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Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

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World Journal of Gastroenterology 2013年第17期19卷 2638-2649页

作者： Lian-Zhen Yu Hai-yang Wang shu-ping yang Zhi-ping Yuan Fang-Yuan Xu Chao Sun Rui-Hua Shi Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University Department of Internal Medicine Affiliated Mingde Hospital of Nanjing Medical University

AIM:To investigate the expression of interleukin (IL)-22 and its related proteins in biopsy specimens from patients with ulcerative colitis (UC) and UC-related carcinogenesis. METHODS:Biopsy specimens were obtained from patients with inactive (n = 10), mild-to-moderately active (n = 30), severely active (n = 34), initial (n = 30), and chronic UC (n = 44), as well as UC patients with dysplasia (n = 10). Specimens from patients without colonic abnormalities (n = 20) served as controls. Chronic colitis in experimental mice was induced by 2.5% dextran sodium sulfate. The expression levels of IL-22, IL-23, IL-22R1 and phosphorylated STAT3 (p- STAT3) were determined by immunohistochemistry. Bcl-2, cyclin D1 and survivin expression was detected by Western blotting. RESULTS:Patients with active UC had significantly more IL-22, IL-23, IL-22R1 and p-STAT3-positive cells than the patients with inactive UC and normal controls. Furthermore, IL-22 and related proteins were closely related to the severity of the colitis. The expression of IL-22 and IL-22R1 in the tissue of initial UC was stronger than in that of chronic UC, whereas the expression of p-STAT3 was significantly increased in chronic UC tissues. In dysplasia tissues, the expression level of IL-22 and related proteins was higher compared with controls. Mouse colitis model showed that expression of IL-22, IL-22R1 and IL-23 was increased with time, p-STAT3 and the downstream gene were also remarkably ***:IL-22/STAT3 signaling pathway may be related to UC and UC-induced carcinogenesis and IL-22 can be used as a biomarker in judging the severity of UC.

关键词： Ulcerative colitis Ulcerative colitis-related carcinogenesis Interleukin-22 Interleukin-22R1 STAT3

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma shu-ping yang Ying Li Tian-tian Xu Ya-lin yang Hui-yong yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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车用钛酸锂电池生命周期评价

中国环境科学 2018年第6期38卷 2371-2381页

作者：殷仁述杨沿平杨阳陈志林湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

为评估车用钛酸锂(LTO)电池对能源、环境与资源的影响,构建了包括重制与二次使用阶段在内的车用锂电池全生命周期评价模型,以某款国产纯电动客车用钛酸锂电池包为评价对象,计算得出每k W·h钛酸锂电池全生命周期的总能量消耗(CED)、全... 详细信息

为评估车用钛酸锂(LTO)电池对能源、环境与资源的影响,构建了包括重制与二次使用阶段在内的车用锂电池全生命周期评价模型,以某款国产纯电动客车用钛酸锂电池包为评价对象,计算得出每k W·h钛酸锂电池全生命周期的总能量消耗(CED)、全球变暖潜值(GWP)和不可再生矿产资源耗竭潜值(ADP(e))分别为2.80×10~4MJ、1.86×10~3kg CO_2eq.以及4.77×10^(-3)kg Sbeq.其全生命周期CED与GWP主要与两个使用阶段中由电池充放电效率引起的能量损耗相关,生产阶段GWP主要来源于正负极材料、铝制材料和N-甲基吡咯烷酮.基于全生命周期存储-释放每MJ能量的视角,发现二次使用可显著降低电池全生命周期GWP;与已有研究中其他锂电池对比可知LTO电池生产阶段GWP最低.

关键词：生命周期评价钛酸锂能量消耗全球变暖潜值资源耗竭潜值

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峰后裂隙岩石非线性损伤特性与数值模拟研究

岩土力学 2017年第7期38卷 2128-2136页

作者：谢璨李树忱平洋李景龙李术才山东大学岩土与结构工程研究中心山东济南250061 中国建筑股份有限公司技术中心北京101300

在地下洞室、隧道等工程中,裂隙岩石峰值强度后的损伤破坏特性及演化机制对控制围岩稳定至关重要,目前,对岩石峰后的损伤破坏特性研究不充分,认识不全面,易出现大体积塌方、大变形等工程事故。针对峰后裂隙岩石的力学性质,开展室内三轴... 详细信息

在地下洞室、隧道等工程中,裂隙岩石峰值强度后的损伤破坏特性及演化机制对控制围岩稳定至关重要,目前,对岩石峰后的损伤破坏特性研究不充分,认识不全面,易出现大体积塌方、大变形等工程事故。针对峰后裂隙岩石的力学性质,开展室内三轴试验,分析其非线性损伤破坏特性;假设岩石损伤满足Weibull分布规律,引入损伤变量,推导出峰后裂隙岩石非线性损伤破裂本构方程;将上述本构方程与能量耗散原理、应变能密度理论相结合,建立了峰后裂隙岩石的非线性损伤破坏准则;采用FISH语言开发了基于上述破坏准则的峰后岩石损伤破裂计算程序,用连续的方法模拟分析了峰后裂隙岩石的非连续损伤破裂过程,揭示了裂隙岩石峰后损伤破坏特性及其演化规律,并与裂隙岩石的三轴压缩试验结果进行了对比。结果表明:上述本构方程与判别准则能较好地模拟峰后裂隙岩石非线性损伤破裂过程。为有效控制围岩稳定提供一种新的理论分析手段。

关键词：非线性损伤应变能密度理论峰值强度后数值模拟

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei shu-Hui Fan Li Chen Jie Wang Xiao-Qian yang Chun-Hao yang Shi-Jun He Jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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液态金属In凝固过程中微观结构转变的模拟研究

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物理学报 2004年第9期53卷 3119-3124页

作者：刘让苏覃树萍侯兆阳陈晓莹刘凤翔湖南大学应用物理系长沙410082

采用分子动力学方法对液态金属In的快速凝固过程进行计算机模拟跟踪研究 .运用HA键型指数法和原子成团类型指数法分析了金属原子In的成键类型和形成的原子团簇结构 .发现 :与通常的液态金属 (如Al)相反 ,随着温度的降低 ,二十面体及与... 详细信息

采用分子动力学方法对液态金属In的快速凝固过程进行计算机模拟跟踪研究 .运用HA键型指数法和原子成团类型指数法分析了金属原子In的成键类型和形成的原子团簇结构 .发现 :与通常的液态金属 (如Al)相反 ,随着温度的降低 ,二十面体及与二十面体相关的 1 5 5 1键越来越少 ;与四方体 ,六角密堆积相关的 1 4 2 1 ,1 4 2 2和 1 4 31键数目总和变化很小 ;而与菱面体相关的 1 32l,1 31 1 ,1 30 1和 1 2 0 1的数目却随着温度的降低而显著增加 ,逐渐占据优势 .最后形成一种新型的以菱面体结构为主、夹杂着立方体 (fcc ,bcc)、六角密集等团簇结构所组成的非晶态结构 ,而原来在金属Al的非晶态结构中占绝对优势的二十面体及各种类型多面体团簇结构 ,在此已经完全消失 .这正是非晶态金属In的g(r)曲线分裂的第二峰的顺序为前低后高 ,而与非晶态金属Al的g(r)曲线 (其分裂的第二蜂的顺序为前高后低 )

关键词：微结构转变液态金属铟团簇结构分子动力学计算机模拟半导体材料

Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite

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Earth and Planetary Physics 2025年第1期9卷 188-193页

作者： JiaWen Tang Sai Zhang FuLiang Xiao HongMing yang Si Liu YiHua He Chang yang YuYue Jin ZhouKun Deng ping Li Archie James Johnston School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Province Higher Education Key Laboratory of Modeling and Monitoring on the Near-Earth Electromagnetic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Auroral Kilometric Radiation(AKR)is a common radio emission,which can contribute to the magnetosphere−ionosphere−atmosphere *** emissions have been observed in all magnetic planet magnetospheres of the solar *** this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500−4500 km and invariant latitude(|ILAT|)=60°−80°has been analyzed.63045 AKR samples have been identified with~48%(52%)samples on the dayside(nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05−08 and 18−22(02−05 and 12−17)in the northern(southern)*** distinct MLT asymmetry is associated with the direction of Bxof the interplanetary magnetic *** addition,the occurrence rate on the nightside clearly increases as the index *** study further enriches *** and understanding of AKR in the magnetosphere as well as other similar radio emissions.

关键词： asymmetry auroral kilometric radiation interplanetary magnetic field

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耳针法对中风后轻度抑郁患者的影响

光明中医 2015年第3期30卷 550-552页

作者：杨青杨淑萍李晓青山东省潍坊市中医院潍坊261041

目的探讨耳针对中风后轻度抑郁患者的影响。方法将60例中风后轻度抑郁患者随机分为试验组与对照组各为30例。试验组在常规治疗护理的基础上,于入院1周后给予耳针护理干预,对照组只接受常规治疗护理。两组患者分别于干预前、干预两周后... 详细信息

目的探讨耳针对中风后轻度抑郁患者的影响。方法将60例中风后轻度抑郁患者随机分为试验组与对照组各为30例。试验组在常规治疗护理的基础上,于入院1周后给予耳针护理干预,对照组只接受常规治疗护理。两组患者分别于干预前、干预两周后比较两组患者的抑郁评分的改善。结果干预两周后实验组SDS得分较对照组明显下降,差异有统计学意义(P<0.05)。结论通过耳穴压豆法可以改善中风后轻度抑郁患者的抑郁状况。

关键词：耳针中风轻度抑郁

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多种金属离子对白蜡虫碱性磷酸酶活性的影响

四川大学学报（自然科学版） 2002年第1期39卷 132-135页

作者：赵欣平舒畅杨芳刘克武喻东四川大学生命科学学院成都610064

研究了多种金属离子对白蜡虫碱性磷酸酶活性的影响 .结果表明 :Li+ ,Na+ ,K+ 对酶活力没有影响 .Ca2 + ,Mg2 + ,Ba2 + ,Mn2 + ,Co2 + 有激活作用 ;而Zn2 + ,Cu2 + ,Cd2 + ,Pb2 + 有抑制作用 .Ca2 + 是有效的激活剂 ,表现为非竞争性激活... 详细信息

研究了多种金属离子对白蜡虫碱性磷酸酶活性的影响 .结果表明 :Li+ ,Na+ ,K+ 对酶活力没有影响 .Ca2 + ,Mg2 + ,Ba2 + ,Mn2 + ,Co2 + 有激活作用 ;而Zn2 + ,Cu2 + ,Cd2 + ,Pb2 + 有抑制作用 .Ca2 + 是有效的激活剂 ,表现为非竞争性激活效应 .Cu2 + 为有效的抑制剂 ,表现为非竞争性抑制效应 .酶液经EDTA透析处理后活力完全丧失 ,失活的酶可用加入Zn2 + 和Ca2 + 复活 .

关键词：白蜡虫碱性磷酸酶金属离子酶活性非竞争性激活效应非竞争性抑制效应铜钙