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A Scalable Infrastructure for Online Performance Analysis on CFD Application

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Chinese Journal of Aeronautics 2012年第4期25卷 546-558页

作者： hu Kai DING Yi ZHANG Xinyu JIANG shu School of Computer Science and Engineering Beihang UniversityBeijing 100191China

The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and *** response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational *** a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous *** infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage *** paper analyzes and elaborates this infrastructure in detail with respect to its design and ***,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.

关键词： computational aerodynamics computational fluid dynamics scalability online analysis data transmission data storage

Field investigation of intelligent compaction for hot mix asphalt resurfacing

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 47-55页

作者： Wei hu Xiang shu Baoshan huANG Mark WOODS Department of Civil and Environmental Engineering The University of Tennessee Knoxville TN 37996 USA Division of Materials and Tests Tennessee Department of Transportation 6601 Centennial Blvd. Nashville TN 37243 USA

Intelligent compaction （IC） is a relatively new technology for asphalt paving industry. The present study evaluated the effectiveness and potential issues of the IC technology for flexible pavement resurfacing construction using two field projects. In the first project, a geostatistical semivariogram model was established and the parameters derived from it were compared with univariate statistical parameters for the Compaction Meter Value （CMV） data. Further analyses illustrated the effect of temperature on the CMV value and compaction uniformity. In the second project, a multivariate analysis was performed between in situ tests and IC data. The possibility of combining various IC data to predict the asphalt layer density and improve the current quality control and assurance system was discussed.

关键词： intelligent compaction compaction meter value (CMV) semivariogram multivariate analysis

Early Paleozoic geodynamic evolution of the Eastern Central Asian Orogenic Belt: Insights from granitoids in the Xing’an and Songnen blocks

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Geoscience Frontiers 2020年第6期11卷 1975-1992页

作者： Xin-Lu hu shu-Zhen Yao Cheng-Yin Tan Guo-Ping Zeng Zhen-Ju Ding Mou-Chun he Faculty of Earth Resources China University of GeosciencesWuhan430074China National Demonstration Center for Experimental Mineral Exploration Education China University of GeosciencesWuhan430074China heilongjiang Mining Group Limited Liability Company Harbin150036China Wuhan Center China Geological SurveyWuhan430205China

The early Paleozoic tectonic framework and evolutionary history of the eastern Central Asian Orogenic Belt(CAOB)is poorly *** we present zircon U-Pb geochronology,whole rock geochemistry,and Sr-NdHf isotope data of the early Paleozoic granitoids in eastern CAOB to investigate the petrogenesis and geodynamic *** early Paleozoic granitoids from the Songnen Block yield zircon U-Pb ages of 523-490 Ma,negative εNd(t)values of-6.7 to-0.8,and values of-8.6 to 7.1,indicating they were generated by partial melting of ancient crustal materials with various degrees of mantle *** generally show affinities to A-type granites,implying their generation from an extensional environment after the collision between the Songnen and Jiamusi *** comparison,the early Paleozoic granitoids from the Xing’an Block have zircon U-Pb ages of 480-465 Ma,εNd(t)values of-5.4 to 5.4,andεHf(t)values of-2.2 to 12.9,indicating a dominated juvenile crustal source with some input of ancient crustal *** belong to I-type granites and were likely related to subduction of the Paleo-Asian *** statistics of TDM2 Hf model ages of the granitoids indicate that the Erguna and Jiamusi blocks contain a significant proportion of Mesoproterozoic crystalline basement,while the Xing’an Block is dominated by a Neoproterozoic *** on these observations,the early Paleozoic evolutionary history of eastern GAOB can be divided into four stages:(1)before 540 Ma,the Erguna,Xing’an,Songnen,and Jiamusi blocks were discrete microcontinents separated by different branches of the Paleo-Asian Ocean;(2)540-523 Ma,the Jiamusi Block collided with the Songnen Block along the Mudanjiang suture;(3)ca.500 Ma,the Erguna Block accreted onto the Xing’an Block along the Xinlin-Xiguitu suture;(4)ca.480 Ma,the Paleo-Asian Ocean started a double-side subduction beneath the united Erguna-Xing’an and Songnen-Jiamusi blocks.

关键词： Early Paleozoic U–Pb geochronology Sr-Nd-Hf isotopes NE China Central Asian Orogenic Belt

Disparities in tree mortality among plant functional types(PFTs)in a temperate forest:Insights into size-dependent and PFT-specific patterns

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Forest Ecosystems 2024年第4期11卷 480-490页

作者： Man hu Hang Shi Rui he Bingbin Wen Haikun Liu Kerong Zhang Xiao shu Haishan Dang Quanfa Zhang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China Danjiangkou Wetland Ecosystem Field Scientific Observation and Research Station Chinese Academy of Sciences&Hubei ProvinceWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Forest&Nature Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 267Melle-Gontrode9090Belgium

Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains *** study analysed size-dependent tree mortality in a temperate forest,encompassing 46 tree species and 32,565 individuals across different PFTs(i.e.,evergreen conifer *** broadleaf species,shade-tolerant ***-intolerant species).By employing all-subset regression procedures and logistic generalized linear mixed-effects models,we identified distinct mortality patterns influenced by biotic and abiotic *** results showed a stable mortality patte rn in eve rgreen conifer species,contrasted by a declining pattern in deciduous broadleaf and shadetolerant,as well as shade-intolerant species,across size *** contribution to tree mortality of evergreen conifer species shifted from abiotic to biotic factors with increasing size,while the mortality of deciduous broadleaf species was mainly influenced by biotic factors,such as initial diameter at breast height(DBH)and conspecific negative *** shade-tolerant species,the mortality of small individuals was mainly determined by initial DBH and conspecific negative density dependence,whereas the mortality of large individuals was subjected to the combined effect of biotic(competition from neighbours)and abiotic factors(i.e.,convexity and pH).As for shade-intolerant species,competition from neighbours was found to be the main driver of tree mortality throughout their growth ***,these insights enhance our understanding of forest dynamics by revealing the size-dependent and PFT-specific tree mortality patterns,which may inform strategies for maintaining forest diversity and resilience in temperate forest ecosystems.

关键词： Size-dependent tree mortality Plant functional type Neighbourhood competition Topography variables Soil properties

Homeostasis of Synapses:Expansion During Wakefulness,Contraction During Sleep

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Neuroscience Bulletin 2017年第3期33卷 359-360页

作者： Chao he Zhian hu Department of Physiology Collaborative Innovation Centerfor Brain ScienceThird Military Medical UniversityChongqing 400038China

Sleep is a universal biological process occurring in almost every species of animal,and the loss of sleep has detrimental effects,especially impairments in cognition[1,2].Yet,the neuronal function of sleep is still on... 详细信息

关键词： synaptic neuronal homeostasis universal potentiation hypothesis cognition Homer shrinkage greatest

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Control of MSC Differentiation by Tuning the Alkyl Chain Length of Phe- nylboroinc Acid Based Low-molecular-weight Gelators

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Journal of Bionic Engineering 2018年第4期15卷 682-692页

作者： Jing he Yalong hu Fang Wu Bin he Wenxia Gao National Engineering Research Centre for Biomaterials Sichuan University Chengdu 610064 China College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325027 China

The physical environment plays a critical role in modulating stem cell differentiation into specific lineages. In this study, we designed and synthesized a series of low-molecular-weight gels （LMWGs） with different moduli based on phenylboronic acid derivatives. The moduli of the LMWGs were readily tuned by varying the alkyl chain without any chemical crosslinker. The cell responses to the gels were evaluated with mesenchymal stem cell （MSCs）, in respect of cell morphology, proliferation and differentiation. The prepared gels were non-toxic to MSCs, suggesting good biocompatibility. The hydrogel stiffness exerted a striking modulation effect on MSC fate decisions, where MSCs were inclined to differentiate into osteoblasts in stiff LMWGs and into chondrocytes in soft LMWGs. The pivotal elastic modulus of the LMWGs to drive MSC differentiation into osteoblastic lineage and chondrocytic lineage were approximately 20 kPa - 40 kPa and 1 kPa - 10 kPa, respectively. Overall, our results demonstrated that the modification ofhydrogel stiffness via tuning the alkyl chain was a simple but effective approach to regulate MSC differentiation into specific lineage, which might have important implications in the design of LMWGs for tissue engineering applications.

关键词： low-molecular-weight gels phenylboronic acid alkyl chain mesenchymal stem cell osteoblast differentiation chondrocytic differentiation

Hyperthyroidism-associated coronary spasm:A case of non-ST segment elevation myocardial infarction with thyrotoxicosis

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Journal of Geriatric Cardiology 2011年第4期8卷 258-259页

作者： Xiao-hu Kuang shu-Yang Zhang Chinese Academy of Medical Sciences&Peking Union Medical College&Peking Union Medical College Hospital Beijing 100730China Department of Cardiology Peking Union Medical College HospitalShuai Fu Yuan 1Beijing 100730China

Hyperthyroidism is associated with many heart *** state has a relationship with coronary *** present a case of a non-menopausal woman with hyperthyroidism who complained of chest *** diagnosis of coronary spasm was confirmed by coronary angiography(CAG).She is treated well with anti-thyrotoxicosis and anti-anginal *** recommend not use CAG as the first diagnostic choice among the patients with medication-uncontrolled hyperthyroidism and chest pain.

关键词： hyperthyroidism coronary spasm coronary angiography beta-blocker

The Domination of g-evaluations and Choquet Evaluations

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Acta Mathematica Sinica,English Series 2013年第5期29卷 1027-1032页

作者： Kun he Ming Shang hu Department of Mathematics Donghua University School of Mathematics Shandong University

In this paper, we obtain that a convex g evaluation can be dominated by the corresponding Choquet evaluation if and only if g has the form g（t, y, z） =uty ＋ h（t, z）, where h（t, z） is positively homogeneous and ... 详细信息

关键词： BSDEs g-expectations g-evaluations Choquet evaluations