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World Journal of Gastroenterology 2014年第16期20卷 4771-4777页

作者： Yan-Min zhang shu-kun zhang Nai-Qiang Cui Tianjin Medical University Intensive Care UnitTianjin Nankai Hospital Tianjin Nankai Hospital Department of Surgery Tianjin Nankai Hospital

AIM: To investigate whether mesenteric lymph from rats with severe intraperitoneal infection (SII) induces lung injury in healthy rats.

关键词： Severe intraperitoneal infection, Mesenteric lymph, Acute lung injury, Toll-like receptor 4, Nuclear factor κ B

Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 117-120页

作者： Nai-Qiang Cui, shu-kun zhang, Yun-Feng Cui, Dong-Hua Li,Chang Chen and Xian-Zhong Wu Tianjin, China Institute of Acute Abdominal Diseases and Department of Surgery Department of Surgery Tianjin Nankai Hospital Tianjin 300100 China. yunfengcuidoctor@***

BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.

关键词： SCP2 mRNA expression lithogenic biles cholesterol gallstone

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椎旁肋骨小头粘液软骨肉瘤1例(英文)

癌症 2009年第8期28卷 894-896页

作者：张淑坤王建国朴月善卢德宏青海省人民医院病理学系青海西宁810007 首都医科大学宣武医院病理学系北京100053

A29-year-old man had a mass measuring about2.1cm×2.0cm×1.6cmby CT scan for three *** was hospitalized with a primary diagnosis of *** scan demonstrated a lobular,

关键词：粘液软骨肉瘤推旁肋骨小头病例报告

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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肠型白塞氏病临床病理特征分析3例

世界华人消化杂志 2009年第16期17卷 1689-1692页

作者：张淑坤王建国周世英张梦岚吴彩虹青海省人民医院病理科青海省西宁市810007

目的:探讨肠型白塞氏病的临床特点、病理学特征及鉴别诊断要点.方法:收集肠型白塞氏病确诊患者3例,进行临床资料复习和组织病理学检查.患者均以消化系症状入院,同时患者伴有白塞氏病的主要临床症状.结果:患者溃疡病变多发生于肠系膜附... 详细信息

目的:探讨肠型白塞氏病的临床特点、病理学特征及鉴别诊断要点.方法:收集肠型白塞氏病确诊患者3例,进行临床资料复习和组织病理学检查.患者均以消化系症状入院,同时患者伴有白塞氏病的主要临床症状.结果:患者溃疡病变多发生于肠系膜附着的对侧,溃疡呈圆形,较深;镜下见肠黏膜组织溃疡形成,周围黏膜下淋巴组织增生显著,主要表现以静脉为主的血管炎症.治疗上,糖皮质激素及免疫抑制剂是基础用药,其预后不令人满意.结论:肠型白塞氏病早期诊断有赖于对病史及临床症状的综合分析.肠型白塞氏病无特异性治疗方法,除非合并严重并发症,一般不主张手术治疗.

关键词：肠型白塞氏病临床特点病理特点

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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胰腺实性-假乳头状瘤临床病理观察14例

世界华人消化杂志 2009年第30期17卷 3155-3159页

作者：易敏王嵘王建国周世英张淑坤刘红明青海省肿瘤医院病理科青海省西宁市810007 青海省肿瘤医院肿瘤科青海省西宁市810007 青海省人民医院病理科青海省西宁市810007 西宁市第一人民医院病理科青海省西宁市810000

目的:探讨胰腺实性-假乳头状瘤(SPTP)的临床病理形态特征以及免疫组织化学特点.方法:回顾性总结分析14例SPTP的临床病理资料及免疫组织化学结果,并以5例胰岛细胞瘤为对照(其中3例为非功能性,2例为功能性).结果:14例SPTP患者中男女比例1... 详细信息

目的:探讨胰腺实性-假乳头状瘤(SPTP)的临床病理形态特征以及免疫组织化学特点.方法:回顾性总结分析14例SPTP的临床病理资料及免疫组织化学结果,并以5例胰岛细胞瘤为对照(其中3例为非功能性,2例为功能性).结果:14例SPTP患者中男女比例1∶6,平均年龄28岁,瘤体平均直径7.25cm,包膜均完整,组织学显示肿瘤细胞大小一致,排列成实性片状区和假乳头状区,围绕纤维血管复层排列而形成的假乳头状突起为特征性组织学改变.E-Cadherin、嗜铬素A均为阴性;β-Catenin在细胞核100%表达阳性,胞质阳性率为78.5%(11/14),细胞膜均为阴性;CD10表达阳性.结论:SPTP是好发年轻女性的低度恶性肿瘤,有特征性的假乳头结构;β-Catenin与E-Cadherin的异常表达可能与肿瘤的发生相关.

关键词：胰腺实性-假乳头状瘤临床病理免疫组织化学鉴别诊断

洛美沙星的铕离子荧光探针时间分辨荧光法测定

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分析测试学报 2010年第2期29卷 147-151页

作者：曹文丽于永丽徐淑坤张秀娟东北大学理学院辽宁沈阳110004

采用时间分辨荧光法，以铕离子为荧光探针，依据Eu3＋La3＋-LMX—SDS稀土共发光体系，建立了测定洛美沙星（LMX）含量的新方法。研究了配合物的紫外及荧光光谱，分析了配合物的发光机理，考察了溶液pH值、缓冲溶液种类及反应试剂加入量... 详细信息

采用时间分辨荧光法，以铕离子为荧光探针，依据Eu3＋La3＋-LMX—SDS稀土共发光体系，建立了测定洛美沙星（LMX）含量的新方法。研究了配合物的紫外及荧光光谱，分析了配合物的发光机理，考察了溶液pH值、缓冲溶液种类及反应试剂加入量对配合物荧光强度的影响。在优化的实验条件下，配合物荧光强度和洛美沙星浓度呈线性关系，相关系数为0．9990，线性范围为5．0×10-7-1．0×10～mol／L。方法的检出限为6．8×10mol／L，对5．0×10-6mol／L的洛美沙星溶液测定11次，RSD为0，6％。将该方法用于尿液中洛美沙星含量的测定，回收率为94％～104％。

关键词：铕洛美沙星荧光探针时间分辨荧光法

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress