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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

北京近郊浅山地区的野生豹猫分布及环境影响因素

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生物多样性 2024年第8期32卷 54-64页

作者：韩思成陆道炜韩宇辰栗若寒杨晶孙戈杨陆钱俊伟方翔罗述金北京大学生命科学学院蛋白质与植物基因研究国家重点实验室北京大学前沿交叉学科研究院北京大学-清华大学生命科学联合中心北京大学生态研究中心北京100871 北京大学元培学院北京100871 中国林业科学研究院森林生态环境与自然保护研究所北京100091 北京大学体育教研部北京100871

豹猫(Prionailurus bengalensis)是亚洲特有的小型野生猫科动物,当华北豹(Panthera pardus japonensis)等大型食肉类绝迹后,成为北京地区温带森林生态系统的主要捕食者,是衡量其所在生态网络完整性的底线。本研究自2022年10月至2023年6... 详细信息

豹猫(Prionailurus bengalensis)是亚洲特有的小型野生猫科动物,当华北豹(Panthera pardus japonensis)等大型食肉类绝迹后,成为北京地区温带森林生态系统的主要捕食者,是衡量其所在生态网络完整性的底线。本研究自2022年10月至2023年6月在北京西部一段环绕北京城区的马蹄形山地(定名为“京西半月湾”),沿百望山–香山–西山–鹫峰–阳台山–妙峰山–凤凰岭–白虎涧一线共计开展16次徒步调查,总路线覆盖180 km,通过粪便样品的非损伤性采样和DNA分子遗传学物种鉴定,获得258个豹猫分布位点,确定了距离北京城区最近的浅山地区豹猫种群的广泛存在。本研究基于豹猫分布位点和选取的8个环境变量,构建了豹猫物种分布的集合模型。结果显示,在栖息地完整的情况下,豹猫的分布主要受人为干扰因素影响,其中到道路、不透水层等人类设施的距离对豹猫分布的解释率最高,为42.71%;其次是徒步强度,解释率为20.12%。人类设施作为一种较强程度的人为干扰,到此类生境的距离与豹猫的分布概率呈正相关,豹猫的适宜栖息地与城市环境中的人类设施保持1,000 m以上的缓冲距离。徒步强度作为相对温和的人为干扰与豹猫的分布呈负相关,但总体影响有限,豹猫对于适度的人类活动表现出一定的生态可塑性和耐受能力。本研究结果表明,在确保栖息地连续和食物链完整的前提下,将人类干扰控制在适度范围内,华北温带森林生态系统中以豹猫为代表的捕食者野生动物,即便在毗邻北京城区的近郊浅山地区也有续存的希望。

关键词：京西半月湾豹猫人兽共存非损伤性采样物种分布模型

How the white tiger lost its color, but kept its stripes

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Science China(Life Sciences) 2014年第10期57卷 1041-1043页

作者： XU Xiao luo shu-jin College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

The fantastic range of animal coloration is produced by pigment particles of colored material or microscopic struc- tures in scales, bristles or feathers that give rise to brilliant iridescent colors. In mammals, except for a few exceptions involving nanoor micro-scale structural color （e.g., the blue faces of male baboons）, fur color is determined by the pigment melanin. Melanin is synthesized and stored in melanosomes, a lysosomal organelle of melanocyte, and transferred to adjacent keratinocytes and hairs. There are two types of melanin： eumelanin （black to brown） and pheomelanin （red to yellow）. The amount, ratio and distribution of eumelanin and pheomelanin in hair determine the coat color of an animal： everything from bright white to light cream to red to iet black.

关键词：颜色黑素细胞白虎条纹哺乳动物颜料颗粒微观尺度黑色素

Control of Halo-Chaos in Beam Transport Network via Neural Network Adaptation with Time-Delayed Feedback

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Communications in Theoretical Physics 2006年第1期45卷 117-120页

作者： FANG jin-Qing luo Xiao-shu Guo-Xian China institute of Atomic Energy P.O. Box 275-27 Beijing 102413 China Department of Physics and Electronic Science Guangxi Normal University Guilin 541004 China

Subject of the halo-chaos control in beam transport networks （channels） has become a key concerned issue for many important applications of high-current proton beam since 1990＇. In this paper, the magnetic field adaptive control based on the neural network with time-delayed feedback is proposed for suppressing beam halo-chaos in the beam transport network with periodic focusing channels. The envelope radius of high-current proton beam is controlled to reach the matched beam radius by suitably selecting the control structure and parameter of the neural network, adjusting the delayed-time and control coefficient of the neural network.

关键词： beam transport network periodic focusing channels high-current proton beam halo-chaos neural network adaptation control time-delayed feedback

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang Jun Zhan Yiyuan Xue Feng luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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高校大学生个人求助行为的法律问题探析

黑龙江生态工程职业学院学报 2017年第5期30卷 60-62页

作者：谢雅惠陈晓佳刘树荣罗进伟福建师范大学法学院福建福州350117

研究大学生个人求助的方式,对由大学生发起的个人求助的范围进行界定,区分个人求助和个人募捐,进而阐述大学生个人求助的合法性,分析大学生个人求助存在的法律问题,探讨受助人、捐赠人之间的法律关系以及相互间的权利义务关系。建议通... 详细信息

研究大学生个人求助的方式,对由大学生发起的个人求助的范围进行界定,区分个人求助和个人募捐,进而阐述大学生个人求助的合法性,分析大学生个人求助存在的法律问题,探讨受助人、捐赠人之间的法律关系以及相互间的权利义务关系。建议通过高校志愿者协会构建大学生个人求助平台,建立信息公证制度、捐赠监督和反馈机制和撤销赠与制度,使大学生高校内开展的个人求助的行为合法、高效。

关键词：个人求助个人募捐大学生个人求助平台

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi Sheng Hu Haifeng Bao Na Yao Wei luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期 157-162页

作者： Rong-De He Yun-Lei luo Qiu-Quan Pan Qi-Wei Yao Xing-Zhong shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

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