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Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors

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Nuclear Science and Techniques 2024年第4期35卷 200-207页

作者： Lan-Kun Li Ming-Yi Dong Ze Gao Liang-Cheng-Long Jin shu-Jun zhao School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Particle Detection and Electronics(Institute of High Energy Physics CAS)Beijing 100049China University of Chinese Academy of Science Beijing 100049China University of South China Hengyang 421001China

In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance *** the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and *** study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam *** were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope *** simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be *** with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.

关键词： Silicon Pixel Detectors Beam Telescope Multiple Coulomb Scattering Spatial Resolution

The guest CH_(3)CN molecule triggers solid-state photochromism in a Cu_(2)I_(2)-based MOF for advanced time-dependent encryption and inkless erasable printing

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Chinese Chemical Letters 2024年第3期35卷 532-537页

作者： Meng-Juan Wang Bo Li Yong-Li Wei shu-Na zhao shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang 473061China

It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention ***,a 2D Cu_(2)I_(2)-based MOF with photoresponsive spiropyran(SP)groups orderly installed on its skeleton is *** structural isomerization from SP to colored merocyanine(MC)form can be triggered by removing the CH_(3)CN ***,the degree of structural isomerization and the retention time can be adjusted by controlling the amount of CH_(3)CN guests,exhibiting dynamic photochromic behavior with multicolor states and tunable retention *** on these advantages,time-dependent information encryption is successfully ***,the long retention time(>72 h)of the MC form under daylight conditions in the CH_(3)CN-removed Cu_(2)I_(2)-based MOF and good repeatability make it promising in various applications,such as temporary calendars,price-cards,billboards,and reusable identity *** work provides a novel design strategy to fabricate multi-functional MOF-based smart materials for challenging applications of time-dependent information encryption and inkless erasable printing.

关键词： Stimuli-responsive materials Spiropyran Solid-state photochromism Time-dependent encryption Inkless erasable printing

Mn-based cathode materials for rechargeable batteries

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Science China Chemistry 2024年第1期67卷 87-105页

作者： Xu Zhang Shiqi Liu Boya Wang Guoqing Wang Haozhe Du Xuanyu Wang Haidong Zhang shu zhao Lin Wang Haijun Yu Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Create Energy&Benefit Future Co.Ltd. Beijing 100176China

The rapid expansion of renewable energies asks for great progress of energy-storage technologies for sustainable energy supplies,which raises the compelling demand of high-performance rechargeable *** satisfy the huge demand from the coming energy-storage market,the resource and cost-effectiveness of rechargeable batteries become more and more ***(Mn)as a key transition element with advantages including high abundance,low cost,and low toxicity derives various kinds(spinels,layered oxides,polyanions,Prussian blue analogs,etc.)of high-performance Mn-based electrode materials,especially cathodes,for rechargeable batteries ranging from Li-ion batteries,Na-ion batteries,aqueous batteries,to multivalent metal-ion *** is anticipated that Mn-based materials with Mn as the major transition-metal element will constitute a flourishing family of Mn-based rechargeable batteries(Mn RBs)for large-scale and differentiated energy-storage *** the other hand,several critical issues including Jahn-Teller effect,Mn dissolution,and O release greatly hinder the pace of Mn RBs,which require extensive material optimizations and battery/system *** review aims to provide an investigation about Mn-based materials and batteries for the coming energy-storage demands,with compelling issues and challenges that must be overcome.

关键词： manganese cathode materials Mn-based rechargeable batteries energy storage

Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

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Signal Transduction and Targeted Therapy 2024年第1期9卷 40-43页

作者： Huili Chen Shengyang Fu Xiangyu Li Meng Shi Jiazhen Qian shu zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin C.Zheng Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of Medicine200065 ShanghaiChina Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine200434 ShanghaiChina

Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely ***,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4–6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4 Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4,7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4–6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question.

关键词： involvement inflammation media

Drp-1、PGC-1α在胎粪吸入综合征新生大鼠肺组织中的作用及其机制

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解放军医学杂志 2024年第3期49卷 265-271页

作者：徐洁莹赵淑华大理大学临床医学院云南大理白族自治州671000 大理大学第一附属医院儿科暨云南省儿科疾病临床医学分中心云南大理白族自治州671000

目的探讨动力相关蛋白1(Drp-1)、过氧化物酶体增殖物激活受体γ共激活因子1-α(PGC-1α)在胎粪吸入综合征(MAS)新生大鼠肺组织中的作用及其机制。方法50只2~3周龄SD新生大鼠随机分为5组(n=10):对照组、模型组与SN50低、中、高浓度组。... 详细信息

目的探讨动力相关蛋白1(Drp-1)、过氧化物酶体增殖物激活受体γ共激活因子1-α(PGC-1α)在胎粪吸入综合征(MAS)新生大鼠肺组织中的作用及其机制。方法50只2~3周龄SD新生大鼠随机分为5组(n=10):对照组、模型组与SN50低、中、高浓度组。对照组气管暴露后,气管内注入2ml/kg生理盐水,其余各组气管内注入2ml/kg的胎粪悬浮液;24h后对照组、模型组不予处理,SN50低、中、高浓度组腹腔注射10、30、60μg/ml浓度SN50各100μl。6h后处死各组大鼠,检测X线胸片、肺大体观、肺湿/干重比(W/D),HE染色观察肺组织病理变化,Westernblotting检测新生大鼠肺组织中NF-κB(p65)、p-NF-κBp65(p-p65)、Drp-1、PGC-1α蛋白的表达变化,免疫组织化学方法观察新生大鼠肺组织中p65、Drp-1、PGC-1α等相关蛋白表达。结果与对照组比较,模型组胸片及大体观可见炎性浸润,W/D、肺损伤病理评分明显升高(P0.05),而SN50中、高浓度组PGC-1α蛋白表达水平明显升高(P0.05)。免疫组化检测结果显示,与对照组比较,模型组p65、Drp-1蛋白表达水平明显升高(P0.05),而SN50中、高浓度组Drp-1蛋白表达水平明显降低(P<0.05),PGC-1α蛋白表达水平明显升高(P<0.05)。结论胎粪吸入可诱导新生大鼠肺组织炎症,其机制可能与增强氧化应激、促进线粒体功能障碍、激活Drp-1/NF-κB信号通路,以及抑制PGC-1α蛋白表达有关。

关键词：胎粪吸入综合征核因子-κB 氧化应激线粒体

“立法者并不总是法则的创作者”——对康德一个晦涩命题的三种理解

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湖北大学学报（哲学社会科学版） 2024年第3期51卷 1-11,178页

作者：舒远招湖南大学岳麓书院湖南长沙410082

“立法者是根据法则的责任的创作者,但并不总是法则的创作者”,这是康德在《道德形而上学》导论中提出的一个晦涩命题,学者们作出了很不相同的理解。埃里克·沃特金斯认为,康德主张上帝和人既是立法者,又是法则的创作者。这种理解是对... 详细信息

“立法者是根据法则的责任的创作者,但并不总是法则的创作者”,这是康德在《道德形而上学》导论中提出的一个晦涩命题,学者们作出了很不相同的理解。埃里克·沃特金斯认为,康德主张上帝和人既是立法者,又是法则的创作者。这种理解是对康德命题的明显误解,没有看出康德明确否定了上帝这位立法者同时是法则的创作者。刘凤娟认为,康德主张上帝和人的立法理性作为立法者并非法则的创作者,惟有执行理性的唯一立法、在特定情境中创作具体法则的自由意志(任意)才是法则的创作者。这种理解在很大程度上改变了康德命题的本来含义,没有看出康德命题主要是针对上帝这一立法者而提出来的,因而改变了在上帝的意志与人的理性之间的对比框架,在立法理性与执法意志的对比框架中把执行理性立法的意志当作法则的创作者。康德这一命题的本来含义应是,上帝这个立法者并非法则的创作者,我们自己的立法理性才是法则的创作者。这样理解,可以得到康德大量同主题文本的支持。康德把上帝视为立法者,表明他的立法者概念需要在其道德宗教中加以理解;他把我们自己的立法理性视为法则的创作者,则表明他在法则的创作者问题上坚持了启蒙思想原则。

关键词：康德道德法则立法者创作者上帝纯粹实践理性

核输出蛋白1抑制剂塞利尼索在淋巴瘤中的研究进展

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肿瘤学杂志 2024年第7期30卷 604-610页

作者：高诗琦赵曙哈尔滨医科大学附属肿瘤医院

核输出蛋白1(exportin 1,XPO1)是一种细胞中主要的核输出蛋白，负责大量蛋白质以及多种RNA由胞核到胞质的输出。XPO1在多种恶性肿瘤中过表达，并导致调节蛋白在细胞内分布不均、肿瘤细胞增殖失控。因此，靶向XPO1迅速成为多种癌症的一... 详细信息

核输出蛋白1(exportin 1,XPO1)是一种细胞中主要的核输出蛋白，负责大量蛋白质以及多种RNA由胞核到胞质的输出。XPO1在多种恶性肿瘤中过表达，并导致调节蛋白在细胞内分布不均、肿瘤细胞增殖失控。因此，靶向XPO1迅速成为多种癌症的一种潜在治疗方法。塞利尼索是全球首个上市的XPO1抑制剂，在多种实体瘤及血液恶性肿瘤中表现出优异的抗肿瘤活性，美国食品药品监督管理局已批准其用于复发性/难治性多发性骨髓瘤及弥漫大B细胞淋巴瘤的治疗。全文就塞利尼索在淋巴瘤中临床前研究和临床研究的应用进展进行综述。

关键词：选择性核输出蛋白抑制剂核输出蛋白1 塞利尼索淋巴瘤靶向治疗

基于尾灯灯语的混行交通流车辆驾驶意图识别模型研究

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重庆交通大学学报（自然科学版） 2024年第2期43卷 48-56页

作者：赵树恩赵东宇重庆交通大学机电与车辆工程学院重庆400074

针对长期存在自动驾驶车辆(autonomous vehicle,AV)与人工驾驶车辆(human-driven vehicle,HV)混行的交通现状,结合深度学习和HSV颜色特征提取方法,提出了一种在混行交通环境下基于尾灯灯语的车辆驾驶意图识别模型。以Mask R-CNN(mask re... 详细信息

针对长期存在自动驾驶车辆(autonomous vehicle,AV)与人工驾驶车辆(human-driven vehicle,HV)混行的交通现状,结合深度学习和HSV颜色特征提取方法,提出了一种在混行交通环境下基于尾灯灯语的车辆驾驶意图识别模型。以Mask R-CNN(mask region proposal convolutional neural network)车辆模型检测出的感兴趣区域RoI(region of interest)为限制,将区域内的HV作为研究对象,根据尾灯位置相关性,在HV车尾区域添加纵横向约束来定位传递灯语信号的左右尾灯;在规定的灯语组合及转向灯闪烁频率基础上,提出了一种基于时间序列的灯语识别算法,运用多目标判别相关性滤波CSRT(channel and spatial relatability tracking)跟踪HV尾灯并统计尾灯时序状态;以动态灯语作为输入,构建基于尾灯灯语的驾驶意图识别模型;使用基于真实路况信息的Cityspaces数据集和交通流视频数据对模型进行训练、验证和测试。研究结果表明:基于尾灯灯语的驾驶意图识别模型对视频流车辆尾灯检测准确率和召回率分别为96.0%、98.2%,对驾驶意图识别的平均准确率达到了95.9%,单帧识别耗时为20 ms,为高速混行环境下的AV决策规划提供了有效的理论依据。

关键词：交通工程驾驶意图识别灯语识别自动驾驶 Mask R-CNN 交互行为

基于模块度感知图自编码器的重叠社区发现模型

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清华大学学报（自然科学版） 2024年第8期64卷 1319-1329页

作者：陈洁刘斌斌赵姝张燕平安徽大学计算机科学与技术学院合肥230601 计算智能与信号处理教育部重点实验室(安徽大学) 合肥230601

图自编码器模型作为网络表示学习的代表性方法,在链路预测和节点分类任务方面性能表现优异。然而,图自编码器模型在处理社区发现任务时通常只考虑局部节点连边的重建而忽略了社区全局结构的影响,尤其是在多个社区存在重叠节点的情况下,... 详细信息

图自编码器模型作为网络表示学习的代表性方法,在链路预测和节点分类任务方面性能表现优异。然而,图自编码器模型在处理社区发现任务时通常只考虑局部节点连边的重建而忽略了社区全局结构的影响,尤其是在多个社区存在重叠节点的情况下,难以准确判断节点归属关系和社区分布。针对此问题,该文提出了一种面向重叠社区发现的无监督模块度感知图自编码器模型(modularity-aware graph autoencoder model for overlapping community detection,GAME),GAME采用一种高效的模块度损失函数,该函数在网络嵌入过程中保留社区关系的同时,能重构损失并更新编码器的参数,以提高模型针对重叠社区发现任务的性能,进而将GAME得到的社区隶属度矩阵以概率-节点形式进行社区分配。该文提出的GAME在10个公开数据集上进行实验验证,并与主流的基于表示学习的重叠社区发现模型进行对比。实验结果表明:在归一化互信息(normalized mutual information,NMI)评估指标下,GAME模型性能优于主流模型,证明该模型有效。

关键词：社区发现重叠社区图自编码器模块度最大化社区隶属度矩阵

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