检索结果-南通市图书馆

Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

引用

Journal of Geriatric Cardiology 2024年第4期21卷 407-420页

作者： Jian-Guo CUI Feng TIAN Yu-Hao MIAO Qin-Hua JIN Ya-Jun SHI Li LI Meng-Jun SHEN Xiao-Ming XIE shu-lin zhang Yun-Dai CHEN School of Medicine Nankai UniversityTianjinChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Joint Laboratory of Bioimaging Technology and Applications SAS-SIM-IT&MEDIShanghaiChina Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghaiChina

OBJECTIVE To evalu ate the role of resting magnetocardiography in identifying seve re coronary artery stenosis in patients with suspected coronary artery *** A total of 513 patients with angina symptoms were included and divided into two groups based on the extent of coronary artery disease determined by angiography:the non-severe coronary stenusis group(linical *** performance of the models was evaluated using receiver operating characteristic curves,accuracy,sensitivity,specificity,positive predictive value(PPV) and ne gative predictive value(NPV).Calibration plots and decision curve analysis were performed to investigate the clinical utility and performance of the models,*** In the severe coronary stenosis group,QR_MCTDd,S_MDp,and TT_(MA)C_(50) were significantly higher than those in the non-severe coronary stenosis group(10,46±10.66 vs,5.11±6.07,P <0.001;7.2±8.64 vs.4.68±6.95,P=0.003;0.32±57.29 vs.0.26±57.29,P <0.001).While,QR_MV_(amp),R_(MA),and T_(MA) in the severe coronary stenosis group were lower(0.23±0.16 vs.0.28±0.16,P<0.001;55.06±48.68 vs.59.24±53.01,P<0.001;51.67±39.32 vs. 60.45±51.33,P <0.001).Seven MFM parameters were integrated into the model,resulting in an area under the curve of 0.810(95% CI:0.765-0.855).The sensitivity,specificity,PPV,NPV,and accurecy were 71.7%,80.4%,93.3%,42.8 %,and 73.5%;*** combined model exhibited an area under the curve of 0.845(95% CI:0.798-0.892).The sensitivity,specificity,PPV,NPV,and accuracy were 84.3%,73.8%,92.6%,54.6%,and 82.1%;*** curves demonstrate d excellent agreement between the nomogram prediction and actual *** decision curve analysis showed that the c ombine d model provided greater net benefit compared to the magnetocardingraphy model.C

关键词： coronary stenosis specificity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A synthetic optically pumped gradiometer for magnetocardiography measurements

引用

Chinese Physics B 2020年第4期29卷 215-217页

作者： shu-lin zhang Ning Cao Joint Laboratory of Bioimaging Technology and Applications CAS-SIMIT&MEDIShanghai 201899China State Key Laboratory of Functional Materials for Informatics Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences(CAS)Shanghai 200050China Centre for Excellence in Superconducting Electronics Chinese Academy of SciencesShanghai 200050China Shanghai Medi Instruments Ltd. Shanghai 201899China

Magnetocardiography(MCG)measurement is important for investigating the cardiac biological ***,the extremely weak MCG signal was detected by using superconducting quantum interference devices(SQUIDs).As a room-temperature magnetic-field sensor,optically pumped magnetometer(OPM)has shown to have comparable sensitivity to that of SQUIDs,which is very suitable for biomagnetic *** this paper,a synthetic gradiometer was constructed by using two OPMs under spin-exchange relaxation-free(SERF)conditions within a moderate magnetically shielded room(MSR).The magnetic noise of the OPM was measured to less than 70 fT/Hz1/*** a baseline of 100 mm,noise cancellation of about 30 dB was *** was successfully measured with a signal to noise ratio(SNR)of about 37 *** synthetic gradiometer technique was very effective to suppress the residual environmental fields,demonstrating the OPM gradiometer technique for highly cost-effective biomagnetic measurements.

关键词： optically pumped magnetometer(OPM) magnetocardiography(MCG) gradiometer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Host susceptibility to persistent hepatitis B virus infection

引用

World Journal of Gastroenterology 2006年第30期12卷 4788-4793页

作者： Ying-Li He Ying-Ren Zhao shu-lin zhang shu-Mei lin Department of Infectious Diseases the First Hospital of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

Genetic epidemiology researches such as twin studies, family-clustering of hepatitis B virus （HBV） infection studies and ethnic difference studies have provided the evidence that host genetic factors play an important role in determining the outcome of HBV infection. The opening questions include which human genes are important in infection and how to find them. Though a number of studies have sought genetic associations between HBV infection/persistence and gene polymorphisms, the candidate gene-based approach is clearly inadequate to fully explain the genetic basis of the disease. With the advent of new genetic markers and automated genotyping, genetic mapping can be conducted extremely rapid. This approach has been successful in some infectious diseases. linkage analysis can find host genes susceptible to HBV and is of great clinical importance.

关键词： Hepatitis B virus Susceptibility Association study linkage study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Specification Test of Stochastic Diffusion Models

引用

Acta Mathematicae Applicatae Sinica 2013年第3期29卷 529-540页

作者： shu-lin zhang Zheng-hong WEI Qiu-xiang BI School of Statistics Southwestern University of Finance and Economics College of Mathematics and Computational Science University of Shenzhen Department of Fixed Income Guangfa SecuritiesCo.Ltd.

In this paper, we propose a hypothesis testing approach to checking model mis-specification in continuous-time stochastic diffusion model. The key idea behind the development of our test statistic is rooted in the generalized information equality in the context of martingale estimating equations. We propose a bootstrap resampling method to implement numerically the proposed diagnostic procedure. Through intensive simulation studies, we show that our approach is well performed in the aspects of type I error control, power improvement as well as computational efficiency.

关键词： Stochastic diffusion model martingale estimating function generalized information equality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Screening and identification of interacting proteins with hepatitis B virus core protein in leukocytes and cloning of new gene C1

引用

World Journal of Gastroenterology 2006年第7期12卷 1043-1048页

作者： shu-Mei lin Jun Cheng Yin-Ying Lu shu-lin zhang Qian Yang Tian-Yan Chen Min Liu lin Wang Department of Infectious Diseases The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Institute of Infectious Diseases Ditan Hospital 13 Ditan Park Anwai Street Dongcheng District Beijing 100011 China

AIM： To investigate the biological function of HBcAg in pathogenesis of HBV replication in peripheral blood mononuclear cells （PBMCs）.METHODS： HBcAg region was amplified by polymerase chain reaction （PCR） and HBV HBcAg bait plasmid pGBKT7-HBcAg was constructed by routine molecular biological methods. Then the recombinant plasmid DNA was transformed into yeast AH109. After the HBV core protein was expressed in AH109 yeast strains （Western blot analysis）, yeast-two hybrid screening was performed by mating AH109 with Y187 containing leukocyte cDNA library plasmid. Diploid yeast cells were plated on synthetic dropout nutrient medium （SD/-Trp-Leu-His- Ade）（QDO） and synthetic dropout nutrient medium （SD/-Trp-Leu-His-Ade）（TDO）. The second screening was performed with the LacZ report gene （ yeast cells were grown in QDO medium containing X-a-gal）. The interaction between HBV core protein and the protein obtained from positive colonies was further confirmed by repeating yeast-two hybrid. After plasmid DNA was extracted from blue colonies and sequenced, the results were analyzed by bioinformatic methods.RESULTS： Eighteen colonies were obtained and sequenced, including hypermethylated in cancer 2 （3 colones）, eukaryotic translation elongation factor 2 （2 colones）, acetyl-coenzyme A synthetase 3 （1 colone）, DNA polymerase gamma （1 colone）, putative translation initiation factor （1 colone）, chemokine （C-C motif） receptor 5 （1 colone）, mitochondrial ribosomal protein L41 （1 colone）, kyot binding protein genes （1 colone）, RanBPM （1 colone）, HBeAg-binding protein 3 （1 colone）, programmed cell death 2 （1 colone）. Four new genes with unknown function were identified.CONCLUSION： Successful cloning of genes of HBV core protein interacting proteins in leukocytes may provide some new clues for studying the biological functions of HBV core protein.

关键词： Hepatitis B virus Core protein Yeast twohybrid system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system

引用

World Journal of Gastroenterology 2005年第36期11卷 5659-5665页

作者： Yan-Ping Huang Jun Cheng shu-lin zhang lin Wang Jiang Guo Yan Liu Yuan Yang Li-Ying zhang Gui-Qin Bai Xue-Song Gao Dong ji shu-Mei lin Qing Shao The First Hospital of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Institute of Infectious Diseases Ditan Hospital Anwai Street Beijing 100011 China

AIM： To investigate the biological function of F protein by yeast two-hybrid system. METHODS： We constructed F protein bait plasmid by cloning the gene of F protein into pGBKT7, then recombinant plasmid DNA was transformed into yeast AH109 （a type）. The transformed yeast AH109 was mated with yeast Y187 （α type） containing liver cDNA library plasmid in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium （SD/-Trp-Leu-HisAde） containing X-α-gal for selection and screening. After extracting and sequencing plasmids from positive （blue） colonies, we underwent sequence analysis by bioinformatics. RESULTS： Thirty-six colonies were selected and sequenced. Among them, 11 colonies were zymogen granule protein, 5 colonies were zinc finger protein, 4 colonies were zinc-α-2-glycoprotein, 1 colony was sialyltransferase, 1 colony was complement control protein factor I, 1 colony was vitronectin, and 2 colonies were new genes with unknown function. CONCLUSION： The yeast two-hybrid system is an effective method for identifying hepatocyte proteins interacting with F protein of hepatitis C virus. F protein may bind to different proteins. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Hepatitis C virus F protein Yeast two-hybridsystem

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Screening of genes of proteins interacting with p7 protein of hepatitis C virus from human liver cDNA library by yeast two-hybrid system

引用

World Journal of Gastroenterology 2005年第30期11卷 4709-4714页

作者： Yan-Ping Huang shu-lin zhang Jun Cheng lin Wang Jiang Guo Yan Liu Yuan Yang Li-Ying zhang Gui-Qin Bai Xue Song Gao Dong Ji shu-Mei lin Yan-Wei Zhong Qing Shao The First Hospital of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Institute of Infectious Diseases Ditan Hospital Anwai Street Beijing 100011 China

AIM： To investigate the biological function of p7 protein and to look for proteins interacting with p7 protein in hepatocytes. METHODS： We constructed p7 protein bait plasmid by cloning the gene of p7 protein into pGBKTT, then transformed it into yeast AH109 （a type）. The transformed yeast was mated with yeast Y187 （α type） containing liver cDNA library plasmid, pACT2 in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium （SD/- Trp-Leu-His-Ade） containing x-α-gal for selection and screening. After extracting and sequencing of plasmids from blue colonies, we performed sequence analysis by bioinformatics. RESULTS： Fifty colonies were selected and sequenced. Among them, one colony was Homo sapiens signal sequence receptor, seven colonies were Homo sapiens H19, seven colonies were immunoglobulin superfamily containing leucine-rich repeat, three colonies were spermatid peri-nuclear RNA binding proteins, two colonies were membrane-spanning 4-domains, 24 colonies were cancer-associated antigens, four colonies were nudeoporin 214 ku and two colonies were CLL-associated antigens. CONCLUSION： The successful cloning of gene of protein interacting with p7 protein paves a way for the study of the physiological function of p7 protein and its assodated protein.

关键词： Hepatitis C virus p7 protein Interacting proteins Yeast two-hybrid system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strengthening Project Management to Attain Overseas Blocks with High Potential for Exploration

引用

Frontiers of Engineering Management 2016年第4期3卷 331-337页

作者： shu-lin zhang CNOOC Research Institute

New overseas venture evaluation is key for oversea exploration of Chinese oil companies,whose credibility directly determine the degree of success of exploration for overseas *** uniqueness of new overseas venture evaluation in short assessing cycle and limited data make project management *** management includes human resource allocation,quality control and effective *** China National Offshore Oilfield Corporation(CNOOC),the new overseas venture evaluation system has been *** system includes quality control system and assurance for new overseas venture evaluation,geological evaluation norms for overseas oil & gas exploration,regulations for new overseas venture evaluation and seismic interpretation methodology and procedure for new overseas venture *** by the new overseas venture evaluation system,three-level quality control and management of data-room visit are strictly reinforced,which guarantees the efficiency and quality of new overseas venture *** a result the new overseas venture evaluation boosts the development of young explorationists and leads to breakthroughs in exploring potential target areas of CNOOC and in the discovery of giant oil and gas fields,which underpins the development of overseas business in CNOOC.

关键词： new overseas venture evaluation exploration project management quality management assessing system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aerodynamic/stealth design of S-duct inlet based on discrete adjoint method

引用

Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 725-746页

作者： Jun DENG Ke ZHAO lin ZHOU Wei zhang Bowen shu Jiangtao HUANG Zhenghong GAO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aerospace Technology Institute of China Aerodynamic Research and Development CenterMianyang 621000Sichuan ProvinceChina

It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very *** this study,an aerodynamic/stealth optimization design method for an S-duct inlet is *** upwind scheme is introduced to the aerodynamic adjoint equation to resolve the shock wave and flow *** multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal S-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth *** the aerodynamic and stealth characteristics of the inlet are effectively ***,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteristics and stealth characteristics is the centerline and crosssectional *** S-duct is smoothed,and the cross-sectional area is increased to improve the aerodynamic characteristics,while it is completely opposite for the stealth *** radar cross section(RCS)is reduced by phase cancelation for low frequency *** method is suitable for the aerodynamic/stealth design of the aircraft airframe-inlet system.

关键词： S-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

引用

China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE shuang-yi GAO Jian LI Yong-ran JIANG shu-xin zhang Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：