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Risk factors of poor prognosis and portal vein tumor thrombosis after curative resection of solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 68-73页

作者： Li Zhou Jing-An Rui Shao-Bin Wang shu-guang chen Qiang Qu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical College

BACKGROUND:Predictors of poor prognosis of solitary hepatocellular carcinoma(SHCC),a subgroup encompassing most patients with the malignancy,are still ***,risk factors for portal vein tumor thrombosis(PVTT) in SHCC are *** present study was designed to address this ***:Clinicopathological and follow-up data for 156 consecutive patients with SHCC following curative hepatic resection were analyzed using uni-and multi-variate ***:Univariate analysis showed that PVTT,tumornode-metastasis(TNM) stage,Edmondson-Steiner grade and preoperative serum alpha-fetoprotein(AFP) level were associated with the overall and disease-free survival,whereas tumor size only influenced the overall *** multivariate Cox regression tests,Edmondson-Steiner grade and TNM stage were independent prognostic markers for both overall and diseasefree *** addition,the Chi-square test showed that AFP level and Edmondson-Steiner grade were correlated with *** them,only Edmondson-Steiner grade was shown to be of independent significance for PVTT in multi-variate logistic regression ***,AFP,the sole preoperative factor for PVTT,was not adequately sensitive and ***:Factors relating to post-surgical prognosis and PVTT in SHCC are all *** these,EdmondsonSteiner grade and TNM stage might be of particular importance in survival *** addition,accurate prediction of PVTT by clinicopathological parameters before surgery remains difficult.

关键词： solitary hepatocellular carcinoma curative resection prognosis portal vein tumor thrombosis

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Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： guang-Xiang Gu shu-Ting Pan Yi-chen Fan chen chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

Constructing robust NiFe LDHs-NiFe alloy gradient hybrid bifunctional catalyst for overall water splitting:one-step electrodeposition and surface reconstruction

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Rare Metals 2023年第7期42卷 2272-2283页

作者： Yi-Fei chen Jia-Hong Li Tian-Tian Liu Si-Hang You Peng Liu Fu-Jin Li Meng-Qi Gao shu-guang chen Fei-Fei Zhang School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha410114China Faculty of Engineering Department of Materials Science and EngineeringNational University of SingaporeSingapore117576Singapore School of Materials Science and Engineering Jilin UniversityChangchun130022China

NiFe layered double hydroxides(NiFe LDHs)have been intensively developed for the oxygen evolution reaction(OER)in alkaline media;however,their unsatisfactory hydrogen evolution reaction(HER)performance limits their practical application in overall water ***,a simple and efficient one-step electrodeposition method is used to accomplish in situ growth of NiFe LDHsNiFe alloy gradient hybrid coatings on a carbon cloth(CC).Within the binder-free electrode,NiFe LDHs nanosheets with a low-crystalline nature exhibit highly active bifunctional OER/HER activities,and the NiFe alloy acts as a stable electron highway and strong skeleton bridge between NiFe LDHs and the *** the electrodes are simultaneously employed as the cathode and anode for overall water splitting,they require low cell potentials of 1.441 V at10 mA·cm^(-2)and 1.703 V at 100 mA·cm^(-2),respectively,and they demonstrate outstanding stability at a current density greater than 100 mA·cm^(-2)for more than 100 *** is one of the best bifunctional OER and HER catalysts for overall water *** lattice defects and surface reconstructions crucially contribute to the bifunctional OER/HER activities of NiFe *** simple and scalable synthesis approach presents an intriguing paradigm for industrial production,and the fabricated electrode has potential application in high-current-density water splitting.

关键词： Bifunctional Electrodeposition Gradient hybrid NiFe layered double hydroxides(NiFe LDHs) Overall water splitting

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Both the 5th and 6th Editions of TNM Staging System Fail to Independently Predict Long-term Prognosis after Radical Hepatectomy in Hepatocellular Carcinoma Sized > or = 5cm

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Chinese Medical Sciences Journal 2009年第4期24卷 220-226页

作者： Li Zhou Jing-an Rui Da-xiong Ye Shao-bin Wang shu-guang chen Qiang Qu Department of General Surgery Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100032 China

Objective To validate the predictive power of the 5th and 6th editions of TNM staging system(TNM-5,TNM-6) in a Chinese patient cohort with hepatocellular carcinoma(HCC) sized > or = 5 cm after radical *** Consecutive 121 patients with HCC sized > or = 5 cm undergoing radical hepatectomy between January 1995 and December 2002 were *** impact of clinicopathological variables on prognosis was determined by univariate and multivariate analyses,after excluding 2 perioperative *** In univariate analysis,TNM-5 stage did not show prognostic significance for overall or disease-free survival,as opposed to TNM-6 stage,Edmondson-Steiner grade,portal vein tumor thrombosis(PVTT),vascular invasion,satellite nodule,Child-Pugh grade,and hepatitis B surface antigen(HBsAg) *** these significant variables were entered in multivariate analysis,Edmondson-Steiner grade was the sole independent prognosticator for both overall and disease-free survival,whereas Child-Pugh grade independently influenced disease-free ***,TNM-6 stage lost its predictive potential in multivariate *** Neither TNM-5 nor TNM-6 staging system is revealed to be independently prognostic in patients with HCC sized > or = 5 cm after radical ***,TNM-6 calls for more support in many subsets of HCC patients.

关键词： hepatocellular carcinoma TNM-5 TNM-6 radical hepatectomy prognostic factor

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