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Drug-eluting beads transarterial chemoembolization sequentially combined with radiofrequency ablation in the treatment of untreated and recurrent hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2020年第8期12卷 355-368页

作者： Yan Zhang Mei-Wu Zhang Xiao-Xiang Fan Da-Feng Mao Quan-Hua Ding Lu-Hui Zhuang shu-yi lv Department of Interventional Therapy Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo 315010Zhejiang ProvinceChina Department of Gastroenterology Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina

BACKGROUND Drug-eluting beads transarterial chemoem-bolization(DEB-TACE)has the advantages of slow and steady release,high local concentration,and low incidence of adverse drug reactions compared to the traditional *** combined with sequentially ultrasound-guided radiofrequency ablation(RFA)therapy has strong anti-cancer effects and little side effects,but there are fewer related long-term studies until *** To explore the outcome of DEB-TACE sequentially combined with RFA for patients with primary hepatocellular carcinoma(HCC).METHODS Seventy-six patients with primary HCC who underwent DEB-TACE sequentially combined with RFA were *** patients with untreated HCC were included in Group A,and 36 patients with recurrent HCC were included in Group *** addition,40 patients with untreated HCC who were treated with hepatectomy were included in Group *** serological examination,preoperative magnetic resonance imaging examination,and post-treatment computed tomography enhanced examination were performed for all *** efficacy was graded as complete remission(CR),partial remission(PR),stable disease and progressive disease at the 3rd,6th,and *** patients were followed up for 3 years and their overall survival(OS),disease-free survival(DFS)were *** The efficacy of Group A and Group C was similar(P>0.05),but the alanine aminotransferase,aspartate aminotransferase and total bilirubin of Group A were lower than those of Group C(all P0.05).The OS rates in Group A and Group B(90%,82.3%,and 66.4%)were simil

关键词： Drug-eluting beads transarterial chemoembolization Ultrasound Radiofrequency ablation Hepatocellular carcinoma Untreated Recurrent

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Digital twin driven and intelligence enabled content delivery in end-edge-cloud collaborative 5G networks

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Digital Communications and Networks 2024年第2期10卷 328-336页

作者： Bo yi Jianhui lv Xingwei Wang Lianbo Ma Min Huang College of Computer Science and Engineering Northeastern UniversityShenyang110169China Pengcheng Lab. Shenzhen518055China College of Software Northeastern UniversityShenyang110819China College of Information Science and Engineering Northeastern UniversityShenyang110819China

The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low ***,these massive devices will lead to explosive traffic growth,which in turn cause great burden for the data transmission and content *** challenge can be eased by sinking some critical content from cloud to *** this case,how to determine the critical content,where to sink and how to access the content correctly and efficiently become new *** work focuses on establishing a highly efficient content delivery framework in the IoE *** particular,the IoE environment is re-constructed as an end-edge-cloud collaborative system,in which the concept of digital twin is applied to promote the *** on the digital asset obtained by digital twin from end users,a content popularity prediction scheme is firstly proposed to decide the critical content by using the Temporal Pattern Attention(TPA)enabled Long Short-Term Memory(LSTM)***,the prediction results are input for the proposed caching scheme to decide where to sink the critical content by using the Reinforce Learning(RL)***,a collaborative routing scheme is proposed to determine the way to access the content with the objective of minimizing *** experimental results indicate that the proposed schemes outperform the state-of-the-art benchmarks in terms of the caching hit rate,the average throughput,the successful content delivery rate and the average routing overhead.

关键词： Digital twin IoE Content delivery Caching Routing

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Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3295-3311页

作者： Ao Wang yi Zhang Xinting lv Guang Liang Department of Pharmacy and Institute of Inflammation Zhejiang Provincial Affiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationYanbian UniversityYanji 133002China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’homeostasis and *** physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological *** of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic ***,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is ***,based on the current research status of targeted therapy,we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver *** an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical ***,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.

关键词： Tyrosine phosphorylation PTPs Signal transduction CLDs HCC Allosteric inhibitor PROTACs Drug development

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Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

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Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu lv Xiaohu GE yi ZHONG Qiang LI Yong XIAO School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling

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Anti-aging performance improvement and enhanced combustion efficiency of boron via the coating of PDA

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Defence Technology（防务技术） 2024年第3期33卷 399-410页

作者： shuai Ma Qinghai shu Mengyang Zhang Hongyu Huang Yansong Shi Xijuan lv shuai Zhao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(MOE) Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing100081China Tangshan Research Institute of Beijing Institute of Technology Tangshan063000HebeiChina

Boron is an ambitious fuel in energetic materials since its high heat release values,but its application is prohibited by low combustion efficiency and oxidization during *** polydopamine(PDA)was introduced into boron particles,investigating the impact of PDA content on the energetic behavior of *** results indicated that the PDA coating formed a fishing net structure on the surface of boron *** heat release results showed that the combustion calorific value of B@PDA was higher than that of the raw ***,the actual combustion heat of boron powder in B@10%PDA increased by 38.08%.Meanwhile,the DSC peak temperature decreased by 100.65℃under similar oxidation rate compared to raw ***,the B@PDA@AP and B@AP composites were prepared,and their combustion properties were *** was demonstrated that B@10%PDA@AP exhibited superior performance in terms of peak pressure and burning time,*** peak pressure is 12.43 kPa more than B@AP and burning time is 2.22 times higher than B@***,the coating of PDA effectively inhibits the oxidization of boron during storage and enhances the energetic behavior of boron and corresponding composites.

关键词： Boron particles Polydopamine Anti-aging performance improvement Heat release

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Hydrogen release of NaBH_(4) below 60 ℃ with binary eutectic mixture of xylitol and erythritol additive

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Chinese Journal of Chemical Engineering 2024年第7期71卷 225-234页

作者： Yugang shu Jiaguang Zheng Chengguo Yan Ao Xia Meiling lv Zhenxuan Ma Zhendong Yao School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China

NaBH_(4) was widely regarded as a low-cost hydrogen storage material due to its high-mass hydrogen capacity of approximately 10.8%(mass)and high volumetric hydrogen capacity of around 115 g·L^(–1).However,it exhibits strong stability and requires temperatures above 500℃ for hydrogen release in practical *** this study,two polyhydric alcohols,xylitol and erythritol(XE),were prepared as a binary eutectic sugar alcohol through a grinding-melting *** binary eutectic sugar alcohol was used as a proton-hydrogen carrier to destabilize NaBH_(4).The 19NaBH_(4)-16XE composite material prepared by ball milling could start releasing hydrogen at 57.5℃,and the total hydrogen release can reach over 88.8%(4.45%(mass))of the theoretical *** the 19NaBH_(4)-16XE composite was pressed into solid blocks,the volumetric hydrogen capacity of the block-shaped composite could reach 67.2 g·L^(–1).By controlling the temperature,the hydrogen desorption capacity of the NaBH_(4)-XE composite material was controllable,which has great potential for achieving solid-state hydrogen production from NaBH_(4).

关键词： Hydrogen Desorption Binary mixture NaBH_(4) Xylitol Erythritol

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Equilibrium Reinsurance Strategy and Mean Residual Life Function

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 758-777页

作者： Dan-ping LI lv CHEN Lin-yi QIAN Wei WANG School of Statistics Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China Academy of Statistics and Interdisciplinary Sciences Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,we analyze the relationship between the equilibrium reinsurance strategy and the tail of the distribution of the *** Mean Residual Life(MRL)has a close relationship with the tail of the distribution,we consider two classes of risk distributions,Decreasing Mean Residual Life(DMRL)and Increasing Mean Residual Life(IMRL)distributions,which can be used to classify light-tailed and heavy-tailed distributions,*** assume that the underlying risk process is modelled by the classical CramérLundberg model *** the mean-variance criterion,by solving the extended Hamilton-Jacobi-Bellman equation,we derive the equilibrium reinsurance strategy for the insurer and the reinsurer under DMRL and IMRL,***,we analyze how to choose the reinsurance premium to make the insurer and the reinsurer agree with the same reinsurance *** find that under the case of DMRL,if the distribution and the risk aversions satisfy certain conditions,the insurer and the reinsurer can adopt a reinsurance premium to agree on a reinsurance strategy,and under the case of IMRL,the insurer and the reinsurer can only agree with each other that the insurer do not purchase the reinsurance.

关键词： mean residual life excess-of-loss reinsurance insurer reinsurer stochastic control

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Spherical Bi_(2)O_(3)/ATO catalyst with N_(2)pre-reduction electrocatalytic reduction of CO_(2)to formic acid

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Journal of Environmental Sciences 2024年第6期140卷 331-340页

作者： Junying yi Yuli Chen Dongze Lai Bihong lv Xiaomin Wu Guohua Jing Department of Environmental Science&Engineering College of Chemical EngineeringHuaqiao UniversityXiamenFujian 361021China

To achieve carbon neutrality,the Chinese government needs to gain a comprehensive understanding of the sources and drivers of greenhouse gas(GHG)emissions,particularly at the county *** County in eastern China is a typical example of an industrial transformation from quarrying to a low-carbon *** study analyzed the decoupling types and structural characteristics of GHG emissions and the driving factors of carbon dioxide(CO_(2))emissions in the Anji from 2006 to 2019,and explored the differences between countylevel and provincial-level or city-level *** was observed that energy-related activities are the main source of GHG emissions in Anji and that economic development is the driving factor behind the increasing CO_(2)***,industrial transformation and upgradation coupled with the alternative use of clean energy limit the growth of GHG *** study details the GHG emissions of county during the industrial transformation stage and provides corresponding policy recommendations for county governments.

关键词： N_(2)prereduction CO_(2)electroreduction Bi_(2)O_(3)/ATO catalyst Formate

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Pollution characteristics and quantitative source apportionment of heavy metals within a zinc smelting site by GIS-based PMF and APCS-MLR models

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Journal of Environmental Sciences 2024年第10期144卷 100-112页

作者： Huagang lv Zhihuang Lu Guangxuan Fu Sifang lv Jun Jiang yi Xie Xinghua Luo Jiaqing Zeng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Zhuzhou Qingshuitang Technology Co. Ltd.Zhuzhou 412000China New World Environment Protection Group of Hunan Changsha 410083China

The abandoned smelters present a substantial pollution threat to the nearby soil and *** this study,63 surface soil samples were collected from a zinc smelter to quantitatively describe the pollution characteristics,ecological risks,and source apportionment of heavy metal(loid)s(HMs).The results revealed that the average contents of Zn,Cd,Pb,As,and Hg were 0.4,12.2,3.3,5.3,and 12.7 times higher than the risk screening values of the construction sites,***,the smelter was accumulated heavily with Cd and Hg,and the contribution of Cd(0.38)and Hg(0.53)to ecological risk was 91.58%.ZZ3 and ZZ7 were the most polluted workshops,accounting for 25.7%and 35.0%of the pollution load and ecological risk,*** influence of soil parent materials on pollution was minor compared to various workshops within the *** with PMF,APCS-MLR and GIS analysis,four sources of HMs were identified:P1(25.5%)and A3(18.4%)were atmospheric deposition from the electric defogging workshop and surface runoff from the smelter;P2(32.7%)and A2(20.9%)were surface runoff of As-Pb foul acid;P3(14.5%)and A4(49.8%)were atmospheric deposition from the leach slag drying workshop;P4(27.3%)and A1(10.8%)were the smelting process of zinc *** paper described the distribution characteristics and specific sources of HMs in different process workshops,providing a new perspective for the precise remediation of the smelter by determining the priority control factors.

关键词： Smelter site Heavy metal(loid)s Source apportionment Positive matrix factorization Absolute principal component score-multiple linear regression

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Lath-like phases formed at an extremely high temperature in a Mg-RE(RE=rare earth)-Al alloy

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Rare Metals 2024年第8期43卷 3937-3945页

作者： Bo Deng shu-Hui lv Qiang Yang Dong-Yue Zhao Jun-Yuan Fan Xin Qiu School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Chongqing Research Institute Changchun University of Science and TechnologyChongqing 401135China

Thermal stable intermetallic particles are important for the heat resistance of magnesium(Mg)*** this work,many lath-like particles formed in α-Mg grains of a Mg-8Gd-3Sm-0.7Al casting alloy when heat-treated at 873 ***-resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM) characterizations indicate that most of them are Mg-containing Al_(2)(Gd,Sm),with the atomic ratio of Mg:Al:(Gd,Sm) being ~1:1:1;a small part of them with relatively wider thickness are long-period stacking ordered(LPSO) phases simultaneously containing both 14H and 18R *** followed common orientation relationships with Mg matrix as those reported in previous *** addition,many Mg laths were observed in the primary blocky Al_(2)(Gd,Sm) phase at grain boundaries,where the atomic ratio of Al:(Gd,Sm) in the Al_(2)(Gd,Sm) matrix was 2:***,density functional theory(DFT) calculations illustrated the detail structure of the re-constructed Mg/Al_(2)RE interface and simultaneously deduced the underlying reason for the re-dissolution of the newly formed Mg-containing Al_(2)(Gd,Sm) plates in α-Mg matrix.

关键词： Magnesium alloy HAADF-STEM Microstructures Intermetallic particles Orientation relationships Interfaces

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