检索结果-南通市图书馆

Sleep deprivation reorganizes the dynamic configurations of default mode network activity during recovery sleep

Science China(Technological Sciences) 2022年第7期65卷 1456-1469页

作者： CUI Yan WU ShengDun ZHAO Shi LONG TianYao JIAN ZhaoXin yu shuang ZHANG Ge BISWAL Bharat GUO DaQing XIA Yang YAO DeZhong The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuro InformationCentre for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Chinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengdu 610072China Research Unit of Neuro Information(2019RU035) Chinese Academy of Medical SciencesChengdu 611731China Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNew Jersey 07102USA School of Electrical Engineering Zhengzhou UniversityZhengzhou 450001China

Sleep deprivation causes disturbances of the neural activity, leading to the impairment of brain functions. However, the exact mechanism of sleep deprivation and how it affects the dynamics of brain activity during the recovery sleep remains unclear. In the current study, we performed sleep deprivation experiments on ten adult rats, and recorded the local field potentials from default mode network(DMN) regions during sleep before and after sleep deprivation. The DMN dynamics was assessed with the configurations of coactive micropatterns(CAMPs) using our previously proposed CAMP method. Our analysis revealed that the effects of sleep deprivation on DMN dynamics in the slow-wave sleep(SWS) state and the rapid eye-movement sleep(REM)state were disparate. Dynamic configurations of DMN activity in the SWS state were significantly impaired after sleep deprivation, with increased occurrence of low-activity CAMP and reorganized transition structure across three CAMPs. Moreover,enhanced functional connectivity and improved efficiencies in all CAMP networks were observed during the SWS state in the recovery sleep. However, there were no significant alterations in either DMN dynamics or CAMP network structures in the REM sleep state after sleep deprivation. Our results described the alterations of DMN dynamics in different sleep states after sleep deprivation, and illustrated the differential effects of sleep deprivation on two sleep states. These findings demonstrated the underlying neural mechanisms of the effects of sleep deprivation on DMN activity during sleep and increased our understanding of the physiological roles of the DMN in maintain sleep homeostasis after sleep deprivation.

关键词： sleep deprivation sleep state default mode network coactive micropattern dynamic configuration efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

干旱胁迫对冬小麦物质转运和不同小穗位籽粒产量的影响

引用

植物营养与肥料学报 2024年第6期30卷 1211-1221页

作者：陈志豪王艳杰常旭虹王德梅刘希伟杨玉双石书兵赵广才新疆农业大学农学院新疆乌鲁木齐830000 中国农业科学院作物科学研究所/农业农业部作物生理生态重点实验室北京100081

【目的】探究不同冬小麦品种物质转运和不同小穗位产量对拔节至成熟期干旱胁迫的响应。【方法】试验以常规品种济麦22和抗旱品种中麦36为材料,在自动防雨水肥控制池内进行,采用测墒补灌技术实现水分条件的控制。设置顶端小穗形成期到成... 详细信息

【目的】探究不同冬小麦品种物质转运和不同小穗位产量对拔节至成熟期干旱胁迫的响应。【方法】试验以常规品种济麦22和抗旱品种中麦36为材料,在自动防雨水肥控制池内进行,采用测墒补灌技术实现水分条件的控制。设置顶端小穗形成期到成熟期持续干旱(WS:40%~45%FC,FC为田间持水量)和对照处理(CK:80%~85%FC)。调查拔节后不同小穗位小花发育动态,强、弱势粒灌浆速率和产量等指标,以及各器官花前、花后干物质积累运转量。【结果】1)干旱胁迫促进济麦22穗中部和上部的小花原基发育进程,显著减少了小花原基数量,导致穗部发育不平衡,而对中麦36各部位小花原基发育进程和数量无显著影响。2)干旱胁迫下,抗旱品种中麦36的开花前营养器官贮藏干物质转运量(Pre-DT)和转运率(Pre-DTE)较对照条件下分别显著降低34.8%和33.2%,降低了花前贮藏干物质运转对籽粒的贡献率(Pre-DCR),但开花后干物质积累量(Post�DA)及其对籽粒的贡献率(Post-DCR)分别提高5.1%和25.7%;常规品种济麦22的花前营养器官贮藏干物质转运量对籽粒的贡献率比对照提高了32.1%,Post-DA和Post-DCR分别降低了40.4%和21.3%。干旱胁迫下,中麦36 Pre-DCR的下降主要因为茎秆Pre-DCR的降低,而济麦22的Pre-DCR比对照提高了1.4倍,主要是由穗轴和颖壳Pre-DCR的增加所致。3)济麦22叶鞘、茎秆及穗轴+颖壳中的干物质向籽粒转运受到干旱的抑制,而中麦36仅茎秆和穗轴+颖壳受到干旱的抑制。与正常条件相比,干旱致使济麦22的籽粒灌浆速率下降42%,对中麦36无显著影响。济麦22上部和中部小穗位强势粒受干旱影响较大,而中麦36上部小穗位弱势粒受干旱影响较大,表现为济麦22的穗粒数、单粒重和单穗产量降幅(7.6%、15.9%和24.3%)均高于中麦36(3.3%、9.5%和16.3%)。【结论】抗旱品种主要靠开花后干物质积累来增加籽粒产量,而常规品种主要靠转运开花前营养器官贮藏干物质来增加籽粒产量。干旱胁迫条件下,常规品种济麦22的籽粒产量降幅显著高于抗旱品种中麦36,主要原因是干旱导致济麦22不同小穗位小花原基的发育不平衡,叶鞘、茎秆及穗轴+颖壳的干物质转移到籽粒的过程均受抑制,且中部和上部小穗位强势粒受到影响,导致灌浆速率显著降低。抗旱品种中麦36在干旱胁迫下通过降低茎秆开花前营养器官贮藏干物质转运量,提高开花后营养器官干物质积累量对籽粒贡献率应对干旱胁迫,且干旱胁迫主要影响弱势粒。

关键词：小麦干旱胁迫强弱势粒物质转运产量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

农业科技支撑巩固拓展脱贫攻坚成果同乡村振兴有效衔接研究——以四川民族地区为例

引用

西南农业学报 2024年第6期37卷 1386-1392页

作者：张雄龚一耘周评平陈沧桑王军吴海军蒋存馨杨双羽四川省农业科学院成都610066 四川省农业科学院茶叶研究所成都610066

巩固拓展脱贫攻坚成果同乡村振兴有效衔接是新时期“三农”工作最重要的任务之一,而农业科技对乡村产业振兴起着关键作用。四川民族地区普遍存在农业科技创新投入强度不够、现代农业基础薄弱、农业科技人才供给不足、农业科技创新机制... 详细信息

巩固拓展脱贫攻坚成果同乡村振兴有效衔接是新时期“三农”工作最重要的任务之一,而农业科技对乡村产业振兴起着关键作用。四川民族地区普遍存在农业科技创新投入强度不够、现代农业基础薄弱、农业科技人才供给不足、农业科技创新机制不完善、农户科技文化素质相对偏低、内生动力不足等问题,建议从构建农业科技创新和成果转化同时发力的科技支撑体系,建设高能级科技成果示范转化平台提升科技供给水平,完善农业生产经营组织体系,完善农业信息化和机械化服务体系,建立农产品质量安全与标准化体系,强化农业科技人才培养体系六个方面入手,实现四川省少数民族地区巩固拓展脱贫攻坚成果同乡村全面振兴有力有效精准衔接。

关键词：农业科技民族地区乡村振兴脱贫攻坚四川省

来源：

维普期刊数据库博看期刊

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

温度影响BAC去除饮用水中氨氮的生物学机理

引用

中国给水排水 2024年第15期40卷 44-49页

作者：牛佳余爽汤旸旸黄怡婷龚珑聪王悦陈泽昕鲁雯琪陈晓晨福建理工大学生态环境与城市建设学院福建省水污染阻控与系统智能技术工程研究中心福建福州350118 福州市自来水有限公司福建福州350001 福州大学环境与安全工程学院福建福州350108

针对低温时饮用水深度处理工艺生物活性炭(BAC)无法高效去除水中氨氮的问题,选用实际水厂运行中的BAC搭建滤柱连续培养反应器,通过室内控制实验,对比常温和低温下不同层BAC的氨氮去除效果及其硝化潜势,并运用分子生物学技术解析BAC上氨... 详细信息

针对低温时饮用水深度处理工艺生物活性炭(BAC)无法高效去除水中氨氮的问题,选用实际水厂运行中的BAC搭建滤柱连续培养反应器,通过室内控制实验,对比常温和低温下不同层BAC的氨氮去除效果及其硝化潜势,并运用分子生物学技术解析BAC上氨氧化古菌(AOA)和氨氧化细菌(AOB)的群落丰度和群落结构。结果表明,尽管低温时BAC各层去除氨氮的效率低于常温,但在一个反冲洗周期的后段仍能够达到常温时的氨氮去除效果,且其硝化潜势高于常温。低温下BAC上氨氧化微生物丰度高于常温,且AOA的数量变化最大(增加2个数量级)。针对功能基因amoA的T-RFLP分析发现,A-OTU2和A-OTU3以及B-OTU5分别为低温下主导的AOA和AOB。今后应更加关注低温下AOA及特定菌种在BAC上的定植及活性促进问题。

关键词：温度氨氮生物活性炭氨氧化古菌氨氧化细菌群落结构

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective limb remote ischemic post-conditioning against high-intraocular-pressure-induced retinal injury in mice

引用

International Journal of Ophthalmology(English edition) 2022年第4期15卷 560-567页

作者： Qi-Jiang Zhu Lei Zhang shuang-yu Lyu Zhan-Jun Cui En-She Jiang Jun Wang School of Clinical Medicine Henan UniversityKaifeng 475001Henan ProvinceChina Henan International Joint Laboratory for Nuclear Protein Regulation Henan UniversityKaifeng 475001Henan ProvinceChina School of Basic Medical Sciences Henan UniversityKaifeng 475001Henan ProvinceChina Institute of Nursing and Health School of Nursing and HealthHenan UniversityKaifeng 475001Henan ProvinceChina

AIM: To determine whether limb remote ischemic postconditioning(LRIC) protects against high-intraocularpressure(IOP)-induced retinal injur y, and to identify underlying molecular mechanisms. METHODS: In mice, IOP was increased to 110 mm Hg for 50 min and LRIC applied to the unilateral leg for three occlusion cycles(5 min/release). Three animal groups(control, high IOP, and high IOP+LRIC) were arranged in this study. Plasma was collected from LRIC treated mice. Retinal histology, oxidative stress were determined by histological section staining and chemical kit. C/EBP homologous protein(CHOP), and Iba-1 parameters were evaluated by immunofluorescent staining and Western blot. RESULTS: The data showed that LRIC treatment alleviated the retinal histological disorganization and ganglion cell loss induced by high IOP. The CHOP, Iba-1 expression and oxidative stress marker also were inhibited by LRIC treatment. To further explore underlying mechanisms, plasma from LRIC treated animals was intravenously transfused into high-IOP animals. The results showed plasma injection decreased caspase 9 expression and DHE staining signals compared with that in high IOP retinas. CONCLUSION: These data suggest that LRIC treatments exert retinal protective effects against high-IOP *** humoral factors release into the circulation by LRIC may contribute to homeostatic protection by reducing monocyte infiltration and/or microglia activation.

关键词： retina ischemic conditioning high intraocular pressure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electron engineering of nickel phosphide for Ni^(δ+) in electrochemical nitrate reduction to ammonia

引用

Nano Research 2024年第6期17卷 4864-4871页

作者： Jie Hu Hao Huang Miao yu shuang Wang Jinping Li College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China School of Sustainable Energy Materials and Science Jinhua Advanced Research InstituteJinhua 321000China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

The electrochemical reduction of nitrate to ammonia(ENRA)provides an efficient approach to remove nitrate pollution and achieve ammonia production ***,inspired by bio-enzyme in denitrifying bacteria,a carbon-coated nickel phosphide(NiPC)nanosheet derived from metal-organic frameworks(MOFs)is proposed as an efficient catalyst for *** electron engineering,controllable Ni^(δ+)in nickel phosphide is achieved by regulating the degree of phosphating,which enhances its activity for the hydrogenation of *** the result,Niδ+becomes one of dominating factors determining the efficiency of the ENRA reaction in nickel *** optimal NiPC catalyst exhibits impressive property toward ENRA:NH_(4)^(+)Faraday efficiency of 96.68%,NH4+selectivity of 99.04%,and nitrate conversion rate of 90.43%under low nitrate concentration(200 mg·L^(−1)).This work opens a new avenue for the design of next-generation catalysts through electron engineering for ENRA.

关键词： electron engineering transition metal phosphide nitrate reduction ammonia production metal-organic frameworks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

影像组学在乳腺癌分子分型及肿瘤微环境研究中的应用

引用

广东医科大学学报 2024年第2期42卷 209-213页

作者：林立夫刘子霖刘玉双陈晓东广东医科大学附属第二医院放射影像科广东湛江524000 广东医科大学附属医院医学影像中心广东湛江524001

乳腺癌发病率居全球女性恶性肿瘤之首。随着科技进步,乳腺疾病诊断技术也从传统阅片诊断向人工智能辅助诊断的方向发展,包括影像组学、机器学习和深度学习等技术。影像组学是一种综合利用多模态医学影像数据的定量分析方法,旨在提取和... 详细信息

乳腺癌发病率居全球女性恶性肿瘤之首。随着科技进步,乳腺疾病诊断技术也从传统阅片诊断向人工智能辅助诊断的方向发展,包括影像组学、机器学习和深度学习等技术。影像组学是一种综合利用多模态医学影像数据的定量分析方法,旨在提取和分析影像中的大量特征,并将其与临床、病理、分子等数据关联,以实现个体化的疾病诊断、预测和治疗策略的制定。该文旨在综述影像组学在乳腺癌研究中的进展,特别关注分子分型的识别和肿瘤微环境的探索。

关键词：影像组学乳腺癌分子分型肿瘤微环境

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Degradation mechanism of 2,4,6-trinitrotoluene in supercritical water oxidation

引用

Journal of Environmental Sciences 2007年第12期19卷 1430-1435页

作者： CHANG shuang-jun LIU yu-cun College of Chemical Engineering and Environment North University of China Taiyuan 030051 China

The 2,4,6-trinitrotoluene （TNT） is a potential carcinogens and TNT contaminated wastewater, which could not be effectively disposed with conventional treatments. The supercritical water oxidation （SCWO） to treat TNT contaminated wastewater was studied in this article, The TNT concentration in wastewater was measured by high-performance liquid chromatograph （HPLC） and the degraded intermediates were analyzed using GC-MS. The results showed that SCWO could degrade TNT efficiently in the presence of oxygen. The reaction temperature, pressure, residence time and oxygen excess were the main contributing factors in the process. The decomposition of TNT was accelerated as the temperature or residence time increased. At 550℃, 24 MPa, 120 s and oxygen excess 300%, TNT removal rate could exceed 99.9%. Partial oxidation occured in SCWO without oxygen. It was concluded that supercritical water was a good solvent and had excellent oxidation capability in the existence of oxygen. The main intermediates of TNT during SCWO included toluene, 1,3,5-trinitrobenzene, nitrophenol, naphthalene, fluorenone, dibutyl phthalate, alkanes and several dimers based on the intermediate analysis. Some side reactions, such as coupled reaction, hydrolysis reaction and isomerization reaction may take place simultaneously when TNT was oxidized by SCWO.

关键词： supercritical water oxidation TNT degradation mechanism wastewater treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical efficacy of laparoscopic cholecystectomy plus cholangioscopy for the treatment of cholecystolithiasis combined with choledocholithiasis

引用

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2080-2087页

作者： Chao-Hui Liu Zhi-Wei Chen Zhe yu Hong-yu Liu Jian-Sheng Pan shuang-shuang Qiu Department of General Surgery The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)Quanzhou 362000Fujian ProvinceChina Department of General Surgery Anxi Hospital of Traditional Chinese MedicineQuanzhou 362499Fujian ProvinceChina

BACKGROUND Currently,endoscopic retrograde cholangiopancreatography(ERCP)plus laparoscopic cholecystectomy(LC)is the main treatment for cholecystolithiasis combined with ***,the treatment is unsatisfactory,and the development of better therapies is *** To determine the clinical efficacy of LC plus cholangioscopy for cholecystolithiasis combined with *** Patients(n=243)with cholecystolithiasis and choledocholithiasis admitted to The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)between January 2019 and December 2023 were included in the study;111 patients(control group)underwent ERCP+LC and 132 patients(observation group)underwent LC+laparoscopic common bile duct exploration(LCBDE).Surgical success rates,residual stone rates,complications(pancreatitis,hyperamylasemia,biliary tract infection,and bile leakage),surgical indicators[intraoperative blood loss(IBL)and operation time(OT)],recovery indices(postoperative exhaust/defecation time and hospital stay),and serum inflammatory markers[C-reactive protein(CRP)],tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were *** No significant differences in surgical success rates and residual stone rates were detected between the observation and control ***,the complication rate,IBL,OT,postoperative exhaust/defecation time,and hospital stays were significantly reduced in the observation group compared with the control ***,CRP,TNF-α,and IL-6 Levels after treatment were reduced in the observation group compared with the levels in the control *** These results indicate that LC+LCBDE is safer than ERCP+LC for the treatment of cholecystolithiasis combined with *** surgical risks and postoperative complications were lower in the observation group compared with the control ***,patients may recover quickly with less inflammation after LCBDE.

关键词： Laparoscopic common bile duct exploration Endoscopic retrograde cholangiopancreatography Laparoscopic cholecystectomy Cholecystolithiasis Choledocholithiasis Clinical efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小檗碱类成分对乙酰胆碱酯酶的抑制作用及血脑屏障透过性分析

引用

中国实验方剂学杂志 2024年第9期30卷 116-124页

作者：潘福璐刘洋刘慧宁于爽李雪岩王新宇祁东盈柴晓钰王倩倩易紫容潘艳丽北京中医药大学中药学院北京102488 中国中医科学院中医药信息研究所北京100700

目的:从药靶结合亲和力和动力学角度研究非洲防己碱等小檗碱类成分对乙酰胆碱酯酶的抑制作用;并在不同多成分背景下研究这类成分的血脑屏障透过性。方法:采用Ellman改良的光度检测法测量非洲防己碱等小檗碱类成分对乙酰胆碱酯酶的半数... 详细信息

目的:从药靶结合亲和力和动力学角度研究非洲防己碱等小檗碱类成分对乙酰胆碱酯酶的抑制作用;并在不同多成分背景下研究这类成分的血脑屏障透过性。方法:采用Ellman改良的光度检测法测量非洲防己碱等小檗碱类成分对乙酰胆碱酯酶的半数抑制浓度(IC50);采用酶活恢复方法测定这类成分与乙酰胆碱酯酶结合的动力学参数(Koff);采用超高效液相色谱-高分辨率质谱法(UPLC-HRMS)对各成分在不同背景下(药材与复方)透过血脑屏障到达脑组织的定性分析。结果:非洲防己碱等小檗碱类成分对乙酰胆碱酯酶有较强的抑制活性,其IC_(50)可达到纳摩尔级,并且多个生物碱成分具有优于阳性药盐酸多奈哌齐的药靶结合动力学特征(更小的Koff,P<0.01),表明该类成分可在乙酰胆碱酯酶上持续更长时间的抑制;非洲防己碱等小檗碱类成分以单体形式、以及在黄连和黄柏药材提取物和复方黄连解毒汤的多成分背景下都可以透过血脑屏障到达脑组织。结论:非洲防己碱等小檗碱类成分对乙酰胆碱酯酶具有较强的抑制作用且在多种成分背景下均可入脑。这在药效物质基础层面上可以佐证临床上复方黄连解毒汤改善阿尔茨海默病的效果,为阐明复方黄连解毒汤的药效物质基础提供了数据支持。

关键词：非洲防己碱乙酰胆碱酯酶药靶结合亲和力血脑屏障

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：