Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy
作者机构：State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and EngineeringUniversity of Science and Technology of ChinaHefei 230026China College of ChemistryJilin UniversityChangchun 130012China Department of Breast SurgeryGeneral Surgery Centerthe First Hospital of Jilin UniversityChangchun 130021China Department of ChemistryTsinghua UniversityBeijing 100084China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2024年第17卷第4期
页 面：2941-2948页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：supported by the financial aid from the Ministry of Science and Technology of China(Nos.2021YFF0701800,and 2022YFB3503700) the National Natural Science Foundation of China(No.22020102003) the International Partnership Program of Chinese Academy of Sciences(No.121522KYSB20190022) Department of Science and Technology of Jilin Province(Nos.20220101063JC,and 20200201423JC) the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.Y201947)
主 题：upconversion nanoparticle aggregation-induced emission direct lanthanide-triplet energy transfer Förster resonance energy transfer photodynamic therapy
摘 要：Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant *** therapy(PDT)is an emerging treatment modality,and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enhance the generation of reactive oxygen species(ROS).Although the upconversion nanoparticles(UCNPs)modified with the photosensitizers could achieve PDT with strong penetration depth under near-infrared light irradiation,the ROS generated by traditional single-pathway PDT is still ***,we developed a novel nanoconjugate(UCNP-Ce6/AIEgen)for dual-pathway reinforced PDT,in which the UCNPs were co-modified with chlorin e6(Ce6)and luminogen with aggregation-induced emission(AIEgen).Due to the presence of AIEgen,UCNP-Ce6/AIEgen could avoid aggregation-caused luminescence quenching in biological water environments and convert upconversion luminescence(UCL)of UCNPs to Ce6-activatable ***,under the irradiation of 808 nm laser,UCNP-Ce6/AIEgen can not only undergo direct lanthanide-triplet energy transfer to activate Ce6,but also convert the UCL of UCNPs to the light that can activate Ce6 through Fӧrster resonance energy transfer to generate more ROS,thus promoting tumor cell *** work broadens the applications of nanoconjugates of lanthanide-based inorganic materials and organic dyes,and provides a conception for reinforced PDT of tumors.
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