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Neuroscience Bulletin 2021年第2期37卷 166-182页

作者： Wen Zhang Shuai-shuai Li Ying Han Xiao-Hong Xu Institute of Neuroscience State Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 200031China

Despite extensive characterization of sex differences in the medial preoptic area(mpoa)of the hypothalamus,we know surprisingly little about whether or how male and female mpoa neurons differ electrophysiologically,especially in terms of neuronal firing and behavioral pattern generation.In this study,by performing whole-cell patch clamp recordings of the mpoa,we investigated the influences of sex,cell type,and gonadal hormones on the electrophysiological properties of mpoa neurons.Notably,we uncovered significant sex differences in input resistance(male>female)and in the percentage of neurons that displayed post-inhibitory rebound(male>female).Furthermore,we found that the current mediated by the T-type Ca^(2+)channel(IT),which is known to underlie post-inhibitory rebound,was indeed larger in male mpoa neurons.Thus,we have identified salient electrophysiological properties of mpoa neurons,namely IT and post-inhibitory rebound,that are male-biased and likely contribute to the sexually dimorphic display of behaviors.

关键词： Electrophysiological properties Sex differences mpoa Post-inhibitory rebound T-type calcium channels

The medial preoptic area and the regulation of parental behavior

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Neuroscience Bulletin 2014年第5期30卷 863-865页

作者： Kumi O.Kuroda Michael Numan Research Unit for Affiliative Social Behavior RIKEN Brain Science Institute Rio Rancho

The preoptic area （POA） is located in the most anterior part of the hypothalamus and is bordered dorsally by the anterior commissure and anteroventrally by the nucleus of the diagonal band of Broca[1]. Accumulating evidence from developmental neurobiology suggests, however, that the POA may be a separate entity from hypothalamus, and may actually be part of the basal telencephalon[2,3]. Both the hypothalamus and POA are highly complex and heterogeneous areas, containing multiple nuclei, each of which has specific fundamental functions for survival. Among these, the POA contains nuclei involved in the regulation of blood osmolality and temperature （the median preoptic nucleus）, sleep （the ventrolateral preoptic and suprachiasmatic nuclei）, ovulation （gonadotropin-releasing hormone neurons scattered mainly in the ventral part of the POA）, male sexual behavior （the medial preoptic nucleus）, and parental behavior （the central part of the medial POA, cmpoa）.

关键词： mpoa The medial preoptic area and the regulation of parental behavior area

Medial Preoptic Area Modulates Courtship Ultrasonic Vocalization in Adult Male Mice

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Neuroscience Bulletin 2019年第4期35卷 697-708页

作者： Shu-Chen Gao Yi-Chao Wei Shao-Ran Wang Xiao-Hong Xu Institute of Neuroscience State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China University of the Chinese Academy of Sciences Beijing 100049 China

Adult male mice emit highly complex ultrasonic vocalizations(USVs)in response to female conspecifics.Such US Vs,thought to facilitate courtship behaviors,are routinely measured as a behavioral index in mouse models of neurodevelopmental and psychiatric disorders such as autism.While the regulation of US Vs by genetic factors has been extensively characterized,the neural mechanisms that control USV production remain largely unknown.Here,we report that optogenetic activation of the medial preoptic area(mpoa)elicited the production of USVs that were acoustically similar to courtship US Vs in adult mice.Moreover,mpoa vesicular GABA transporter-positive(Vgat +)neurons were more effective at driving USV production than vesicular glutamate transporter 2-positive neurons.Furthermore,ablation of mpoa Vgat+ neurons resulted in altered spectral features and syllable usage of USVs in targeted males.Together,these results demonstrate that the mpoa plays a crucial role in modulating courtship USVs and this may serve as an entry point for future dissection of the neural circuitry underlying USV production.

关键词： mpoa Optogenetics Vgat Vglut2 Ultrasonic vocalization Courtship

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mpoa及其性能的仿真研究

华中理工大学学报 1999年第5期27卷 29-31页

作者：傅永魁赵信杨宗凯徐晓东华中理工大学电子与信息工程系华中地区网络中心

描述了ＭＰＯＡ的基本原理，用软件的方法对其进行仿真，说明ＭＰＯＡ可提高网络的性能．讨论了仿真中的包失序现象，简要分析了它对性能的影响．

关键词： mpoa ATM NHRP 仿真局域网

ATM上的多重协议一对mpoa的分析与探讨

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计算机工程与设计 1997年第5期18卷 21-27页

作者：栾达李星艺郑建兵复旦大学计算机科学系

ＡＴＭ技术正应用于高速网际互连之中，以其不同于传统路由器的特点而逐步显示出其优越特性。文中介绍了ＡＴＭ上的多重协议－ＭＰＯＡ的３种模型详细分析了它们的路由特点、信息格式、基本操作等内容。讨论了它们各自的优缺点及解决措施。

关键词： ATM 多重协议 mpoa 计算机网络

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mpoa在ATM网络中的应用

电讯技术 1999年第4期39卷 55-58页

作者：叶吉祥蒋加伏胡小兵长沙交通学院计算机系长沙电力学院

本文通过对ＭＰＯＡ优势的讨论，提出了一些建立ＡＴＭ网络时应考虑的问题，应用ＭＰＯＡ和捷径解决诸如网络安全性，虚拟网络，用户的动态配置等传统问题，特别是解决传统路由器瓶颈。

关键词： ATM网络广域网安全性 mpoa

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ATM 主干网环境下的局域网互连技术

上海交通大学学报 1998年第6期32卷 140-144页

作者：黄海明诸鸿文顾尚杰上海交通大学电子工程系

通过对现有的三类在ＡＴＭ主干网络环境中局域网互连的技术——局域网仿真、ＩＰＯｖｅｒＡＴＭ和ＭＰＯＡ进行分析和比较，给出了它们在具体应用上的特点，由此给出第三层交换技术的实现原理．通过对现有产品技术的比较，指出了第三层... 详细信息

通过对现有的三类在ＡＴＭ主干网络环境中局域网互连的技术——局域网仿真、ＩＰＯｖｅｒＡＴＭ和ＭＰＯＡ进行分析和比较，给出了它们在具体应用上的特点，由此给出第三层交换技术的实现原理．通过对现有产品技术的比较，指出了第三层交换技术的关键．由于路由器在高速网络环境下的瓶颈效应十分明显，因此在ＡＴＭ网络环境下应尽量避免使用．ＭＰＯＡ将路由功能从传统的路由器中分类出来，独立用硬件进行实现，从而大大减少了由此引起的性能下降．目前，第三层交换技术采用了同样的技术路线，用于提高网络的整体性能．

关键词：局域网仿真 mpoa ATM网互连