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Mechanistic study of lipid metabolism disorders in diabetic kidney disease treated with GLQMP based on network pharmacology,molecular docking and in vitro experiments

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Traditional Medicine Research 2024年第2期9卷 42-51页

作者： shu-man liu Zi-Jie Yan man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:In this study,we used network pharmacology and molecular docking combined with vitro experiments to explore the potential mechanism of action of Gualou Qumai pill(GLQMP)against ***:We screened effective compounds and drug targets using Chinese medicine systemic pharmacology database and analysis platform and Chinese medicine molecular mechanism bioinformatics analysis tools;and searched for DKD targets using human online Mendelian genetics and gene *** potential targets of GLQMP for DKD were obtained through the intersection of drug targets and disease *** software was applied to build herbal medicine-active compound-target-disease networks and analyze them;protein-protein interaction networks were analyzed using the STRING database platform;gene ontology and Kyoto Encyclopedia of Genes and Genomes were used for gene ontology and gene and genome encyclopedia to enrich potential targets using the DAVID database;and the AutoDock Vina 1.1.2 software for molecular docking of key targets with corresponding key *** vitro experiments were validated by CCK8,oil red O staining,TC,TG,RT-qPCR,and Western ***:Through network pharmacology analysis,a total of 99 potential therapeutic targets of GLQMP for DKD and the corresponding 38 active compounds were obtained,and 5 core compounds were *** constructing the protein-protein interaction network and performing network topology analysis,we found that PPARA and PPARG were the key targets,and then we molecularly docked these two key targets with the 38 active compounds,especially the 5 core compounds,and found that PPARA and PPARG had good binding ability with a variety of *** vitro experiments showed that GLQMP was able to ameliorate HK-2 cell injury under high glucose stress,improve cell viability,reduce TC and TG levels as well as decrease the accumulation of lipid droplets,and RT-qPCR and Western blot confirmed that GLQMP was able to promote the expressi

关键词： Gualou Qumai pill diabetic kidney disease disorder of lipid metabolism network pharmacology molecular docking

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Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

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Traditional Medicine Research 2024年第11期9卷 27-37页

作者： Zi-Jie Yan Yu Kang shu-man liu Fang-Yu Wang man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

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Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research International 2024年第6期31卷 1344-1354页

作者： Peng-bo liu shu-sen Cheng Yu-qing Xue Xiao-man Cheng Zhao liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

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Monosomic Addition Lines of Flowering Chinese Cabbage(*** *** *** ***)-Chinese Kale(*** *** ***)

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Agricultural Sciences in China 2008年第6期7卷 656-663页

作者： WANG Xin-e ZHANG Cheng-he XUAN shu-xin man Hong liu Hai-he SHEN shu-xing College of Horticulture Agricultural University of Hebei Baoding 071001 P.R.China

Interspecific alien addition lines have played significant roles in gene mapping, intergenomic gene transfer and chromosomal homoeological identification between closely related species. Selection of alien addition lines was conducted by karyotype analysis and morphological observation with the reference of parents. Triploid interspecies hybrid （AAC, 2n = 3x = 29） was obtained from Brassica campestris ssp. chinensis var. parachinensis Qinglu 9601 （tetraploid, AAAA, 2n = 4x = 40） x B. oleracea var. alboglabra Baihua 9705 （diploid, CC, 2n = 2x = 18） by immature hybrid embryo culture in vitro. Five different alien monosomic addition lines （AA ＋ C2, AA ＋ C3, AA ＋ C4, AA ＋ C6, AA ＋ C7） were obtained from the backcross progenies of AAC x AA. Each alien monosomic addition line has some specific morphological characters. It is feasible to obtain alien addition lines from the progenies of AAC × AA by karyotype analysis and morphological observation based on the reference of parents

关键词： flowering Chinese cabbage Chinese kale allotriploid alien addition lines

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Broad gain,continuous-wave operation of InP-based quantum cascade laser atλ~11.8μm

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Chinese Physics B 2021年第12期30卷 413-417页

作者： Huan Wang Jin-Chuan Zhang Feng-Min Cheng Zeng-Hui Gu Ning Zhuo Shen-Qiang Zhai Feng-Qi liu Jun-Qi liu shu-man liu Zhan-Guo Wang Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Academy of Quantum Information Sciences Beijing 100193China

We demonstrate a broad gain,continuous-wave(CW)operation InP-based quantum cascade laser(QCL)emitting at 11.8μm with a modified dual-upper-state(DAU)and diagonal transition active region design.A 3 mm cavity length,16.5μm average ridge wide QCL with high-reflection(HR)coatings demonstrates a maximum peak power of 1.07 W at 283 K and CW output power of 60 m W at 293 *** device also shows a broad and dual-frequency lasing spectrum in pulsed mode and a maximum average power of 258.6 mW at 283 ***,the full width at half maximum(FWHM)of the electroluminescent spectrum measured at subthreshold current is 2.37μm,which indicates a broad gain spectrum of the *** tuning range of 1.38μm is obtained by a grating-coupled external cavity(EC)Littrow configuration,which is beneficial for gas detection.

关键词： dual-upper-state(DAU) quantum cascade lasers external cavity gas detection

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Disparities in tree mortality among plant functional types(PFTs)in a temperate forest:Insights into size-dependent and PFT-specific patterns

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Forest Ecosystems 2024年第4期11卷 480-490页

作者： man Hu Hang Shi Rui He Bingbin Wen Haikun liu Kerong Zhang Xiao shu Haishan Dang Quanfa Zhang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China Danjiangkou Wetland Ecosystem Field Scientific Observation and Research Station Chinese Academy of Sciences&Hubei ProvinceWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Forest&Nature Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 267Melle-Gontrode9090Belgium

Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains *** study analysed size-dependent tree mortality in a temperate forest,encompassing 46 tree species and 32,565 individuals across different PFTs(i.e.,evergreen conifer *** broadleaf species,shade-tolerant ***-intolerant species).By employing all-subset regression procedures and logistic generalized linear mixed-effects models,we identified distinct mortality patterns influenced by biotic and abiotic *** results showed a stable mortality patte rn in eve rgreen conifer species,contrasted by a declining pattern in deciduous broadleaf and shadetolerant,as well as shade-intolerant species,across size *** contribution to tree mortality of evergreen conifer species shifted from abiotic to biotic factors with increasing size,while the mortality of deciduous broadleaf species was mainly influenced by biotic factors,such as initial diameter at breast height(DBH)and conspecific negative *** shade-tolerant species,the mortality of small individuals was mainly determined by initial DBH and conspecific negative density dependence,whereas the mortality of large individuals was subjected to the combined effect of biotic(competition from neighbours)and abiotic factors(i.e.,convexity and pH).As for shade-intolerant species,competition from neighbours was found to be the main driver of tree mortality throughout their growth ***,these insights enhance our understanding of forest dynamics by revealing the size-dependent and PFT-specific tree mortality patterns,which may inform strategies for maintaining forest diversity and resilience in temperate forest ecosystems.

关键词： Size-dependent tree mortality Plant functional type Neighbourhood competition Topography variables Soil properties

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Beam steering characteristics in high-power quantum-cascade lasers emitting at∼4.6µm

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Chinese Physics B 2021年第3期30卷 96-99页

作者： Yong-Qiang Sun Jin-Chuan Zhang Feng-Min Cheng Chao Ning Ning Zhuo Shen-Qiang Zhai Feng-Qi liu Jun-Qi liu shu-man liu Zhan-Guo Wang Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Academy of Quantum Information Sciences Beijing 100193China

A beam steering effect of high-power quantum cascade(QC) lasers emitting at 4.6 μm was investigated. The continuous wave(CW) output power of an uncoated, 6-mm-long, 7.5-μm-wide buried-heterostructure QC laser at 25℃ was as high as 854.2 m W. The maximum beam steering angle was offset by ±14.2° from the facet normal(0°) in pulsed mode. The phenomenon was judged explicitly by combining the diffraction limit theory and Fourier transform of the spectra. It was also verified by finite element method software simulation and the calculation of two-dimensional(2 D)effective-index model. The observed steering is consistent with a theory for coherence between the two lowest order lateral modes. Therefore, we have established an intrinsic linkage between the spectral instabilities and the beam steering by using the Fourier transform of the spectra, and further presented an extremely valid method to judge the beam steering. The content of this method includes both three equidistant peak positions in the Fourier transform of the spectra and the beam quality located between once the diffraction limit(DL) and twice the DL.

关键词： beam steering quantum cascade lasers fourier transform of the spectra 2D effective-index model

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Tunable characteristic of phase-locked quantum cascade laser arrays

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Chinese Physics B 2021年第10期30卷 292-296页

作者： Zeng-Hui Gu Jin-Chuan Zhang Huan Wang Peng-Chang Yang Ning Zhuo Shen-Qiang Zhai Jun-Qi liu Li-Jun Wang shu-man liu Feng-Qi liu Zhan-Guo Wang Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

A multimode interference(MMI)structure is designed to simplify the fabrication of quantum cascade laser(QCL)phase-locked *** MMI geometry is optimized with a sufficient output channel distance to accommodate conventional photolithography and wet etching process by which power amplifier array is fabricated without using the complicated two-step etching-regrowth or dry etching *** far-field pattern with periodically modulated peaks reveals that the beams from the arrays are ***,the frequency tuning performance of the MMI-based phase-locked arrays is studied using the Littrow-configuration external cavity structure.A wavelength tuning range of more than 60 cm^(−1) is demonstrated,which will eventually realize the high power,frequency tunable,large-scale phase-locked arrays,and their application in spectroscopy.

关键词： multimode interference(MMI) phase-locked quantum cascade laser(QCL) external cavity

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APPROXIMATION PROBLEMS ON THE SMOOTHNESS CLASSES

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Acta Mathematica Scientia 2024年第5期44卷 1721-1734页

作者： Yongping liu man LU School of Mathematical Sciences Beijing Normal UniversityBeijing100875China

This paper investigates the relative Kolmogorov n-widths of 2π-periodic smooth classes in■.We estimate the relative widths of■and its generalized class K_(p)■(P_(r)),where K_(p)H^(ω)(Pr)is defined by a self-conjugate differential operator P_(r)(D)induced by■Also,the modulus of continuity of the r-th derivative,or r-th self-conjugate differential,does not exceed a given modulus of continuityω.Then we obtain the asymptotic results,especially for the case p=∞,1≤q≤∞.

关键词： relative width self-conjugate differential operator asymptotic estimate

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Numerical simulations for radon migration and exhalation behavior during measuring radon exhalation rate with closed-loop method

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Nuclear Science and Techniques 2024年第1期35卷 81-95页

作者： Ming Xia Yong-Jun Ye shu-Yuan liu School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001China

Accurate measurements of the radon exhalation rate help identify and evaluate radon risk regions in the *** these measurement methods,the closed-loop method is frequently ***,traditional experiments are insufficient or cannot analyze the radon migration and exhalation patterns at the gas–solid interface in the accumulation *** CFD-based technique was applied to predict the radon concentration distribution in a limited space,allowing radon accumulation and exhalation inside the chamber intuitively and *** this study,three radon exhalation rates were defined,and two structural ventilation tubes were designed for the *** consistency of the simulated results with the variation in the radon exhalation rate in a previous experiment or analytical solution was *** effects of the vent tube structure and flow rate on the radon uniformity in the chamber;permeability,insertion depth,and flow rate on the radon exhalation rate and the effective diffusion coefficient on back-diffusion were *** on the results,increasing the inser-tion depth from 1 to 5 cm decreased the effective decay constant by 19.55%,whereas the curve-fitted radon exhalation rate decreased(lower than the initial value)as the deviation from the initial value increased by approximately 7%.Increasing the effective diffusion coefficient from 2.77×10^(-7) to 7.77×10^(-6) m^(2) s^(-1) made the deviation expand from 2.14 to 15.96%.The conclusion is that an increased insertion depth helps reduce leakage in the chamber,subject to notable back-diffusion,and that the closed-loop method is reasonably used for porous media with a low effective diffusion coefficient in view of the back-diffusion *** CFD-based simulation is expected to provide guidance for the optimization of the radon exhalation rate measurement method and,thus,the accurate measurement of the radon exhalation rate.

关键词： Radon exhalation Numerical simulation Accumulation chamber

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