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Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin Xiang shu He Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long ma Ying Sun Yongpeng Qin Yi Chen Wen Li Xiangyu Wang Gong Chen Wenliang Lei Guangdong-Hong Kong-macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory for Neuroimmunology in Health and Diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIB-KU Leuven Center for Brain&Disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous *** r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing *** this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse ***-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local *** addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable ***,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural *** conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocyte-to-neuron conversion Ca2+imaging direct lineage conversion glia astrocyte in vivo reprogramming lineage-tracing mice NeuroD1 neuron two-photon imaging

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Catalytic recycling of polyesters via a binuclear catalyst

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Science China Chemistry 2024年第2期67卷 426-427页

作者： Bo Sun Ding ma Beijing National Laboratory for Molecular Science New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

Plastics play a crucial role in modern society life. While the increasing use of plastics and rapid accumulation of plastic waste in nature environment have caused severe environmental crisis and the waste of carbon resources. Catalytic upcycling is a promising approach to transform plastic waste into high value-added chemicals to achieve a sustainable circular economy.

关键词： Catalytic polyester catalyst

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Exploring the functional roles of small-molecule metabolites in disease research:Recent advancements in metabolomics

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Chinese Chemical Letters 2024年第8期35卷 93-100页

作者： Aolei Tan Xiaoxiao ma Department of Precision Instrument Tsinghua UniversityBeijing 100084China

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in ***,an essential scientific discipline,is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during *** the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and *** comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic *** scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

关键词： Metabolites Small molecules Biological functions Physiological processes Diseases

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Partial regularity and nonlinear potential estimates for Stokes systems with super-quadratic growth

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Science China mathematics 2024年第7期67卷 1525-1554页

作者： Lingwei ma Zhenqiu Zhang School of mathematical Sciences Tianjin Normal UniversityTianjin300387China School of mathematical Sciences and LPMC Nankai UniversityTianjin300071China

This paper builds a bridge between partial regularity theory and nonlinear potential theory for the following generalized stationary Stokes system with super-quadratic growth and continuous coefficients:-div A(x,Du)+■π=f,div u=0,where Du is the symmetric part of the gradient■*** first establish anε-regularity criterion involving both the excess functional of the symmetric gradient Du and Wolff potentials of the nonhomogeneous term f to guarantee the local vanishing mean oscillation(VMO)-regularity of Du in an open subset Ω_(u) of Ω with full *** anε-regularity criterion leads to a pointwise Wolff potential estimate of Du,which immediately infers that Du is partially C^(0)-regular under appropriate ***,we give a local continuous modulus estimate of Du.

关键词： nonlinear Stokes system partial regularity Wolff potential estimates continuous modulus estimates

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Current status of cognition and skin care behavior in adolescent patients with acne:A survey in China

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Chinese Medical Journal 2024年第4期137卷 476-477页

作者： Jing Tian Hong shu Qiufang Qian Zhong Shen Chunyu Zhao Li Song Ping Li Xiuping Han Hua Qian Jinping Chen Hua Wang Lin ma Yuan Liang Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Dermatology Kunming Children’s HospitalKunmingYunnan 650034China Department of Dermatology Children’s Hospital of ShanghaiChildren’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Loreal China Co. LtdShanghai 200040China Department of Dermatology Henan Children’s HospitalChildren’s Hospital Affiliated to Zhengzhou UniversityZhengzhou Hospital Beijing Children’s HospitalZhengzhou Children’s HospitalZhengzhouHenan 450052China Department of Dermatology Shenzhen Children’s HospitalShenzhenGuangdong 518026China Department of Dermatology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China Department of Dermatology Children’s Hospital of Soochow UniversitySuzhouJiangsu 215025China Department of Dermatology Guangzhou Women and Children's Medical CenterGuangzhouGuangdong 510623China Department of Dermatology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China

To the Editor:Acne vulgaris(AV)is a common inflammatory skin ***-based epidemiological studies have reported associations between dietary habits,lifestyle factors,family history,and the occurrence and development of acne.^([1–4])This study investigated the skincare behavior and cognition of patients with AV regarding predisposing factors using a designed electronic questionnaire.

关键词： patients dietary behavior

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Nuance of inward rectifying potassium(Kir) channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： Benjamin Garland Linlin ma Griffith Institute for Drug Discovery & School of Environment and Science Griffith University

Neurodegenerative disorders are highly prevalent and diverse in nature. Their manifestation largely depends on the cell types involved, with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological traits. The two most prevalent neurodegenerative diseases worldwide,

关键词： K-ATP CHANNELS PARKINSONS-DISEASE MODEL

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3D simulation of image-defined complex internal features using the numerical manifold method

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Science China(Technological Sciences) 2024年第4期67卷 1023-1039页

作者： WU Jie ma GuoWei School of civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China Tianjin Key Laboratory for Prefabricated Building and Intelligent Construction Tianjin 300401China

The numerical simulation of internal features,such as inclusions and voids,is important to analyze their impact on the performance of composite ***,the complex geometries of internal features and the induced continuous-discontinuous(C-D)deformation fields are challenges to their numerical *** this study,a 3D approach using a simple mesh to simulate irregular internal geometries is developed for the first *** the help of a developed voxel crack model,image models that are efficient when recording complex geometries are directly imported into the *** reconstructions,which are usually labor-intensive,are excluded from this ***,using image models as the geometric input,image processing techniques are applied to detect material interfaces and develop contact ***,the C-D deformations of the complex internal features are directly calculated based on the numerical manifold *** accuracy and convergence of the developed3D approach are examined based on multiple *** 3D C-D simulation of sandstones with naturally formed complex microfeatures demonstrates the capability of the developed approach.

关键词： 3D continuous-discontinuous simulation image-based simulation complex internal features numerical manifold method voxel crack model structured mesh

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Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China mathematics 2024年第1期67卷 211-236页

作者： Qi Lü Bowen ma School of mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

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深低温保存下高效抗冻多肽的合理设计和机理探讨

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Engineering 2024年第3期34卷 164-173页

作者： Haishan Qi Yihang Gao Lin Zhang Zhongxin Cui Xiaojie Sui Jianfan ma Jing Yang Zhiquan shu Lei Zhang Department of Biochemical Engineering School of Chemical Engineering and TechnologyFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE)Tianjin UniversityTianjin 300350China School of Engineering and Technology University of Washington TacomaTacomaWA 98402USA

The development of effective antifreeze peptides to control ice growth has attracted a significant amount of attention yet still remains a great ***,we propose a novel design method based on in-depth investigation of repetitive motifs in various ice-binding proteins(IBPs)with evolution *** this way,several peptides with notable antifreeze activity were *** particular,a designed antifreeze peptide named AVD exhibits ideal ice recrystallization inhibition(IRI),solubility,and biocompatibility,making it suitable for use as a cryoprotective agent(CPA).A mutation analysis and molecular dynamics(MD)simulations indicated that the Thr6 and Asn8 residues of the AVD peptide are fundamental to its ice-binding capacity,while the Ser18 residue can synergistically enhance their interaction with ice,revealing the antifreeze mechanism of ***,to evaluate the cryoprotection potential of AVD,the peptide was successfully employed for the cryopreservation of various cells,which demonstrated significant post-freezing cell *** work opens up a new avenue for designing antifreeze materials and provides peptide-based functional modules for synthetic biology.

关键词： Antifreeze peptides Evolution analysis Ice recrystallization inhibition Molecular dynamics simulation Cryopreservation Synthetic biology

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Take Every Step Firmly with Sharp Eyes

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Chinese Journal of Chemistry 2024年第10期42卷 1065-1066页

作者： Shengming ma Chinese Journal of Chemistry

Chinese Journal of Chemistry(CJC)is committed to becoming a prominent international journal for chemistry and the related *** are working very hard towards this *** offers a diverse range of manuscript types,including... 详细信息

关键词： journal becoming diverse

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