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Acta Mechanica Sinica 2011年第5期27卷 730-737页

作者： Zhe-Qi Lin Hae Chang Gea shu-tian liu Department of Engineering Mechanics Dalian University of Technology116024 Dalian China Department of Mechanical and Aerospace Engineering Rutgers The State University of New JerseyPiscataway NJ 08854 USA

Converting ambient vibration energy into electrical energy by using piezoelectric energy harvester has attracted a lot of interest in the past few *** this paper,a topology optimization based method is applied to simultaneously determine the optimal layout of the piezoelectric energy harvesting devices and the optimal position of the mass *** objective function is to maximize the energy harvesting performance over a range of vibration *** excitation method （PEM） is adopted to analyze structural stationary random responses,and sensitivity analysis is then performed by using the adjoint *** examples are presented to demonstrate the validity of the proposed approach.

关键词： Topology optimization · Energy harvesting · Piezoelectric material ··

Design optimization of the S-frame to improve crashworthiness

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Acta Mechanica Sinica 2014年第4期30卷 589-599页

作者： shu-tian liu Ze-Qi Tong Zhi-Liang Tang Zong-Hua Zhang State Key Laboratory of Structure Analysis for Industrial Equipment Dalian University of Technology

In this paper, the S-frames, the front side rail structures of automobile, were investigated for crashworthihess. Various cross-sections including regular polygon, nonconvex polygon and multi-cell with inner stiffener sections were investigated in terms of energy absorption of S-frames. It was determined through extensive numerical simulation that a multi-celI S-frame with double vertical internal stiffeners can absorb more energy than the other configurations. Shape optimization was also carried out to improve energy absorption of the S-frame with a rectangular section. The center composite design of experiment and the sequential response surface method （SRSM） were adopted to construct the approximate design sub-problem, which was then solved by the feasible direction method. An innovative double S- frame was obtained from the optimal result. The optimum configuration of the S-frame was crushed numerically and more plastic hinges as well as shear zones were observed during the crush process. The energy absorption efficiency of the structure with the optimal configuration was improved compared to the initial configuration.

关键词： Thin-walled structure S-frame Axial crush Response surface Crashworthiness

Right- and left-sided colorectal cancersrespond differently to cetuximab

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Chinese Journal of Cancer 2015年第9期34卷 36-45页

作者： Feng Wang Long Bai tian-shu liu Department of Medical Oncology Sun Yat-sen University Cancer Center: State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Zhongshan Hospital Fudan University

Introduction Right-sided colon cancer （RSCC） and left-sided colorectal cancer （LSCRC） differ with respect to theirbiology and genomic patterns. This study aimed to examine whether the primary tumor location is associated withthe response to cetuximab in patients with metastatic colorectal cancer （mCRC）.Methods： Patients with mCRC treated with cetuximab and standard chemotherapy as first- or second-line treatmentswere compared with randomly chosen patients who were treated with chemotherapy alone between 2005 and *** main outcome measures were the overall response rate （ORR）, progression-free survival （PFS）, and overall survival （OS）.The differences in the outcome were analyzed by using the chi-squared test, Student＇s t test, and Kaplan-Meier ***： The treatment results of 206 patients with mCRC treated with cetuximab and standard chemotherapy asfirst- or second-line treatments were compared with those of 210 patients who were treated with chemotherapyalone. As a first-line treatment, cetuximab with chemotherapy was associated with a significantly higher ORR（49.4 % vs. 28.6 %, P = 0.005） as well as longer PFS （9.1 vs. 6.2 months, P = 0.002） and OS （28.9 vs. 20.1 months,P = 0.036） than chemotherapy alone in patients with LSCRC. However, cetuximab neither improved the ORR（36.4 % vs. 26.2 %, P = 0.349） nor prolonged PFS （5.6 vs. 5.7 months, P = 0.904） or OS （25.1 vs. 19.8 months, P = 0.553） inpatients with RSCC. As a second-line treatment, cetuximab exhibited a tendency to improve the ORR （23.5 % vs. 10.2 %,P = 0.087） and prolong PFS （4.9 vs. 3.5 months, P = 0.064）, and it significantly prolonged OS （17.1 vs. 12.4 months,P = 0.047） compared with chemotherapy alone in the patients with LSCRC. In contrast, as a second-line treatment,cetuximab neither improved the ORR （7.1 % vs. 11.4 %, P = 0.698） nor prolonged PFS （3.3 vs. 4.2 months, P = 0.761） orOS （13.4 vs. 13.0 months, P=0.652） in patients with ***： The addition of cetuximab to chemotherapy

关键词： Colorectal neoplasms, Cetuximab, Left-sided, Right-sided, Chemotherapy

Propagation factor of electromagnetic concentric rings Schell-model beams in non-Kolmogorov turbulence

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Chinese Physics B 2017年第2期26卷 206-212页

作者： Zhen-Zhen Song Zheng-Jun liu Ke-Ya Zhou Qiong-Ge Sun shu-tian liu Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Automatic Test and Control Harbin Institute of Technology Harbin 150001 China Beijing Institute of Space Mechanics and Electricity Beijing 100094 China

We derive an analytical expression for the propagation factor（known as M2-factor） of electromagnetic concentric rings Schell-model（EM CRSM） beams in non-Kolmogorov turbulence by utilizing the extended Huygens–Fresnel diffraction integral formula and the second-order moments of the Wigner distribution function（WDF）. Our results show that the EM CRSM beam has advantage over the scalar CRSM beam for reducing the turbulence-induced degradation under suitable conditions. The EM CRSM beam with multi-rings far-fields in free space is less affected by the turbulence than the one with dark-hollow far-fields or the electromagnetic Gaussian Schell-model（EGSM） beam. The dependence of the M2-factor on the beam parameters and the turbulence are investigated in detail.

关键词： atmospheric propagation partial coherence atmospheric turbulence

Application of nanoparticles in cast steel:An overview

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China Foundry 2020年第2期17卷 111-126页

作者： Feng Qiu tian-shu liu Xin Zhang Fang Chang Shi-li shu Hong-yu Yang Qing-long Zhao Qi-chuan Jiang Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China

The innovative and environmentally friendly methodologies for comprehensively enhancing the performances of high-strength steels without damage to plasticity,toughness and heat/corrosion/fatigue resistance are being *** recent years,nanoparticles elevate the field of high-strength *** is proposed that nanoparticles have the potential to replace conventional semi-coherent intermetallic compounds,carbides and alloying to optimize the *** fabrication process is simplified and the cost is lower compared with the traditional *** research effort has been directed towards high-performance cast steels reinforced with nanoparticles due to potential application in major *** are found to be capable of notably optimizing the nucleation behavior and precipitate *** prominently optimized microstructure configuration and performances of cast steel can be acquired *** this review,the lattice matching and valence electron criterion between diverse nanoparticles and steel are summarized,and the existing various preparation methods are compared and *** present,there are four main methods to introduce nanoparticles into steel:external nanoparticle method,internal nanoparticle method,in-situ reaction method,and additive manufacturing *** four methods have their own advantages and limitations,*** this review,the synthesis,selection principle and strengthening mechanism of nanoparticles in cast steels for the above four methods are discussed in ***,the main preparation methods and microstructure manipulation mechanism of the steel reinforced with different nanoparticles have been systematically ***,the development and future potential research directions of the application of nanoparticles in cast steel are prospected.

关键词： nanoparticles high-performance steel strengthening mechanism preparation method microstructure manipulation mechanism

Review on laser directed energy deposited aluminum alloys

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International Journal of Extreme Manufacturing 2024年第2期6卷 84-131页

作者： tian-shu liu Peng Chen Feng Qiu Hong-Yu Yang Nicholas Tan Yew Jin Youxiang Chew Di Wang Ruidi Li Qi-Chuan Jiang Chaolin Tan Singapore Institute of Manufacturing Technology(SIMTech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025People’s Republic of China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025People’s Republic of China School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Lightweight aluminum(Al)alloys have been widely used in frontier fields like aerospace and automotive industries,which attracts great interest in additive manufacturing(AM)to process high-value Al *** a mainstream AM technique,laser-directed energy deposition(LDED)shows good scalability to meet the requirements for large-format component manufacturing and ***,LDED Al alloys are highly challenging due to their inherent poor printability(*** laser absorption,high oxidation sensitivity and cracking tendency).To further promote the development of LDED high-performance Al alloys,this review offers a deep understanding of the challenges and strategies to improve printability in LDED Al *** porosity,cracking,distortion,inclusions,element evaporation and resultant inferior mechanical properties(worse than laser powder bed fusion)are the key challenges in LDED Al *** parameter optimizations,in-situ alloy design,reinforcing particle addition and field assistance are the efficient approaches to improving the printability and performance of LDED Al *** underlying correlations between processes,alloy innovation,characteristic microstructures,and achievable performances in LDED Al alloys are *** benchmark mechanical properties and primary strengthening mechanism of LDED Al alloys are *** review aims to provide a critical and in-depth evaluation of current progress in LDED Al *** opportunities and perspectives in LDED high-performance Al alloys are also outlined.

关键词： additive manufacturing laser directed energy deposition(LDED) aluminum alloys printability aluminum matrix composite auxiliary fields mechanical properties

Neoadjuvant chemotherapy for advanced gastric cancer:A meta-analysis

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World Journal of Gastroenterology 2010年第44期16卷 5621-5628页

作者： Wei Li tian-shu liu Jing Qin Yi-Hong Sun Department of Medical Oncology Shanghai Zhongshan Hospital Fudan University Shanghai 200032 China Department of General Surgery ShanghaiZhongshan HospitalFudan UniversityShanghai 200032China

AIM:To study the value of neoadjuvant chemotherapy (NAC) for advanced gastric cancer by performing a meta-analysis of the published ***:All published controlled trials of NAC for advanced gastric cancer vs no therapy before surgery were *** that included patients with metastases at enrollment were *** included Cochrane Library of Clinical Comparative Trials,MEDLINE,Embase,and American Society of Clinical Oncology meeting abstracts from 1978 to *** censor date was up to April *** outcome was the odds ratio (OR) for improving overall survival rate of patients with advanced gastric *** outcome was the OR for down-staging tumor and increasing R0 resection in patients with advanced gastric *** analyses were also *** calculations and statistical tests were performed using RevMan 5.0 *** cancer enrolled in 14 trials were divided into NAC group (n=1054) and control group (n=1217).The patients were followed up for a median time of 54 *** significantly improved the survival rate [OR=1.27,95% confidence interval (CI):1.04-1.55],tumor stage (OR=1.71,95% CI:1.26-2.33) and R0 resection rate (OR=1.51,95% CI:1.19-1.91) of patients with advanced gastric *** obvious safety concerns were raised in these ***:NAC can improve tumor stage and survival rate of patients with advanced gastric cancer with a rather good safety.

关键词： Gastric cancer Neoadjuvant chemotherapy Survival Meta-analysis

Stereotactic body radiotherapy combined with sintilimab in patients with recurrent or oligometastatic hepatocellular carcinoma: A phase Ⅱ clinical trial

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World Journal of Gastroenterology 2023年第24期29卷 3871-3882页

作者： Yi-Xing Chen Ping Yang Shi-Suo Du Yuan Zhuang Cheng Huang Yong Hu Wen-Chao Zhu Yi-Yi Yu tian-shu liu Zhao-Chong Zeng Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Stereotactic body radiotherapy(SBRT)and programmed cell death 1 inhibitors have shown potential in treating hepatocellular carcinoma(HCC)in retrospective *** To evaluate the efficacy of combining SBRT with sintilimab for patients with recurrent or oligometastatic *** This trial involved patients with recurrent or oligometastatic HCC intravenously treated with SBRT plus sintilimab every 3 wk for 12 mo or until disease *** primary endpoint was progression-free survival(PFS).RESULTS Twenty-five patients were enrolled from August 14,2019,to August 23,*** median treatment duration was 10.2(range,0.7-14.6)*** was delivered at a median dose of 54(range,48-60)Gy in 6(range,6-10)*** median follow-up time was 21.9(range,10.3-39.7)mo,and 32 targeted lesions among 25 patients were evaluated for treatment response according to the Response Evaluation Criteria in Solid Tumors version *** median PFS was 19.7 mo[95%confidence interval(CI):16.9-NA],with PFS rates of 68%(95%CI:52-89)and 45.3%(95%CI:28-73.4)at 12 and 24 mo,*** median overall survival(OS)was not reached,with OS rates of 91.5%(95%CI:80.8-100.0)and 83.2%(95%CI:66.5-100.0)at 12 and 24 mo,*** 1-and 2-year local control rate were 100%and 90.9%(95%CI:75.4%-100.0%),*** confirmed objective response rate and disease control rate was 96%,and 96%,*** adverse events were graded as 1 or 2,and grade 3 adverse events were observed in three *** SBRT plus sintilimab is an effective,well-tolerated treatment regimen for patients with recurrent or oligometastatic HCC.

关键词： Stereotactic body radiotherapy Programmed cell death 1 Sintilimab Hepatocellular carcinoma Efficacy and safety

Isobaric tags for relative and absolute quantitation-based quantitative proteomic analysis of X-linked inhibitor of apoptosis and H2AX in etoposide-induced renal cell carcinoma apoptosis

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Chinese Medical Journal 2019年第24期132卷 2941-2949页

作者： tian-shu liu Chao Chen Biao Zhou Bo-Wen Xia Zong-Ping Chen Yong Yan Department of Urology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Vascular Surgery People's Hospital of Peking UniversityBeijing 100044China Department of Urology The Affiliated Hospital of Zunyi Medical CollegeZunyiGuizhou 563000China

Background:X-linked inhibitor of apoptosis(XIAP)is a vital factor in the anti-apoptosis mechanism of tumors and is highly expressed in renal cell carcinoma(RCC).However,the mechanism through which XIAP regulates DNA damage repair is *** study investigated the regulatory mechanism of XIAP in etoposide-induced apoptosis in two Caki-1 cell lines with high or low XIAP ***:The two cell lines were established using RNA interference *** differentially expressed proteins in the two cell lines were globally analyzed through an isobaric tags for relative and absolute quantitation-based quantitative proteomics *** analysis revealed 255,375,362,and 5 differentially expressed proteins after 0,0.5,3,and 12 h of drug stimulation,respectively,between the two cell *** identified differentially expressed proteins were involved in numerous biological *** addition,the expression of histone proteins(H1.4,H2AX,H3.1,H3.2,and H3.3)was drastically altered,and the effects of XIAP silencing were accompanied by the marked downregulation of ***-protein interactions were assessed and confirmed through immunofluorescence and Western blot ***:The results suggested that XIAP may act as a vital cell signal regulator that regulates the expression of DNA repair-related proteins,such as H2AX,and influences the DNA repair ***:Given these functions,XIAP may be the decisive factor in determining the sensitivity of RCC cell apoptosis induction in response to chemotherapeutic agents.

关键词： Apoptosis H2AX iTRAQ Renal cell carcinoma X-linked inhibitor of apoptosis

Excitation of anti-symmetric coupled spoof SPPs in 3D SIS waveguides based on coupling

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Chinese Physics B 2016年第7期25卷 538-541页

作者：田莉莉陈杨刘建龙郭凯周可雅高扬刘树田 Department of Physics Harbin Institute of Technology Harbin 150001 China School of Electrical Enginnering & Information Northeast Petroleum University Daqing 163318 China College of Electronic Engineering Heilongjiang University Harbin 150080 China

According to the electromagnetic field distributions, there exist two kinds of coupled spoof surface plasmon polaritons（SSPPs）, the symmetric and anti-symmetric modes, in the three-dimensional（3D） subwavelength spoof–insulator–spoof（SIS） waveguide. We study the dispersion and excitation of the two kinds of coupled SSPPs supported by the 3D SIS waveguide. The evolution of the dispersion with the thickness and gap width of the waveguide is numerically investigated,and we give a theoretical analysis according to the coupling mechanism. Specially, based on the coupling mechanism,we design a zipper structure, through which the excitation and propagation of the anti-symmetric coupled modes can be realized effectively.

关键词： waveguides surface plasmons microwave technology