Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones

作     者：Nai-Qiang Cui, Shu-Kun Zhang, Yun-Feng Cui, Dong-Hua Li,Chang Chen and Xian-Zhong Wu Tianjin, China Institute of Acute Abdominal Diseases and Department of Surgery 

作者机构：Department of Surgery Tianjin Nankai Hospital Tianjin 300100 China. yunfengcuidoctor@*** 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2005年第4卷第1期

页      面：117-120页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by a grant from the Health Bureau of Tianjin  China(No. 00kyzd8) 

主　　题：SCP2 mRNA expression lithogenic biles cholesterol gallstone 

摘      要：BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.