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Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice

Neural Regeneration Research 2019年第2期14卷 298-305页

作者： Yan-Ping Wu hua-Ying Gao shu-hua ouyang Hiroshi Kurihara Rong-Rong He Yi-Fang Li Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of Pharmacy Jinan University Anti-Stress and Health Research Center College of Pharmacy Jinan University

Stress has been suggested to disturb the 5-hydroxytryptamine system and decrease neurogenesis, which contribute to the development of depression. Few studies have investigated the effect of predator stress, a type of psychological stress, on depression and hippocampal neurogenesis in adult mice; we therefore investigated this in the present study. A total of 35 adult male Kunming mice were allocated to a cat stress group, cat odor stress group, cat stress + fluoxetine group, cat odor stress + fluoxetine group, or a control group(no stress/treatment). After 12 days of cat stress or cat odor stress, behavioral correlates of depression were measured using the open field test, elevated plus maze test, and dark-avoidance test. The concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured using high-performance liquid chromatography-electrochemical detection. Neurogenesis was also analyzed using a bromodeoxyuridine and doublecortin double-immunostaining method. Cat stress and cat odor stress induced depression-like behaviors; this effect was stronger in the cat stress model. Furthermore, compared with the control group, cat stress mice exhibited lower 5-hydroxytryptamine concentrations, higher 5-hydroxyindoleacetic acid concentrations, and significantly fewer bromodeoxyuridine+/doublecortin+-labeled cells in the dentate gyrus, which was indicative of less neurogenesis. The changes observed in the cat stress group were not seen in the cat stress + fluoxetine group, which suggests that the effects of predator stress on depression and neurogenesis were reversed by fluoxetine. Taken together, our results indicate that depression-like behaviors induced by predator stress are associated with the inhibition of hippocampal neurogenesis.

关键词： nerve regeneration depressive disorder cat stress cat odor stress behavioral evaluation open field test elevated plus maze test dark-avoidance test 5-hydroxytryptamine 5-hydroxyindoleacetic acid hippocampal neurogenesis neural regeneration

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Novel insights into stress-induced susceptibility to influenza:corticosterone impacts interferon-βresponses by Mfn2-mediated ubiquitin degradation of MAVS

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Signal Transduction and Targeted Therapy 2020年第1期5卷 782-793页

作者： Zhuo Luo Li-Fang Liu Ying-Nan Jiang Lu-Ping Tang Wen Li shu-hua ouyang Long-Fang Tu Yan-Ping Wu Hai-Biao Gong Chang-Yu Yan Shan Jiang Yu-Hui Lu Tongzheng Liu Zhenyou Jiang Hiroshi Kurihara Yang Yu Xin-Sheng Yao Yi-Fang Li Rong-Rong He Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Institute of Tumor Pharmacology College of PharmacyJinan UniversityGuangzhou 510632China Department of Microbiology and Immunology Basic Medicine CollegeJinan UniversityGuangZhou 510632China

Although stress has been known to increase the susceptibility of pathogen infection,the underlying mechanism remains *** this study,we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with the influenza virus(H1N1)and obviously aggravated lung ***(CORT),a main type of glucocorticoids in rodents,was secreted in the plasma of stressed *** further found that this stress hormone significantly boosted virus replication by restricting mitochondrial antiviral signaling(MAVS)protein-transduced IFN-βproduction without affecting its mRNA level,while the deficiency of MAVS abrogated stress/CORT-induced viral susceptibility in ***,the effect of CORT was mediated by proteasome-dependent degradation of MAVS,thereby resulting in the impediment of MAVS-transduced IFN-βgeneration in vivo and in ***,RNA-seq assay results indicated the involvement of Mitofusin 2(Mfn2)in this ***-and loss-offunction experiments indicated that Mfn2 interacted with MAVS and recruited E3 ligase SYVN1 to promote the polyubiquitination of ***-immunoprecipitation experiments clarified an interaction between any two regions of Mfn2(HR1),MAVS(C-terminal/TM)and SYVN1(TM).Collectively,our findings define the Mfn2-SYVN1 axis as a new signaling cascade for proteasome-dependent degradation of MAVS and a‘fine tuning’of antiviral innate immunity in response to influenza infection under stress.

关键词： influenza ubiquitin MAVS

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Caffeine improves stress-induced decline of hippocampal neurogenesis in chronic water immersion restraint mice

Caffeine improves stress-induced decline of hippocampal neur...

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中国化学会第十届全国天然有机化学学术会议

作者： Zhong-Fu Mao Xiao-Mei Chen shu-hua ouyang Rong-Rong He Yi-Fang Li Hiroshi Kurihara Institute of Traditional Chinese Medicine and Natural Products Jinan University

＜正＞Caffeine is the most consumed pychostimulant in the world,and it is known to affect basic and fundamental human processes such as sleep,arousal,cognition and learning and *** continues through adulthood in the hippocampus and olfactory bulb of mammals,and neurogenesis recession is considered the main mechanism of neurodegenerative diseases.A growing

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Chicken extract affects learning and memory in restraint-stressed C57BL/6J mice

Chicken extract affects learning and memory in restraint-str...

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中国化学会第十届全国天然有机化学学术会议

作者： Yu-Jia Zhai shu-hua ouyang Xiao-Xiao Li Yi-Fang Li Rong-Rong He Hiroshi Kurihara Pharmacy College Jinan University

＜正＞In the present study,we studied the effects of Chicken Extract（CE）on learning and memory in restraint-stressed *** week-old male C57BL/6J mice were randomly divided into four groups as follows:normal control,restraint stress control,low dosage of CE（12 mL/kg/d）,and high dosage of CE（24 mL/kg/d）.The normal control group and restrain stress control group received

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荒漠化重建地区土壤有机碳动态研究

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水土保持学报 2004年第3期18卷 74-77,89页

作者：程淑兰欧阳华牛海山王琳田玉强张锋中国科学院地理科学与资源研究所北京100101 中国科学院研究生院北京100039

土壤有机碳(Soilorganiccarbon,SOC)是反映土地荒漠化的重要指标。本研究以陕西省榆林市为例,开展小区域沙漠化重建地区SOC动态的实证研究。SOC数据来源于1982年土壤普查和2003年重复采样,土样的采集、分析和统计方法分别为土钻取土法... 详细信息

土壤有机碳(Soilorganiccarbon,SOC)是反映土地荒漠化的重要指标。本研究以陕西省榆林市为例,开展小区域沙漠化重建地区SOC动态的实证研究。SOC数据来源于1982年土壤普查和2003年重复采样,土样的采集、分析和统计方法分别为土钻取土法、重铬酸钾氧化法、吸管法和面积加权法。研究结果表明:SOC含量与粗砂粒显著负相关(R=-0.50,a=0.01),与粘粒显著正相关(R=-0.45,a=0.05),20年间土壤颗粒细化趋势比较明显;20年间原始剖面、1m深和耕层SOC含量、密度和储量都有不同程度的增加,其中对人类活动最敏感的耕层土壤变化最显著,SOC含量、密度和储量分别增加了0.55g/kg,0.15kg/m2,10.07GgC。该研究结果表明防风固沙、可持续性农耕等措施会卓有成效地促进土地沙漠化的恢复和重建。

关键词：荒漠化重建地区土壤有机碳动态分析

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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv shu-Meng Han Li-Yun He Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

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Diagnosis and Design Improvement of the Internal Flow Field in an Automotive Cooling Fan Based on Boundary Vorticity Dynamics, Part Ⅰ: Blade Profile Scaling and Rotation

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Journal of Thermal Science 2022年第6期31卷 2411-2423页

作者： PENG Zhigang ouyang hua WU Yadong TIAN Jie School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Brose Electric Motors Company Limited Shanghai 201801China

To optimize the aerodynamic performance of the automobile cooling fan(ACF), the internal flow field of the original fan was numerically simulated. According to the theory of boundary vorticity dynamics(BVD), the distribution laws of the boundary vorticity flux(BVF) on the blade surface and the circumferential vorticity(CV) at the wake plane of the fan were analyzed, and the underlying various negative factors, such as vortex shedding, separated flow and complicated secondary flow, on the fan blade surface and its dynamic source were diagnosed. Combined with the velocity triangle theory, the mathematical relationship between the BVF diagnosis and the geometrical characteristics of the blade profile(hereinafter referred to as profile) is used to guide the design improvement of the blade. The analysis found that at the same speed, the extension and rotation of the profile could match a smaller input torque at the same flow rate and pressure rise, thereby improving the efficiency of the fan. The test results confirmed the above conclusion. The peak efficiency of the improved fan has been increased by 2.3%, and the aerodynamic performance in the low-flow-rate has been improved. The conclusion of the study shows the applicability of the BVD theory in the diagnosis and design improvement of ACF internal flow.

关键词： boundary vorticity flux automotive cooling fan design improvement blade profile

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Modal Analysis of Axial Compressor Tip Rotating Instability under Varying Operating Conditions

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Journal of Thermal Science 2023年第4期32卷 1345-1356页

作者： LI Tao WU Yadong TIAN Jie ouyang hua School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Engineering Research Centre of Gas Turbine and Civil Aero Engine Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China

The full annulus numerical research was performed on a low-speed compressor rotor to investigate the rotating instability in the tip *** frequency spectra show the existence of rotating instability at narrow stable operating *** the decrease of flow rate,31 cells of flow disturbance can be found in the instantaneous flow *** distribution of vortex suggests that the circumferential propagation of the interaction between tip leakage vortex and adjacent blade brings about these *** dynamic mode decomposition(DMD)method and spatial discrete Fourier transform(SDFT)were applied to obtain the circumferential mode features,and the results indicate that the rotating instability is associated with the 31 cells of flow *** the DMD method was further applied on the pressure data from a circle and an annulus domain,so as to extract different mode components with the corresponding spatial structures,frequencies and *** results suggest that DMD modes can display the flow feature and explore the evolution of each instability source in the tip flow field.

关键词： axial compressor rotating instability flow structure circumferential mode dynamic mode decomposition

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COMPUTATIONAL AND EXPERI-MENTAL STUDY ON TIP LEAKAGE VORTEX OF CIRCUMFERENTIAL SKEWED BLADES

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Chinese Journal of Mechanical Engineering 2007年第2期20卷 82-87页

作者： LI Yang ouyang hua DU Zhaohui School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China

In the steady operation condition, the experiments and the numerical simulations are used to investigate the tip leakage flow fields in three low pressure axial flow fans with three kinds of circumferential skewed rotors, including the radial rotor, the forward-skewed rotor and the back- ward-skewed rotor. The three-dimensional viscous flow fields of the fans are computed. In the experiments, the two-dimensional plane particle image velocimetry （PIV） system is used to measure the flow fields in the tip region of three different pitchwise positions of each fan. The results show that the computational results agree well with the experimental data in the flow field of the tip region of each fan. The tip leakage vortex core segments based on method of the eigenmode analysis can display clearly some characteristics of the tip leakage vortex, such as the origination position of tip leak- age vortex, the development of vortex strength, and so on. Compared with the radial rotor, the other two skewed rotors can increase the stability of the tip leakage vortex and the increment in the forward-skewed rotor is more than that in the backward-skewed one. Among the tip leakage vortices of the three rotors, the velocity of the vortex in the forward-skewed rotor is th6 highest in the circumferential direction and the lowest in the axial direction.

关键词： Low pressure axial flow fan Tip leakage vortex Particle image velocimetry (PIV) Eigenmode analysis

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Numerical Investigation on Aeroelastic Behavior of Composite Material Plate Excited by Pulsed Air Jet

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Journal of Thermal Science 2018年第4期27卷 364-372页

作者： XIE Hairun WU Yadong WANG Anjenq ouyang hua School of Mechanical Engineering Shanghai Jiao Tong University

Nowadays, carbon fiber composite material is becoming more and more popular in aero engine industry due to its high specific strength and stiffness. Laminate carbon fiber composite material is widely used to manufacture the high load wide chord fan blade, containment casing, etc. The aeroelastic behavior of composite product is critical for the optimization of the product design and manufacturing. In order to explore its aeroelastic property, this paper discusses the coupled simulation of aerodynamic excitation applied on laminate composite material plate. Mechanical behavior of composite material plate is different from that of isotropic material plate such as metal plate, because it is anisotropy and has relative high mechanical damping due to resin between plies. These plates to be studied are designed using 4 different layup configurations which follow the design methods for composite fan blade. The numerical simulation of force response analysis mainly uses single frequency mechanical force input to simulate the electromagnetic shakers or other actuators, which could transmit mechanical force to the test parts. Meanwhile, pulsed air excitation is another way to "shake" the test parts. This excitation method induces aero damping into the test part and simulates the unsteady flow in aero engine, which could cause aeroelastic problems, such as flutter, forced response and non-synchronous vibration(NSV). In this study, numerical simulation using coupled method is conducted to explore the characteristics of laminate composite plates and the property of aerodynamic excitation force generated by pulsed air jet device. Modal analysis of composite plate shows that different ply stacking sequences have a significant impact on the plate vibration characteristics. Air pulse frequency and amplitude in flow field analysis are calibrated by hot wire anemometer results. As the air pulse frequency and amplitude are varied, incident angle of flow and layup configurations of plat

关键词： aeroelasticity pulsed air jet composite plate

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