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Large isolated fibrous tumors in the upper esophagus: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 543-549页

作者： Jia-Jia yu Huan-shuang Pei yu Meng Department of Anesthesiology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Solitary fibrous tumors(SFT)are rare spindle cell tumors that are usually benign.A total of 10 cases of SFTs in the upper esophagus have ever been ***,we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal *** also provide a literature review of the current *** SUMMARY We report the case of a 49 year old male with“cough aggravation and wheezing after exercise”,who underwent esophagectomy for a large isolated fibrous tumor compressing the tracheal membrane in the upper *** advise the use of a single-lumen tube with a blocker in patients with difficult airways to reduce the incidence of airway injury and fibrinoscopy at all stages of the perioperative period to guide airway *** case study is the first report of the anesthetic management of a large,isolated fibrous tumor compressing the tracheal membrane in the upper *** This rare case emphasizes the importance of perioperative management of anesthesia in patients with large isolated fibrous tumors of the upper esophagus that compress the tracheal *** use of blocker reduce the incidence of airway injury and fibrinoscopy at the perioperative period to guide airway mana-gement.

关键词： Upper esophagus Isolated fibrous tumor Tracheal membrane Peak airway pressure Case report

2012—2022年天津市和平区疑似预防接种异常反应监测分析

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职业与健康 2024年第12期40卷 1692-1696页

作者：于爽李思凡宋丽丽李晓静天津市和平区疾病预防控制中心计免科

目的通过分析2012—2022年天津市和平区疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征及监测系统各项指标,了解AEFI发生规律,评价天津市和平区AEFI监测敏感性,为监测工作提供指导。方法采用描述流行病... 详细信息

目的通过分析2012—2022年天津市和平区疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征及监测系统各项指标,了解AEFI发生规律,评价天津市和平区AEFI监测敏感性,为监测工作提供指导。方法采用描述流行病学方法对从中国疾病疾病预防控制信息系统AEFI报告模块导出的2012—2022年天津市和平区AEFI个案资料进行分析。结果2012—2022年和平区共报告AEFI 232例,报告发生率为28.72/10万,呈波动下降趋势;疫苗接种剂次以第一剂为主,共123例,占53.02%;男女性别比为1.23∶1;<2岁组报告数最多,其中0~<1岁组的儿童占37.07%,1~<2岁组占31.90%;第二、三季度病例数最多,分别占35.78%和28.02%。反应发生时间以接种后1天内为主,占81.47%;反应类型以一般反应为主,占80.17%;异常反应症状以各类过敏性皮疹为主,占76.92%;发生率较高疫苗为含麻类疫苗、百白破(青少年)、23价肺炎疫苗。结论天津市和平区AEFI监测系统运行良好,但监测的敏感性不足,应加强培训和督导,增强报告意识;规范排查接种禁忌,准确实施疫苗接种,强化接种后告知,严格执行接种后30 min留观制度,杜绝接种差错,减少偶合症,重点提升成人门诊的监测敏感性。

关键词：预防接种疫苗疑似预防接种异常反应监测

三种含水蛭中药制剂溶出曲线、体外抗凝活性与胃肠稳定性试验

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中国医院药学杂志 2024年第6期44卷 671-676页

作者：柴晓钰王倩倩李雪岩刘慧宁于爽王新宇刘洋北京中医药大学中药学院北京102488

目的:评估3种含水蛭中药制剂脑血康滴丸、活血通脉胶囊、脉血康胶囊体外溶出曲线、抗凝活性与胃肠稳定性。方法:采用4种p H值溶出介质和浆板法,及Lowry法测定3种含水蛭中药制剂不同时间点的水蛭多肽含量,计算溶出曲线,相似因子f_(2)评... 详细信息

目的:评估3种含水蛭中药制剂脑血康滴丸、活血通脉胶囊、脉血康胶囊体外溶出曲线、抗凝活性与胃肠稳定性。方法:采用4种p H值溶出介质和浆板法,及Lowry法测定3种含水蛭中药制剂不同时间点的水蛭多肽含量,计算溶出曲线,相似因子f_(2)评估溶出相似性;通过HPLC方法测定产物对硝基苯胺(p-nitroaniline,p NA)生成量,评估3种含水蛭中药制剂对凝血酶的抑制活性;测定3种含水蛭中药制剂与胃蛋白酶温孵之后凝血酶抑制活性的变化,以及枯草菌素、酪蛋白和脱氧胆酸钠加入后对制剂抗凝活性下降的改善。结果:在水介质中,脑血康滴丸和活血通脉胶囊的溶出行为相似(f_(2)=56.1);在其他溶出介质中,3种中药制剂溶出曲线均不相似,脑血康滴丸的溶出速度最快,且在测定时间内溶出量更多。水蛭多肽质量浓度均为10 mg·m L^(–1)时,脑血康滴丸、活血通脉胶囊、脉血康胶囊对凝血酶平均抑制率分别为97.9%、85.5%、59.4%。与胃蛋白酶温孵30 min后,脑血康滴丸、脉血康胶囊、活血通脉胶囊对凝血酶抑制活性平均保留率分别为64.2%、33.0%、10.7%。枯草菌素、酪蛋白和脱氧胆酸钠3种成分均具有阻止胃蛋白酶对活血通脉胶囊和脉血康胶囊抗凝活性影响的作用。脱氧胆酸钠、胃蛋白酶和脉血康胶囊共同温孵后,抗凝活性相较于无脱氧胆酸钠提高了4.0倍;枯草菌素、胃蛋白酶和活血通脉胶囊共同温孵后,抗凝活性提高了2.4倍。结论:本研究体外评估了3种含水蛭中药制剂的溶出曲线、抗凝活性与胃肠道稳定性,为3种中药制剂体内药效活性研究提供了数据参考。

关键词：含水蛭中药制剂溶出曲线抗凝血酶活性胃蛋白酶降解

Effects of cooling rate on vermicular graphite percentage in a brake drum produced by onestep cored wire injection

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China Foundry 2015年第5期12卷 349-353页

作者： yu-shuang Feng Ze-sheng Ji He-sheng Wu Yong-cheng Feng School of Materials Science and Engineering Harbin University of Science and Technology Harbin Kedewei Metallurgy Co. Ltd. Shandong Ductile Iron Pipes Co. Ltd.

In this research, a vermicular graphite cast iron brake drum was produced by cored wire injection in a one-step method. Silica sand and low-density alumina-silicate ceramic were used as molding materials in order to investigate the effect of cooling rate on percentage of vermicular graphite and mechanical properties of the brake drum casting. Several thermocouples were inserted into the casting in the desired positions to measure the temperature change. By means of one-step cored wire injection, the two residual concentrations of Mg and RE were effectively controlled in the ranges of 0.013%-0.017% and 0.019%-0.025%, respectively, which are crucial for the production of vermicular graphite cast iron and the formation of vermicular graphite. In addition, the cooling rate had a significant effect on the vermicular graphite percentage. In the case of the silica mold brake drum casting, there was an obvious difference in the cooling rate with the wall change, leading to a change in vermicular graphite percentage from 70.8% to 90%. In the low-density alumina-silicate ceramic mold casting, no obvious change in temperature was detected by the thermocouples and the percentage of the vermicular graphite was stable at 85%. Therefore, the vermicular graphite cast iron brake drum with a better combination of mechanical properties could be obtained.

关键词： cored wire injection in one-step vermicular graphite cast iron cooling rate vermicular graphite percentage brake drum

Novel pneumatically assisted atomization device for living cell delivery:application of sprayed mesenchymal stem cells for skin regeneration

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Bio-Design and Manufacturing 2022年第1期5卷 220-232页

作者： Lixing Zhang Xintao Yan Li An Meijia Wang Xi Xu Zhonglin Ma Mengting Nie Fangzhou Du Jingzhong Zhang shuang yu Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163China Zhengzhou Institute of Engineering and Technology Affiliated with SIBET Zhengzhou 450001China Xuzhou Medical University Xuzhou 221004China Academy for Engineering and Technology Fudan UniversityShanghai 200433China

Large cutaneous wounds pose a severe medical problem and may be deadly in cases when regeneration is ***,topical stem cell therapy has been realized as a promising strategy for wound healing and skin ***,stem cells must be administrated uniformly to the wound area,otherwise treatment will be ineffective,which has been a limitation of current administration ***,the delivery pressure and nozzle features of most clinical cell spray devices are unknown,which may significantly affect the viability of sprayed cells and their capacity for ***,we developed a novel pneumatically assisted atomization device(PAAD)in which cell suspensions were uniformly atomized at a low delivery *** optimized the applied fluidic pressure and air pressure to maximize cell survival and function for the application of multiple cell types,while ensuring uniform dispersal across the wound ***,we found that the application of sprayed umbilical cord-derived mesenchymal stem cells to wound sites significantly accelerated wound healing and promoted appendage regeneration on an excisional cutaneous wound ***,the novel PAAD system delivered living cells uniformly and maintained the viability and differentiation of sprayed cells,strongly suggesting its potential for application in clinical cell therapy,especially for large,irregular,and severe skin wounds.

关键词： Cell delivery Skin wound Wound healing Spray application Cell-spray autografting Stem cell therapy

番茄SlSUTs基因家族的生物信息学及表达分析

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齐齐哈尔大学学报（自然科学版） 2024年第1期40卷 75-80,86页

作者：王家文巩元勇闫飞赵丽华余霜攀枝花学院生物与化学工程学院四川攀枝花617000

利用生物信息学方法对番茄SUTs基因家族成员基因及蛋白质序列进行生物信息学分析,并对基因的表达特性进行研究。番茄SlSUTs基因家族共有3个成员,蛋白质的分子质量在54.15~64.99 k D之间;3个基因均匀分布在4号、5号和11号染色体上;基因... 详细信息

利用生物信息学方法对番茄SUTs基因家族成员基因及蛋白质序列进行生物信息学分析,并对基因的表达特性进行研究。番茄SlSUTs基因家族共有3个成员,蛋白质的分子质量在54.15~64.99 k D之间;3个基因均匀分布在4号、5号和11号染色体上;基因的内含子和外显子结构模式有3种,差异显著。番茄SlSUTs和拟南芥AtSUTs氨基酸都具有2种基序存在形式,且相同基序形式的基序位置存在关系一致。番茄和拟南芥SUTs蛋白的二级结构都有4种,其中α螺旋占比最多,β折叠占比最少,蛋白具有11或12个跨膜结构域,亚细胞定位都在细胞膜上。植物SUTs基因的进化关系遵循物种种属的亲缘关系,番茄SlSUTs基因与葡萄的进化关系更相近。番茄SlSUTs基因在不同组织和果实不同发育时期的表达都不相同,说明SlSUTs基因的表达具有一定的组织特异性。

关键词：番茄 SUTs基因生物信息学表达模式

秸秆长期还田对不同土层土壤微生物群落多样性及结构的影响

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中国土壤与肥料 2024年第8期 79-91页

作者：崔钰爽牛宏进王美琦陈晓波李梦璐孙世友黄亚丽河北科技大学环境科学与工程学院河北科技大学食品与生物学院河北省农林科学院农业资源环境研究所

为了探索秸秆还田对不同深度土层土壤微生物多样性及群落构成。采用可培养方法、试剂盒酶活性测定方法和高通量测序技术，以15年秸秆还田定位试验土壤为研究对象，测定秸秆还田对小麦收获期0～10、10～20和20～30 cm土层土壤微生物种群... 详细信息

为了探索秸秆还田对不同深度土层土壤微生物多样性及群落构成。采用可培养方法、试剂盒酶活性测定方法和高通量测序技术，以15年秸秆还田定位试验土壤为研究对象，测定秸秆还田对小麦收获期0～10、10～20和20～30 cm土层土壤微生物种群数量、酶活性以及细菌、真菌多样性和群落结构的影响。结果表明，长期秸秆还田增加了3个土层土壤酶活性和可培养微生物数量，0～10 cm土层的土壤脲酶、过氧化氢酶、蔗糖酶、碱性磷酸酶、纤维素酶活性以及细菌、真菌、氨化细菌、亚硝化细菌及纤维素降解菌的数量与对照差异显著（P<0.05）；且秸秆还田的土壤酶活性和微生物数量效应随土壤深度的增加而降低。长期秸秆还田显著增加了10～20 cm土层的细菌ACE指数、Chao1指数、Shannon指数等α多样性指数（P<0.05），改变了各土层土壤的细菌和真菌β多样性。另外，长期秸秆还田还改变了细菌和真菌的群落结构，且对细菌群落结构影响较大，0～10 cm土层中酸杆菌门（Acidobacteria）、变形菌门（Proteobacteria）、浮霉菌门（Planctomycetes）和Latescibacteria均显著增加（P<0.05）。随着土壤深度的加深，细菌群落结构差异性越来越小。另外，秸秆还田能够使细菌群落间的相互作用连接更加紧密，但会降低真菌群落的稳定性。综上所述，长期秸秆还田对土壤酶活性、可培养微生物数量及细菌群落结构和多样性具有明显正向效应，且对土壤中细菌的积极影响更大。

关键词：长期秸秆还田土壤酶活性微生物数量微生物群落结构

Elevational and temporal patterns of pollination success in distylous and homostylous buckwheats(Fagopyrum)in the Hengduan Mountains

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Plant Diversity 2024年第5期46卷 661-670页

作者： Ling-yun Wu shuang-Quan Huang Ze-yu Tong Faculty of Resources and Environmental Science Hubei UniversityWuhan 430062China Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China

Reproductive strategies of sexually dimorphic plants vary in response to the ***,we ask whether the sexual systems of Fagopyrum species(i.e.,selfing homostylous and out-crossing distylous)represent distinct adaptive strategies to increase reproductive success in changing alpine *** answer this question,we determined how spatial and temporal factors(e.g.,elevation and peak flowering time)affect reproductive success(i.e.,stigmatic pollen load)in nine wild Fagopyrum species(seven distylous and two homostylous)among 28 populations along an elevation gradient of 1299-3315 m in the Hengduan Mountains,southwestern *** also observed pollinators and conducted hundreds of hand pollinations to investigate inter/intra-morph compatibility,self-compatibility and pollen limitation in four Fagopyrum species(two distylous and two homostylous).We found that Fagopyrum species at higher elevation generally had bigger flowers and more stigmatic pollen loads;lateflowering individuals had smaller flowers and lower pollen *** pollen deposition was more variable in distylous species than in homostylous *** seed set was not pollenlimited in all species,we found that fruit set was much lower in distylous species,which rely on frequent pollinator visits,than in homostylous species capable of autonomous *** findings that pollination success increases at high elevations and decreases during the flowering season suggest that distylous and homostylous species have spatially and temporally distinct reproductive strategies related to environment-dependent pollinator activity.

关键词： Biodiversity hotspot Elevation gradient Fagopyrum Stigmatic pollen load Temporal pattern

Electron engineering of nickel phosphide for Ni^(δ+) in electrochemical nitrate reduction to ammonia

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Nano Research 2024年第6期17卷 4864-4871页

作者： Jie Hu Hao Huang Miao yu shuang Wang Jinping Li College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China School of Sustainable Energy Materials and Science Jinhua Advanced Research InstituteJinhua 321000China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

The electrochemical reduction of nitrate to ammonia(ENRA)provides an efficient approach to remove nitrate pollution and achieve ammonia production ***,inspired by bio-enzyme in denitrifying bacteria,a carbon-coated nickel phosphide(NiPC)nanosheet derived from metal-organic frameworks(MOFs)is proposed as an efficient catalyst for *** electron engineering,controllable Ni^(δ+)in nickel phosphide is achieved by regulating the degree of phosphating,which enhances its activity for the hydrogenation of *** the result,Niδ+becomes one of dominating factors determining the efficiency of the ENRA reaction in nickel *** optimal NiPC catalyst exhibits impressive property toward ENRA:NH_(4)^(+)Faraday efficiency of 96.68%,NH4+selectivity of 99.04%,and nitrate conversion rate of 90.43%under low nitrate concentration(200 mg·L^(−1)).This work opens a new avenue for the design of next-generation catalysts through electron engineering for ENRA.

关键词： electron engineering transition metal phosphide nitrate reduction ammonia production metal-organic frameworks