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Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1675-1689页

作者： Lei Ma Chong Chen Chunxing Zhao Tong Li Lingyu Ma Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien chuang Rong Xiang Yunping Luo Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Collaborative Innovation Center for Biotherapy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Lung Cancer Surgery Tianjin Medical University General HospitalTianjin 300052China Immunology Research Center National Health Research InstitutesZhunanMiaoliTaiwanROC Department of Immunology Nankai UniversityTianjin 300071China

Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung *** stem cells(CSCs)have been identified as a crucial player in immunotherapy-related ***,a form of cell death driven by iron-dependent lipid peroxidation,is highly regulated by cellular metabolism remolding and has been shown to have synergistic effects when combined with *** adaption of CsCs drives tumor resistance,yet the mechanisms of their ferroptosis defense in tumor immune evasion remain ***,through metabolomics,transcriptomics,a lung epithelialspecific Cptla-knockout mouse model,and clinical analysis,we demonstrate that CPT1A,a key rate-limiting enzyme of fatty acid oxidation,acts with L-carnitine,derived from tumor-associated macrophages to drive ferroptosis-resistance and CD8^(+)T cells inactivation in lung ***,CPT1A restrains ubiquitination and degradation of c-Myc,while c-Myc transcriptionally activates CPT1A *** CPT1A/c-Myc positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system and reduces the amount of phospholipid polyunsaturated fatty acids through ACSL4 downregulating,thereby suppressing ferroptosis in ***,targeting CPT1A enhances immune checkpoint blockadeinduced anti-tumor immunity and tumoral ferroptosis in tumor-bearing *** results illustrate the potential of a mechanismguided therapeutic strategy by targeting a metabolic vulnerability in the ferroptosis of CsCs to improve the efficacy of lung cancer immunotherapy.

关键词： immunotherapy metabolism peroxidation

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Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-Hao Huang Li-Wen Lee Jrhau Lung Yu-Che Ou Chien-Hui hung Huei-Chieh chuang Min-Chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,P<0.001).CONCLUSION Achieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen Li Yu-Hang Liu Deng Pan Meng-Hao Xia Qiang Zhang Yu-chuang Li Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

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Reinforcing oxygen electrocatalytic activity via selective dualphase heterointerface engineering for rechargeable Zn-air batteries

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Rare Metals 2024年第4期43卷 1524-1536页

作者： Chao Cheng chuang Zhi Zhong-Ti Sun Yong-Qiang Ming Ting-Ting Xiang Qing-Chao Zhu Zi-Rui Wu Bing Li Yi Li Cheng Jin Yong Cao Juan Yang School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming650093China

Dual-phase heterointerface electrocatalysts(DPHE)constructed by oxygen reduction reaction(ORR)-and oxygen evolution reaction(OER)-active elements exhibit excellent bifunctional activity and long-term durability due to the abundant interface exposure and synergistic catalytic ***,low-dimensional N-doped graphene nanoribbons(N-GNRs)coupling with ultrathin CoO nanocomposites(N-GNRs/CoO)were controllably fabricated through a facile two-step approach using synthesized Co(OH)_2 nanosheet as CoO *** functional theory(DFT)calculations and experimental characterizations prove that the formation of interface between N-GNRs and CoO can induce local charge redistribution,contributing to the improvement of catalytic activity and *** optimal N-GNRs/CoO DPHE possesses hierarchically porous architectures and presents outstanding bifunctional activities with a small potential gap of 0.729 V between the potential at 10 mA·cm^(-2)for OER and the halfwave potential for ORR,which outperforms Pt/C+IrO_(2)and the majority of noble-metal-free bifunctional ***-and solid-state rechargeable Zn-air batteries assembled with N-GNRs/CoO as the cathode also display high peak power density and fantastic cycle stability,superior to that of benchmark Pt/C+IrO_(2)*** is anticipated to offer significant benefits toward high activity,stability and mechanical flexibility bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries.

关键词： Interface engineering Graphene nanoribbons CoO Bifunctional electrocatalyst Zn-air batteries

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GmDFB1,an ARM-repeat superfamily protein,regulates floral organ identity through repressing siRNA-and miRNA-mediated gene silencing in soybean

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Journal of Integrative Plant Biology 2024年第8期66卷 1620-1638页

作者： Jie Li Wenxiao Zhang Qing Lu Jiaqi Sun chuang Cheng Shiyu Huang shuo Li Qiang Li Wei Zhang Chuanen Zhou Bin Liu Fengning Xiang The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

The development of flowers in soybean(Glycine max)is essential for determining the yield potential of the *** silencing pathways are involved in modulating flower development,but their full elucidation is still ***,we conducted a forward genetic screen and identified an abnormal flower mutant,deformed floral bud1-1(Gmdfb1-1),in *** mapped and identified the causal gene,which encodes a member of the armadillo(ARM)-repeat *** small RNA sequencing(sRNA-seq),we found an abnormal accumulation of small interfering RNAs(si RNAs)and microRNA(miRNAs)in the Gmdfb1 *** further demonstrated that GmDFB1 interacts with the RNA exosome cofactor SUPER KILLER7(Gm SKI7).Additionally,GmDFB1 interacts with the PIWI domain of ARGONAUTE 1(GmAGO1)to inhibit the cleavage efficiency on the target genes of s *** enhanced gene silencing mediated by siRNA and miRNA in the Gmdfb1 mutants leads to the downregulation of their target genes associated with flower *** study revealed the crucial role of GmDFB1 in regulating floral organ identity in soybean probably by participating in two distinct gene silencing pathways.

关键词： ARM-repeat superfamily protein ARGONAUTE 1 SUPER KILLER 7 flower development gene silencing small RNAs soybean

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Enhanced charge collection of AgNWs-based top electrode to realize high-performance,all-solution processed organic solar cells

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Science China Chemistry 2024年第10期67卷 3347-3356页

作者： Juanyong Wan Yang Chen Weijie Chen Jinfeng Xia Guang Zeng Jianlei Cao chuang Jin Yunxiu Shen Xiaoxiao Wu Haiyang Chen Junyuan Ding Xue-mei Ou Yaowen Li Yongfang Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Jiangsu Sidike New Materials Science and Technology Co. Ltd.Suqian 215400China

All-solution processed organic solar cells are the ultimate aim of printable photovoltaics,but their electrical losses arising from poor contact of top electrodes greatly limit efficiency *** solve the problem,a solution-processed hybrid top electrode was constructed using silver nanowires(AgNWs)as the skeleton and ZnO nanoparticles(ZnO-NPs)as the *** constructing the skeleton,a spin-rinsing treatment was first used to reduce the amount of the residual insulating polyvinylpyrrolidone wrapped around the AgNWs to promote intimate contact among the AgNWs in the ***,the ZnO-NPs matrix was deposited onto the AgNWs skeleton,bridging the AgNWs skeleton with the underlayer ZnO-NPs electron transporting layer(ETL).The underlayer ZnO-NPs ETL can also induce the growth of the ZnO-NPs matrix to minimize lattice mismatch,which creates additional transport channels from the ETL to the AgNWs skeleton for charge *** a result,the obtained electrode significantly enhances the electrical contact in the device,thus delivering record power conversion efficiencies of 16.04%and 14.54%for rigid and flexible all-solution processed OSCs,respectively.

关键词： solution-processed top electrode organic solar cells AgNWs electrical contact

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Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： Hui-Ling Hu Serena Zhe-chuang Li Ai-Ying Feng Hao-Xi Zhong Jing-Feng Mu Mei-Zhou Liu Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology Research Institute Beijing 100176China

AIM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography

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Topological phases and edge modes of an uneven ladder

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Chinese Physics B 2024年第8期33卷 154-168页

作者：商文创韩熠宁 Shimpei Endo 高超 Department of Physics Zhejiang Normal UniversityJinhua 321004China Key Laboratory of Optical Information Detection and Display Technology of Zhejiang Zhejiang Normal UniversityJinhua 321004China Department of Engineering Science The University of Electro-CommunicationsTokyo 182-8585Japan

We investigate the topological properties of a two-chain quantum ladder with uneven legs,i.e.,the two chains differ in their periods by a factor of *** an uneven ladder presents rich band structures classified by the closure of either direct or indirect *** also provides opportunities to explore fundamental concepts concerning band topology and edge modes,including the difference of intracellular and intercellular Zak phases,and the role of the inversion symmetry(IS).We calculate the Zak phases of the two kinds and find excellent agreement with the dipole moment and extra charge *** also find that configurations with IS feature a pair of degenerate two-side edge modes emerging as the closure of the direct bandgap,while configurations without IS feature one-side edge modes emerging as not only the closure of both direct and indirect bandgaps but also within the band ***,by projecting to the two sublattices,we find that the effective Bloch Hamiltonian corresponds to that of a generalized Su–Schrieffer–Heeger model or the Rice–Mele model whose hopping amplitudes depend on the *** this way,the topological phases can be efficiently extracted through winding *** propose that uneven ladders can be realized by spin-dependent optical lattices and their rich topological characteristics can be examined by near future experiments.

关键词： ladder model symmetry-protected topological phase topological invariant bulk-boundary correspondence

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中国式教育现代化背景下教育研究国际学术话语体系建构

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西南大学学报（社会科学版） 2024年第1期50卷 201-211页

作者：杨创华东师范大学教育学部上海200062

加速建构教育研究国际学术话语体系,是中国式现代化在教育领域的具体表达,是将中国教育智慧融入国际教育学术话语体系、提升教育研究自主性的时代使命与战略要求。中国式教育现代化为国际学术话语体系的建立提供了丰富的本土资源,有力... 详细信息

加速建构教育研究国际学术话语体系,是中国式现代化在教育领域的具体表达,是将中国教育智慧融入国际教育学术话语体系、提升教育研究自主性的时代使命与战略要求。中国式教育现代化为国际学术话语体系的建立提供了丰富的本土资源,有力支撑着话语的中国特色。但中国教育研究的话语体系及其研究还比较滞后,主动参与建构教育研究国际学术话语体系已成为中国教育理论研究深化和走向世界的迫切需要。中国教育研究国际学术话语体系的建构受个体情感、学术竞争、学科竞争与强国政治需求的驱动,存在“经验注脚”的知识再生产模式、“以石攻石”的定量研究惯习、“结构异质”的学术与实践场域、“普适为王”的理论革新误区、“知识诅咒”的知识输出羁绊等困境。中国式教育现代化背景下教育研究国际学术话语体系建构的策略包括:提升对中国差异性教育问题的认知;选择适切的研究方法与有序的入场策略;缩短教育理论与实践之间的应用链条;发展普适、准确与简洁的折中理论;展开与国际主流研究理论的对话。

关键词：中国式现代化教育现代化国际化话语体系自主性

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伦理与演化博弈:道德起源与本质的哲学探究

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哲学动态 2024年第3期 91-101,127,128页

作者：刘闯复旦大学哲学学院中国科学院哲学研究所

伦理学研究的道德价值与行为规范似乎无法在客观世界的经验事实中找到踪影,也不可能从其中推演出来。既然科学是研究客观经验事实的学问,那么伦理学与科学似乎无法相容。可是,人类是自然之物,关于人的客观事实似乎不可能跳出科学的范畴... 详细信息

伦理学研究的道德价值与行为规范似乎无法在客观世界的经验事实中找到踪影,也不可能从其中推演出来。既然科学是研究客观经验事实的学问,那么伦理学与科学似乎无法相容。可是,人类是自然之物,关于人的客观事实似乎不可能跳出科学的范畴,因此,伦理学与科学的不相容是个大问题。然而,科学解释有两种类型:一种为研究事物“动力因”的进路,另一种为研究事物“目的因”的进路。物质科学的自然规范性属于前一种,达尔文进(演)化论则属于后一种。道德规范在前一种进路中得不到解释其实不足为奇,因为解释它需要知道它是如何演化出来的。达尔文早已有关于道德起源的思想和初步理论,之后演化博弈论又提供了更丰富的资源,但仍然与我们的目标存在差距。结合集体或社会实在论的相关思想,可以更有效地解决伦理学与科学相悖的难题。

关键词：道德起源群体选择道德表达主义集体意向性社会本体论

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