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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury

Neural Regeneration Research 2020年第7期15卷 1259-1265页

作者： Xin Chen Yan Chai Shao-Bo Wang Jia-Chong Wang shu-yuan yue Rong-Cai Jiang Jian-Ning Zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjinChina Department of Neurosurgery Ordos Central HospitalOrdosInnerMongolia Autonomous RegionChina Department of Neurosurgery Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityChangshaHunan ProvinceChina

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid *** illness-related corticosteroid insufficiency can easily occur after traumatic brain injury,but few studies have examined this occurrence.A multicenter,prospective,cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of critical illness-related corticosteroid insufficiency during the sub-acute phase of traumatic brain *** hundred and forty patients with acute traumatic brain injury were enrolled from the neurosurgical departments of three tertiary-level hospitals in China,and the critical illness-related corticosteroid insufficiency incidence,critical-illness-related corticosteroid insufficiency-related risk factors,complications,and 28-day mortality among these patients was *** illness-related corticosteroid insufficiency was diagnosed in patients with plasma total cortisol levels less than 10μg/dL(275.9 nM)on post-injury day 4 or when serum cortisol was insufficiently suppressed(less than 50%)during a dexamethasone suppression test on post-injury day *** results demonstrated that critical illness-related corticosteroid insufficiency occurred during the sub-acute phase of traumatic brain injury in 5.6%of patients with mild injury,22.5%of patients with moderate injury,and 52.2%of patients with severe *** brain injury-induced critical illness-related corticosteroid insufficiency was strongly correlated to injury severity during the sub-acute stage of traumatic brain *** brain injury patients with critical illness-related corticosteroid insufficiency frequently presented with hemorrhagic cerebral contusions,diffuse axonal injury,brain herniation,and *** in the incidence of hospital-acquired pneumonia,gastrointestinal bleeding,and 28-day mortality were observed between patients with and without critical i

关键词： brain herniation corticosteroid critical illness-related corticosteroid dexamethasone suppression test diffuse axonal injury gastrointestinal bleeding hemorrhagic cerebral contusions hospital-acquired pneumonia insufficiency prognosis traumatic brain injury

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Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury

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Neural Regeneration Research 2017年第8期12卷 1322-1328页

作者： Zi-wei Zhou Ya-dan Li Wei-wei Gao Jie-li Chen shu-yuan yue Jian-ning Zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Tianjin Neurological Institute Tianjin China Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System Ministry of Education Tianjin China Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin China Intensive Care Units Tianjin Huanhu Hospital Tianjin China Department of Neurology Henry Ford Hospital Detroit MI USA

A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.

关键词： nerve regeneration cold water swimming cognitive deficits endothelial progenitor cells angiogenesis neural repair stress Morriswater maze fluid percussion injury model CD34 Von Willebrand factor neural regeneration

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Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei Jia Wenying Zhang Tao Luo Yongtao Li Jianhong shu Julie Strand yuan yue Stig Purup Jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Animal and Veterinary Sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

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Use of a compact high-definition two-dimensional exoscope in surgical treatment of large vestibular schwannoma

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Chinese Medical Journal 2020年第11期133卷 1292-1297页

作者： Xin Chen Xiang-Liang Gao Yan Chai Ming-Ming Shi Jian-Ning Zhang shu-yuan yue Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin 300052China

Background::Extra-corporeal video telescope operating monitor system provides a necessary instrument to perform high-precision neurosurgical procedures that could substitute or supplement the traditional surgical *** present study was designed to evaluate a compact high-definition two-dimensional exoscope system for assisting in surgical removal of large vestibular schwannoma(VS),as an alternative to a binocular surgical ***::Patients with Koos grade 3 and grade 4 VS undergoing surgery were enrolled in this prospective cohort study between January 2013 and June *** demographics and tumor characteristics(size,Koos grade,composition[cystic or solid mass])were matched between the two groups of *** following outcome measurements were compared between the two groups:duration of surgery,volume of blood loss,extent of tumor resection,number of operating field adjustments,pre-and post-operative facial and cochlear nerve function evaluated at 3 months post-surgery,complications and surgeons’***::A total of 81 patients received tumor resection through the retrosigmoid approach under either an exoscope(cases,n=39)or a surgical microscope(control,n=42).Patients in the two groups had comparable tumor location(P=0.439),Koos grading(P=0.867),and composition(P=0.891).While no significant differences in the duration of surgery(P=0.172),extent of tumor resection(P=0.858),facial function(P=0.838),and hearing ability(P=1.000),patients operated on under an exoscope had less blood loss(P=0.036)and a fewer field adjustments(P<0.001).Both primary and assistant surgeons reported a high level of comfort operating under the exoscope(P=0.001 and P<0.001,respectively).Conclusions::The compact high-definition two-dimensional exoscope system provides a safe and efficient means to assist in removing large VSs,as compared to a surgical *** the acquaintance with a visual perception through a dynamic hint and stereoscopically vie

关键词： Vestibular schwannoma Exoscope Telescope video monitor Operating microscope

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Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 199-208页

作者： yue-Qi yuan Xing-yuan Yan Fang Zheng Ming Yan Department of Ophthalmology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Laboratory Medicine&Center for Gene Diagnosis Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

AIM:To explore the effect of co-host non-coding RNA(ncRNA)MIR503HG/miR-503-5p on the angiogenesis of ***:MIR503HG/miR-503-5p/fibroblast growth factor 2(FGF2)expression levels in pterygium tissues,control conjunctival tissues,and human pterygium fibroblasts(HPF)were examined by reverse transcription-polymerase chain reaction(qRT-PCR)and immunohistochemical *** of MIR503HG/miR-503-5p on low molecular weight FGF2(LWM FGF2),migration and angiogenesis of human retinal microvascular endothelial cells(HRMEC)were determined in an HPF and HRMEC co-culture model using Western blots,wound healing assay,Matrigel-based tube formation assay,and Transwell ***:MIR503HG/miR-503-5p/FGF2 pathway was actively increased in pterygium tissue and there was a negative correlation between the expression of the two ***2 expression level was positively correlated with MIR503HG and negatively correlated with *** MIR503HG/miR-503-5p did not affect the migration and angiogenesis of HRMECs cultured separately,but significantly affected migration and angiogenesis of HRMEC in HPF and HRMEC co-culture *** blotting revealed that MIR503HG/miR-503-5p overexpression significantly increased LMW FGF2 expression in ***:MIR503HG/miR-503-5p inhibits HRMEC migration and angiogenic function by interfering with the interaction between HPF and endothelial cells via reducing LMW FGF2 in HPF.

关键词： pterygium MIR503HG miR-503-5p fibroblast growth factor 2 angiogenesis

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Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 268-274页

作者： Lin Fu Jiang-Tao Lou yue Guo Pei-Juan Wang Rong-Rong Le shu-Xia Xu Guo-Xing Li yuan-Bo Liang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325003Zhejiang ProvinceChina

AIM:To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification(KDB-Phaco)in Chinese patients with primary open angle glaucoma(POAG).METHODS:This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for *** pressure(IOP),glaucoma medications and surgical complications were *** 1 and success 2 was defined as 5-21 mm Hg and 5-18 mm Hg,and success plus was determined if additional criteria of IOP reduction≥20%from baseline was reached.A corrected IOP by adding 3 mm Hg for each medication was used to do correlation ***’s proportional hazards regression model was used to test the hazard ratio for factors associated with surgical ***:After a 12-month follow up,the IOP decreased from 28.1±6.3 to 13.8±3.0 mm Hg(47.92%reduction,P<0.001),and the medications used decreased from 2.0(1.0)to 0.0(0.0)(95%reduction,P<0.001).The mean IOP of all postoperative visits were lower than preoperative IOP(all P<0.001),so as the number of glaucoma medications(all P<0.001).Complete success 1 and qualified success 1 were 87.80%and 100.00%*** complete success 1 plus and qualified success 1 plus were 85.37%and 97.56%,*** 82.93%and 90.24%of patients got complete success 2 and qualified success 2 while 80.49%and 87.80%of patients satisfied complete success 2 plus and qualified success 2 ***(r=-0.511,P=0.001)and visual acuity(VA;r=-0.321,P=0.041)were negatively correlated with postoperative corrected IOP at 12mo,while anterior chamber depth(r=0.432,P=0.005),mean deviation(r=0.617,P<0.001)and visual field index(r=0.524,P<0.001)were positively correlated with *** VA(OR=33.092,P=0.004)and MD(OR=1.481,P=0.018)were hazard factors associated with failure based on qualified success as 18 mm *** main complications of KDB were hyphema(9.30%),IOP spike(11.63%)and peripheral anterior synechia(6.98%).CONCLUSI

关键词： Kahook Dual Blade goniotomy primary open angle glaucoma success rate risk factors

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Dietary supplementation with N‑acetyl‑L‑cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs

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Journal of Animal Science and Biotechnology 2025年第1期16卷 167-181页

作者： Linghua Cheng Zhicheng Shi yuan yue yue Wang Yusheng Qin Wei Zhao Yupei Hu Qin Li Min Guo Lei An shumin Wang Jianhui Tian Frontiers Science Center for Molecular Design Breeding(MOE) State Key Laboratory of Animal Biotech BreedingKey Laboratory of Animal GeneticsBreeding and Reproduction of the Ministry of Agriculture and Rural AffairsNational Engineering Laboratory for Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Exogenous gonadotropin-controlled ovarian stimulation is the critical step in animal reproductive management,such as pig,sheep,bovine and other *** helps synchronize ovulation or stimulate multiple ***,a number of evidence indicated an unexpected decrease in pregnancy outcomes following ovarian *** study aimed to explore the underlying mechanism of the pregnancy defect and develop a practical rescue *** Compared with those in the control group,gilts that underwent ovarian stimulation showed a decrease in pregnancy rate,farrowing rate,and total number of piglets *** gilts also showed an increase in estra-diol(E_(2))*** supraphysiologicalE_(2) level was correlated with the decrease in the number of piglets ***,we found that high levels ofE_(2) impair uterine receptivity,as shown by the overproliferation of endo-metrial epithelial *** vitro mechanistic studies demonstrated that high levels ofE_(2) hyperactivate FGF-FGFR-ERK signaling cascade in the uterine endometrium,and in turn induces overproliferation of endometrial epithelial *** note,N-acetyl-L-cysteine(NAC)supplementation effectively inhibits ERK hyperphosphorylation and ameliorates endometrial epithelial ***,in vivo experiments indicated that dietary NAC supplementa-tion,compared with ovarian stimulation group,improves the uterine receptivity in gilts,and significantly increases the pregnancy rate and total number of piglets *** Ovarian stimulation-induced supraphysiological levels ofE_(2) impairs uterine receptivity by hyperactivat-ing FGF-FGFR-ERK signaling cascade,thereby reducing pregnancy rate and litter *** NAC to a con-ventional diet for gilts ameliorates hyperactivated ERK signaling and improves uterine receptivity,thus rescuing adverse pregnancy outcomes following ovarian stimulation.

关键词： Estradiol Gonadotropin Implantation N-acetyl-L-cysteine Ovarian stimulation Uterine receptivity

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Crevice corrosion of reinforcing steel in carbonated simulated concrete pore solutions contaminated by chloride

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Journal of Iron and Steel Research International 2025年第1期32卷 293-311页

作者： Peng-peng Wu yuan-pei Gong Shao-hua Zhang yue-zhong Zhang Bao-sheng Liu Guang-ling Song College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina College of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen518055GuangdongChina School of Mechanical and Mining Engineering Centre for Advanced Materials Processing and Manufacturing(AMPAM)The University of QueenslandSt LuciaQLD4072Australia State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen UniversityXiamen361005FujianChina

The crevice corrosion of the reinforcing steel in the carbonated simulated concrete pore solutions(SCPSs)containing 0.04 mol/L chloride was *** comparison,the steel without crevice covered on its surface was also *** showed that the crevice corrosion in the uncarbonated SCPS was not triggered and the steel remained passivity by suppressing the anodic dissolution in the crevice *** SCPS was carbonated to have pH values of 10.5 and 11.5,the crevice corrosion was easier to be activated than the widely reported pitting corrosion owing to the rapid oxygen depletion within the crevice,but the crevice corrosion damage might be alleviated to a certain extent due to the relative compact surface film formed inside the *** further carbonation led to the activation dissolution of both the crevice interior and exterior,causing the more serious corrosion *** process of the crevice corrosion was systematically analyzed by combining the electrochemical measurement results and Evens polarization diagram.

关键词： Crevice corrosion Reinforcing steel Carbonation Electrochemical test Rust Evens polarization diagram

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Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： Zhi-Min Lin Han-yuan Gao shu-Han Shi yue-Ting Li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

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Highly sensitive plasmonic nanoridge hyperbolic metamaterial for biosensing

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Photonics Research 2025年第1期13卷 113-124页

作者： XINZHAO yue TAO WANG YAOHUA CAI RUOQIN YAN LU WANG HUIMIN WANG ENZE LV XUYANG yuan JINWEI ZENG XUEWEN shu JIAN WANG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Artificially designed hyperbolic metamaterials (HMMs) with extraordinary optical anisotropy can support highly sensitive plasmonic sensing detections, showcasing significant potential for advancements in medical research and clinical diagnostics. In this study, we develop a gold nanoridge HMM and disclose the plasmonic sensing physical mechanism based on this type of HMM through theoretical and experimental studies. We determine that the high modal group velocity of plasmonic guided modes stemming from a large transverse permittivity of HMMs directly results in high sensitivity. By combining electron-beam lithography, oxygen plasma etching, and electroplating,the fabricated gold nanoridge array possesses an extremely high structural filling ratio that is difficult to obtain through conventional processes. This leads to a large transverse permittivity and enables highly confined and ultra-sensitive bulk plasmon–polariton (BPP) guided modes. By exciting these modes in the visible to near-infrared region, we achieve a record sensitivity of 53,300 nm/RIU and a figure of merit of 533. Furthermore, the developed plasmonic nanoridge HMM sensor exhibits an enhanced sensitivity of two orders of magnitude compared to that of the same type of HMM sensor in label-free biomolecule detection. Our study not only offers a promising avenue for label-free biosensing but also holds great potential to enhance early disease detection and monitoring.

关键词： Modal dispersion Refractive index Scanning electron microscopy Surface plasmon resonance Total internal reflection Waveguide modes

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