Enrichment of Strategic Mineral Resources Kunming University of Science and TechnologyKunming 650093China

Malachite is a common copper oxide mineral that is often enriched using the sulfidization-xanthate flotation ***,the direct sulfidization method cannot yield copper concentrate ***,a new sulfidization flotation process was developed to promote the efficient recovery of *** this study,Cu^(2+) was used as an activator to interact with the sample surface and increase its reaction sites,thereby strengthening the mineral sulfidization process and *** to single copper ion activation,the flota-tion effect of malachite significantly increased after stepwise Cu^(2+) *** potential,X-ray photoelectron spectroscopy(XPS),time-of-flight secondary ion mass spectroscopy(ToF-SIMS),scanning electron microscopy and energy dispersive spectrometry(SEM-EDS),and atomic force microscopy(AFM)analysis results indicated that the adsorption of S species was significantly enhanced on the mineral surface due to the increase in active Cu sites after Cu^(2+) stepwise ***,the proportion of active Cu-S spe-cies also increased,further improving the reaction between the sample surface and subsequent ***-transform infrared spec-troscopy(FT-IR)and contact angle tests implied that the xanthate species were easily and stably adsorbed onto the mineral surface after Cu^(2+) stepwise activation,thereby improving the hydrophobicity of the mineral ***,the copper sites on the malachite sur-face after Cu^(2+) stepwise activation promote the reactivity of the mineral surface and enhance sulfidization flotation of malachite.

关键词： malachite copper ions stepwise activation flotation mechanism enhanced sulfidization