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Concomitant extrahepatic autoimmune diseases do not compromise the long-term outcomes of primary biliary cholangitis

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 577-582页

作者： Sha Chen Meng-Qi li Wei-Jia Duan Bu-Er li shu-xiang li Ting-Ting Lv lin Ma Ji-Dong Jia liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive Diseases95 Yong’an RoadBeijing 100050China

Background:Primary biliary cholangitis(PBC)patients often have concomitant extrahepatic autoimmune(EHA)diseases including Sjögren’s syndrome(SS),systemic sclerosis(SSc),rheumatoid arthritis(RA),and autoimmune thyroid *** present study aimed to describe the prevalence of EHA diseases in PBC and explore the impact of EHA diseases on the long-term outcomes of PBC in Chinese ***:Medical records of PBC patients diagnosed in our institute were retrospectively ***-tients were followed up by a standardized telephone *** endpoints were defined as liver-related death and/or liver ***:Totally 247 of the 985(25.1%)PBC patients enrolled in the study had at least one concomi-tant EHA ***ögren’s syndrome(n=140,14.2%)was the most frequent one,followed by rheuma-toid arthritis(RA)(n=56,5.7%)and Hashimoto’s thyroiditis(n=45,4.6%).Patients with EHA dis-eases were more common in females(Plic acid,the incidence of hepatic events,or transplant-free *** and EHA≥2 were protective factors for hepatic events in univariate Cox analysis,but the results became insignificant in multivariate ***:Concomitant EHA diseases were common in PBC patients but did not compromise the long-term outcomes of PBC.

关键词： Primary biliary cholangitis Extrahepatic autoimmune diseases Sjögren’s syndrome Rheumatoid arthritis Prognosis

Scalar-pseudoscalar pair production at the Large Hadron Collider at NLO+NLL accuracy in QCD

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Chinese Physics C 2021年第12期45卷 8-21页

作者： He-Yi li Ren-You Zhang Yu Zhang Wen-Gan Ma Ming-Ming Long shu-xiang li State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China School of Physics and Materials Science Anhui UniversityHefei 230601China

We thoroughly investigate both transverse momentum and threshold resummation effects on scalar-pseudoscalar pair production via quark-antiquark annihilation at the 13 TeV Large Hadron Collider at QCD NLO+NLL accuracy.A factorization method is introduced to properly supplement the soft-gluon(threshold)resummation contribution from parton distribution functions to the resummed results obtained by the Collins-Soper-Ster-man resummation *** find that the impact of the threshold-resummation improved PDFs is comparable to the resummation effect of the partonic matrix element and can even predominate in high invariant mass ***,the loop-induced gluon-gluon fusion channel in the type-I two-Higgs-doublet model is considered in our *** numerical results show that the electroweak production via quark-antiquark annihilation dominates over the gluon-initiated QCD production by 1-2 orders of magnitude.

关键词： scalar-pseudoscalar pair production two-Higgs-doublet model resummation

Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats

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World Journal of Diabetes 2023年第8期14卷 1249-1258页

作者： Hong Long Lei Zhao Zhong-Sheng Xiao shu-xiang li Qiu-lin Huang shuai Xiao liang-liang Wu Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Obesity usually causes diabetes mellitus(DM)and is a serious danger to human *** 2 DM(T2DM)mostly occurs along with *** obesityinduced DM is caused by an excessive long-term diet and surplus *** surgery can improve the symptoms of T2DM in some obese *** different types of bariatric surgery may have different *** To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in *** Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery(RYGB),sleeve gastrectomy(SG),or gastric banding(GB).Glucose and insulin tolerance tests,analyses of biochemical parameters,histological examination,western blot,and quantitative real-time polymerase chain reaction were *** In comparison to the sham operation group,the RYGB,SG,and GB groups had decreased body weight and food intake,reduced glucose intolerance and insulin insensitivity,downregulated biochemical parameters,alleviated morphological changes in the liver and kidneys,and decreased levels of protein kinase Cβ/*** effect in the RYGB group was better than that in the SG and GB *** These results suggest that RYGB,SG and GB may be helpful for the treatment of foodborne obesity-induced DM.

关键词： Diabetes mellitus Obesity Bariatric surgeries liver and kidney function

Decentralized fault diagnosis of discrete-event systems with unreliable sensors using linear temporal logic

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Science China(Information Sciences) 2025年第1期68卷 322-341页

作者： Weijie DONG Shaoyuan li xiang YIN Key Laboratory of System Control and Information Processing Ministry of EducationDepartment of Automation Shanghai Jiao Tong University

In this paper,we investigate a decentralized diagnosis problem of a discrete-evnt system(DES) subject to unreliable sensors,where the sensor observations of local diagnosers may be non-deterministic as a result of possible *** studies on decentralized robust diagnosis can only deal with different types of sensor failures separately,e.g.,all sensors suffer from the same type of sensor failures such as intermittent sensor failures or permanent sensor ***,since sensors of different local diagnosers may face different external environments and have different internal characteristics,sensors corresponding to different local diagnosers may also have their own fault *** this paper,we propose a flexible framework of decentralized diagnosis for DES subject to unreliable sensors such that sensors of different local diagnosers are permitted to have different types of sensor *** this end,we extend the existing decentralized diagnosis framework to the case where there exist common sensors broadcasting their observations to all local *** apply linear temporal logic(LTL) to constrain infinite behaviors of private sensors of local diagnosers and common ***,a new notion of φ-codiagnosability is proposed as the necessary and sufficient condition for the existence of a decentralized diagnoser that works correctly under sensors,satisfying LTL-based sensor ***,we provide an effective approach to verify the φ-codiagnosability.

关键词： discrete event systems decentralized diagnosis codiagnosability automata

Abiotic aerobic oxidation pathways of stibnite revealed by oxygen and sulfur isotope systematics of sulfate

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Journal of Environmental Sciences 2025年第1期147卷 83-92页

作者： Ningjie He shu li Xiaoqian li Yaning Tang Jiaxue Yang Jianwei Zhou School of Environment Studies China University of GeosciencesWuhan 430074China Key Laboratory of Mine Ecological Effects and Systematic Restoration Ministry of Natural ResourcesBeijing 100081China State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution Ministry of Ecology and EnvironmentWuhan 430074China Institute of Geological Survey China University of GeosciencesWuhan 430074China

The environmental threat posed by stibnite is an important geoenvironmental issue of current *** better understand stibnite oxidation pathways,aerobic abiotic batch experiments were conducted in aqueous solution with varyingδ^(18)O_(H_(2)O) value at initial neutral pH for different lengths of time(15-300 days).The sulfate oxygen and sulfur isotope compositions as well as concentrations of sulfur and antimony species were *** sulfur isotope fractionation factor(△^(34)S_(SO4-stibnite))values decreased from 0.8‰to-2.1‰during the first 90 days,and increased to 2.6‰at the 180 days,indicating the dominated intermediate sulfur species such as S_(2)O_(3)^(2-),S0,and H_(2)S(g)involved in Sb2S3 oxidation *** incorporation of O into sulfate derived from O_(2)(~100%)indicated that the dissociated O_(2)was only directly adsorbed on the stibnite-S sites in the initial stage(0-90 days).The proportion of O incorporation into sulfate from water(27%-52%)increased in the late stage(90-300 days),which suggested the oxidation mechanism changed to hydroxyl attack on stibnite-S sites promoted by nearby adsorbed O_(2)on stibnite-Sb *** exchange of oxygen between sulfite and water may also contributed to the increase of water derived O into SO42-.The new insight of stibnite oxidation pathway contributes to the understanding of sulfide oxidation mechanism and helps to interpret field data.

关键词： Sulfide oxidation δ^(34)S_(SO4) δ^(18)O_(SO4) Oxygen source of sulfate

Crop Yield,N Uptake and Nitrates in a Fluvo-Aquic Soil Profile

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Pedosphere 2004年第1期14卷 131-136页

作者： ZHANGshu-xiang liXiu-Ying liXiao-Ping YUANFeng-Ming YAOZhao-Hua SUNYong-lin ZHANGFu-Dao InstituteofSoilsandFertilizers ChineseAcademyofAgriculturalSciencesBeijing100081（China）

The effects of different chemical fertilizer combinations (N, P and K) oncrop yield, N uptake and nitrate distribution and accumulation to a depth of 100 cm were studied ina cinnamon fluvo-aquic soil profile (Beijing) with a continuous winter wheat-summer maize croppingsystem for nine years. The experiment consisted of 7 treatments: no fertilizer control (CK); Nalone, N in combination with K (NK), P (NP), and P and K (NPK and N1PK); and P and K in combinationwithout N (PK). The rate of N was 150 kg ha^(-1) for the N treatments except Treatment N1PK withhigher N rate (195 kg ha^(-1)), and the rates of P (P_2O_5) and K (K2O) were 75 and 37.5 kg ha^(-1),respectively. The applications of N combined with P and K (NK, NP and NPK) resulted in higher cropyields than a single application of N. The yields followed the order: NPK > NP > N1PK > PK > NK > N> CK for winter wheat, and NPK > N1PK > NP > NK > N > PK > CK for summer maize. Supplement of N withP or K, or both P and K resulted in a higher average N uptake of the two crops, which was in adecreasing order NPK > NP > N1PK > NK > N > PK > CK. The combinations also increased apparent Nrecovery more than N alone and CK. The nitrate content in the profile was thus reduced more in thecombination treatments. The nitrate accumulation in the soil profiles followed the order: N > NK >N1PK > NPK > NP > CK > PK. Higher N uptake by the adequately fertilized crops (Treatment NPK)reduced nitrate accumulation in the profile and thus reduced nitrate leaching. The optimum N:P:Kratio was thus of paramount importance in increasing yields and N uptake of crops and reducingnitrate leaching losses.

关键词： fertilizer combination N uptake nitrate distribution and accumulation yield

Recent progress in flexible sensors based on 2D materials

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Journal of Semiconductors 2025年第1期46卷 130-142页

作者： xiang li Guancheng Wu Caofeng Pan Rongrong Bao School of Physics Beihang UniversityBeijing 100191China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

With the rapid development of the internet of things(IoT)and wearable electronics,the role of flexible sensors is becoming increasingly irreplaceable,due to their ability to process and convert information ***-dimensional(2D)materials have been widely welcomed by researchers as sensitive layers,which broadens the range and application of flexible sensors due to the advantages of their large specific surface area,tunable energy bands,controllable thickness at the atomic level,stable mechanical properties,and excellent optoelectronic *** review focuses on five different types of 2D materials for monitoring pressure,humidity,sound,gas,and so on,to realize the recognition and conversion of human body and environmental ***,the main problems and possible solutions of flexible sensors based on 2D materials as sensitive layers are summarized.

关键词： 2D materials flexible sensors layered structure solution method

Detecting dynamic structural evolution based on in-situ high-energy X-ray diffraction technology for sodium layered oxide cathodes

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Chinese Chemical Letters 2025年第2期36卷 146-160页

作者： Yan-Jiang li shu-Lei Chou Yao Xiao Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon Neutralization

The detrimental phase transformations of sodium layered transition metal oxides（NaxTMO2） during desodiation/sodiation seriously suppress their practical applications for sodium ion batteries（SIBs）. Undoubtedly, comprehensively investigating of the dynamic crystal structure evolutions of NaxTMO2associating with Na ions extraction/intercalation and then deeply understanding of the relationships between electrochemical performances and phase structures drawing support from advanced characterization techniques are indispensable. In-situ high-energy X-ray diffraction（HEXRD）, a powerful technology to distinguish the crystal structure of electrode materials, has been widely used to identify the phase evolutions of NaxTMO2and then profoundly revealed the electrochemical reaction processes. In this review, we begin with the descriptions of synchrotron characterization techniques and then present the advantages of synchrotron X-ray diffraction（XRD） over conventional XRD in detail. The optimizations of structural stability and electrochemical properties for P2-, O3-, and P2/O3-type NaxTMO2cathodes through single/dual-site substitution, high-entropy design, phase composition regulation, and surface engineering are *** dynamic crystal structure evolutions of NaxTMO2polytypes during Na ion extraction/intercalation as well as corresponding structural enhancement mechanisms characterizing by means of HEXRD are concluded. The interior relationships between structure/component of NaxTMO2polytypes and their electrochemical properties are discussed. Finally, we look forward the research directions and issues in the route to improve the electrochemical properties of NaxTMO2cathodes for SIBs in the future and the combined utilizations of multiple characterization techniques. This review will provide significant guidelines for rational designs of high-performance NaxTMO2cathodes.

关键词： Electrochemistry In-situ high-energy X-ray diffraction Layered oxides Phase evolutions Sodium-ion batteries

Unraveling atomistic and electronic origins of multiaxial magnetic anisotropy

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 175-182页

作者： Boyu liu Xueyang li Junsheng Feng Changsong Xu Hongjun xiang Key Laboratory of Computational Physical Sciences(Ministry of Education) Institute of Computational Physical SciencesState Key Laboratory of Surface Physics and Department of PhysicsFudan UniversityShanghai200433China Shanghai Qi Zhi Institute Shanghai200030China School of Physics and Material Engineering Hefei Normal UniversityHefei230601China

Multiaxial magnetic anisotropy(MA)refers to the phenomenon that multiple axes of the magnetic crystal correspond to different energy *** with the common uniaxial magnetic anisotropy,multiaxial MA facilitates novel forms of applications in ***,by combining the first-principles-based spin Hamiltonian and tight-binding(TB)method,we reveal the microscopic origins,instead of the common phenomenological understanding,of biaxial MA and triaxial *** the example system of NiO,it is found that the multiple minima result from the fourth-order and the sixth-order single ion interactions,while the difference between[110]and[110]directions originates from a second-order bond-dependent anisotropic pair interaction(i.e.,the so-called Gamma interaction).Moreover,through the application of a newly developed general spin dependent TB approach,it is revealed that the triaxial MA arises from the special spin-orbital entangled Hund term,which is different from the orbital-independent Hund term in the usual Slater Koster TB *** work thus not only leads to a thorough understanding of the multiaxial MA in NiO,but also establishes a methodology that can be widely used to explore the microscopic origins of MA in different magnets.

关键词： multiaxial magnetic anisotropy origin of multiaxial magnetic mnisotropy effective spin Hamiltonian tight-binding model antiferromagnetism