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BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages

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Journal of Molecular Cell Biology 2019年第1期11卷 14-25页

作者： shu-wen qian Meng-Yuan Wu Yi-Na Wang Ya-Xin Zhao Ying Zou Jia-Bao Pan Yan Tang Yang Liu Liang Guo Qi-Qun Tang Key Laboratory of Metabolism and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai 200032China

Thermogenic beige fat improves metabolism and prevents *** evidence shows that the activation of M2 macrophages stimulates beige adipogenesis,whereas the activation of Ml macrophages,which play a major role in inflammation,impedes beige ***,the identification of factors that regulate adipose tissue macrophages(ATMs)will help clarify the mechanism involved in ***,we found that one of the secreted proteins in adipose tissue,namely,BMP4,alters the ATM profile in subcutaneous adipose tissue by activating M2 and inhibiting Ml ***,the BMP4-stimutated p38/MAPK/STAT6/PI3K-AKT signalling pathway is ***,BMP4 improved the potency of M2 macrophages to induce beige fat *** that the overexpression of BMP4 in adipose tissue promotes the beiging of subcutaneous adipose tissue and improves insulin sensitivity,these findings provide evidence that BMP4 acts as an activator of beige fat by targeting immuno-metabolic pathways.

关键词： BMP4 fat browning adipose tissue macrophages

BMP4-stimulated angiogenesis and adipogenesis contribute to adipocytes recruitment in subcutaneous white adipose tissue during beiging

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BMP4-stimulated angiogenesis and adipogenesis contribute to ...

Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： shu-wen qian Yan Tang Qi-qun Tang Key Laboratory of Metabolism and Molecular Medicine the Ministry of Education

Adipose tissues are important organs for energy homeostasis. White adipose tissue(WAT)stores energy in the form of triglycerides, whereas brown adipose tissue(BAT) dissipatesenergy in the form of heat. Adipose tissue expands to accommodate changes in energyavailability through hypertrophy of existing adipocytes and by initiating adipogenic differentiationof stem cells. Accumulation of visceral WAT is associated with adverse metabolicoutcomes, whereas increased amounts of subcutaneous WAT has been viewed as beneficialin its metabolic effects. WAT, especially in some subcutaneous depots will undergo‘beiging’- the process of acquiring characteristics of BAT- following cold exposure ortreatment with adrenergic activators or antidiabetic drugs, thiazolidinediones. De novoadipogeneis of subcutaneous WAT is evidenced during ‘beiging’ after cold exposure,which is accompanied by switching on an angiogenesis. However, the mechanisms bywhich adipogenesis is coordinated angiogeneis are largely unknown. Our previous workshowed BMP4 acquires subcutaneous WAT with BAT activity(beiging) along with increasednumber of both stromal vascular cells and mature adipocytes, indicating thatBMP4 both recruits and activates the beige adipocytes. In the present study, we found increasednumber of vascular endothelia in subcutaneous WAT of transgenic mice overexpressingBMP4, and decreased of that in knockouts. In ex vivo angiogenesis assay, sproutingfrom adipose tissue fragement was enhanced in tissues taken from BMP4 transgenicmice, or directly stimulated by BMP4 treatment. EdU labeling study detected EdU positivecells in both stromal vascular and mature adipocyte fraction of subcutaneous WAT, andthat was increased in mature adipocytes from transgenic mice, indicating BMP4 stimulatedstem cells proliferation as well as adipogenic differentiation. PDGFRβ positive pericytesaround blood microvessels were further evidenced to be the cell population regulated byBMP4, as most of the EdU positive SVF c

关键词： BMP4 adipogenesis angiogenesis WAT BAT

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Stimulation of histamine H4 receptor participates in cold-in...

An analysis of patents for anesthetic laryngoscopes

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Ya-Xin Zhao Jia-Bao Pan shu-wen qian Qi-Qun Tang The Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationInstitutes of Biomedical SciencesDepartment of Biochemistry and Molecular BiologyDepartment of Endocrinology and Metabolism of Zhongshan HospitalFudan University

While many studies have shown that histamine and its signaling regulate energy homeostasis through the central nervous system (CNS), their roles in adipose tissues remain poorly understood. We found the HrH4expression was significantly induced in subcutaneous adipose tissue in response to cold exposure by both quantitative PCR and Western blot. Functions of HrH4 in the browning process of white adipose tissue(WAT) and energy expenditure were explored after subcutaneous injection of HrH4 knockdown adenovirus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 825-832页

作者： Cheng-dong JI Xin PAN Yuan-chang XIONG Xuan GUO shu-wen qian Chang XU qiang-qiang FU Zhi-ping YANG Yu MA Yue-zhu WAN Department of Anesthesiology Yangpu Hospital School of Medicine Tongji University Central Laboratory Yangpu Hospital School of Medicine Tongji University Department of Anesthesiology Changhai Hospital the Second Military Medical University

The anesthetic laryngoscope is one of the most popular medical tools for obtaining a clear view of the larynx and facilitates tracheal intubation. The number of anesthetic laryngoscope patents, coming mainly from the anesthesiologists, has rapidly increased. Each product has a specialized use for particular patients. However, it is unclear to what extent anesthetic laryngoscopy gained acceptance in operating theaters. By retrieving patent data for more than 90 countries from the Online Retrieval of Bibliographic Information Time-share(ORBIT) system, we reviewed the anesthetic laryngoscope patent literature published before July 6, 2015, and manually analyzed patent status, general development trends, areas of competition, technology patentees, and technology classifications. The study showed that the number of anesthetic laryngoscope patent applications has stayed at a high level in the last decade. Most patent activity was carried out in the USA, with China and a number of European countries trailing behind. In addition, the patent analysis provided an opportunity to understand the trends in the development of anesthetic laryngoscope technology, to identify shortcomings in clinical use of anesthetic laryngoscopes, to assist medical manufacturing specialists in improving the design and products, and to suggest to anesthesiologists modifications of the clinical signs of difficult tracheal intubation based on the new commercial anesthetic laryngoscopes applied in the front-line.

关键词： Patent literature analysis Anesthetic laryngoscope Technology Data analysis Innovation dynamics

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基于局部曲线拟合的电压失稳预防控制算法

电力系统保护与控制 2013年第12期41卷 36-40页

作者：钟浩舒文倩唐民富三峡大学电气与新能源学院湖北宜昌443002 湘西电业局湖南吉首416000

为了快速获得预想失稳故障下的电压稳定预防控制方案,提出了一种基于局部曲线拟合的电压失稳预防控制算法。在深入研究电压稳定鞍结分岔点特性的基础上,利用局部曲线拟合方程式推导了一种无需分岔点处雅可比矩阵零特征值所对应左特征向... 详细信息

为了快速获得预想失稳故障下的电压稳定预防控制方案,提出了一种基于局部曲线拟合的电压失稳预防控制算法。在深入研究电压稳定鞍结分岔点特性的基础上,利用局部曲线拟合方程式推导了一种无需分岔点处雅可比矩阵零特征值所对应左特征向量即可快速计算负荷裕度灵敏度的方法。根据所求得的灵敏度建立失稳故障的预防控制模型,给出了预防电压失稳的控制方案。对IEEE-57节点系统的仿真结果表明,所提方法能够快速、准确地计算系统负荷裕度灵敏度,并且能够有效地将系统运行点拉回电压稳定安全域。

关键词：失稳故障鞍结分岔局部曲线拟合灵敏度预防控制

Down-regulation of β1,4-galactosyltransferase 5 activates BMPsignaling pathway and promotes adipocyte commitment through BMPRIA

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Down-regulation of β1,4-galactosyltransferase 5 activates B...

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

中国生物化学与分子生物学会第十一次会员代表大会暨201...

作者： shu-Fen Li Liu-Ling Xiao shu-wen qian Zhi-Chun Zhang Yue Zhao Jing-Hui Jiang Qi-Qun Tang Xi Li Key Laboratory of Molecular Medicine the Ministry of Education

Glycosylation of proteins is one of the most important post-translational *** of glycosyltransferases and aberrant glycosylation have been implicated inmany different diseases due to changes associated with protein location and *** show here thatβ1,4-galactosyltransferase 5(B4GalT5)expression is positivelycorrelated with obesity in *** pluripotent mesenchymal C3H10T1/2 cells,downregulationof B4GalT5 induces cells commitment to the adipocyte lineage without BMP2/4treatment which is essential for adipocyte *** silencing of Smad4and p38MAPK suggested that both Smad and p38 MAPK pathways are involved in this ***,B4GalT5knockdown decreases BMPRIA glycosylation,boost endocytosis ofBMPRIA,thus provokes redistribution of BMPRIA and promotes the BMP signaling ***,disruption of B4GalT5 expression in adipose tissue by adenovirusshRNA in high fat diet mouse model increases adipocyte ratio of total tissue cells,improves insulin sensitivity and reduces *** results demonstrate B4GalT5downregulation activate BMP signaling pathway and thus promote adipocytic commitmentthrough modifying BMPRIA and regulating its cellular location.

关键词： β1 4-galactosyltransferase 5 BMP signaling pathway adipocyte commitmentB MPRIA

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： qian Yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

β-淀粉样蛋白寡聚体对人神经母细胞瘤SH-SY5Y细胞Munc-18表达的调节

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细胞生物学杂志 2005年第2期27卷 178-182页

作者：钱淑文冯琼朱粹青复旦大学上海医学院医学神经生物国家重点实验室上海200032

为了观察阿尔茨海默病(AD)起始因素β-淀粉样蛋白(Aβ)对Munc-18表达的调节作用,采用Zn2+诱导制备Aβ寡聚体,分化的人神经母细胞瘤SH-SY5Y细胞经纳摩尔浓度Aβ寡聚体作用后用免疫印迹和流式细胞术的方法检测SH-SY5Y细胞的Munc-18蛋白水... 详细信息

为了观察阿尔茨海默病(AD)起始因素β-淀粉样蛋白(Aβ)对Munc-18表达的调节作用,采用Zn2+诱导制备Aβ寡聚体,分化的人神经母细胞瘤SH-SY5Y细胞经纳摩尔浓度Aβ寡聚体作用后用免疫印迹和流式细胞术的方法检测SH-SY5Y细胞的Munc-18蛋白水平,用MTT法分析纳摩尔浓度Aβ寡聚体的细胞毒性。结果发现,1nmol/L Aβ寡聚体作用1天后,SH-SY5Y细胞的Munc-18蛋白水平明显下调,随后逐渐增加。高浓度的Aβ寡聚体也有相似的作用效应,但抑制Munc-18蛋白表达的效应更明显。另外,相同浓度Aβ单体对Munc-18表达没有明显的影响,纳摩尔浓度的Aβ寡聚体也没有对细胞代谢产生显著的抑制。结果表明,纳摩尔水平Aβ寡聚体对Munc-18的表达有调节作用。

关键词： β-淀粉样蛋白寡聚体人神经母细胞瘤阿尔茨海默病 Munc-18蛋白病理机制

The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model

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The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism D...