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Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2019年第41期25卷 6248-6257页

作者： shuai-shuai xu Hua-Xiang xu Wen-Quan Wang Shuo Li Hao Li Tian-Jiao Li Wu-Hu Zhang Liang Liu Xian-Jun Yu Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 20032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China

BACKGROUND Platelets have been reported to participate in tumor cell growth,extravasation,epithelial–mesenchymal transition,metastasis,and drug ***,the importance of platelets in pancreatic neuroendocrine tumor(pNET)lacks adequate literature *** predictive value of tumor-infiltrating platelets(TIPs)in pNET remains *** To investigate the relationship between TIPs and the prognosis of patients with pNET following radical *** In total,113 patients who had undergone radical surgical resection with a pathologic diagnosis of pNET were enrolled in this *** analysis of cluster of differentiation 42b(CD42b)expression in the tumor specimens was performed to determine the presence of *** and multivariate analyses were used to analyze the prognostic value of *** TIPs were observed in intratumoral areas in 54 *** basic characteristics nor preoperative platelet-associated indicators showed a significant relationship with the presence of TIPs(all P>0.05).Patients with positive intratumoral CD42b expression had worse overall survival(P=0.005)and recurrence-free survival(P0.05).CONCLUSION TIPs are a useful prognostic biomarker for patients with resectable pNET,and their detection represents a promising tool for pNET treatment strategy decisions.

关键词： Tumor-infiltrating platelets Pancreatic neuroendocrine tumor Survival Recurrence Platelet count Mean platelet volume Platelet-to-lymphocyte ratio

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Haemoglobin,albumin,lymphocyte and platelet predicts postoperative survival in pancreatic cancer

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World Journal of Gastroenterology 2020年第8期26卷 828-838页

作者： shuai-shuai xu Shuo Li Hua-Xiang xu Hao Li Chun-Tao Wu Wen-Quan Wang He-Li Gao Wang Jiang Wu-Hu Zhang Tian-Jiao Li Quan-Xing Ni Liang Liu Xian-Jun Yu Department of Pancreatic Surgery Fudan UniversityShanghai Cancer CenterShanghai 20032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

BACKGROUND Systemic inflammation and nutrition status play an important role in cancer *** combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP),consisting of haemoglobin,albumin,lymphocytes,and platelets,is considered as a novel marker to reflect both systemic inflammation and nutrition ***,no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical *** To evaluate the prognostic value of preoperative HALP in pancreatic cancer *** The preoperative serum levels of hemoglobin,albumin,lymphocyte counts,and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical *** relationship between postoperative survival and the preoperative level of HALP was *** Low levels of HALP were significantly associated with lymph node metastasis(P=0.002),poor tumor differentiation(P=0.032),high TNM stage(P=0.008),female patients(P=0.005)and tumor location in the head of the pancreas(P<0.001).Low levels of HALP were associated with early recurrence[7.3 mo vs 16.3 mo,P<0.001 for recurrence-free survival(RFS)]and short survival[11.5 mo vs 23.6 mo,P<0.001 for overall survival(OS)]in patients with resected pancreatic adenocarcinoma.A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor *** Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer.

关键词： Pancreatic adenocarcinoma HALP Systemic inflammation Nutrition status Postoperative survival

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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong xu Shoumin xuan shuai Chen Dan Liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong Gao shuai Hou Shanshan xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

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基于最优化线性波数光谱仪的谱域光学相干层析成像系统

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物理学报 2018年第10期67卷 91-98页

作者：吴彤孙帅帅王绪晖王吉明赫崇君顾晓蓉刘友文南京航空航天大学理学院应用物理系南京210016

相比传统光谱仪,基于线性波数光谱仪的谱域光学相干层析(OCT)无需对非线性波数干涉光谱数据进行重采样和插值,可大大减少数据计算量并提高成像灵敏度.通过模拟计算干涉光谱信号和点扩散函数,以点扩散函数半峰全宽值的倒数作为评价准则,... 详细信息

相比传统光谱仪,基于线性波数光谱仪的谱域光学相干层析(OCT)无需对非线性波数干涉光谱数据进行重采样和插值,可大大减少数据计算量并提高成像灵敏度.通过模拟计算干涉光谱信号和点扩散函数,以点扩散函数半峰全宽值的倒数作为评价准则,可以优化包括色散棱镜材料的折射率、顶角角度以及衍射光栅和色散棱镜之间旋转角角度的线性波数光谱仪的结构参数.根据优化结果,实验中选用F2玻璃等边色散棱镜,以光栅-棱镜间旋转角角度为21.8°搭建了最优化线性波数光谱仪,并引入谱域OCT成像系统.实验测得成像系统的轴向分辨率达到8.52μm,灵敏度达到91 dB,6 dB成像深度达到1.2 mm.结合具有通用并行计算能力的图形处理卡,在无需重采样和插值的情况下可实时处理和显示人手指指甲皮肤接缝处的横断面OCT图像,验证了基于最优化线性波数光谱仪的谱域OCT系统的成像性能.

关键词：线性波数光谱仪优化轴向分辨率灵敏度

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： shuai xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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On Sampled-Data PI Control for Nonlinear Systems

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Journal of Systems Science & Complexity 2024年第6期37卷 2511-2529页

作者： xu shuai LI Chanying Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

This paper studies sampled-data proportional-integral(PI)control for a basic class of nonlinear uncertain *** authors claim that a process with the first-order dynamics can achieve zero steady-state error through a sa... 详细信息

关键词： Nonlinear systems sampled-data PI control setpoint tracking uncertainties zero steadystate error

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Steel scrap melting model for a dephosphorisation basic oxygen furnace

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Journal of Iron and Steel Research International 2020年第8期27卷 972-980页

作者： shuai Deng An-jun xu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Dephosphorisation basic oxygen furnaces (deP-BOFs) greatly differ from conventional BOFs in the melting process, especially its many limits on adding scrap. A mathematical model of the steel scrap melting process was established in MATLAB to investigate the mechanism of scrap melting in deP-BOF in terms of coupling effects of the carbon content of the molten steel, temperature, scrap preheating and converter blowing time on the melting rate and size of the steel scraps. The scrap melting rate was influenced by both the heat and mass transfer during the melting process: at 1350℃, when the carbon content was increased from 4.5 to 5.0 mass%, the scrap melting rate increased by 43%;for the carbon content of 4.5 mass%, when the temperature was increased from 1350 to 1400℃, the scrap melting rate increased by 60%. The carbonisation was found to be the restrictive step of the scrap melting process in deP-BOFs with respect to conventional ones. The scrap heating from room temperature to 800℃ reduced the crusting thickness on the scrap surface but there was no obvious influence on the melting rate. The scrap melting size in the deP-BOF was rather limited by its low melting rate and short melting time.

关键词： Scrap Melting Dephosphorisation basic oxygen furnace Mathematical model Heat transfer Mass transfer

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Robust detection algorithm with triple constraints for cooperative target based on spectral residual

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Journal of Systems Engineering and Electronics 2017年第4期28卷 654-660页

作者： shuai Hao Yongmei Cheng xu Ma School of Electrical and Control Engineering Xi'an University of Science and Technology College of Automation Northwestern Polytechnical University

The accurate detection of cooperative targets plays a key and foundational role in unmanned aerial vehicle (UAV) landing autonomously. The standard method based on fixed threshold is too susceptible to both illumination variations and interference. To overcome issues above, a robust detection algorithm with triple constraints for cooperative targets based on spectral residual (TCSR) is proposed. Firstly, by designing an asymmetric cooperative target, which comprises red background, green H and triangle target, the captured original image is converted into a Lab color space, whose saliency map is yielded by constructing the spectral residual. Then, the triple constraints are developed according to the prior knowledge of the cooperative target. Finally, the salient region in saliency map is considered as the cooperative target, and it meets the triple constraints. Experimental results in complex environments show that the proposed TCSR outperforms the standard methods in higher detection accuracy and lower false alarm rate.

关键词： saliency detection cooperative target spectral residual triple constraints

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Sex Differences in Electrophysiological Properties of Mouse Medial Preoptic Area Neurons Revealed by In Vitro Whole-cell Recordings

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Neuroscience Bulletin 2021年第2期37卷 166-182页

作者： Wen Zhang shuai-shuai Li Ying Han Xiao-Hong xu Institute of Neuroscience State Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 200031China

Despite extensive characterization of sex differences in the medial preoptic area(mPOA)of the hypothalamus,we know surprisingly little about whether or how male and female mPOA neurons differ electrophysiologically,especially in terms of neuronal firing and behavioral pattern *** this study,by performing whole-cell patch clamp recordings of the mPOA,we investigated the influences of sex,cell type,and gonadal hormones on the electrophysiological properties of mPOA ***,we uncovered significant sex differences in input resistance(male>female)and in the percentage of neurons that displayed post-inhibitory rebound(male>female).Furthermore,we found that the current mediated by the T-type Ca^(2+)channel(IT),which is known to underlie post-inhibitory rebound,was indeed larger in male mPOA ***,we have identified salient electrophysiological properties of mPOA neurons,namely IT and post-inhibitory rebound,that are male-biased and likely contribute to the sexually dimorphic display of behaviors.

关键词： Electrophysiological properties Sex differences mPOA Post-inhibitory rebound T-type calcium channels

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