Sex Differences in Electrophysiological Properties of Mouse Medial Preoptic Area Neurons Revealed by In Vitro Whole-cell Recordings

作     者：Wen Zhang Shuai-shuai Li Ying Han Xiao-Hong Xu Wen Zhang;Shuai-shuai Li;Ying Han;Xiao-Hong Xu

作者机构：Institute of NeuroscienceState Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyShanghai 200031China University of the Chinese Academy of SciencesBeijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence TechnologyShanghai 200031China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第2期

页      面：166-182页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：This work was supported by Grants from the National Natural Science Foundation of China(31871066,31922028 and 31900721) Shanghai Municipal Science and Technology Major Project(2018SHZDZX05) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32000000) 

主　　题：Electrophysiological properties Sex differences mPOA Post-inhibitory rebound T-type calcium channels 

摘      要：Despite extensive characterization of sex differences in the medial preoptic area(mPOA)of the hypothalamus,we know surprisingly little about whether or how male and female mPOA neurons differ electrophysiologically,especially in terms of neuronal firing and behavioral pattern *** this study,by performing whole-cell patch clamp recordings of the mPOA,we investigated the influences of sex,cell type,and gonadal hormones on the electrophysiological properties of mPOA ***,we uncovered significant sex differences in input resistance(malefemale)and in the percentage of neurons that displayed post-inhibitory rebound(malefemale).Furthermore,we found that the current mediated by the T-type Ca^(2+)channel(IT),which is known to underlie post-inhibitory rebound,was indeed larger in male mPOA ***,we have identified salient electrophysiological properties of mPOA neurons,namely IT and post-inhibitory rebound,that are male-biased and likely contribute to the sexually dimorphic display of behaviors.